Ontology type: schema:ScholarlyArticle
2014-08
AUTHORSD S L Toh, L L Tan, D C W Aw, S M Pang, S H Lim, T Thirumoorthy, H Y Lee, Y K Tay, S K Tan, A Vasudevan, A Lateef, Y Y Chong, Y C Chan, C Loke, C L Chan, E S C Koay, E C Ren, E J D Lee, C Sung
ABSTRACTTo study the possible genetic associations with adverse drug reactions (ADR), the Singapore Health Sciences Authority (HSA) has piloted a program to collect DNA and phenotype data of ADR cases as part of its pharmacovigilance program. Between 2009 and 2012, HSA screened 158 cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). To assess the association between HLA-B*1502 and carbamazepine (CBZ)-induced SJS/TEN, 13 cases and 26 drug-tolerant controls were analyzed. All 13 CBZ-SJS/TEN cases and 3/26 controls were HLA-B*1502 positive (odds ratio 181, 95% confidence interval: 8.7-3785, P=6.9 × 10(-8)). Discussions of the finding with the Ministry of Health and an expert panel led to the decision to make HLA-B*1502 testing the standard of care prior to first use of CBZ in Asians and to subsidize the genotyping test at public hospitals. This program illustrates the role of a regulatory authority in advancing the use of pharmacogenetics for drug safety. More... »
PAGES316
http://scigraph.springernature.com/pub.10.1038/tpj.2013.46
DOIhttp://dx.doi.org/10.1038/tpj.2013.46
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24394201
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"10.1038/tpj.2013.46"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1034531541"
]
}
],
"sameAs": [
"https://doi.org/10.1038/tpj.2013.46",
"https://app.dimensions.ai/details/publication/pub.1034531541"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T14:18",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117100_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/tpj201346"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/tpj.2013.46'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/tpj.2013.46'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/tpj.2013.46'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/tpj.2013.46'
This table displays all metadata directly associated to this object as RDF triples.
360 TRIPLES
21 PREDICATES
70 URIs
35 LITERALS
23 BLANK NODES