Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-06

AUTHORS

C Fernandez-Rozadilla, J B Cazier, V Moreno, M Crous-Bou, E Guinó, G Durán, M J Lamas, R López, S Candamio, E Gallardo, L Paré, M Baiget, D Páez, L A López-Fernández, L Cortejoso, M I García, L Bujanda, D González, V Gonzalo, L Rodrigo, J M Reñé, R Jover, A Brea-Fernández, M Andreu, X Bessa, X Llor, R Xicola, C Palles, I Tomlinson, S Castellví-Bel, A Castells, C Ruiz-Ponte, A Carracedo

ABSTRACT

The development of genotyping technologies has allowed for wider screening for inherited causes of variable outcomes following drug administration. We have performed a genome-wide association study (GWAS) on 221 colorectal cancer (CRC) patients that had been treated with 5-fluorouracil (5-FU), either alone or in combination with oxaliplatin (FOLFOX). A validation set of 791 patients was also studied. Seven SNPs (rs16857540, rs2465403, rs10876844, rs10784749, rs17626122, rs7325568 and rs4243761) showed evidence of association (pooled P-values 0.020, 9.426E-03, 0.010, 0.017, 0.042, 2.302E-04, 2.803E-03) with adverse drug reactions (ADRs). This is the first study to explore the genetic basis of inter-individual variation in toxicity responses to the administration of 5-FU or FOLFOX in CRC patients on a genome-wide scale. More... »

PAGES

209

References to SciGraph publications

  • 2008-10. Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy in BRITISH JOURNAL OF CANCER
  • 2008-10. Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs in NATURE GENETICS
  • 2004-09. Pharmacogenomics: bench to bedside in NATURE REVIEWS DRUG DISCOVERY
  • 2010-06. Uncovering the roles of rare variants in common disease through whole-genome sequencing in NATURE REVIEWS GENETICS
  • 2010-08. UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy in BRITISH JOURNAL OF CANCER
  • 2007-11. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges in NATURE REVIEWS DRUG DISCOVERY
  • 2010-04. Origins and functional impact of copy number variation in the human genome in NATURE
  • 2010-04. Genome-wide association studies in pharmacogenomics in NATURE REVIEWS GENETICS
  • 2010-04. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls in NATURE
  • 2009-09. Molecular markers of response and toxicity to FOLFOX chemotherapy in metastatic colorectal cancer in BRITISH JOURNAL OF CANCER
  • 2007-06. DPYD*5 gene mutation contributes to the reduced DPYD enzyme activity and chemotherapeutic toxicity of 5-FU in MEDICAL ONCOLOGY
  • 1999-09. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response in NATURE CELL BIOLOGY
  • 2006-02. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies in NATURE GENETICS
  • 2009-04. Toxic effects and their management: daily clinical challenges in the treatment of colorectal cancer in NATURE REVIEWS CLINICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/tpj.2012.2

    DOI

    http://dx.doi.org/10.1038/tpj.2012.2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024470628

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22310351


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Pharmacological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Clinical Trials, Phase II as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug-Related Side Effects and Adverse Reactions", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorouracil", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genotyping Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leucovorin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organoplatinum Compounds", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pharmacogenetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Santiago de Compostela", 
              "id": "https://www.grid.ac/institutes/grid.11794.3a", 
              "name": [
                "Galician Public Foundation of Genomic Medicine (FPGMX)-Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER)-Genomics Medicine Group-Hospital Cl\u00ednico Santiago de Compostela-University of Santiago de Compostela, Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fernandez-Rozadilla", 
            "givenName": "C", 
            "id": "sg:person.0770606235.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770606235.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cazier", 
            "givenName": "J B", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Barcelona", 
              "id": "https://www.grid.ac/institutes/grid.5841.8", 
              "name": [
                "Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Centre (IDIBELL), CIBERESP, Barcelona, Spain", 
                "Faculty of Medicine, University of Barcelona, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moreno", 
            "givenName": "V", 
            "id": "sg:person.011345406334.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011345406334.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Catal\u00e0 d'Oncologia", 
              "id": "https://www.grid.ac/institutes/grid.418701.b", 
              "name": [
                "Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Centre (IDIBELL), CIBERESP, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Crous-Bou", 
            "givenName": "M", 
            "id": "sg:person.01262540655.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262540655.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Catal\u00e0 d'Oncologia", 
              "id": "https://www.grid.ac/institutes/grid.418701.b", 
              "name": [
                "Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Centre (IDIBELL), CIBERESP, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guin\u00f3", 
            "givenName": "E", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Complejo Hospitalario Universitario de Santiago", 
              "id": "https://www.grid.ac/institutes/grid.411048.8", 
              "name": [
                "Oncology Pharmacy Unit, Complexo Hospitalario Universitario of Santiago (CHUS), Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dur\u00e1n", 
            "givenName": "G", 
            "id": "sg:person.0707507403.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707507403.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Complejo Hospitalario Universitario de Santiago", 
              "id": "https://www.grid.ac/institutes/grid.411048.8", 
              "name": [
                "Oncology Pharmacy Unit, Complexo Hospitalario Universitario of Santiago (CHUS), Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lamas", 
            "givenName": "M J", 
            "id": "sg:person.0731433417.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731433417.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Complejo Hospitalario Universitario de Santiago", 
              "id": "https://www.grid.ac/institutes/grid.411048.8", 
              "name": [
                "Clinical Oncology Department, Complexo Hospitalario Universitario of Santiago (CHUS), Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00f3pez", 
            "givenName": "R", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Complejo Hospitalario Universitario de Santiago", 
              "id": "https://www.grid.ac/institutes/grid.411048.8", 
              "name": [
                "Clinical Oncology Department, Complexo Hospitalario Universitario of Santiago (CHUS), Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Candamio", 
            "givenName": "S", 
            "id": "sg:person.01237557125.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237557125.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Complejo Hospitalario Universitario de Santiago", 
              "id": "https://www.grid.ac/institutes/grid.411048.8", 
              "name": [
                "Clinical Oncology Department, Complexo Hospitalario Universitario of Santiago (CHUS), Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gallardo", 
            "givenName": "E", 
            "id": "sg:person.01170520205.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170520205.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Molecular Genetics Unit, Hospital de Santa Creu I Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Par\u00e9", 
            "givenName": "L", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Molecular Genetics Unit, Hospital de Santa Creu I Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baiget", 
            "givenName": "M", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Medic Oncology Department, Hospital de Santa Creu I Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "P\u00e1ez", 
            "givenName": "D", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital General Universitario Gregorio Mara\u00f1\u00f3n", 
              "id": "https://www.grid.ac/institutes/grid.410526.4", 
              "name": [
                "Pharmacogenetics & Pharmacogenomics Laboratory, Servicio de Farmacia, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00f3pez-Fern\u00e1ndez", 
            "givenName": "L A", 
            "id": "sg:person.011121376320.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011121376320.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital General Universitario Gregorio Mara\u00f1\u00f3n", 
              "id": "https://www.grid.ac/institutes/grid.410526.4", 
              "name": [
                "Pharmacogenetics & Pharmacogenomics Laboratory, Servicio de Farmacia, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cortejoso", 
            "givenName": "L", 
            "id": "sg:person.01075326457.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075326457.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital General Universitario Gregorio Mara\u00f1\u00f3n", 
              "id": "https://www.grid.ac/institutes/grid.410526.4", 
              "name": [
                "Pharmacogenetics & Pharmacogenomics Laboratory, Servicio de Farmacia, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Garc\u00eda", 
            "givenName": "M I", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of the Basque Country", 
              "id": "https://www.grid.ac/institutes/grid.11480.3c", 
              "name": [
                "Gastroenterology Department, Donostia Hospital, CIBERehd, University of the Basque Country, San Sebasti\u00e1n, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bujanda", 
            "givenName": "L", 
            "id": "sg:person.01270567120.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270567120.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Gastroenterology Department, Hospital de Santa Creu I Sant Pau, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gonz\u00e1lez", 
            "givenName": "D", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Gastroenterology, Hospital Cl\u00ednic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gonzalo", 
            "givenName": "V", 
            "id": "sg:person.01106165406.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106165406.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Central University Hospital of Asturias", 
              "id": "https://www.grid.ac/institutes/grid.411052.3", 
              "name": [
                "Gastroenterology Department, Hospital Universitario Central de Asturias, Oviedo, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rodrigo", 
            "givenName": "L", 
            "id": "sg:person.01113500452.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113500452.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Arnau de Vilanova", 
              "id": "https://www.grid.ac/institutes/grid.411443.7", 
              "name": [
                "Gastroenterology Department, Hospital Universitari Arnau de Vilanova, Lleida, IRBLleida, Universitat de Lleida, Lleida, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Re\u00f1\u00e9", 
            "givenName": "J M", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital General Universitario de Alicante", 
              "id": "https://www.grid.ac/institutes/grid.411086.a", 
              "name": [
                "Gastroenterology Department, Hospital General de Alicante, Alicante, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jover", 
            "givenName": "R", 
            "id": "sg:person.01336606454.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336606454.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Santiago de Compostela", 
              "id": "https://www.grid.ac/institutes/grid.11794.3a", 
              "name": [
                "Galician Public Foundation of Genomic Medicine (FPGMX)-Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER)-Genomics Medicine Group-Hospital Cl\u00ednico Santiago de Compostela-University of Santiago de Compostela, Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brea-Fern\u00e1ndez", 
            "givenName": "A", 
            "id": "sg:person.01221263235.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221263235.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Del Mar", 
              "id": "https://www.grid.ac/institutes/grid.411142.3", 
              "name": [
                "Gastroenterology Department, Hospital del Mar, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andreu", 
            "givenName": "M", 
            "id": "sg:person.01223210724.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223210724.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Del Mar", 
              "id": "https://www.grid.ac/institutes/grid.411142.3", 
              "name": [
                "Gastroenterology Department, Hospital del Mar, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bessa", 
            "givenName": "X", 
            "id": "sg:person.0633441364.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633441364.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Section of Digestive Diseases and Nutrition, University of Illinois at Chicago, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Llor", 
            "givenName": "X", 
            "id": "sg:person.0653536023.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653536023.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Section of Digestive Diseases and Nutrition, University of Illinois at Chicago, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xicola", 
            "givenName": "R", 
            "id": "sg:person.01147003760.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147003760.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Palles", 
            "givenName": "C", 
            "id": "sg:person.0675176254.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675176254.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK", 
                "NIHR Comprehensive Biomedical Research Centre, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tomlinson", 
            "givenName": "I", 
            "id": "sg:person.01177572330.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177572330.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Gastroenterology, Hospital Cl\u00ednic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Castellv\u00ed-Bel", 
            "givenName": "S", 
            "id": "sg:person.01175036460.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175036460.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Gastroenterology, Hospital Cl\u00ednic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Castells", 
            "givenName": "A", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Santiago de Compostela", 
              "id": "https://www.grid.ac/institutes/grid.11794.3a", 
              "name": [
                "Galician Public Foundation of Genomic Medicine (FPGMX)-Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER)-Genomics Medicine Group-Hospital Cl\u00ednico Santiago de Compostela-University of Santiago de Compostela, Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ruiz-Ponte", 
            "givenName": "C", 
            "id": "sg:person.01317326011.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317326011.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Santiago de Compostela", 
              "id": "https://www.grid.ac/institutes/grid.11794.3a", 
              "name": [
                "Galician Public Foundation of Genomic Medicine (FPGMX)-Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER)-Genomics Medicine Group-Hospital Cl\u00ednico Santiago de Compostela-University of Santiago de Compostela, Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carracedo", 
            "givenName": "A", 
            "id": "sg:person.010033641400.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010033641400.26"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature08979", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003788883", 
              "https://doi.org/10.1038/nature08979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08979", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003788883", 
              "https://doi.org/10.1038/nature08979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(07)61866-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004094612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004662407", 
              "https://doi.org/10.1038/nrclinonc.2009.16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004662407", 
              "https://doi.org/10.1038/nrclinonc.2009.16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(07)61058-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005710018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-0304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006086077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bth457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008081196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-2665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008382373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.25516", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008443664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.25516", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008443664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009205998", 
              "https://doi.org/10.1038/ng1706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009205998", 
              "https://doi.org/10.1038/ng1706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkm076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009468905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02698048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017223534", 
              "https://doi.org/10.1007/bf02698048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02698048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017223534", 
              "https://doi.org/10.1007/bf02698048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-2076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018943215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/519795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019061180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-2169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019702225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020313480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djh015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021519515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024966420", 
              "https://doi.org/10.1038/nrd1497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024966420", 
              "https://doi.org/10.1038/nrd1497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(00)03167-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027743530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028117811", 
              "https://doi.org/10.1038/sj.bjc.6605776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.0020190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029170965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.293.16.1986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030093947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030444175", 
              "https://doi.org/10.1038/ng.237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032847121", 
              "https://doi.org/10.1038/nrg2751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032847121", 
              "https://doi.org/10.1038/nrg2751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041110958", 
              "https://doi.org/10.1038/sj.bjc.6605239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041110958", 
              "https://doi.org/10.1038/sj.bjc.6605239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81730-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041137101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041544141", 
              "https://doi.org/10.1038/nrd2423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2008.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042186096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/14622416.10.2.161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042274007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra040958", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048848178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/12971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050573089", 
              "https://doi.org/10.1038/12971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/12971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050573089", 
              "https://doi.org/10.1038/12971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050625874", 
              "https://doi.org/10.1038/nrg2779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050625874", 
              "https://doi.org/10.1038/nrg2779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050841785", 
              "https://doi.org/10.1038/sj.bjc.6604671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08516", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052442014", 
              "https://doi.org/10.1038/nature08516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08516", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052442014", 
              "https://doi.org/10.1038/nature08516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00008571-200210000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060289966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00008571-200210000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060289966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00008571-200210000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060289966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2307/1390807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069468261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2000.18.16.2938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074684744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075566864", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-06", 
        "datePublishedReg": "2013-06-01", 
        "description": "The development of genotyping technologies has allowed for wider screening for inherited causes of variable outcomes following drug administration. We have performed a genome-wide association study (GWAS) on 221 colorectal cancer (CRC) patients that had been treated with 5-fluorouracil (5-FU), either alone or in combination with oxaliplatin (FOLFOX). A validation set of 791 patients was also studied. Seven SNPs (rs16857540, rs2465403, rs10876844, rs10784749, rs17626122, rs7325568 and rs4243761) showed evidence of association (pooled P-values 0.020, 9.426E-03, 0.010, 0.017, 0.042, 2.302E-04, 2.803E-03) with adverse drug reactions (ADRs). This is the first study to explore the genetic basis of inter-individual variation in toxicity responses to the administration of 5-FU or FOLFOX in CRC patients on a genome-wide scale.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/tpj.2012.2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3627457", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3633982", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3636942", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4577566", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1027238", 
            "issn": [
              "1470-269X", 
              "1473-1150"
            ], 
            "name": "The Pharmacogenomics Journal", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "13"
          }
        ], 
        "name": "Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration", 
        "pagination": "209", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "74943ecdfa09b676abc054af830f06dd7913e1285c3534bc885194c675edc365"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22310351"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101083949"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/tpj.2012.2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1024470628"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/tpj.2012.2", 
          "https://app.dimensions.ai/details/publication/pub.1024470628"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T18:58", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000438.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/tpj20122"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/tpj.2012.2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/tpj.2012.2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/tpj.2012.2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/tpj.2012.2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    545 TRIPLES      21 PREDICATES      86 URIs      41 LITERALS      29 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/tpj.2012.2 schema:about N023b526bacde46e28045efcab0f5700e
    2 N0aeab218a17a4df7874368f74bfa99ff
    3 N19252eb6f5be4305b5c460ac2204f2a5
    4 N2f28410fc87f434c8e9208937114fd12
    5 N33e5c8c417e641c8bd37be9527c0fb4a
    6 N3d97d8202a3449b0afa007e15064b6bc
    7 N5d7b18b841c3462c9e78a8969aeb3594
    8 N70d307f0e2d54d0cbb05802e02bd70e2
    9 N7187cf0f67af4054a8d15877949958eb
    10 N7f45eafa1c9846b780fc7dde4b762b9b
    11 N85730ebeeaba4ad591d64250e3373abb
    12 N861705c5e9504a77a92cf6b61b2efb2b
    13 N9cd433d5bbd34bc7947b8700696e3484
    14 Nba808b8ba3f348eaa3dd4b1474444413
    15 Nc97bd1c3f0284f47bf7df4e47b70ef68
    16 Nc9ecc3e3998f482ab454523642df6a69
    17 Ne42811289ecf4be19fc4bdf095e12dcc
    18 Nf1e40d078ad74635a9b1fe699d12ada5
    19 Nf5efcdeddf6444abaf9e64523374a067
    20 Nf7bea0e90c894b23bda7b896f76392df
    21 anzsrc-for:06
    22 anzsrc-for:0604
    23 schema:author N01c80b313f7d413486b323fa35b26de6
    24 schema:citation sg:pub.10.1007/bf02698048
    25 sg:pub.10.1038/12971
    26 sg:pub.10.1038/nature08516
    27 sg:pub.10.1038/nature08979
    28 sg:pub.10.1038/ng.237
    29 sg:pub.10.1038/ng1706
    30 sg:pub.10.1038/nrclinonc.2009.16
    31 sg:pub.10.1038/nrd1497
    32 sg:pub.10.1038/nrd2423
    33 sg:pub.10.1038/nrg2751
    34 sg:pub.10.1038/nrg2779
    35 sg:pub.10.1038/sj.bjc.6604671
    36 sg:pub.10.1038/sj.bjc.6605239
    37 sg:pub.10.1038/sj.bjc.6605776
    38 https://app.dimensions.ai/details/publication/pub.1075566864
    39 https://doi.org/10.1001/jama.293.16.1986
    40 https://doi.org/10.1002/ijc.25516
    41 https://doi.org/10.1016/j.ajhg.2008.06.005
    42 https://doi.org/10.1016/s0092-8674(00)81730-4
    43 https://doi.org/10.1016/s0140-6736(00)03167-6
    44 https://doi.org/10.1016/s0140-6736(07)61058-7
    45 https://doi.org/10.1016/s0140-6736(07)61866-2
    46 https://doi.org/10.1056/nejmra040958
    47 https://doi.org/10.1086/519795
    48 https://doi.org/10.1093/bioinformatics/bth457
    49 https://doi.org/10.1093/jnci/djh015
    50 https://doi.org/10.1093/nar/gkm076
    51 https://doi.org/10.1097/00008571-200210000-00007
    52 https://doi.org/10.1158/1078-0432.ccr-05-2076
    53 https://doi.org/10.1158/1078-0432.ccr-05-2665
    54 https://doi.org/10.1158/1078-0432.ccr-10-2169
    55 https://doi.org/10.1158/1078-0432.ccr-11-0304
    56 https://doi.org/10.1172/jci915
    57 https://doi.org/10.1200/jco.2000.18.16.2938
    58 https://doi.org/10.1371/journal.pgen.0020190
    59 https://doi.org/10.2217/14622416.10.2.161
    60 https://doi.org/10.2307/1390807
    61 schema:datePublished 2013-06
    62 schema:datePublishedReg 2013-06-01
    63 schema:description The development of genotyping technologies has allowed for wider screening for inherited causes of variable outcomes following drug administration. We have performed a genome-wide association study (GWAS) on 221 colorectal cancer (CRC) patients that had been treated with 5-fluorouracil (5-FU), either alone or in combination with oxaliplatin (FOLFOX). A validation set of 791 patients was also studied. Seven SNPs (rs16857540, rs2465403, rs10876844, rs10784749, rs17626122, rs7325568 and rs4243761) showed evidence of association (pooled P-values 0.020, 9.426E-03, 0.010, 0.017, 0.042, 2.302E-04, 2.803E-03) with adverse drug reactions (ADRs). This is the first study to explore the genetic basis of inter-individual variation in toxicity responses to the administration of 5-FU or FOLFOX in CRC patients on a genome-wide scale.
    64 schema:genre research_article
    65 schema:inLanguage en
    66 schema:isAccessibleForFree true
    67 schema:isPartOf N0636889ba94747d9b952822490ac8871
    68 N70c11ed7048c4236b0e86c3047465096
    69 sg:journal.1027238
    70 schema:name Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration
    71 schema:pagination 209
    72 schema:productId N4b707bef50e34503a6d53988f45a28ff
    73 N5e69726d7f1b4c84a89237363f4d56bf
    74 N8d0c046ff6bf4b068565723996c13aa8
    75 Nd2df12f8dbb347a9878a816cc1a43e5f
    76 Nf9fedaf87454402a9ef5ab6d4aa67d85
    77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024470628
    78 https://doi.org/10.1038/tpj.2012.2
    79 schema:sdDatePublished 2019-04-10T18:58
    80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    81 schema:sdPublisher N30e061fb82cf48359d14e913b50bb439
    82 schema:url https://www.nature.com/articles/tpj20122
    83 sgo:license sg:explorer/license/
    84 sgo:sdDataset articles
    85 rdf:type schema:ScholarlyArticle
    86 N01c80b313f7d413486b323fa35b26de6 rdf:first sg:person.0770606235.71
    87 rdf:rest N5bbba0a0b8b54d0a929849f2baaee778
    88 N023b526bacde46e28045efcab0f5700e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Adult
    90 rdf:type schema:DefinedTerm
    91 N0636889ba94747d9b952822490ac8871 schema:issueNumber 3
    92 rdf:type schema:PublicationIssue
    93 N081170abb3964d1fa1aae11c37054103 rdf:first sg:person.01175036460.93
    94 rdf:rest N5927f7ac377847cea376c2c6e95c9cff
    95 N093dd798df614ff49c8207726460cf93 rdf:first N2c4328db1fbd45ad910a61fb64a91355
    96 rdf:rest Ne82b366000ff47d39fb894833585399f
    97 N0ae92cab76af403fbdf83561ee66fe4a rdf:first sg:person.01237557125.19
    98 rdf:rest Na1814f000545442b96bc243ffb36b26e
    99 N0aeab218a17a4df7874368f74bfa99ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Fluorouracil
    101 rdf:type schema:DefinedTerm
    102 N0b185c42d1a64e66805c99bb08f51a3d rdf:first sg:person.01177572330.00
    103 rdf:rest N081170abb3964d1fa1aae11c37054103
    104 N0f5ca94feb6d4c61b7abd810db309f3e schema:affiliation https://www.grid.ac/institutes/grid.411048.8
    105 schema:familyName López
    106 schema:givenName R
    107 rdf:type schema:Person
    108 N15696cb57c1b46bfab48ecee6cbc9bfa rdf:first Ncc297253deca4367a722ccff2871ae48
    109 rdf:rest N69bc6238e0fd4639946d385cf3ec5a98
    110 N19252eb6f5be4305b5c460ac2204f2a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Middle Aged
    112 rdf:type schema:DefinedTerm
    113 N209cb2d8399e401ab93ebe27f63595de schema:affiliation N2e8ecdb7a8574dfd87a8af5f8f0f670a
    114 schema:familyName González
    115 schema:givenName D
    116 rdf:type schema:Person
    117 N224eeee128df4757a743199a510d585a rdf:first sg:person.0653536023.58
    118 rdf:rest Nd99725794d2845b19b70fe71bfa20951
    119 N2c0a2bb3a4aa45898e88582fc815e339 schema:name Department of Gastroenterology, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Spain
    120 rdf:type schema:Organization
    121 N2c4328db1fbd45ad910a61fb64a91355 schema:affiliation Nd197cf4debad4040a63de0f4568a8cab
    122 schema:familyName Paré
    123 schema:givenName L
    124 rdf:type schema:Person
    125 N2e8ecdb7a8574dfd87a8af5f8f0f670a schema:name Gastroenterology Department, Hospital de Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
    126 rdf:type schema:Organization
    127 N2ed77d5ac40a441d81318faa27bd7b6f rdf:first N209cb2d8399e401ab93ebe27f63595de
    128 rdf:rest Ne66a4dd1d50f436ba9551d36a0ff47ef
    129 N2f28410fc87f434c8e9208937114fd12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Humans
    131 rdf:type schema:DefinedTerm
    132 N30e061fb82cf48359d14e913b50bb439 schema:name Springer Nature - SN SciGraph project
    133 rdf:type schema:Organization
    134 N33e5c8c417e641c8bd37be9527c0fb4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Treatment Outcome
    136 rdf:type schema:DefinedTerm
    137 N38b1934c53e0497a9dd0c353537318ff rdf:first Nbee57e6af35040d3b9bf241702b4fc0a
    138 rdf:rest Nc324c9a5754240c58fc73c783aff97ee
    139 N3d97d8202a3449b0afa007e15064b6bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Genome-Wide Association Study
    141 rdf:type schema:DefinedTerm
    142 N3dea9ac5b98e48c1a0b2152ea37fc8e4 rdf:first sg:person.0707507403.61
    143 rdf:rest Ndff77b6cf0664baa8f0959c6c78aa07f
    144 N4b707bef50e34503a6d53988f45a28ff schema:name pubmed_id
    145 schema:value 22310351
    146 rdf:type schema:PropertyValue
    147 N4df49343367940ed8523627a84c22e85 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    148 schema:familyName Cazier
    149 schema:givenName J B
    150 rdf:type schema:Person
    151 N4e0b40eb3e014fb49e6f739423f3eda0 rdf:first sg:person.011345406334.22
    152 rdf:rest Nfc8e08f93ce7434c90e3e9ac5e367b31
    153 N4f8aa2095da8443fb3f3527490477535 rdf:first N6f749dc1685946cfa50b952f1c766a1e
    154 rdf:rest Nf88be356f3464e889c5967e0b3793583
    155 N50bbf079e1fb400e954065b45db35ecb rdf:first sg:person.01075326457.23
    156 rdf:rest N15696cb57c1b46bfab48ecee6cbc9bfa
    157 N5927f7ac377847cea376c2c6e95c9cff rdf:first Na5a7e83b6a42421a9e0edc20f989c0db
    158 rdf:rest Ne31fae4a68f641f0a4a978fb216922fb
    159 N5bbba0a0b8b54d0a929849f2baaee778 rdf:first N4df49343367940ed8523627a84c22e85
    160 rdf:rest N4e0b40eb3e014fb49e6f739423f3eda0
    161 N5d7b18b841c3462c9e78a8969aeb3594 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Leucovorin
    163 rdf:type schema:DefinedTerm
    164 N5dea8b737dff4638a5852c8a622adf0c schema:name Department of Gastroenterology, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Spain
    165 rdf:type schema:Organization
    166 N5e69726d7f1b4c84a89237363f4d56bf schema:name doi
    167 schema:value 10.1038/tpj.2012.2
    168 rdf:type schema:PropertyValue
    169 N69bc6238e0fd4639946d385cf3ec5a98 rdf:first sg:person.01270567120.20
    170 rdf:rest N2ed77d5ac40a441d81318faa27bd7b6f
    171 N6f749dc1685946cfa50b952f1c766a1e schema:affiliation Nc9553ad917ac46bb975c7858908a3099
    172 schema:familyName Páez
    173 schema:givenName D
    174 rdf:type schema:Person
    175 N70c11ed7048c4236b0e86c3047465096 schema:volumeNumber 13
    176 rdf:type schema:PublicationVolume
    177 N70d307f0e2d54d0cbb05802e02bd70e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Female
    179 rdf:type schema:DefinedTerm
    180 N7187cf0f67af4054a8d15877949958eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Biomarkers, Pharmacological
    182 rdf:type schema:DefinedTerm
    183 N7f45eafa1c9846b780fc7dde4b762b9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Drug-Related Side Effects and Adverse Reactions
    185 rdf:type schema:DefinedTerm
    186 N85730ebeeaba4ad591d64250e3373abb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Pharmacogenetics
    188 rdf:type schema:DefinedTerm
    189 N861705c5e9504a77a92cf6b61b2efb2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Polymorphism, Single Nucleotide
    191 rdf:type schema:DefinedTerm
    192 N8a1ad9d611ec465db428f7f63f63b821 rdf:first sg:person.010033641400.26
    193 rdf:rest rdf:nil
    194 N8d0c046ff6bf4b068565723996c13aa8 schema:name readcube_id
    195 schema:value 74943ecdfa09b676abc054af830f06dd7913e1285c3534bc885194c675edc365
    196 rdf:type schema:PropertyValue
    197 N942e8c37f3a148028b9371605cd26fda schema:name Molecular Genetics Unit, Hospital de Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
    198 rdf:type schema:Organization
    199 N97e6178b70404ccca5d6a241dc51a88b schema:name Department of Gastroenterology, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Barcelona, Spain
    200 rdf:type schema:Organization
    201 N98124cee1cff4d10ab762f625717a9a7 schema:affiliation N942e8c37f3a148028b9371605cd26fda
    202 schema:familyName Baiget
    203 schema:givenName M
    204 rdf:type schema:Person
    205 N9cd433d5bbd34bc7947b8700696e3484 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Clinical Trials, Phase II as Topic
    207 rdf:type schema:DefinedTerm
    208 N9d90dace60b148309405956908b436e7 rdf:first Ne130a70298c7437bad42bae47d4cada4
    209 rdf:rest N3dea9ac5b98e48c1a0b2152ea37fc8e4
    210 Na1814f000545442b96bc243ffb36b26e rdf:first sg:person.01170520205.62
    211 rdf:rest N093dd798df614ff49c8207726460cf93
    212 Na5a7e83b6a42421a9e0edc20f989c0db schema:affiliation N97e6178b70404ccca5d6a241dc51a88b
    213 schema:familyName Castells
    214 schema:givenName A
    215 rdf:type schema:Person
    216 Nb1b308ca0e3e4e0f99c0cba552ba48b0 rdf:first sg:person.01221263235.92
    217 rdf:rest Nc2080ad3a39a42e99e2fc6942ee05a5d
    218 Nba808b8ba3f348eaa3dd4b1474444413 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Antineoplastic Combined Chemotherapy Protocols
    220 rdf:type schema:DefinedTerm
    221 Nbee57e6af35040d3b9bf241702b4fc0a schema:affiliation https://www.grid.ac/institutes/grid.411443.7
    222 schema:familyName Reñé
    223 schema:givenName J M
    224 rdf:type schema:Person
    225 Nc2080ad3a39a42e99e2fc6942ee05a5d rdf:first sg:person.01223210724.55
    226 rdf:rest Nf325897a78fe4ab6af25110ba5047b2b
    227 Nc324c9a5754240c58fc73c783aff97ee rdf:first sg:person.01336606454.81
    228 rdf:rest Nb1b308ca0e3e4e0f99c0cba552ba48b0
    229 Nc9553ad917ac46bb975c7858908a3099 schema:name Medic Oncology Department, Hospital de Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
    230 rdf:type schema:Organization
    231 Nc97bd1c3f0284f47bf7df4e47b70ef68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Male
    233 rdf:type schema:DefinedTerm
    234 Nc9ecc3e3998f482ab454523642df6a69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Genotyping Techniques
    236 rdf:type schema:DefinedTerm
    237 Ncc297253deca4367a722ccff2871ae48 schema:affiliation https://www.grid.ac/institutes/grid.410526.4
    238 schema:familyName García
    239 schema:givenName M I
    240 rdf:type schema:Person
    241 Nd197cf4debad4040a63de0f4568a8cab schema:name Molecular Genetics Unit, Hospital de Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
    242 rdf:type schema:Organization
    243 Nd1cc0f60fad44c95b04d9129c65085a5 rdf:first sg:person.01113500452.05
    244 rdf:rest N38b1934c53e0497a9dd0c353537318ff
    245 Nd2df12f8dbb347a9878a816cc1a43e5f schema:name dimensions_id
    246 schema:value pub.1024470628
    247 rdf:type schema:PropertyValue
    248 Nd72ccc9e0e654c7cbb0e4b316fa283f0 rdf:first sg:person.0675176254.13
    249 rdf:rest N0b185c42d1a64e66805c99bb08f51a3d
    250 Nd99725794d2845b19b70fe71bfa20951 rdf:first sg:person.01147003760.34
    251 rdf:rest Nd72ccc9e0e654c7cbb0e4b316fa283f0
    252 Ndff77b6cf0664baa8f0959c6c78aa07f rdf:first sg:person.0731433417.62
    253 rdf:rest Ne2fcf1a40edf484b92f136582ddda80f
    254 Ne130a70298c7437bad42bae47d4cada4 schema:affiliation https://www.grid.ac/institutes/grid.418701.b
    255 schema:familyName Guinó
    256 schema:givenName E
    257 rdf:type schema:Person
    258 Ne2fcf1a40edf484b92f136582ddda80f rdf:first N0f5ca94feb6d4c61b7abd810db309f3e
    259 rdf:rest N0ae92cab76af403fbdf83561ee66fe4a
    260 Ne31fae4a68f641f0a4a978fb216922fb rdf:first sg:person.01317326011.37
    261 rdf:rest N8a1ad9d611ec465db428f7f63f63b821
    262 Ne42811289ecf4be19fc4bdf095e12dcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    263 schema:name Colorectal Neoplasms
    264 rdf:type schema:DefinedTerm
    265 Ne66a4dd1d50f436ba9551d36a0ff47ef rdf:first sg:person.01106165406.18
    266 rdf:rest Nd1cc0f60fad44c95b04d9129c65085a5
    267 Ne82b366000ff47d39fb894833585399f rdf:first N98124cee1cff4d10ab762f625717a9a7
    268 rdf:rest N4f8aa2095da8443fb3f3527490477535
    269 Nf1e40d078ad74635a9b1fe699d12ada5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    270 schema:name Aged
    271 rdf:type schema:DefinedTerm
    272 Nf325897a78fe4ab6af25110ba5047b2b rdf:first sg:person.0633441364.93
    273 rdf:rest N224eeee128df4757a743199a510d585a
    274 Nf5efcdeddf6444abaf9e64523374a067 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    275 schema:name Organoplatinum Compounds
    276 rdf:type schema:DefinedTerm
    277 Nf7bea0e90c894b23bda7b896f76392df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    278 schema:name Aged, 80 and over
    279 rdf:type schema:DefinedTerm
    280 Nf88be356f3464e889c5967e0b3793583 rdf:first sg:person.011121376320.52
    281 rdf:rest N50bbf079e1fb400e954065b45db35ecb
    282 Nf9fedaf87454402a9ef5ab6d4aa67d85 schema:name nlm_unique_id
    283 schema:value 101083949
    284 rdf:type schema:PropertyValue
    285 Nfc8e08f93ce7434c90e3e9ac5e367b31 rdf:first sg:person.01262540655.56
    286 rdf:rest N9d90dace60b148309405956908b436e7
    287 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    288 schema:name Biological Sciences
    289 rdf:type schema:DefinedTerm
    290 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    291 schema:name Genetics
    292 rdf:type schema:DefinedTerm
    293 sg:grant.3627457 http://pending.schema.org/fundedItem sg:pub.10.1038/tpj.2012.2
    294 rdf:type schema:MonetaryGrant
    295 sg:grant.3633982 http://pending.schema.org/fundedItem sg:pub.10.1038/tpj.2012.2
    296 rdf:type schema:MonetaryGrant
    297 sg:grant.3636942 http://pending.schema.org/fundedItem sg:pub.10.1038/tpj.2012.2
    298 rdf:type schema:MonetaryGrant
    299 sg:grant.4577566 http://pending.schema.org/fundedItem sg:pub.10.1038/tpj.2012.2
    300 rdf:type schema:MonetaryGrant
    301 sg:journal.1027238 schema:issn 1470-269X
    302 1473-1150
    303 schema:name The Pharmacogenomics Journal
    304 rdf:type schema:Periodical
    305 sg:person.010033641400.26 schema:affiliation https://www.grid.ac/institutes/grid.11794.3a
    306 schema:familyName Carracedo
    307 schema:givenName A
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010033641400.26
    309 rdf:type schema:Person
    310 sg:person.01075326457.23 schema:affiliation https://www.grid.ac/institutes/grid.410526.4
    311 schema:familyName Cortejoso
    312 schema:givenName L
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075326457.23
    314 rdf:type schema:Person
    315 sg:person.01106165406.18 schema:affiliation N2c0a2bb3a4aa45898e88582fc815e339
    316 schema:familyName Gonzalo
    317 schema:givenName V
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106165406.18
    319 rdf:type schema:Person
    320 sg:person.011121376320.52 schema:affiliation https://www.grid.ac/institutes/grid.410526.4
    321 schema:familyName López-Fernández
    322 schema:givenName L A
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011121376320.52
    324 rdf:type schema:Person
    325 sg:person.01113500452.05 schema:affiliation https://www.grid.ac/institutes/grid.411052.3
    326 schema:familyName Rodrigo
    327 schema:givenName L
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113500452.05
    329 rdf:type schema:Person
    330 sg:person.011345406334.22 schema:affiliation https://www.grid.ac/institutes/grid.5841.8
    331 schema:familyName Moreno
    332 schema:givenName V
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011345406334.22
    334 rdf:type schema:Person
    335 sg:person.01147003760.34 schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    336 schema:familyName Xicola
    337 schema:givenName R
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147003760.34
    339 rdf:type schema:Person
    340 sg:person.01170520205.62 schema:affiliation https://www.grid.ac/institutes/grid.411048.8
    341 schema:familyName Gallardo
    342 schema:givenName E
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170520205.62
    344 rdf:type schema:Person
    345 sg:person.01175036460.93 schema:affiliation N5dea8b737dff4638a5852c8a622adf0c
    346 schema:familyName Castellví-Bel
    347 schema:givenName S
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175036460.93
    349 rdf:type schema:Person
    350 sg:person.01177572330.00 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    351 schema:familyName Tomlinson
    352 schema:givenName I
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177572330.00
    354 rdf:type schema:Person
    355 sg:person.01221263235.92 schema:affiliation https://www.grid.ac/institutes/grid.11794.3a
    356 schema:familyName Brea-Fernández
    357 schema:givenName A
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221263235.92
    359 rdf:type schema:Person
    360 sg:person.01223210724.55 schema:affiliation https://www.grid.ac/institutes/grid.411142.3
    361 schema:familyName Andreu
    362 schema:givenName M
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223210724.55
    364 rdf:type schema:Person
    365 sg:person.01237557125.19 schema:affiliation https://www.grid.ac/institutes/grid.411048.8
    366 schema:familyName Candamio
    367 schema:givenName S
    368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237557125.19
    369 rdf:type schema:Person
    370 sg:person.01262540655.56 schema:affiliation https://www.grid.ac/institutes/grid.418701.b
    371 schema:familyName Crous-Bou
    372 schema:givenName M
    373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262540655.56
    374 rdf:type schema:Person
    375 sg:person.01270567120.20 schema:affiliation https://www.grid.ac/institutes/grid.11480.3c
    376 schema:familyName Bujanda
    377 schema:givenName L
    378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270567120.20
    379 rdf:type schema:Person
    380 sg:person.01317326011.37 schema:affiliation https://www.grid.ac/institutes/grid.11794.3a
    381 schema:familyName Ruiz-Ponte
    382 schema:givenName C
    383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317326011.37
    384 rdf:type schema:Person
    385 sg:person.01336606454.81 schema:affiliation https://www.grid.ac/institutes/grid.411086.a
    386 schema:familyName Jover
    387 schema:givenName R
    388 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336606454.81
    389 rdf:type schema:Person
    390 sg:person.0633441364.93 schema:affiliation https://www.grid.ac/institutes/grid.411142.3
    391 schema:familyName Bessa
    392 schema:givenName X
    393 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633441364.93
    394 rdf:type schema:Person
    395 sg:person.0653536023.58 schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    396 schema:familyName Llor
    397 schema:givenName X
    398 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653536023.58
    399 rdf:type schema:Person
    400 sg:person.0675176254.13 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    401 schema:familyName Palles
    402 schema:givenName C
    403 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675176254.13
    404 rdf:type schema:Person
    405 sg:person.0707507403.61 schema:affiliation https://www.grid.ac/institutes/grid.411048.8
    406 schema:familyName Durán
    407 schema:givenName G
    408 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707507403.61
    409 rdf:type schema:Person
    410 sg:person.0731433417.62 schema:affiliation https://www.grid.ac/institutes/grid.411048.8
    411 schema:familyName Lamas
    412 schema:givenName M J
    413 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731433417.62
    414 rdf:type schema:Person
    415 sg:person.0770606235.71 schema:affiliation https://www.grid.ac/institutes/grid.11794.3a
    416 schema:familyName Fernandez-Rozadilla
    417 schema:givenName C
    418 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770606235.71
    419 rdf:type schema:Person
    420 sg:pub.10.1007/bf02698048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017223534
    421 https://doi.org/10.1007/bf02698048
    422 rdf:type schema:CreativeWork
    423 sg:pub.10.1038/12971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050573089
    424 https://doi.org/10.1038/12971
    425 rdf:type schema:CreativeWork
    426 sg:pub.10.1038/nature08516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052442014
    427 https://doi.org/10.1038/nature08516
    428 rdf:type schema:CreativeWork
    429 sg:pub.10.1038/nature08979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003788883
    430 https://doi.org/10.1038/nature08979
    431 rdf:type schema:CreativeWork
    432 sg:pub.10.1038/ng.237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030444175
    433 https://doi.org/10.1038/ng.237
    434 rdf:type schema:CreativeWork
    435 sg:pub.10.1038/ng1706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009205998
    436 https://doi.org/10.1038/ng1706
    437 rdf:type schema:CreativeWork
    438 sg:pub.10.1038/nrclinonc.2009.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004662407
    439 https://doi.org/10.1038/nrclinonc.2009.16
    440 rdf:type schema:CreativeWork
    441 sg:pub.10.1038/nrd1497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024966420
    442 https://doi.org/10.1038/nrd1497
    443 rdf:type schema:CreativeWork
    444 sg:pub.10.1038/nrd2423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041544141
    445 https://doi.org/10.1038/nrd2423
    446 rdf:type schema:CreativeWork
    447 sg:pub.10.1038/nrg2751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032847121
    448 https://doi.org/10.1038/nrg2751
    449 rdf:type schema:CreativeWork
    450 sg:pub.10.1038/nrg2779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050625874
    451 https://doi.org/10.1038/nrg2779
    452 rdf:type schema:CreativeWork
    453 sg:pub.10.1038/sj.bjc.6604671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050841785
    454 https://doi.org/10.1038/sj.bjc.6604671
    455 rdf:type schema:CreativeWork
    456 sg:pub.10.1038/sj.bjc.6605239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041110958
    457 https://doi.org/10.1038/sj.bjc.6605239
    458 rdf:type schema:CreativeWork
    459 sg:pub.10.1038/sj.bjc.6605776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028117811
    460 https://doi.org/10.1038/sj.bjc.6605776
    461 rdf:type schema:CreativeWork
    462 https://app.dimensions.ai/details/publication/pub.1075566864 schema:CreativeWork
    463 https://doi.org/10.1001/jama.293.16.1986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030093947
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1002/ijc.25516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008443664
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/j.ajhg.2008.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042186096
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/s0092-8674(00)81730-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041137101
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/s0140-6736(00)03167-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027743530
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/s0140-6736(07)61058-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005710018
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/s0140-6736(07)61866-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004094612
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1056/nejmra040958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048848178
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1093/bioinformatics/bth457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008081196
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1093/jnci/djh015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021519515
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1093/nar/gkm076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009468905
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1097/00008571-200210000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060289966
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1158/1078-0432.ccr-05-2076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018943215
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1158/1078-0432.ccr-05-2665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008382373
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1158/1078-0432.ccr-10-2169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019702225
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1158/1078-0432.ccr-11-0304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006086077
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1172/jci915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020313480
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1200/jco.2000.18.16.2938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074684744
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1371/journal.pgen.0020190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029170965
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.2217/14622416.10.2.161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042274007
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.2307/1390807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069468261
    506 rdf:type schema:CreativeWork
    507 https://www.grid.ac/institutes/grid.11480.3c schema:alternateName University of the Basque Country
    508 schema:name Gastroenterology Department, Donostia Hospital, CIBERehd, University of the Basque Country, San Sebastián, Spain
    509 rdf:type schema:Organization
    510 https://www.grid.ac/institutes/grid.11794.3a schema:alternateName University of Santiago de Compostela
    511 schema:name Galician Public Foundation of Genomic Medicine (FPGMX)-Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER)-Genomics Medicine Group-Hospital Clínico Santiago de Compostela-University of Santiago de Compostela, Santiago de Compostela, Spain
    512 rdf:type schema:Organization
    513 https://www.grid.ac/institutes/grid.185648.6 schema:alternateName University of Illinois at Chicago
    514 schema:name Section of Digestive Diseases and Nutrition, University of Illinois at Chicago, Chicago, IL, USA
    515 rdf:type schema:Organization
    516 https://www.grid.ac/institutes/grid.410526.4 schema:alternateName Hospital General Universitario Gregorio Marañón
    517 schema:name Pharmacogenetics & Pharmacogenomics Laboratory, Servicio de Farmacia, Hospital General Universitario Gregorio Marañón, Madrid, Spain
    518 rdf:type schema:Organization
    519 https://www.grid.ac/institutes/grid.411048.8 schema:alternateName Complejo Hospitalario Universitario de Santiago
    520 schema:name Clinical Oncology Department, Complexo Hospitalario Universitario of Santiago (CHUS), Santiago de Compostela, Spain
    521 Oncology Pharmacy Unit, Complexo Hospitalario Universitario of Santiago (CHUS), Santiago de Compostela, Spain
    522 rdf:type schema:Organization
    523 https://www.grid.ac/institutes/grid.411052.3 schema:alternateName Central University Hospital of Asturias
    524 schema:name Gastroenterology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
    525 rdf:type schema:Organization
    526 https://www.grid.ac/institutes/grid.411086.a schema:alternateName Hospital General Universitario de Alicante
    527 schema:name Gastroenterology Department, Hospital General de Alicante, Alicante, Spain
    528 rdf:type schema:Organization
    529 https://www.grid.ac/institutes/grid.411142.3 schema:alternateName Hospital Del Mar
    530 schema:name Gastroenterology Department, Hospital del Mar, Barcelona, Spain
    531 rdf:type schema:Organization
    532 https://www.grid.ac/institutes/grid.411443.7 schema:alternateName Hospital Universitari Arnau de Vilanova
    533 schema:name Gastroenterology Department, Hospital Universitari Arnau de Vilanova, Lleida, IRBLleida, Universitat de Lleida, Lleida, Spain
    534 rdf:type schema:Organization
    535 https://www.grid.ac/institutes/grid.418701.b schema:alternateName Institut Català d'Oncologia
    536 schema:name Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Centre (IDIBELL), CIBERESP, Barcelona, Spain
    537 rdf:type schema:Organization
    538 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
    539 schema:name NIHR Comprehensive Biomedical Research Centre, University of Oxford, Oxford, UK
    540 Nuffield Department of Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    541 rdf:type schema:Organization
    542 https://www.grid.ac/institutes/grid.5841.8 schema:alternateName University of Barcelona
    543 schema:name Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Centre (IDIBELL), CIBERESP, Barcelona, Spain
    544 Faculty of Medicine, University of Barcelona, Barcelona, Spain
    545 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...