The effects on human health from stratospheric ozone depletion and its interactions with climate change View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-01-25

AUTHORS

M. Norval, A. P. Cullen, F. R. de Gruijl, J. Longstreth, Y. Takizawa, R. M. Lucas, F. P. Noonan, J. C. van der Leun

ABSTRACT

Ozone depletion leads to an increase in the ultraviolet-B (UV-B) component (280-315 nm) of solar ultraviolet radiation (UVR) reaching the surface of the Earth with important consequences for human health. Solar UVR has many harmful and some beneficial effects on individuals and, in this review, information mainly published since the previous report in 2003 (F. R. de Gruijl, J. Longstreth, M. Norval, A. P. Cullen, H. Slaper, M. L. Kripke, Y. Takizawa and J. C. van der Leun, Photochem. Photobiol. Sci., 2003, 2, pp. 16-28) is discussed. The eye is exposed directly to sunlight and this can result in acute or long-term damage. Studying how UV-B interacts with the surface and internal structures of the eye has led to a further understanding of the location and pathogenesis of a number of ocular diseases, including pterygium and cataract. The skin is also exposed directly to solar UVR, and the development of skin cancer is the main adverse health outcome of excessive UVR exposure. Skin cancer is the most common form of malignancy amongst fair-skinned people, and its incidence has increased markedly in recent decades. Projections consistently indicate a further doubling in the next ten years. It is recognised that genetic factors in addition to those controlling pigment variation can modulate the response of an individual to UVR. Several of the genetic factors affecting susceptibility to the development of squamous cell carcinoma, basal cell carcinoma and melanoma have been identified. Exposure to solar UVR down-regulates immune responses, in the skin and systemically, by a combination of mechanisms including the generation of particularly potent subsets of T regulatory cells. Such immunosuppression is known to be a crucial factor in the generation of skin cancers. Apart from a detrimental effect on infections caused by some members of the herpesvirus and papillomavirus families, the impact of UV-induced immunosuppression on other microbial diseases and vaccination efficacy is not clear. One important beneficial effect of solar UV-B is its contribution to the cutaneous synthesis of vitamin D, recognised to be a crucial hormone for bone health and for other aspects of general health. There is accumulating evidence that UVR exposure, either directly or via stimulation of vitamin D production, has protective effects on the development of some autoimmune diseases, including multiple sclerosis and type 1 diabetes. Adequate vitamin D may also be protective for the development of several internal cancers and infections. Difficulties associated with balancing the positive effects of vitamin D with the negative effects of too much exposure to solar UV-B are considered. Various strategies that can be adopted by the individual to protect against excessive exposure of the eye or the skin to sunlight are suggested. Finally, possible interactions between ozone depletion and climate warming are outlined briefly, as well as how these might influence human behaviour with regard to sun exposure. More... »

PAGES

232-251

References to SciGraph publications

  • 2005-10-06. Sun exposure, sexual behavior and uterine cervical human papilloma virus in INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
  • 2005-08. BRAFE600-associated senescence-like cell cycle arrest of human naevi in NATURE
  • 2003. Health effects from stratospheric ozone depletion and interactions with climate change in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2005-03-21. Ultraviolet B radiation-induced immunosuppression: molecular mechanisms and cellular alterations in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2004-10-20. No association between three xeroderma pigmentosum group C and one group G gene polymorphisms and risk of cutaneous melanoma in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2000-09. Use of cod liver oil during pregnancy associated with lower risk of Type I diabetes in the offspring in DIABETOLOGIA
  • 2004-05-20. Variation of the enhanced biologically damaging solar UV due to clouds in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2003-05-19. Ultraviolet radiation and cutaneous malignant melanoma in ONCOGENE
  • 2004-07-15. Cloud cover and horizontal plane eye damaging solar UV exposures in INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
  • 2004-01-20. XPD gene polymorphism and host characteristics in the association with cutaneous malignant melanoma risk in BRITISH JOURNAL OF CANCER
  • 2004-04-06. Epidermodysplasia verruciformis human papillomavirus types and carcinoma of the conjunctiva: a pilot study in BRITISH JOURNAL OF CANCER
  • 2005-02-16. Teenage girls and elderly women living in northern Europe have low winter vitamin D status in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2005-11-17. Aged human skin removes UVB-induced pyrimidine dimers from the epidermis more slowly than younger adult skin in vivo in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 2005-03. The epidemiology of vitamin D and cancer incidence and mortality: A review (United States) in CANCER CAUSES & CONTROL
  • 2003-05. The herpes simplex virus type 1 ICP0 promoter is activated by viral reactivation stimuli in trigeminal ganglia neurons of transgenic mice in JOURNAL OF NEUROVIROLOGY
  • 1997-08-28. Molecular pathology in basal cell cancer with p53 as a genetic marker in ONCOGENE
  • 2004-09-21. Genetic variation in XRCC1, sun exposure, and risk of skin cancer in BRITISH JOURNAL OF CANCER
  • 2006-02-21. Comparison of risk patterns in carcinoma and melanoma of the skin in men: a multi-centre case–case–control study in BRITISH JOURNAL OF CANCER
  • 2005-06-28. Circulating leukocyte and cytokine responses to measles and poliovirus vaccination in children after ultraviolet radiation exposures in ARCHIVES OF VIROLOGY
  • 2002. The Changing Incidence and Mortality of Melanoma in Australia in CANCERS OF THE SKIN
  • 2002-09-18. Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs in ARCHIVES OF TOXICOLOGY
  • 2004-01-09. Genetic polymorphism of hOGG1 and risk of pterygium in Chinese in EYE
  • 2003-05-19. Human melanocyte senescence and melanoma susceptibility genes in ONCOGENE
  • 2006-02. Trends for in situ and Invasive Melanoma in Queensland, Australia, 1982–2002 in CANCER CAUSES & CONTROL
  • 1999-01. Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus in DIABETOLOGIA
  • 2005-03-07. Ultraviolet irradiation-induced K+ channel activity involving p53 activation in corneal epithelial cells in ONCOGENE
  • 2001-09-20. Neonatal sunburn and melanoma in mice in NATURE
  • 2001-07. Investigations on the liver toxicity of a blend of HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) and HCFC-124 (2-chloro-1,1,1,2-tetrafluoroethane) in guinea-pigs in ARCHIVES OF TOXICOLOGY
  • 2004-03-01. Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice in DIABETOLOGIA
  • 2005-06-15. Suppression of contact hypersensitivity after repeated exposures of humans to low doses of solar simulated radiation in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2002-05-07. Climate change and skin cancer in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2005-07-08. Cyclobutane pyrimidine dimer formation is a molecular trigger for solar-simulated ultraviolet radiation-induced suppression of memory immunity in humans in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2005-04-27. Allele variations in the OCA2 gene (pink-eyed-dilution locus) are associated with genetic susceptibility to melanoma in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2002-11-25. High frequency of BRAF mutations in nevi in NATURE GENETICS
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    URI

    http://scigraph.springernature.com/pub.10.1039/b700018a

    DOI

    http://dx.doi.org/10.1039/b700018a

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17344960


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