Immunoglobulin G fragment C receptor polymorphisms and efficacy of preoperative chemotherapy plus trastuzumab and lapatinib in HER2-positive breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-10

AUTHORS

A Musolino, N Naldi, M V Dieci, D Zanoni, A Rimanti, D Boggiani, P Sgargi, D G Generali, F Piacentini, M Ambroggi, K Cagossi, L Gianni, S Sarti, G Bisagni, A Ardizzoni, P F Conte, V Guarneri

ABSTRACT

Lapatinib enhances antibody-dependent cell-mediated cytotoxicity (ADCC) activity of trastuzumab. FcγR polymorphisms have been associated with both ADCC and clinical activity of trastuzumab in HER2+ breast cancer (BC) patients (pts). We analyzed FcγRIIa-H131R and FcγRIIIa-V158F polymorphisms in the CHER-LOB trial population of HER2+ BCs treated with preoperative chemotherapy plus trastuzumab (arm A), lapatinib (arm B) or both (arm C). Genotyping was successfully performed in 73/121 (60%) pts. A significant improvement in pathological complete response (pCR) rate was observed for the combination arm C, but only in FcγRIIIa V allele carriers (C vs A, 67 vs 27%, P=0.043; C vs B, 67 vs 22%, P=0.012). An independent interaction between arm C and FcγRIIIa V allele was found for pCR (odds ratio=9.4; 95% confidence interval, 2.3-39.6; P=0.003). No significant associations were observed between pCR and FcγRIIa polymorphism, and between pre-treatment tumor-infiltrating lymphocytes and FcγR polymorphisms. Our study provides evidence for a FcγRIIIa V allele-restricted pCR benefit from neoadjuvant trastuzumab plus lapatinib in HER2+ BC. More... »

PAGES

472

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/tpj.2016.51

DOI

http://dx.doi.org/10.1038/tpj.2016.51

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021183880

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27378608


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