Delayed release singlet oxygen sensitizers based on pyridone-appended porphyrins View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09-13

AUTHORS

Susan Callaghan, Mikhail A. Filatov, Elisabeth Sitte, Huguette Savoie, Ross W. Boyle, Keith J. Flanagan, Mathias O. Senge

ABSTRACT

A new type of porphyrin photosensitizer capable of generating singlet oxygen upon irradiation, storing it through binding to pyridone subunits, followed by slow release at 20–40 °C, is reported. The timescale of singlet oxygen release can be varied depending on the pyridone group substitution pattern, forming endoperoxides of different stabilities. Modified tetra- and octa-substituted pyridone-porphyrins showed solubility in water, allowing for straightforward delivery into cells. The effect of delayed singlet oxygen formation due to endoperoxide decomposition was demonstrated on cancer cells in vitro. More... »

PAGES

1371-1374

Identifiers

URI

http://scigraph.springernature.com/pub.10.1039/c7pp00244k

DOI

http://dx.doi.org/10.1039/c7pp00244k

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091286765

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28868558


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