Ontology type: schema:ScholarlyArticle Open Access: True
2017-09-13
AUTHORSSusan Callaghan, Mikhail A. Filatov, Elisabeth Sitte, Huguette Savoie, Ross W. Boyle, Keith J. Flanagan, Mathias O. Senge
ABSTRACTA new type of porphyrin photosensitizer capable of generating singlet oxygen upon irradiation, storing it through binding to pyridone subunits, followed by slow release at 20–40 °C, is reported. The timescale of singlet oxygen release can be varied depending on the pyridone group substitution pattern, forming endoperoxides of different stabilities. Modified tetra- and octa-substituted pyridone-porphyrins showed solubility in water, allowing for straightforward delivery into cells. The effect of delayed singlet oxygen formation due to endoperoxide decomposition was demonstrated on cancer cells in vitro. More... »
PAGES1371-1374
http://scigraph.springernature.com/pub.10.1039/c7pp00244k
DOIhttp://dx.doi.org/10.1039/c7pp00244k
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/28868558
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