Association of the PDE3A-SLCO1C1 locus with the response to anti-TNF agents in psoriasis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-08

AUTHORS

A Julià, C Ferrándiz, E Dauden, E Fonseca, E Fernández-López, J L Sanchez-Carazo, F Vanaclocha, L Puig, D Moreno-Ramírez, J L Lopez-Estebaranz, E Herrera, P de la Cueva, G Ávila, A Alonso, R Tortosa, M López-Lasanta, S Marsal

ABSTRACT

Psoriasis is a prevalent autoimmune disease of the skin that causes significant psychological and physical disability. Tumor necrosis factor (TNF)-blocking agents have proven to be highly efficacious in the management of moderate-to-severe psoriasis. However, a significant percentage of patients do not respond to this treatment. Recently, variation at the PDE3A-SLCO1C1 (phosphodiesterase 3A-SoLute Carrier Organic anion transporter family member 1C1) locus has been robustly associated with anti-TNF response in rheumatoid arthritis. Using a cohort of 130 psoriasis patients treated with anti-TNF therapy, we sought to analyze the association of this locus with treatment response in psoriasis. We found a highly significant association between PDE3A-SLCO1C1 and the clinical response to TNF blockers (P=0.0031). Importantly, the allele that was previously associated with the lack of response to rheumatoid arthritis (G allele, single-nucleotide polymorphism rs3794271) was associated with a higher anti-TNF efficacy in psoriasis. The results of this study are an important step in the characterization of the pharmacogenetic profile associated with anti-TNF response in psoriasis. More... »

PAGES

322

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/tpj.2014.71

    DOI

    http://dx.doi.org/10.1038/tpj.2014.71

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049103251

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25403996


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