Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-10

AUTHORS

M-Y Lee, N Mukherjee, A J Pakstis, S Khaliq, A Mohyuddin, S Q Mehdi, W C Speed, J R Kidd, K K Kidd

ABSTRACT

Cytochrome P450 2E1, gene symbol CYP2E1, is one of a family of enzymes with a central role in activating and detoxifying xenobiotics and endogenous compounds. Genetic variation at this gene has been reported in different human populations, and some association studies have reported increased risk for cancers and other diseases. To the best of our knowledge, multi-single-nucleotide polymorphism haplotypes and linkage disequilibrium (LD) have not been systematically studied for CYP2E1 in multiple populations. Haplotypes can greatly increase the power both to identify patterns of genetic variation relevant for gene expression as well as to detect disease-related susceptibility mutations. We present frequency and LD data and analyses for 11 polymorphisms and their haplotypes that we have studied on over 2600 individuals from 50 human population samples representing the major geographical regions of the world. The diverse patterns of haplotype variation found in the different populations we have studied show that ethnicity may be an important variable helping to explain inconsistencies that have been reported by association studies. More studies clearly are needed of the variants we have studied, especially those in the 5' region, such as the variable number of tandem repeats, as well as studies of additional polymorphisms known for this gene to establish evidence relating any systematic differences in gene expression that exist to the haplotypes at this gene. More... »

PAGES

tpj20089

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/tpj.2008.9

DOI

http://dx.doi.org/10.1038/tpj.2008.9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012404552

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18663376


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