Ontology type: schema:ScholarlyArticle Open Access: True
2010-06
AUTHORSC Catania, C Noberasco, D Minocci, D Radice, E Giovannetti, F Toffalorio, F de Braud, G Pelosi, G Spitaleri, L Spaggiari, M Manzotti, R Danesi, S Boselli, T De Pas
ABSTRACTThe aim of this study was to investigate the influence of histology and site of analysis (primary tumor versus lymph node) on the expression of genes involved in gemcitabine and cisplatin activity in non-small-cell lung cancer (NSCLC). Excision repair cross-complementing-1 (ERCC1), human equilibrative nucleoside transporter-1 (hENT1), deoxycytidine kinase (dCK), 5'-nucleotidase (5'-NT), cytidine deaminase (CDA) and ribonucleotide-reductase regulatory subunits (RRM1 and RRM2) were analyzed by quantitative-reverse transcription-PCR in 88 microdissected samples from 69 chemonaive patients. The results showed different patterns of expression for all studied genes, suggesting a possible stratification of the patients. No difference was observed between primary tumor and lymph node metastasis, as well as in adenocarcinoma and squamous-cell carcinoma specimens, while we found a correlation between the CDA-A79C polymorphism and gene expression levels. These data suggest a similar genetic susceptibility to gemcitabine-cisplatin regimens for squamous cell and adenocarcinoma and support the use of both lymph node and primary tumor for the expression profiling of NSCLC. More... »
PAGES180
http://scigraph.springernature.com/pub.10.1038/tpj.2009.53
DOIhttp://dx.doi.org/10.1038/tpj.2009.53
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/19901957
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JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/tpj.2009.53'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/tpj.2009.53'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/tpj.2009.53'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/tpj.2009.53'
This table displays all metadata directly associated to this object as RDF triples.
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