Applications of pharmacogenomics in regulatory science: a product life cycle review View Full Text


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Article Info

DATE

2018-05-22

AUTHORS

W C Tan-Koi, P C Leow, Y Y Teo

ABSTRACT

With rapid developments of pharmacogenomics (PGx) and regulatory science, it is important to understand the current PGx integration in product life cycle, impact on clinical practice thus far and opportunities ahead. We conducted a cross-sectional review on PGx-related regulatory documents and implementation guidelines in the United States and Europe. Our review found that although PGx-related guidance in both markets span across the entire product life cycle, the scope of implementation guidelines varies across two continents. Approximately one-third of Food and Drug Administration (FDA)-approved drugs with PGx information in drug labels and half of the European labels posted on PharmGKB website contain recommendations on genetic testing. The drugs affected 19 and 15 World Health Organization Anatomical Therapeutic Chemical drug classes (fourth level) in the United States and Europe, respectively, with protein kinase inhibitors (13 drugs in the United States and 16 drugs in Europe) being most prevalent. Topics of emerging interest were novel technologies, adaptive design in clinical trial and sample collection. More... »

PAGES

359

References to SciGraph publications

  • 2017-08. The current state of implementation science in genomic medicine: opportunities for improvement in GENETICS IN MEDICINE
  • 2004-08. Can the pharmaceutical industry reduce attrition rates? in NATURE REVIEWS DRUG DISCOVERY
  • 2012-09-05. Advancing the Science of Medicines Regulation: The Role of the 21st‐Century Medicines Regulator in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2013-05. Gatekeepers and Enablers: How Drug Regulators Respond to a Challenging and Changing Environment by Moving Toward a Proactive Attitude in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2017-03. Health regulatory communications of well-established safety-related pharmacogenomics associations in six developed countries: an evaluation of alignment in THE PHARMACOGENOMICS JOURNAL
  • 2004-04. Medical genetics: A marker for Stevens–Johnson syndrome in NATURE
  • 2014-08. Building pharmacogenetics into a pharmacovigilance program in Singapore: using serious skin rash as a pilot study in THE PHARMACOGENOMICS JOURNAL
  • 2015-06. Pharmacogenomic information in drug labels: European Medicines Agency perspective in THE PHARMACOGENOMICS JOURNAL
  • 2014-03. Next‐Generation Medicines: Past Regulatory Experience and Considerations for the Future in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2010-12. The clinical pharmacogeneticist: An emerging regulatory scientist at the US Food and Drug Administration in HUMAN GENOMICS
  • 2016-04. The genetics of drug efficacy: opportunities and challenges in NATURE REVIEWS GENETICS
  • 2011-02. Charting a course for genomic medicine from base pairs to bedside in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/tpj.2017.47

    DOI

    http://dx.doi.org/10.1038/tpj.2017.47

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29205206


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