Pharmacogenomic diversity in Singaporean populations and Europeans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

L R Brunham, S L Chan, R Li, F Aminkeng, X Liu, W Y Saw, R T H Ong, E N Pillai, B C Carleton, D Toh, S H Tan, S H Koo, E J D Lee, K S Chia, C J D Ross, M R Hayden, C Sung, Y Y Teo

ABSTRACT

Differences in the frequency of pharmacogenomic variants may influence inter-population variability in drug efficacy and risk of adverse drug reactions (ADRs). We investigated the diversity of ∼ 4500 genetic variants in key drug-biotransformation and -response genes among three South East Asian populations compared with individuals of European ancestry. We compared rates of reported ADRs in these Asian populations to determine if the allelic differentiation corresponded to an excess of the associated ADR. We identified an excess of ADRs related to clopidogrel in Singaporean Chinese, consistent with a higher frequency of a known risk variant in CYP2C19 in that population. We also observed an excess of ADRs related to platinum compounds in Singaporean CHS, despite a very low frequency of known ADR risk variants, suggesting the presence of additional genetic and non-genetic risk factors. Our results point to substantial diversity at specific pharmacogenomic loci that may contribute to inter-population variability in drug response phenotypes. More... »

PAGES

555

References to SciGraph publications

  • 2006-03. Interethnic variability of warfarin maintenance requirement is explained by VKORC1 genotype in an Asian population in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2014-04. Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent in THE PHARMACOGENOMICS JOURNAL
  • 2008-09. The Role of Ethnicity in Variability in Response to Drugs: Focus on Clinical Pharmacology Studies in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2005-07. Evaluation of inhibitory drug interactions during drug development: Genetic polymorphisms must be considered in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2009-12. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy in NATURE GENETICS
  • 2014-06. Pharmacogenomics, ancestry and clinical decision making for global populations in THE PHARMACOGENOMICS JOURNAL
  • 2004-06. Evaluation of the Extent of Under-Reporting of Serious Adverse Drug Reactions in DRUG SAFETY
  • 2011-03. Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2013-08. Replication of TPMT and ABCC3 Genetic Variants Highly Associated With Cisplatin‐Induced Hearing Loss in Children in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2011-08. Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450–2C19 (CYP2C19) Genotype and Clopidogrel Therapy in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2008-01. Trends in the globalization of clinical trials in NATURE REVIEWS DRUG DISCOVERY
  • 2012-06. Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin in THE PHARMACOGENOMICS JOURNAL
  • 2008-01. Postmenopausal Hormone Therapy for Disease Prevention: Have We Learned Any Lessons from the Past? in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2001-10. Islands of linkage disequilibrium in NATURE GENETICS
  • 2008-04. PXR, CAR and HNF4α genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients in THE PHARMACOGENOMICS JOURNAL
  • 2009-08. ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2003-12. The International HapMap Project in NATURE
  • 2009-09. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance in NATURE
  • 2013-10. Can population differences in chemotherapy outcomes be inferred from differences in pharmacogenetic frequencies? in THE PHARMACOGENOMICS JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/tpj.2014.22

    DOI

    http://dx.doi.org/10.1038/tpj.2014.22

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004392163

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24861855


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biotransformation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug-Related Side Effects and Adverse Reactions", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Europe", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Variation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Singapore", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "1] Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore [2] Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore [3] Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brunham", 
            "givenName": "L R", 
            "id": "sg:person.0732607452.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732607452.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Agency for Science, Technology and Research", 
              "id": "https://www.grid.ac/institutes/grid.185448.4", 
              "name": [
                "Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chan", 
            "givenName": "S L", 
            "id": "sg:person.012455721572.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012455721572.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Saw Swee Hock School of Public Health, National University of Singapore, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "R", 
            "id": "sg:person.01112307164.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112307164.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aminkeng", 
            "givenName": "F", 
            "id": "sg:person.01055652326.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055652326.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "1] Saw Swee Hock School of Public Health, National University of Singapore, Singapore [2] NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "X", 
            "id": "sg:person.01013600010.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013600010.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Saw Swee Hock School of Public Health, National University of Singapore, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saw", 
            "givenName": "W Y", 
            "id": "sg:person.01354642310.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354642310.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Saw Swee Hock School of Public Health, National University of Singapore, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ong", 
            "givenName": "R T H", 
            "id": "sg:person.014764433702.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014764433702.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Saw Swee Hock School of Public Health, National University of Singapore, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pillai", 
            "givenName": "E N", 
            "id": "sg:person.01046716554.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046716554.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "1] Division of Translational Therapeutics, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada [2] Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, BC, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carleton", 
            "givenName": "B C", 
            "id": "sg:person.01156220406.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156220406.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Health Sciences Authority", 
              "id": "https://www.grid.ac/institutes/grid.413898.f", 
              "name": [
                "Health Sciences Authority, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Toh", 
            "givenName": "D", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Health Sciences Authority", 
              "id": "https://www.grid.ac/institutes/grid.413898.f", 
              "name": [
                "Health Sciences Authority, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tan", 
            "givenName": "S H", 
            "id": "sg:person.07507631617.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07507631617.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Department of Pharmacology, National University of Singapore, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koo", 
            "givenName": "S H", 
            "id": "sg:person.01145365525.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145365525.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Department of Pharmacology, National University of Singapore, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "E J D", 
            "id": "sg:person.012230224034.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012230224034.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "1] Saw Swee Hock School of Public Health, National University of Singapore, Singapore [2] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden [3] Center for Molecular Epidemiology, National University of Singapore, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chia", 
            "givenName": "K S", 
            "id": "sg:person.0577621642.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577621642.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "1] Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada [2] Division of Translational Therapeutics, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ross", 
            "givenName": "C J D", 
            "id": "sg:person.012716326517.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012716326517.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "1] Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore [2] Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hayden", 
            "givenName": "M R", 
            "id": "sg:person.07441112742.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07441112742.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke NUS Graduate Medical School", 
              "id": "https://www.grid.ac/institutes/grid.428397.3", 
              "name": [
                "1] Health Sciences Authority, Singapore [2] Duke-NUS Graduate Medical School, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sung", 
            "givenName": "C", 
            "id": "sg:person.0654122750.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654122750.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "1] Saw Swee Hock School of Public Health, National University of Singapore, Singapore [2] NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore [3] Life Sciences Institute, National University of Singapore, Singapore [4] Department of Statistics and Applied Probability, National University of Singapore, Singapore."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Teo", 
            "givenName": "Y Y", 
            "id": "sg:person.01260753642.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260753642.13"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ajhg.2011.01.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001408750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bth457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008081196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pds.1772", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008338383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pds.1772", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008338383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.tpj.6500478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008451861", 
              "https://doi.org/10.1038/sj.tpj.6500478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2012.26", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010042706", 
              "https://doi.org/10.1038/tpj.2012.26"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs.11.93", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011936657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0801936", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012310134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.clpt.2005.04.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012705372", 
              "https://doi.org/10.1016/j.clpt.2005.04.006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.2009.79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013151888", 
              "https://doi.org/10.1038/clpt.2009.79"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014622763", 
              "https://doi.org/10.1038/ng.478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014622763", 
              "https://doi.org/10.1038/ng.478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.2011.132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015105946", 
              "https://doi.org/10.1038/clpt.2011.132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2010.92", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015420139", 
              "https://doi.org/10.1038/tpj.2010.92"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2009.09.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016066893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.clpt.6100428", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017022753", 
              "https://doi.org/10.1038/sj.clpt.6100428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/91.23.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018329842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs.10.79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019047875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019337542", 
              "https://doi.org/10.1038/nature08309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019337542", 
              "https://doi.org/10.1038/nature08309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0091270009355161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019633702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs.12.104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020478277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.2013.80", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020692663", 
              "https://doi.org/10.1038/clpt.2013.80"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2008.07.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022906755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2013.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022961085", 
              "https://doi.org/10.1038/tpj.2013.24"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2013.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022961085", 
              "https://doi.org/10.1038/tpj.2013.24"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2013.04.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023037248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.2008.141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024517567", 
              "https://doi.org/10.1038/clpt.2008.141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2009.04.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029111661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.095000.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029664825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-08-0411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029718634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bcp.12021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031665934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs.12.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032177481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0360-3016(96)00302-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033464897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033654326", 
              "https://doi.org/10.1038/nature02168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033654326", 
              "https://doi.org/10.1038/nature02168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1001-109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035145457", 
              "https://doi.org/10.1038/ng1001-109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1001-109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035145457", 
              "https://doi.org/10.1038/ng1001-109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.2010.320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036623071", 
              "https://doi.org/10.1038/clpt.2010.320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdg118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037272645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-12-255992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039088452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2013.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045090325", 
              "https://doi.org/10.1038/tpj.2013.13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2013.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045090325", 
              "https://doi.org/10.1038/tpj.2013.13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00002018-200427070-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046928977", 
              "https://doi.org/10.2165/00002018-200427070-00004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00002018-200427070-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046928977", 
              "https://doi.org/10.2165/00002018-200427070-00004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.clpt.2005.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052415761", 
              "https://doi.org/10.1016/j.clpt.2005.11.006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052671339", 
              "https://doi.org/10.1038/nrd2441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2008.04.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053514177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/381000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058673096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e328301a869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e328301a869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e328301a869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e328301a869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e3283396c4e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e3283396c4e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e3283396c4e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e3283396c4e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e31826aac73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e31826aac73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e31826aac73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064357227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078460104", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-12", 
        "datePublishedReg": "2014-12-01", 
        "description": "Differences in the frequency of pharmacogenomic variants may influence inter-population variability in drug efficacy and risk of adverse drug reactions (ADRs). We investigated the diversity of \u223c 4500 genetic variants in key drug-biotransformation and -response genes among three South East Asian populations compared with individuals of European ancestry. We compared rates of reported ADRs in these Asian populations to determine if the allelic differentiation corresponded to an excess of the associated ADR. We identified an excess of ADRs related to clopidogrel in Singaporean Chinese, consistent with a higher frequency of a known risk variant in CYP2C19 in that population. We also observed an excess of ADRs related to platinum compounds in Singaporean CHS, despite a very low frequency of known ADR risk variants, suggesting the presence of additional genetic and non-genetic risk factors. Our results point to substantial diversity at specific pharmacogenomic loci that may contribute to inter-population variability in drug response phenotypes.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/tpj.2014.22", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1027238", 
            "issn": [
              "1470-269X", 
              "1473-1150"
            ], 
            "name": "The Pharmacogenomics Journal", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "14"
          }
        ], 
        "name": "Pharmacogenomic diversity in Singaporean populations and Europeans", 
        "pagination": "555", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "14ed8af4dae1ad7a21646ad8ef2f1385d4fb84667d55f35caa30d2a4a5cdfc3c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24861855"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101083949"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/tpj.2014.22"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1004392163"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/tpj.2014.22", 
          "https://app.dimensions.ai/details/publication/pub.1004392163"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000436.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/tpj201422"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/tpj.2014.22'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/tpj.2014.22'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/tpj.2014.22'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/tpj.2014.22'


     

    This table displays all metadata directly associated to this object as RDF triples.

    384 TRIPLES      21 PREDICATES      80 URIs      27 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/tpj.2014.22 schema:about N0ead69009e5740dc8413e26479733d9f
    2 N21b4cc1554144bc5b150463842e6c31d
    3 N31efa45e671d453f964fa2cc5c2b3cc7
    4 N4c343b4ee6524f72a7dba4e07b385423
    5 N7ae567185ce84638a25b62b6fe47213a
    6 Nc45f70ad5e954b1e873f839e9f399b27
    7 anzsrc-for:06
    8 anzsrc-for:0604
    9 schema:author Nc73e35b74dc14f1ebb5bd1319faaee85
    10 schema:citation sg:pub.10.1016/j.clpt.2005.04.006
    11 sg:pub.10.1016/j.clpt.2005.11.006
    12 sg:pub.10.1038/clpt.2008.141
    13 sg:pub.10.1038/clpt.2009.79
    14 sg:pub.10.1038/clpt.2010.320
    15 sg:pub.10.1038/clpt.2011.132
    16 sg:pub.10.1038/clpt.2013.80
    17 sg:pub.10.1038/nature02168
    18 sg:pub.10.1038/nature08309
    19 sg:pub.10.1038/ng.478
    20 sg:pub.10.1038/ng1001-109
    21 sg:pub.10.1038/nrd2441
    22 sg:pub.10.1038/sj.clpt.6100428
    23 sg:pub.10.1038/sj.tpj.6500478
    24 sg:pub.10.1038/tpj.2010.92
    25 sg:pub.10.1038/tpj.2012.26
    26 sg:pub.10.1038/tpj.2013.13
    27 sg:pub.10.1038/tpj.2013.24
    28 sg:pub.10.2165/00002018-200427070-00004
    29 https://app.dimensions.ai/details/publication/pub.1078460104
    30 https://doi.org/10.1002/pds.1772
    31 https://doi.org/10.1016/j.ajhg.2011.01.010
    32 https://doi.org/10.1016/j.ajhg.2013.04.021
    33 https://doi.org/10.1016/j.ijrobp.2008.07.034
    34 https://doi.org/10.1016/j.ijrobp.2009.09.031
    35 https://doi.org/10.1016/j.jacc.2009.04.053
    36 https://doi.org/10.1016/j.lungcan.2008.04.010
    37 https://doi.org/10.1016/s0360-3016(96)00302-1
    38 https://doi.org/10.1056/nejmoa0801936
    39 https://doi.org/10.1086/381000
    40 https://doi.org/10.1093/annonc/mdg118
    41 https://doi.org/10.1093/bioinformatics/bth457
    42 https://doi.org/10.1093/jnci/91.23.2001
    43 https://doi.org/10.1097/fpc.0b013e328301a869
    44 https://doi.org/10.1097/fpc.0b013e3283396c4e
    45 https://doi.org/10.1101/gr.095000.109
    46 https://doi.org/10.1111/bcp.12021
    47 https://doi.org/10.1158/1078-0432.ccr-08-0411
    48 https://doi.org/10.1177/0091270009355161
    49 https://doi.org/10.1182/blood-2009-12-255992
    50 https://doi.org/10.1212/wnl.0b013e31826aac73
    51 https://doi.org/10.2217/pgs.10.79
    52 https://doi.org/10.2217/pgs.11.93
    53 https://doi.org/10.2217/pgs.12.104
    54 https://doi.org/10.2217/pgs.12.24
    55 schema:datePublished 2014-12
    56 schema:datePublishedReg 2014-12-01
    57 schema:description Differences in the frequency of pharmacogenomic variants may influence inter-population variability in drug efficacy and risk of adverse drug reactions (ADRs). We investigated the diversity of ∼ 4500 genetic variants in key drug-biotransformation and -response genes among three South East Asian populations compared with individuals of European ancestry. We compared rates of reported ADRs in these Asian populations to determine if the allelic differentiation corresponded to an excess of the associated ADR. We identified an excess of ADRs related to clopidogrel in Singaporean Chinese, consistent with a higher frequency of a known risk variant in CYP2C19 in that population. We also observed an excess of ADRs related to platinum compounds in Singaporean CHS, despite a very low frequency of known ADR risk variants, suggesting the presence of additional genetic and non-genetic risk factors. Our results point to substantial diversity at specific pharmacogenomic loci that may contribute to inter-population variability in drug response phenotypes.
    58 schema:genre research_article
    59 schema:inLanguage en
    60 schema:isAccessibleForFree true
    61 schema:isPartOf N3770a59268904d879636984bd81b2e87
    62 Ne86035c71bd34ebcad948c55ccfcf5b7
    63 sg:journal.1027238
    64 schema:name Pharmacogenomic diversity in Singaporean populations and Europeans
    65 schema:pagination 555
    66 schema:productId N2fc3efbecfc8479d807620df33192883
    67 N5f6c1f9157274bf9a3f2d53ef91e4e78
    68 Na1a0f57cd94843768fe3763a25ec0374
    69 Ndbbd4eb31f524113bc4e5e697d9e5d4d
    70 Nef0ae662fc1f4ed59ecb69250c850f97
    71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004392163
    72 https://doi.org/10.1038/tpj.2014.22
    73 schema:sdDatePublished 2019-04-10T13:57
    74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    75 schema:sdPublisher Nafa615c7848d4219bd78968e3364b447
    76 schema:url https://www.nature.com/articles/tpj201422
    77 sgo:license sg:explorer/license/
    78 sgo:sdDataset articles
    79 rdf:type schema:ScholarlyArticle
    80 N0a8560bae65240b9ba54d042fe1f901c rdf:first sg:person.01112307164.37
    81 rdf:rest Ne96f9ce5baeb4b95971b04ac77d679bd
    82 N0ead69009e5740dc8413e26479733d9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Biotransformation
    84 rdf:type schema:DefinedTerm
    85 N21b4cc1554144bc5b150463842e6c31d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Europe
    87 rdf:type schema:DefinedTerm
    88 N2fc3efbecfc8479d807620df33192883 schema:name readcube_id
    89 schema:value 14ed8af4dae1ad7a21646ad8ef2f1385d4fb84667d55f35caa30d2a4a5cdfc3c
    90 rdf:type schema:PropertyValue
    91 N3071b4bc2ee04d599c69c722757a88c6 rdf:first sg:person.012230224034.79
    92 rdf:rest Nc5c5c224fbe047ec8cf4d22647f844d1
    93 N31efa45e671d453f964fa2cc5c2b3cc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Singapore
    95 rdf:type schema:DefinedTerm
    96 N3770a59268904d879636984bd81b2e87 schema:volumeNumber 14
    97 rdf:type schema:PublicationVolume
    98 N4153ce5a7c414d469389fe917d1e40d0 rdf:first sg:person.01354642310.31
    99 rdf:rest N7e39d56df7d844f9885f5f90b75626c1
    100 N446430df348140648951618b929ed913 rdf:first sg:person.01260753642.13
    101 rdf:rest rdf:nil
    102 N4c343b4ee6524f72a7dba4e07b385423 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Genetic Variation
    104 rdf:type schema:DefinedTerm
    105 N5f6c1f9157274bf9a3f2d53ef91e4e78 schema:name dimensions_id
    106 schema:value pub.1004392163
    107 rdf:type schema:PropertyValue
    108 N646d0305bf4d417b98b8b0e3840ed4ab rdf:first sg:person.01046716554.37
    109 rdf:rest N8e661ced8dd04cad98c6b2bdc5b0905d
    110 N7ae567185ce84638a25b62b6fe47213a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Drug-Related Side Effects and Adverse Reactions
    112 rdf:type schema:DefinedTerm
    113 N7e39d56df7d844f9885f5f90b75626c1 rdf:first sg:person.014764433702.46
    114 rdf:rest N646d0305bf4d417b98b8b0e3840ed4ab
    115 N8406cfb03a0c4c998518a8b5177cff71 rdf:first sg:person.01145365525.48
    116 rdf:rest N3071b4bc2ee04d599c69c722757a88c6
    117 N8e661ced8dd04cad98c6b2bdc5b0905d rdf:first sg:person.01156220406.25
    118 rdf:rest Nb5dbdec6749544cfb80a607564a5342d
    119 Na1a0f57cd94843768fe3763a25ec0374 schema:name pubmed_id
    120 schema:value 24861855
    121 rdf:type schema:PropertyValue
    122 Na770a2c622a747b2b24b2da7893b0257 rdf:first sg:person.012455721572.74
    123 rdf:rest N0a8560bae65240b9ba54d042fe1f901c
    124 Nafa615c7848d4219bd78968e3364b447 schema:name Springer Nature - SN SciGraph project
    125 rdf:type schema:Organization
    126 Nb387d26ea3f5437392619aa95df4a7d4 rdf:first sg:person.07507631617.45
    127 rdf:rest N8406cfb03a0c4c998518a8b5177cff71
    128 Nb5dbdec6749544cfb80a607564a5342d rdf:first Nd7cc3437b7b344ba8326a4790b188f60
    129 rdf:rest Nb387d26ea3f5437392619aa95df4a7d4
    130 Nb9cba1b53f564d969453fe53b97d8526 rdf:first sg:person.07441112742.03
    131 rdf:rest Nfbfbf7edc5394933ab0de0207a85cd06
    132 Nc1a47b09434d43639ab3e1fe9d22bd04 rdf:first sg:person.01013600010.49
    133 rdf:rest N4153ce5a7c414d469389fe917d1e40d0
    134 Nc2359d20d8e74fbeb23b0a786da6a555 rdf:first sg:person.012716326517.51
    135 rdf:rest Nb9cba1b53f564d969453fe53b97d8526
    136 Nc45f70ad5e954b1e873f839e9f399b27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Humans
    138 rdf:type schema:DefinedTerm
    139 Nc5c5c224fbe047ec8cf4d22647f844d1 rdf:first sg:person.0577621642.83
    140 rdf:rest Nc2359d20d8e74fbeb23b0a786da6a555
    141 Nc73e35b74dc14f1ebb5bd1319faaee85 rdf:first sg:person.0732607452.33
    142 rdf:rest Na770a2c622a747b2b24b2da7893b0257
    143 Nd7cc3437b7b344ba8326a4790b188f60 schema:affiliation https://www.grid.ac/institutes/grid.413898.f
    144 schema:familyName Toh
    145 schema:givenName D
    146 rdf:type schema:Person
    147 Ndbbd4eb31f524113bc4e5e697d9e5d4d schema:name nlm_unique_id
    148 schema:value 101083949
    149 rdf:type schema:PropertyValue
    150 Ne86035c71bd34ebcad948c55ccfcf5b7 schema:issueNumber 6
    151 rdf:type schema:PublicationIssue
    152 Ne96f9ce5baeb4b95971b04ac77d679bd rdf:first sg:person.01055652326.52
    153 rdf:rest Nc1a47b09434d43639ab3e1fe9d22bd04
    154 Nef0ae662fc1f4ed59ecb69250c850f97 schema:name doi
    155 schema:value 10.1038/tpj.2014.22
    156 rdf:type schema:PropertyValue
    157 Nfbfbf7edc5394933ab0de0207a85cd06 rdf:first sg:person.0654122750.87
    158 rdf:rest N446430df348140648951618b929ed913
    159 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Biological Sciences
    161 rdf:type schema:DefinedTerm
    162 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    163 schema:name Genetics
    164 rdf:type schema:DefinedTerm
    165 sg:journal.1027238 schema:issn 1470-269X
    166 1473-1150
    167 schema:name The Pharmacogenomics Journal
    168 rdf:type schema:Periodical
    169 sg:person.01013600010.49 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    170 schema:familyName Liu
    171 schema:givenName X
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013600010.49
    173 rdf:type schema:Person
    174 sg:person.01046716554.37 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    175 schema:familyName Pillai
    176 schema:givenName E N
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046716554.37
    178 rdf:type schema:Person
    179 sg:person.01055652326.52 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    180 schema:familyName Aminkeng
    181 schema:givenName F
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055652326.52
    183 rdf:type schema:Person
    184 sg:person.01112307164.37 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    185 schema:familyName Li
    186 schema:givenName R
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112307164.37
    188 rdf:type schema:Person
    189 sg:person.01145365525.48 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    190 schema:familyName Koo
    191 schema:givenName S H
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145365525.48
    193 rdf:type schema:Person
    194 sg:person.01156220406.25 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    195 schema:familyName Carleton
    196 schema:givenName B C
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156220406.25
    198 rdf:type schema:Person
    199 sg:person.012230224034.79 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    200 schema:familyName Lee
    201 schema:givenName E J D
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012230224034.79
    203 rdf:type schema:Person
    204 sg:person.012455721572.74 schema:affiliation https://www.grid.ac/institutes/grid.185448.4
    205 schema:familyName Chan
    206 schema:givenName S L
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012455721572.74
    208 rdf:type schema:Person
    209 sg:person.01260753642.13 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    210 schema:familyName Teo
    211 schema:givenName Y Y
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260753642.13
    213 rdf:type schema:Person
    214 sg:person.012716326517.51 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    215 schema:familyName Ross
    216 schema:givenName C J D
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012716326517.51
    218 rdf:type schema:Person
    219 sg:person.01354642310.31 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    220 schema:familyName Saw
    221 schema:givenName W Y
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354642310.31
    223 rdf:type schema:Person
    224 sg:person.014764433702.46 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    225 schema:familyName Ong
    226 schema:givenName R T H
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014764433702.46
    228 rdf:type schema:Person
    229 sg:person.0577621642.83 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    230 schema:familyName Chia
    231 schema:givenName K S
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577621642.83
    233 rdf:type schema:Person
    234 sg:person.0654122750.87 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
    235 schema:familyName Sung
    236 schema:givenName C
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654122750.87
    238 rdf:type schema:Person
    239 sg:person.0732607452.33 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    240 schema:familyName Brunham
    241 schema:givenName L R
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732607452.33
    243 rdf:type schema:Person
    244 sg:person.07441112742.03 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    245 schema:familyName Hayden
    246 schema:givenName M R
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07441112742.03
    248 rdf:type schema:Person
    249 sg:person.07507631617.45 schema:affiliation https://www.grid.ac/institutes/grid.413898.f
    250 schema:familyName Tan
    251 schema:givenName S H
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07507631617.45
    253 rdf:type schema:Person
    254 sg:pub.10.1016/j.clpt.2005.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012705372
    255 https://doi.org/10.1016/j.clpt.2005.04.006
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1016/j.clpt.2005.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052415761
    258 https://doi.org/10.1016/j.clpt.2005.11.006
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/clpt.2008.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024517567
    261 https://doi.org/10.1038/clpt.2008.141
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/clpt.2009.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013151888
    264 https://doi.org/10.1038/clpt.2009.79
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/clpt.2010.320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036623071
    267 https://doi.org/10.1038/clpt.2010.320
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/clpt.2011.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015105946
    270 https://doi.org/10.1038/clpt.2011.132
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/clpt.2013.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020692663
    273 https://doi.org/10.1038/clpt.2013.80
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nature02168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033654326
    276 https://doi.org/10.1038/nature02168
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nature08309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019337542
    279 https://doi.org/10.1038/nature08309
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/ng.478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014622763
    282 https://doi.org/10.1038/ng.478
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/ng1001-109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035145457
    285 https://doi.org/10.1038/ng1001-109
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nrd2441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052671339
    288 https://doi.org/10.1038/nrd2441
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/sj.clpt.6100428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017022753
    291 https://doi.org/10.1038/sj.clpt.6100428
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/sj.tpj.6500478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008451861
    294 https://doi.org/10.1038/sj.tpj.6500478
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/tpj.2010.92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015420139
    297 https://doi.org/10.1038/tpj.2010.92
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/tpj.2012.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010042706
    300 https://doi.org/10.1038/tpj.2012.26
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/tpj.2013.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045090325
    303 https://doi.org/10.1038/tpj.2013.13
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/tpj.2013.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022961085
    306 https://doi.org/10.1038/tpj.2013.24
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.2165/00002018-200427070-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046928977
    309 https://doi.org/10.2165/00002018-200427070-00004
    310 rdf:type schema:CreativeWork
    311 https://app.dimensions.ai/details/publication/pub.1078460104 schema:CreativeWork
    312 https://doi.org/10.1002/pds.1772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008338383
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.ajhg.2011.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001408750
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.ajhg.2013.04.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023037248
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/j.ijrobp.2008.07.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022906755
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/j.ijrobp.2009.09.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016066893
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/j.jacc.2009.04.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029111661
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/j.lungcan.2008.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053514177
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/s0360-3016(96)00302-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033464897
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1056/nejmoa0801936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012310134
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1086/381000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058673096
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1093/annonc/mdg118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037272645
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1093/bioinformatics/bth457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008081196
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1093/jnci/91.23.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018329842
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1097/fpc.0b013e328301a869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340612
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1097/fpc.0b013e3283396c4e schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340830
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1101/gr.095000.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029664825
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1111/bcp.12021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031665934
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1158/1078-0432.ccr-08-0411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029718634
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1177/0091270009355161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019633702
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1182/blood-2009-12-255992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039088452
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1212/wnl.0b013e31826aac73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064357227
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.2217/pgs.10.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019047875
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.2217/pgs.11.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011936657
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.2217/pgs.12.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020478277
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.2217/pgs.12.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032177481
    361 rdf:type schema:CreativeWork
    362 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
    363 schema:name 1] Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada [2] Division of Translational Therapeutics, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.
    364 1] Division of Translational Therapeutics, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada [2] Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, BC, Canada.
    365 1] Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore [2] Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.
    366 1] Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore [2] Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore [3] Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.
    367 Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.
    368 rdf:type schema:Organization
    369 https://www.grid.ac/institutes/grid.185448.4 schema:alternateName Agency for Science, Technology and Research
    370 schema:name Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore.
    371 rdf:type schema:Organization
    372 https://www.grid.ac/institutes/grid.413898.f schema:alternateName Health Sciences Authority
    373 schema:name Health Sciences Authority, Singapore.
    374 rdf:type schema:Organization
    375 https://www.grid.ac/institutes/grid.4280.e schema:alternateName National University of Singapore
    376 schema:name 1] Saw Swee Hock School of Public Health, National University of Singapore, Singapore [2] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden [3] Center for Molecular Epidemiology, National University of Singapore, Singapore.
    377 1] Saw Swee Hock School of Public Health, National University of Singapore, Singapore [2] NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore [3] Life Sciences Institute, National University of Singapore, Singapore [4] Department of Statistics and Applied Probability, National University of Singapore, Singapore.
    378 1] Saw Swee Hock School of Public Health, National University of Singapore, Singapore [2] NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore.
    379 Department of Pharmacology, National University of Singapore, Singapore.
    380 Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
    381 rdf:type schema:Organization
    382 https://www.grid.ac/institutes/grid.428397.3 schema:alternateName Duke NUS Graduate Medical School
    383 schema:name 1] Health Sciences Authority, Singapore [2] Duke-NUS Graduate Medical School, Singapore.
    384 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...