Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03

AUTHORS

Amanda A Seyerle, Colleen M Sitlani, Raymond Noordam, Stephanie M Gogarten, Jin Li, Xiaohui Li, Daniel S Evans, Fangui Sun, Maarit A Laaksonen, Aaron Isaacs, Kati Kristiansson, Heather M Highland, James D Stewart, Tamara B Harris, Stella Trompet, Joshua C Bis, Gina M Peloso, Jennifer A Brody, Linda Broer, Evan L Busch, Qing Duan, Adrienne M Stilp, Christopher J O’Donnell, Peter W Macfarlane, James S Floyd, Jan A Kors, Henry J Lin, Ruifang Li-Gao, Tamar Sofer, Raúl Méndez-Giráldez, Steven R Cummings, Susan R Heckbert, Albert Hofman, Ian Ford, Yun Li, Lenore J Launer, Kimmo Porthan, Christopher Newton-Cheh, Melanie D Napier, Kathleen F Kerr, Alexander P Reiner, Kenneth M Rice, Jeffrey Roach, Brendan M Buckley, Elsayed Z Soliman, Renée de Mutsert, Nona Sotoodehnia, André G Uitterlinden, Kari E North, Craig R Lee, Vilmundur Gudnason, Til Stürmer, Frits R Rosendaal, Kent D Taylor, Kerri L Wiggins, James G Wilson, Yii-Der I Chen, Robert C Kaplan, Kirk Wilhelmsen, L Adrienne Cupples, Veikko Salomaa, Cornelia van Duijn, J Wouter Jukema, Yongmei Liu, Dennis O Mook-Kanamori, Leslie A Lange, Ramachandran S Vasan, Albert V Smith, Bruno H Stricker, Cathy C Laurie, Jerome I Rotter, Eric A Whitsel, Bruce M Psaty, Christy L Avery

ABSTRACT

Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict ventricular arrhythmias. We examined whether common single-nucleotide polymorphisms (SNPs) modified the association between thiazide use and QT or its component parts (QRS interval, JT interval) by performing ancestry-specific, trans-ethnic and cross-phenotype genome-wide analyses of European (66%), African American (15%) and Hispanic (19%) populations (N=78 199), leveraging longitudinal data, incorporating corrected standard errors to account for underestimation of interaction estimate variances and evaluating evidence for pathway enrichment. Although no loci achieved genome-wide significance (P<5 × 10-8), we found suggestive evidence (P<5 × 10-6) for SNPs modifying the thiazide-QT association at 22 loci, including ion transport loci (for example, NELL1, KCNQ3). The biologic plausibility of our suggestive results and simulations demonstrating modest power to detect interaction effects at genome-wide significant levels indicate that larger studies and innovative statistical methods are warranted in future efforts evaluating thiazide-SNP interactions. More... »

PAGES

215

References to SciGraph publications

  • 2014. Sources of Interindividual Variability in ENZYME KINETICS IN DRUG METABOLISM
  • 2014-06. Pharmacogenomics, ancestry and clinical decision making for global populations in THE PHARMACOGENOMICS JOURNAL
  • 2000-06. QT interval in twins in JOURNAL OF HUMAN HYPERTENSION
  • 2005-10. A haplotype map of the human genome in NATURE
  • 2014-04. Functional characterization of 32 CYP2C9 allelic variants in THE PHARMACOGENOMICS JOURNAL
  • 2010-04. Gene–environment-wide association studies: emerging approaches in NATURE REVIEWS GENETICS
  • 2015-02. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways in NATURE NEUROSCIENCE
  • 2009-05-29. PANTHER Pathway: An Ontology-Based Pathway Database Coupled with Data Analysis Tools in PROTEIN NETWORKS AND PATHWAY ANALYSIS
  • 2014-01. Gene–environment interactions in common mental disorders: an update and strategy for a genome-wide search in SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
  • 2003-12. The International HapMap Project in NATURE
  • 2015-08. Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics in SCIENTIFIC REPORTS
  • 2014-07. Selection bias in rheumatic disease research in NATURE REVIEWS RHEUMATOLOGY
  • 2011-12. Comparisons of seven algorithms for pathway analysis using the WTCCC Crohn's Disease dataset in BMC RESEARCH NOTES
  • 2015-11. Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval in HUMAN GENETICS
  • 2010-03-18. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C in NATURE
  • 2010-09. Integrating common and rare genetic variation in diverse human populations in NATURE
  • 2013-05. Pathway analysis of genome-wide data improves warfarin dose prediction in BMC GENOMICS
  • 2015-12. Biological interpretation of genome-wide association studies using predicted gene functions in NATURE COMMUNICATIONS
  • 2014-02. Drug–gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval in THE PHARMACOGENOMICS JOURNAL
  • 2014-02. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans in THE PHARMACOGENOMICS JOURNAL
  • 2010-10-28. A map of human genome variation from population-scale sequencing in NATURE
  • 2014-08. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization in NATURE GENETICS
  • 2005-04. Gene–environment interactions in human diseases in NATURE REVIEWS GENETICS
  • 2012-11. An integrated map of genetic variation from 1,092 human genomes in NATURE
  • 2013-06. Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression in THE PHARMACOGENOMICS JOURNAL
  • 2014-06. A partition-based approach to identify gene-environment interactions in genome wide association studies in BMC PROCEEDINGS
  • 2014. Methodological Issues Relevant to Observational Studies, Registries, and Administrative Health Databases in Rheumatology in UNDERSTANDING EVIDENCE-BASED RHEUMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/tpj.2017.10

    DOI

    http://dx.doi.org/10.1038/tpj.2017.10

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090745769

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28719597


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