Global variation in CYP2C8–CYP2C9 functional haplotypes View Full Text


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Article Info

DATE

2009-08

AUTHORS

William C Speed, Soonmo Peter Kang, David P Tuck, Lyndsay N Harris, Kenneth K Kidd

ABSTRACT

We have studied the global frequency distributions of 10 single nucleotide polymorphisms (SNPs) across 132 kb of CYP2C8 and CYP2C9 in approximately 2500 individuals representing 45 populations. Five of the SNPs were in noncoding sequences; the other five involved the more common missense variants (four in CYP2C8, one in CYP2C9) that change amino acids in the gene products. One haplotype containing two CYP2C8 coding variants and one CYP2C9 coding variant reaches an average frequency of 10% in Europe; a set of haplotypes with a different CYP2C8 coding variant reaches 17% in Africa. In both cases these haplotypes are found in other regions of the world at <1%. This considerable geographic variation in haplotype frequencies impacts the interpretation of CYP2C8/CYP2C9 association studies, and has pharmacogenomic implications for drug interactions. More... »

PAGES

283

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/tpj.2009.10

    DOI

    http://dx.doi.org/10.1038/tpj.2009.10

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013705985

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19381162


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/tpj.2009.10'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/tpj.2009.10'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/tpj.2009.10'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/tpj.2009.10'


     

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