In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-02-13

AUTHORS

Susan Callaghan, Mikhail A. Filatov, Huguette Savoie, Ross W. Boyle, Mathias O. Senge

ABSTRACT

The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13–BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad triplet states formed from charge-separated states is sufficient to induce cytotoxicity in human breast cancer cells (MDA-MB-468) at micromolar concentrations. The compounds in this series are promising candidates for photodynamic therapy, especially BAD-17 which displays significant photo-cytotoxicity (15% cell viability) at a concentration of 5 × 10−7 M, with minimal toxicity (89% cell viability) in the absence of light. More... »

PAGES

495-504

Identifiers

URI

http://scigraph.springernature.com/pub.10.1039/c8pp00402a

DOI

http://dx.doi.org/10.1039/c8pp00402a

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111365555

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30644946


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