Interpreting the clinical utility of a pharmacogenomic marker based on observational association studies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-02

AUTHORS

M J Sorich, M Coory

ABSTRACT

It is increasingly recognized that the clinical utility of a pharmacogenomic marker is a fundamental characteristic influencing the likelihood of successful clinical translation. Although appropriately designed and executed randomized controlled trials generally provide the most valid evidence for the clinical utility of a pharmacogenomic marker, such evidence may not always be available. Observational pharmacogenomic association studies are a common form of evidence available, but the assessment of clinical utility based on such evidence is often not straightforward. This paper aims to provide insight into this issue using a range of illustrative examples. More... »

PAGES

1

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Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/tpj.2013.35

DOI

http://dx.doi.org/10.1038/tpj.2013.35

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036049448

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24018622


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