A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04

AUTHORS

A Julià, A Fernandez-Nebro, F Blanco, A Ortiz, J D Cañete, J Maymó, M Alperi-López, B Fernández-Gutierrez, A Olivè, H Corominas, A Erra, I Acosta-Colman, A Alonso, M López-Lasanta, R Tortosa, J Tornero, S Marsal

ABSTRACT

Anti-Tumor Necrosis Factor (anti-TNF) drugs are biologic agents commonly used to treat rheumatoid arthritis (RA). However, anti-TNFs are not effective in approximately one out of four treated patients. We conducted a Genome-Wide Association Study (GWAS) to identify the genetic variation associated with the response to anti-TNF therapy in RA. In the discovery stage, 372 RA patients treated with an anti-TNF agent (infliximab, adalimumab or etanercept) were analyzed and treatment response was defined at 12 weeks of therapy. We found a genome-wide significant association in the MED15 gene with the response to etanercept (P<1.5e-8). Using an independent cohort of 245 RA patients, we performed a replication study of the most significant GWAS associations. We replicated the association at the MED15 locus and found suggestive evidence of association in the previously associated MAFB locus. The results of this study suggest novel mechanisms associated with the response to anti-TNF therapies. More... »

PAGES

147

References to SciGraph publications

  • 2009-10. Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis in NATURE REVIEWS RHEUMATOLOGY
  • 2012-02. A linear complexity phasing method for thousands of genomes in NATURE METHODS
  • 2008-09. Genome-Wide Association Scan Identifies Candidate Polymorphisms Associated with Differential Response to Anti-TNF Treatment in Rheumatoid Arthritis in MOLECULAR MEDICINE
  • 2014-04. Lack of validation of genetic variants associated with anti–tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis in ARTHRITIS RESEARCH & THERAPY
  • 2012-11. An integrated map of genetic variation from 1,092 human genomes in NATURE
  • 2009-04. A census of human transcription factors: function, expression and evolution in NATURE REVIEWS GENETICS
  • 2002-08. A component of the ARC/Mediator complex required for TGFβ/Nodal signalling in NATURE
  • 2014-06. Genetic and epigenetic predictors of responsiveness to treatment in RA in NATURE REVIEWS RHEUMATOLOGY
  • 2003-12. Leukotrienes, mast cells, and T cells in ARTHRITIS RESEARCH & THERAPY
  • 2006-10. Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells in CELL DEATH & DIFFERENTIATION
  • 2014-02. Genetics of rheumatoid arthritis contributes to biology and drug discovery in NATURE
  • 2006-08. Principal components analysis corrects for stratification in genome-wide association studies in NATURE GENETICS
  • 1999-04. Composite co-activator ARC mediates chromatin-directed transcriptional activation in NATURE
  • 2003-05. Evolving concepts of rheumatoid arthritis in NATURE
  • 2002-03. CD69 expression on lymphocytes and interleukin-15 levels in synovial fluids from different inflammatory arthropathies in RHEUMATOLOGY INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/tpj.2015.31

    DOI

    http://dx.doi.org/10.1038/tpj.2015.31

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038303455

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25896534


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adalimumab", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antirheumatic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Arthritis, Rheumatoid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Etanercept", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Loci", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Markers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infliximab", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MafB Transcription Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mediator Complex", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Necrosis Factor-alpha", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Juli\u00e0", 
            "givenName": "A", 
            "id": "sg:person.01161723667.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161723667.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "UGC Reumatolog\u00eda, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Hospital Regional Universitario de M\u00e1laga, Universidad de M\u00e1laga, M\u00e1laga, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fernandez-Nebro", 
            "givenName": "A", 
            "id": "sg:person.01033344335.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033344335.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Complexo Hospitalario Universitario A Coru\u00f1a", 
              "id": "https://www.grid.ac/institutes/grid.411066.4", 
              "name": [
                "Rheumatology Service, INIBIC-Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blanco", 
            "givenName": "F", 
            "id": "sg:person.015462555100.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015462555100.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitario de La Princesa", 
              "id": "https://www.grid.ac/institutes/grid.411251.2", 
              "name": [
                "Rheumatology Service, Hospital Universitario La Princesa, IIS Princesa, IIS La Princesa, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ortiz", 
            "givenName": "A", 
            "id": "sg:person.0645337302.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645337302.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Clinic of Barcelona", 
              "id": "https://www.grid.ac/institutes/grid.410458.c", 
              "name": [
                "Rheumatology Service, Hospital Cl\u00ednic de Barcelona, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ca\u00f1ete", 
            "givenName": "J D", 
            "id": "sg:person.01023454562.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023454562.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Del Mar", 
              "id": "https://www.grid.ac/institutes/grid.411142.3", 
              "name": [
                "Rheumatology Service, Hospital del Mar, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maym\u00f3", 
            "givenName": "J", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Central University Hospital of Asturias", 
              "id": "https://www.grid.ac/institutes/grid.411052.3", 
              "name": [
                "Rheumatology Service, Hospital Universitario Central de Asturias, Oviedo, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alperi-L\u00f3pez", 
            "givenName": "M", 
            "id": "sg:person.0610337763.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610337763.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Cl\u00ednico San Carlos", 
              "id": "https://www.grid.ac/institutes/grid.411068.a", 
              "name": [
                "Rheumatology Service, Hospital Cl\u00ednico San Carlos, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fern\u00e1ndez-Gutierrez", 
            "givenName": "B", 
            "id": "sg:person.01340605322.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340605322.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Germans Trias i Pujol", 
              "id": "https://www.grid.ac/institutes/grid.411438.b", 
              "name": [
                "Rheumatology Service, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oliv\u00e8", 
            "givenName": "A", 
            "id": "sg:person.01236051413.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236051413.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Rheumatology Service, Hospital Mois\u00e8s Broggi, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Corominas", 
            "givenName": "H", 
            "id": "sg:person.0752713423.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752713423.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Rheumatology Service, Hospital Sant Rafael, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Erra", 
            "givenName": "A", 
            "id": "sg:person.0605426502.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605426502.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Acosta-Colman", 
            "givenName": "I", 
            "id": "sg:person.01134516457.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134516457.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alonso", 
            "givenName": "A", 
            "id": "sg:person.01220115153.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220115153.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00f3pez-Lasanta", 
            "givenName": "M", 
            "id": "sg:person.01324540635.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324540635.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tortosa", 
            "givenName": "R", 
            "id": "sg:person.01347302327.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347302327.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitario de Guadalajara", 
              "id": "https://www.grid.ac/institutes/grid.411098.5", 
              "name": [
                "Rheumatology Service, Hospital Universitario De Guadalajara, Guadalajara, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tornero", 
            "givenName": "J", 
            "id": "sg:person.01054353227.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054353227.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marsal", 
            "givenName": "S", 
            "id": "sg:person.01234751326.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234751326.82"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature11632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000661742", 
              "https://doi.org/10.1038/nature11632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002640757", 
              "https://doi.org/10.1038/nmeth.1785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2012-302865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007350640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2007.084715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009203282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016323211", 
              "https://doi.org/10.1038/sj.cdd.4401860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016323211", 
              "https://doi.org/10.1038/sj.cdd.4401860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0068822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017132914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/19789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017329847", 
              "https://doi.org/10.1038/19789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/19789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017329847", 
              "https://doi.org/10.1038/19789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrrheum.2014.16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017706548", 
              "https://doi.org/10.1038/nrrheum.2014.16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017780577", 
              "https://doi.org/10.1038/nature01661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017780577", 
              "https://doi.org/10.1038/nature01661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/519795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019061180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.30130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019357350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020213501", 
              "https://doi.org/10.1038/nature00969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020213501", 
              "https://doi.org/10.1038/nature00969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0007556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021736217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00296-001-0161-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021974965", 
              "https://doi.org/10.1007/s00296-001-0161-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.1780310302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021989941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrrheum.2009.181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022815403", 
              "https://doi.org/10.1038/nrrheum.2009.181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrrheum.2009.181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022815403", 
              "https://doi.org/10.1038/nrrheum.2009.181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.30176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025115121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs.13.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028336195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.37921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029221861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar4504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030946883", 
              "https://doi.org/10.1186/ar4504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031429813", 
              "https://doi.org/10.1038/ng1847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031429813", 
              "https://doi.org/10.1038/ng1847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036490983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043116196", 
              "https://doi.org/10.1038/nature12873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043446290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1003394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044720120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar1017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045509539", 
              "https://doi.org/10.1186/ar1017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2008.092932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046657277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047820135", 
              "https://doi.org/10.1038/nrg2538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047820135", 
              "https://doi.org/10.1038/nrg2538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2012-202405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048869521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/mpd.2001.118534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052362598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20011565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053348954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e3283544043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060341054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e3283544043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060341054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e3283544043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060341054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/2008-00056.liu", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068965089", 
              "https://doi.org/10.2119/2008-00056.liu"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/2008-00056.liu", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068965089", 
              "https://doi.org/10.2119/2008-00056.liu"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1568026611313060005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069194615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077137737", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-04", 
        "datePublishedReg": "2016-04-01", 
        "description": "Anti-Tumor Necrosis Factor (anti-TNF) drugs are biologic agents commonly used to treat rheumatoid arthritis (RA). However, anti-TNFs are not effective in approximately one out of four treated patients. We conducted a Genome-Wide Association Study (GWAS) to identify the genetic variation associated with the response to anti-TNF therapy in RA. In the discovery stage, 372 RA patients treated with an anti-TNF agent (infliximab, adalimumab or etanercept) were analyzed and treatment response was defined at 12 weeks of therapy. We found a genome-wide significant association in the MED15 gene with the response to etanercept (P<1.5e-8). Using an independent cohort of 245 RA patients, we performed a replication study of the most significant GWAS associations. We replicated the association at the MED15 locus and found suggestive evidence of association in the previously associated MAFB locus. The results of this study suggest novel mechanisms associated with the response to anti-TNF therapies. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/tpj.2015.31", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1027238", 
            "issn": [
              "1470-269X", 
              "1473-1150"
            ], 
            "name": "The Pharmacogenomics Journal", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "name": "A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis", 
        "pagination": "147", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b676bdb1673ad73996feeb2e8e0bf5f7d3f3a61bba55f4df626ab0761b42968f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25896534"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101083949"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/tpj.2015.31"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1038303455"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/tpj.2015.31", 
          "https://app.dimensions.ai/details/publication/pub.1038303455"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T18:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/tpj201531"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/tpj.2015.31'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/tpj.2015.31'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/tpj.2015.31'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/tpj.2015.31'


     

    This table displays all metadata directly associated to this object as RDF triples.

    409 TRIPLES      21 PREDICATES      82 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/tpj.2015.31 schema:about N0673c4c80c4c454786c117a66fa8d557
    2 N30e1160cab554407aafcfb18b478b164
    3 N3ce8cd8c89294a1b8fc03f59719ee9b9
    4 N5050e11daabc4ed9967f3106391e0d73
    5 N7be6a355569a4790b41e492ab3f90b19
    6 N947a0ef3400445029cf72a75c32c1e85
    7 N9cc828a8070141af9aa12dcd5f79acc1
    8 N9f25d6d9d5494dacb2a24c45c597d95f
    9 Na35de9b53a224f7686a11556f5c687b2
    10 Nab6b4a27aed846f6a4ef8e84df1b357c
    11 Nc0cbd424b6cc408089783c0754040c5f
    12 Nc9c16bf912f94ce78d123d1bbe5a53ab
    13 Ncb7622f6d63543a3a93501b7ea800293
    14 Ne35ec5c9bc9a424089c9434b61621fc1
    15 Ne92e4e2a410c42ca9a03b4bf73a1a9a6
    16 Nebc6bbf6ceba42eab3a9e0aa51f3c5b5
    17 Nf6959382dca34559b1f292ff88061917
    18 anzsrc-for:06
    19 anzsrc-for:0604
    20 schema:author Nf1564d1aa3984ac69750b3d53f4fc05f
    21 schema:citation sg:pub.10.1007/s00296-001-0161-z
    22 sg:pub.10.1038/19789
    23 sg:pub.10.1038/nature00969
    24 sg:pub.10.1038/nature01661
    25 sg:pub.10.1038/nature11632
    26 sg:pub.10.1038/nature12873
    27 sg:pub.10.1038/ng1847
    28 sg:pub.10.1038/nmeth.1785
    29 sg:pub.10.1038/nrg2538
    30 sg:pub.10.1038/nrrheum.2009.181
    31 sg:pub.10.1038/nrrheum.2014.16
    32 sg:pub.10.1038/sj.cdd.4401860
    33 sg:pub.10.1186/ar1017
    34 sg:pub.10.1186/ar4504
    35 sg:pub.10.2119/2008-00056.liu
    36 https://app.dimensions.ai/details/publication/pub.1077137737
    37 https://doi.org/10.1002/art.1780310302
    38 https://doi.org/10.1002/art.30130
    39 https://doi.org/10.1002/art.30176
    40 https://doi.org/10.1002/art.37921
    41 https://doi.org/10.1067/mpd.2001.118534
    42 https://doi.org/10.1084/jem.20011565
    43 https://doi.org/10.1086/519795
    44 https://doi.org/10.1093/bioinformatics/btq419
    45 https://doi.org/10.1097/fpc.0000000000000042
    46 https://doi.org/10.1097/fpc.0b013e3283544043
    47 https://doi.org/10.1136/annrheumdis-2012-202405
    48 https://doi.org/10.1136/ard.2007.084715
    49 https://doi.org/10.1136/ard.2008.092932
    50 https://doi.org/10.1136/gutjnl-2012-302865
    51 https://doi.org/10.1371/journal.pgen.1000529
    52 https://doi.org/10.1371/journal.pgen.1003394
    53 https://doi.org/10.1371/journal.pone.0007556
    54 https://doi.org/10.1371/journal.pone.0068822
    55 https://doi.org/10.2174/1568026611313060005
    56 https://doi.org/10.2217/pgs.13.60
    57 schema:datePublished 2016-04
    58 schema:datePublishedReg 2016-04-01
    59 schema:description Anti-Tumor Necrosis Factor (anti-TNF) drugs are biologic agents commonly used to treat rheumatoid arthritis (RA). However, anti-TNFs are not effective in approximately one out of four treated patients. We conducted a Genome-Wide Association Study (GWAS) to identify the genetic variation associated with the response to anti-TNF therapy in RA. In the discovery stage, 372 RA patients treated with an anti-TNF agent (infliximab, adalimumab or etanercept) were analyzed and treatment response was defined at 12 weeks of therapy. We found a genome-wide significant association in the MED15 gene with the response to etanercept (P<1.5e-8). Using an independent cohort of 245 RA patients, we performed a replication study of the most significant GWAS associations. We replicated the association at the MED15 locus and found suggestive evidence of association in the previously associated MAFB locus. The results of this study suggest novel mechanisms associated with the response to anti-TNF therapies.
    60 schema:genre research_article
    61 schema:inLanguage en
    62 schema:isAccessibleForFree false
    63 schema:isPartOf N9a91d762788b43739ecb5789fb0335dd
    64 Neb842ccfb3e24990b738f5f84a715001
    65 sg:journal.1027238
    66 schema:name A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis
    67 schema:pagination 147
    68 schema:productId N31b6308b4b3c47f8af1ee627de3e4ff6
    69 N5b1d5107e8a141e1bff31366e62585db
    70 Nb6e94047ce61470f8413815d9423c5ca
    71 Neda58bebe5f14bf68de5087d6d097d88
    72 Nf214a8ed6fd0440fb13937f546e4f8c8
    73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038303455
    74 https://doi.org/10.1038/tpj.2015.31
    75 schema:sdDatePublished 2019-04-10T18:08
    76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    77 schema:sdPublisher N0acabca6fea74770ac5f6f9ae6a16540
    78 schema:url https://www.nature.com/articles/tpj201531
    79 sgo:license sg:explorer/license/
    80 sgo:sdDataset articles
    81 rdf:type schema:ScholarlyArticle
    82 N0673c4c80c4c454786c117a66fa8d557 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Genetic Loci
    84 rdf:type schema:DefinedTerm
    85 N0acabca6fea74770ac5f6f9ae6a16540 schema:name Springer Nature - SN SciGraph project
    86 rdf:type schema:Organization
    87 N15b864cbae2d4a03b1cbfa7748188b63 schema:name Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain
    88 rdf:type schema:Organization
    89 N1ad7309913794786b7f0c33a4b95f76d schema:affiliation https://www.grid.ac/institutes/grid.411142.3
    90 schema:familyName Maymó
    91 schema:givenName J
    92 rdf:type schema:Person
    93 N30e1160cab554407aafcfb18b478b164 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Polymorphism, Single Nucleotide
    95 rdf:type schema:DefinedTerm
    96 N31b6308b4b3c47f8af1ee627de3e4ff6 schema:name pubmed_id
    97 schema:value 25896534
    98 rdf:type schema:PropertyValue
    99 N368993b684d342a2957911f34946604d rdf:first sg:person.01033344335.94
    100 rdf:rest N73030e4e47c94beea62aacc3945903ac
    101 N3ce8cd8c89294a1b8fc03f59719ee9b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Genetic Markers
    103 rdf:type schema:DefinedTerm
    104 N3da06ecf271d4cb696b347d927ca0d73 schema:name Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain
    105 rdf:type schema:Organization
    106 N496599d7db134ef7ab62c86592ae3137 rdf:first sg:person.01220115153.13
    107 rdf:rest N6960868255d34677825b9fc1e3b02649
    108 N5050e11daabc4ed9967f3106391e0d73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Adult
    110 rdf:type schema:DefinedTerm
    111 N55b084de6f974fe6a6584b5baf5fed94 schema:name Rheumatology Service, Hospital Moisès Broggi, Barcelona, Spain
    112 rdf:type schema:Organization
    113 N5b1d5107e8a141e1bff31366e62585db schema:name nlm_unique_id
    114 schema:value 101083949
    115 rdf:type schema:PropertyValue
    116 N6960868255d34677825b9fc1e3b02649 rdf:first sg:person.01324540635.79
    117 rdf:rest Nc81ceb5b5b8a46208336b37bc3a86113
    118 N73030e4e47c94beea62aacc3945903ac rdf:first sg:person.015462555100.41
    119 rdf:rest Nf7b2804523e347039ac3c0fe9bdf04f6
    120 N7be6a355569a4790b41e492ab3f90b19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Tumor Necrosis Factor-alpha
    122 rdf:type schema:DefinedTerm
    123 N7cccc80a6d0a429da6e99cec8dfe3604 schema:name Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain
    124 rdf:type schema:Organization
    125 N85049bc62d28428ca32fe46ab3fc503f rdf:first sg:person.0610337763.75
    126 rdf:rest N9ce51d3fd93f478282fc8351b81f8669
    127 N8e2883f2080a4823bf35c7efcb7c8e17 rdf:first sg:person.01236051413.36
    128 rdf:rest Nff088b27551e43819166d10446c6a26f
    129 N947a0ef3400445029cf72a75c32c1e85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Middle Aged
    131 rdf:type schema:DefinedTerm
    132 N9a91d762788b43739ecb5789fb0335dd schema:issueNumber 2
    133 rdf:type schema:PublicationIssue
    134 N9cc828a8070141af9aa12dcd5f79acc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Genome-Wide Association Study
    136 rdf:type schema:DefinedTerm
    137 N9ce51d3fd93f478282fc8351b81f8669 rdf:first sg:person.01340605322.18
    138 rdf:rest N8e2883f2080a4823bf35c7efcb7c8e17
    139 N9d74463e23af435687db2112d0f4a4ff rdf:first N1ad7309913794786b7f0c33a4b95f76d
    140 rdf:rest N85049bc62d28428ca32fe46ab3fc503f
    141 N9f25d6d9d5494dacb2a24c45c597d95f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Etanercept
    143 rdf:type schema:DefinedTerm
    144 Na35de9b53a224f7686a11556f5c687b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name MafB Transcription Factor
    146 rdf:type schema:DefinedTerm
    147 Na6e5f9d5df014c28b62491a346a27d45 schema:name Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain
    148 rdf:type schema:Organization
    149 Nab6b4a27aed846f6a4ef8e84df1b357c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Mediator Complex
    151 rdf:type schema:DefinedTerm
    152 Nb6e94047ce61470f8413815d9423c5ca schema:name readcube_id
    153 schema:value b676bdb1673ad73996feeb2e8e0bf5f7d3f3a61bba55f4df626ab0761b42968f
    154 rdf:type schema:PropertyValue
    155 Nc0cbd424b6cc408089783c0754040c5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Arthritis, Rheumatoid
    157 rdf:type schema:DefinedTerm
    158 Nc5d249b258fe4f2a98d4b9cb8fcd887b schema:name Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain
    159 rdf:type schema:Organization
    160 Nc62ca73de3a34528abaee8f7814b5ac9 rdf:first sg:person.0605426502.55
    161 rdf:rest Ne3c0191918184e98b596cbcc6d81e473
    162 Nc81ceb5b5b8a46208336b37bc3a86113 rdf:first sg:person.01347302327.41
    163 rdf:rest Nde5e87571b094e2d9035960bec913802
    164 Nc9c16bf912f94ce78d123d1bbe5a53ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Humans
    166 rdf:type schema:DefinedTerm
    167 Ncb7622f6d63543a3a93501b7ea800293 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Infliximab
    169 rdf:type schema:DefinedTerm
    170 Nde5e87571b094e2d9035960bec913802 rdf:first sg:person.01054353227.22
    171 rdf:rest Nf703930f2d1e4cb2838c4b657d484106
    172 Ne35ec5c9bc9a424089c9434b61621fc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Antirheumatic Agents
    174 rdf:type schema:DefinedTerm
    175 Ne3c0191918184e98b596cbcc6d81e473 rdf:first sg:person.01134516457.79
    176 rdf:rest N496599d7db134ef7ab62c86592ae3137
    177 Ne3c394374be948b68c14c380cd2c0f35 schema:name Rheumatology Service, Hospital Sant Rafael, Barcelona, Spain
    178 rdf:type schema:Organization
    179 Ne92e4e2a410c42ca9a03b4bf73a1a9a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Adalimumab
    181 rdf:type schema:DefinedTerm
    182 Neb435e46550d4ec59666950ea8795a04 rdf:first sg:person.01023454562.06
    183 rdf:rest N9d74463e23af435687db2112d0f4a4ff
    184 Neb842ccfb3e24990b738f5f84a715001 schema:volumeNumber 16
    185 rdf:type schema:PublicationVolume
    186 Nebc6bbf6ceba42eab3a9e0aa51f3c5b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Male
    188 rdf:type schema:DefinedTerm
    189 Neda58bebe5f14bf68de5087d6d097d88 schema:name doi
    190 schema:value 10.1038/tpj.2015.31
    191 rdf:type schema:PropertyValue
    192 Nf1564d1aa3984ac69750b3d53f4fc05f rdf:first sg:person.01161723667.17
    193 rdf:rest N368993b684d342a2957911f34946604d
    194 Nf214a8ed6fd0440fb13937f546e4f8c8 schema:name dimensions_id
    195 schema:value pub.1038303455
    196 rdf:type schema:PropertyValue
    197 Nf430cdb1d4cb4b53a5216dbf3bb53bcd schema:name UGC Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain
    198 rdf:type schema:Organization
    199 Nf6959382dca34559b1f292ff88061917 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Female
    201 rdf:type schema:DefinedTerm
    202 Nf703930f2d1e4cb2838c4b657d484106 rdf:first sg:person.01234751326.82
    203 rdf:rest rdf:nil
    204 Nf7b2804523e347039ac3c0fe9bdf04f6 rdf:first sg:person.0645337302.32
    205 rdf:rest Neb435e46550d4ec59666950ea8795a04
    206 Nfc4e196d507743818e3e622edf6602e4 schema:name Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain
    207 rdf:type schema:Organization
    208 Nff088b27551e43819166d10446c6a26f rdf:first sg:person.0752713423.42
    209 rdf:rest Nc62ca73de3a34528abaee8f7814b5ac9
    210 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    211 schema:name Biological Sciences
    212 rdf:type schema:DefinedTerm
    213 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    214 schema:name Genetics
    215 rdf:type schema:DefinedTerm
    216 sg:journal.1027238 schema:issn 1470-269X
    217 1473-1150
    218 schema:name The Pharmacogenomics Journal
    219 rdf:type schema:Periodical
    220 sg:person.01023454562.06 schema:affiliation https://www.grid.ac/institutes/grid.410458.c
    221 schema:familyName Cañete
    222 schema:givenName J D
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023454562.06
    224 rdf:type schema:Person
    225 sg:person.01033344335.94 schema:affiliation Nf430cdb1d4cb4b53a5216dbf3bb53bcd
    226 schema:familyName Fernandez-Nebro
    227 schema:givenName A
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033344335.94
    229 rdf:type schema:Person
    230 sg:person.01054353227.22 schema:affiliation https://www.grid.ac/institutes/grid.411098.5
    231 schema:familyName Tornero
    232 schema:givenName J
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054353227.22
    234 rdf:type schema:Person
    235 sg:person.01134516457.79 schema:affiliation Na6e5f9d5df014c28b62491a346a27d45
    236 schema:familyName Acosta-Colman
    237 schema:givenName I
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134516457.79
    239 rdf:type schema:Person
    240 sg:person.01161723667.17 schema:affiliation Nc5d249b258fe4f2a98d4b9cb8fcd887b
    241 schema:familyName Julià
    242 schema:givenName A
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161723667.17
    244 rdf:type schema:Person
    245 sg:person.01220115153.13 schema:affiliation Nfc4e196d507743818e3e622edf6602e4
    246 schema:familyName Alonso
    247 schema:givenName A
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220115153.13
    249 rdf:type schema:Person
    250 sg:person.01234751326.82 schema:affiliation N7cccc80a6d0a429da6e99cec8dfe3604
    251 schema:familyName Marsal
    252 schema:givenName S
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234751326.82
    254 rdf:type schema:Person
    255 sg:person.01236051413.36 schema:affiliation https://www.grid.ac/institutes/grid.411438.b
    256 schema:familyName Olivè
    257 schema:givenName A
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236051413.36
    259 rdf:type schema:Person
    260 sg:person.01324540635.79 schema:affiliation N15b864cbae2d4a03b1cbfa7748188b63
    261 schema:familyName López-Lasanta
    262 schema:givenName M
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324540635.79
    264 rdf:type schema:Person
    265 sg:person.01340605322.18 schema:affiliation https://www.grid.ac/institutes/grid.411068.a
    266 schema:familyName Fernández-Gutierrez
    267 schema:givenName B
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340605322.18
    269 rdf:type schema:Person
    270 sg:person.01347302327.41 schema:affiliation N3da06ecf271d4cb696b347d927ca0d73
    271 schema:familyName Tortosa
    272 schema:givenName R
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347302327.41
    274 rdf:type schema:Person
    275 sg:person.015462555100.41 schema:affiliation https://www.grid.ac/institutes/grid.411066.4
    276 schema:familyName Blanco
    277 schema:givenName F
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015462555100.41
    279 rdf:type schema:Person
    280 sg:person.0605426502.55 schema:affiliation Ne3c394374be948b68c14c380cd2c0f35
    281 schema:familyName Erra
    282 schema:givenName A
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605426502.55
    284 rdf:type schema:Person
    285 sg:person.0610337763.75 schema:affiliation https://www.grid.ac/institutes/grid.411052.3
    286 schema:familyName Alperi-López
    287 schema:givenName M
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610337763.75
    289 rdf:type schema:Person
    290 sg:person.0645337302.32 schema:affiliation https://www.grid.ac/institutes/grid.411251.2
    291 schema:familyName Ortiz
    292 schema:givenName A
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645337302.32
    294 rdf:type schema:Person
    295 sg:person.0752713423.42 schema:affiliation N55b084de6f974fe6a6584b5baf5fed94
    296 schema:familyName Corominas
    297 schema:givenName H
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752713423.42
    299 rdf:type schema:Person
    300 sg:pub.10.1007/s00296-001-0161-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1021974965
    301 https://doi.org/10.1007/s00296-001-0161-z
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/19789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017329847
    304 https://doi.org/10.1038/19789
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/nature00969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020213501
    307 https://doi.org/10.1038/nature00969
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/nature01661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017780577
    310 https://doi.org/10.1038/nature01661
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/nature11632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000661742
    313 https://doi.org/10.1038/nature11632
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/nature12873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043116196
    316 https://doi.org/10.1038/nature12873
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/ng1847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031429813
    319 https://doi.org/10.1038/ng1847
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/nmeth.1785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002640757
    322 https://doi.org/10.1038/nmeth.1785
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/nrg2538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047820135
    325 https://doi.org/10.1038/nrg2538
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nrrheum.2009.181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022815403
    328 https://doi.org/10.1038/nrrheum.2009.181
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nrrheum.2014.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017706548
    331 https://doi.org/10.1038/nrrheum.2014.16
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/sj.cdd.4401860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016323211
    334 https://doi.org/10.1038/sj.cdd.4401860
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1186/ar1017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045509539
    337 https://doi.org/10.1186/ar1017
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1186/ar4504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030946883
    340 https://doi.org/10.1186/ar4504
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.2119/2008-00056.liu schema:sameAs https://app.dimensions.ai/details/publication/pub.1068965089
    343 https://doi.org/10.2119/2008-00056.liu
    344 rdf:type schema:CreativeWork
    345 https://app.dimensions.ai/details/publication/pub.1077137737 schema:CreativeWork
    346 https://doi.org/10.1002/art.1780310302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021989941
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1002/art.30130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019357350
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1002/art.30176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025115121
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1002/art.37921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029221861
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1067/mpd.2001.118534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052362598
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1084/jem.20011565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053348954
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1093/bioinformatics/btq419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036490983
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1097/fpc.0000000000000042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340259
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1097/fpc.0b013e3283544043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060341054
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1136/annrheumdis-2012-202405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048869521
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1136/ard.2007.084715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009203282
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1136/ard.2008.092932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046657277
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1136/gutjnl-2012-302865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007350640
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1371/journal.pgen.1000529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043446290
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1371/journal.pgen.1003394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044720120
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1371/journal.pone.0007556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021736217
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1371/journal.pone.0068822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017132914
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.2174/1568026611313060005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069194615
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.2217/pgs.13.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028336195
    385 rdf:type schema:CreativeWork
    386 https://www.grid.ac/institutes/grid.410458.c schema:alternateName Hospital Clinic of Barcelona
    387 schema:name Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain
    388 rdf:type schema:Organization
    389 https://www.grid.ac/institutes/grid.411052.3 schema:alternateName Central University Hospital of Asturias
    390 schema:name Rheumatology Service, Hospital Universitario Central de Asturias, Oviedo, Spain
    391 rdf:type schema:Organization
    392 https://www.grid.ac/institutes/grid.411066.4 schema:alternateName Complexo Hospitalario Universitario A Coruña
    393 schema:name Rheumatology Service, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
    394 rdf:type schema:Organization
    395 https://www.grid.ac/institutes/grid.411068.a schema:alternateName Hospital Clínico San Carlos
    396 schema:name Rheumatology Service, Hospital Clínico San Carlos, Madrid, Spain
    397 rdf:type schema:Organization
    398 https://www.grid.ac/institutes/grid.411098.5 schema:alternateName Hospital Universitario de Guadalajara
    399 schema:name Rheumatology Service, Hospital Universitario De Guadalajara, Guadalajara, Spain
    400 rdf:type schema:Organization
    401 https://www.grid.ac/institutes/grid.411142.3 schema:alternateName Hospital Del Mar
    402 schema:name Rheumatology Service, Hospital del Mar, Barcelona, Spain
    403 rdf:type schema:Organization
    404 https://www.grid.ac/institutes/grid.411251.2 schema:alternateName Hospital Universitario de La Princesa
    405 schema:name Rheumatology Service, Hospital Universitario La Princesa, IIS Princesa, IIS La Princesa, Madrid, Spain
    406 rdf:type schema:Organization
    407 https://www.grid.ac/institutes/grid.411438.b schema:alternateName Hospital Universitari Germans Trias i Pujol
    408 schema:name Rheumatology Service, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
    409 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...