Porphyrin-nanosensor conjugates. New tools for the measurement of intracellular response to reactive oxygen species View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-05-12

AUTHORS

Leanne B. Josefsen, Jonathan W. Aylott, Andrew Beeby, Philip Warburton, John P. Boyle, Chris Peers, Ross W. Boyle

ABSTRACT

Reactive oxygen species (ROS) have for some time been implicated in the onset and progression of medical conditions including cancer, ageing, heart disease and Alzheimer’s disease. Recently, it has been postulated that ROS play a much more subtle role in intracellular signalling mechanisms as second messengers. Given the importance of these species in influencing cellular processes, it is surprising that tools for studying intracellular levels of ROS are extremely limited and devices for studying the cells’ response to internally generated ROS are virtually non-existent. In order to study the response of cells to intracellular ROS we have designed a nano-scale device that can both generate ROS and simultaneously monitor the cells’ reaction as a function of changes in the important signalling ion, calcium. Here we report the synthesis, characterisation, and calibration of a new ROS nano- probe and demonstrate its ability to detect cellular response to elevated levels of intracellular ROS. More... »

PAGES

801-811

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1039/c0pp00004c

DOI

http://dx.doi.org/10.1039/c0pp00004c

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038024672

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20463998


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