Variations in the interleukin-1 receptor antagonist gene impact on survival of patients with advanced colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

F Graziano, A Ruzzo, E Canestrari, F Loupakis, D Santini, E Rulli, B Humar, N Galluccio, R Bisonni, I Floriani, P Maltese, A Falcone, G Tonini, V Catalano, A Fontana, L Giustini, G Masi, B Vincenzi, P Alessandroni, M Magnani

ABSTRACT

The interleukin-1 receptor antagonist (IL-1RA) cytokine is thought to counteract tumor angiogenesis/metastasis. Two single nucleotide polymorphisms in the IL-1RA gene (rs4251961 T/C and rs579543 C/T) influence IL-1RA circulating levels with highest production in carriers of the homozygous rs4251961 T/T and rs579543 T/T genotypes. A total of 180 patients with metastatic colorectal cancer were categorized as high IL-1RA producers if they were carriers of at least one of the rs4251961 T/T or rs579543 T/T genotypes (T/T carriers). Median survival times were 35.8 months (95% confidence interval: 29.7-43.7 months) and 28.6 months (95% confidence interval: 25.6-30 months) in 56 T/T carriers and in 124 non-T/T carriers, respectively. The favorable association between T/T carriers' status and survival was significant in the multivariate analysis (P=0.018). Also, T/T carriers and non-T/T carriers were prevalent among patients with Karnofsky performance status 90-100 and 70-80, respectively (P=0.002). These findings encourage additional studies in this field and the evaluation of a recombinant-IL-1RA for anticancer activity. More... »

PAGES

78

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/tpj.2008.16

DOI

http://dx.doi.org/10.1038/tpj.2008.16

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014633745

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19104506


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