Prospective study of EGFR intron 1 (CA)n repeats variants as predictors of benefit from cetuximab and irinotecan in chemo-refractory metastatic ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08

AUTHORS

F Loupakis, C Antoniotti, C Cremolini, W Zhang, D Yang, T Wakatsuki, P Bohanes, M Schirripa, L Salvatore, G Masi, V Ricci, F Graziano, A Ruzzo, L Benhaim, F Marmorino, Y Ning, R El-Khoueiry, A Falcone, H-J Lenz

ABSTRACT

The number of CA tandem repeats (CA)n in a highly polymorphic region of EGFR (epidermal growth factor receptor) intron 1 may affect gene transcription; the potential impact of allelic variants on the efficacy of cetuximab in metastatic colorectal cancer (mCRC) patients is debated for long. This study aimed at prospectively estimating the impact of EGFR intron 1 (CA)n variants on clinical outcome in KRAS exon 2 and BRAF wild-type chemo-refractory mCRC patients, receiving cetuximab and irinotecan. Variants presenting More... »

PAGES

322

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/tpj.2014.1

DOI

http://dx.doi.org/10.1038/tpj.2014.1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000346083

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24513691


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