Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11-29

AUTHORS

M Föcking, P Dicker, L M Lopez, M Hryniewiecka, K Wynne, J A English, G Cagney, D R Cotter

ABSTRACT

The postsynaptic density (PSD) contains a complex set of proteins of known relevance to neuropsychiatric disorders such as schizophrenia and bipolar disorder. We enriched for this anatomical structure in the anterior cingulate cortex of 16 bipolar disorder samples and 20 controls from the Stanley Medical Research Institute. Unbiased shotgun proteomics incorporating label-free quantitation was used to identify differentially expressed proteins. Quantitative investigation of the PSD identified 2033 proteins, among which 288 were found to be differentially expressed. Validation of expression changes of DNM1, DTNA, NDUFV2, SEPT11 and SSBP was performed by western blotting. Bioinformatics analysis of the differentially expressed proteins implicated metabolic pathways including mitochondrial function, the tricarboxylic acid cycle, oxidative phosphorylation, protein translation and calcium signaling. The data implicate PSD-associated proteins, and specifically mitochondrial function in bipolar disorder. They relate synaptic function in bipolar disorder and the energy pathways that underpin it. Overall, our findings add to a growing literature linking the PSD and mitochondrial function in psychiatric disorders generally, and suggest that mitochondrial function associated with the PSD is particularly important in bipolar disorder. More... »

PAGES

e959-e959

References to SciGraph publications

  • 2004-03-31. Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder in NEUROPSYCHOPHARMACOLOGY
  • 2011-11-15. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia in MOLECULAR PSYCHIATRY
  • 2006-04-25. Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders in MOLECULAR PSYCHIATRY
  • 2014-01-22. De novo mutations in schizophrenia implicate synaptic networks in NATURE
  • 2013-10-15. Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders in MOLECULAR PSYCHIATRY
  • 2015-01-19. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways in NATURE NEUROSCIENCE
  • 2015-07-27. An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar Disorder in NEUROPSYCHOPHARMACOLOGY
  • 2006-01-10. Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia in MOLECULAR PSYCHIATRY
  • 2012-12-02. Synaptic scaffold evolution generated components of vertebrate cognitive complexity in NATURE NEUROSCIENCE
  • 2014-04-28. Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice in GENOME MEDICINE
  • 2011-11-02. Abnormal Activity of the MAPK- and cAMP-Associated Signaling Pathways in Frontal Cortical Areas in Postmortem Brain in Schizophrenia in NEUROPSYCHOPHARMACOLOGY
  • 2012-04-18. Impaired mitochondrial function in psychiatric disorders in NATURE REVIEWS NEUROSCIENCE
  • 2004-06. Mitochondrial enzymes in schizophrenia in JOURNAL OF MOLECULAR NEUROSCIENCE
  • <error retrieving object. in <ERROR RETRIEVING OBJECT
  • 2014-11-28. Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes in MOLECULAR BRAIN
  • 2010-06-23. Evidence for Abnormal Forward Trafficking of AMPA Receptors in Frontal Cortex of Elderly Patients with Schizophrenia in NEUROPSYCHOPHARMACOLOGY
  • 2007-10-16. Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder in MOLECULAR PSYCHIATRY
  • 2015-06-02. Altered functional connectivity of the cingulate subregions in schizophrenia in TRANSLATIONAL PSYCHIATRY
  • 2014-07-22. Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia in MOLECULAR PSYCHIATRY
  • 2010-12-19. Characterization of the proteome, diseases and evolution of the human postsynaptic density in NATURE NEUROSCIENCE
  • 2015-10-20. Reduced protein synthesis in schizophrenia patient-derived olfactory cells in TRANSLATIONAL PSYCHIATRY
  • 2015-10-20. Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients in TRANSLATIONAL PSYCHIATRY
  • 2014-01-22. A polygenic burden of rare disruptive mutations in schizophrenia in NATURE
  • 2008-02-12. Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression in MOLECULAR PSYCHIATRY
  • 2004-07-20. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence in MOLECULAR PSYCHIATRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/tp.2016.224

    DOI

    http://dx.doi.org/10.1038/tp.2016.224

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035125449

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27898073


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bipolar Disorder", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blotting, Western", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Energy Metabolism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gyrus Cinguli", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mass Spectrometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitochondria", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitochondrial Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Post-Synaptic Density", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteomics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reference Values", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Schizophrenia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Synaptic Transmission", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.414315.6", 
              "name": [
                "Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "F\u00f6cking", 
            "givenName": "M", 
            "id": "sg:person.0736776645.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736776645.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Epidemiology and Public Health, Royal College of Surgeons in Ireland, Dublin, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.4912.e", 
              "name": [
                "Departments of Epidemiology and Public Health, Royal College of Surgeons in Ireland, Dublin, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dicker", 
            "givenName": "P", 
            "id": "sg:person.01213772572.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213772572.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.414315.6", 
              "name": [
                "Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lopez", 
            "givenName": "L M", 
            "id": "sg:person.01210514711.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210514711.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.414315.6", 
              "name": [
                "Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hryniewiecka", 
            "givenName": "M", 
            "id": "sg:person.01332336073.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332336073.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Proteome Research Centre, UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "Proteome Research Centre, UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wynne", 
            "givenName": "K", 
            "id": "sg:person.01056412062.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056412062.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.414315.6", 
              "name": [
                "Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "English", 
            "givenName": "J A", 
            "id": "sg:person.01360510644.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360510644.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Proteome Research Centre, UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "Proteome Research Centre, UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cagney", 
            "givenName": "G", 
            "id": "sg:person.01014656545.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014656545.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Beaumont Hospital, Dublin, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.414315.6", 
              "name": [
                "Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland", 
                "Department of Psychiatry, Beaumont Hospital, Dublin, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cotter", 
            "givenName": "D R", 
            "id": "sg:person.01250123344.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250123344.62"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrn3229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037495157", 
              "https://doi.org/10.1038/nrn3229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006242137", 
              "https://doi.org/10.1038/sj.mp.4001792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4002098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053352415", 
              "https://doi.org/10.1038/sj.mp.4002098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/jmn:24:2:315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015514598", 
              "https://doi.org/10.1385/jmn:24:2:315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2015.218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008142780", 
              "https://doi.org/10.1038/npp.2015.218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2011.154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034396329", 
              "https://doi.org/10.1038/mp.2011.154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tp.2015.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044558210", 
              "https://doi.org/10.1038/tp.2015.69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gm546", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031790039", 
              "https://doi.org/10.1186/gm546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2008.7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021697054", 
              "https://doi.org/10.1038/mp.2008.7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031108022", 
              "https://doi.org/10.1038/sj.mp.4001830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000329485", 
              "https://doi.org/10.1038/nature12975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023495141", 
              "https://doi.org/10.1038/nn.3922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2010.87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047645475", 
              "https://doi.org/10.1038/npp.2010.87"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006055325", 
              "https://doi.org/10.1038/nn.2719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2014.82", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046573823", 
              "https://doi.org/10.1038/mp.2014.82"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2013.127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047416335", 
              "https://doi.org/10.1038/mp.2013.127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2014.63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004708179", 
              "https://doi.org/10.1038/mp.2014.63"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tp.2015.118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046771966", 
              "https://doi.org/10.1038/tp.2015.118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049383355", 
              "https://doi.org/10.1038/nature12929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035590976", 
              "https://doi.org/10.1038/nn.3276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036287924", 
              "https://doi.org/10.1038/sj.mp.4001558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13041-014-0088-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004295629", 
              "https://doi.org/10.1186/s13041-014-0088-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.npp.1300451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025847412", 
              "https://doi.org/10.1038/sj.npp.1300451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2011.267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033660338", 
              "https://doi.org/10.1038/npp.2011.267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tp.2015.119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000330429", 
              "https://doi.org/10.1038/tp.2015.119"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-11-29", 
        "datePublishedReg": "2016-11-29", 
        "description": "The postsynaptic density (PSD) contains a complex set of proteins of known relevance to neuropsychiatric disorders such as schizophrenia and bipolar disorder. We enriched for this anatomical structure in the anterior cingulate cortex of 16 bipolar disorder samples and 20 controls from the Stanley Medical Research Institute. Unbiased shotgun proteomics incorporating label-free quantitation was used to identify differentially expressed proteins. Quantitative investigation of the PSD identified 2033 proteins, among which 288 were found to be differentially expressed. Validation of expression changes of DNM1, DTNA, NDUFV2, SEPT11 and SSBP was performed by western blotting. Bioinformatics analysis of the differentially expressed proteins implicated metabolic pathways including mitochondrial function, the tricarboxylic acid cycle, oxidative phosphorylation, protein translation and calcium signaling. The data implicate PSD-associated proteins, and specifically mitochondrial function in bipolar disorder. They relate synaptic function in bipolar disorder and the energy pathways that underpin it. Overall, our findings add to a growing literature linking the PSD and mitochondrial function in psychiatric disorders generally, and suggest that mitochondrial function associated with the PSD is particularly important in bipolar disorder.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/tp.2016.224", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045271", 
            "issn": [
              "2158-3188"
            ], 
            "name": "Translational Psychiatry", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "6"
          }
        ], 
        "keywords": [
          "mitochondrial function", 
          "postsynaptic density", 
          "tricarboxylic acid cycle", 
          "label-free quantitation", 
          "synaptic function", 
          "protein translation", 
          "proteomic analysis", 
          "bioinformatics analysis", 
          "shotgun proteomics", 
          "expression changes", 
          "oxidative phosphorylation", 
          "acid cycle", 
          "metabolic pathways", 
          "calcium signaling", 
          "energy pathways", 
          "protein", 
          "Stanley Medical Research Institute", 
          "bipolar disorder sample", 
          "bipolar disorder", 
          "Western blotting", 
          "pathway", 
          "Dnm1", 
          "proteomics", 
          "NDUFV2", 
          "anterior cingulate cortex", 
          "phosphorylation", 
          "complex set", 
          "signaling", 
          "Medical Research Institute", 
          "DTNA", 
          "psychiatric disorders", 
          "neuropsychiatric disorders", 
          "cingulate cortex", 
          "function", 
          "blotting", 
          "SSBP", 
          "disorders", 
          "disorder sample", 
          "translation", 
          "anatomical structures", 
          "analysis", 
          "cycle", 
          "cortex", 
          "schizophrenia", 
          "Research Institute", 
          "quantitative investigation", 
          "quantitation", 
          "structure", 
          "changes", 
          "density", 
          "findings", 
          "relevance", 
          "control", 
          "Institute", 
          "set", 
          "investigation", 
          "samples", 
          "literature", 
          "validation"
        ], 
        "name": "Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder", 
        "pagination": "e959-e959", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1035125449"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/tp.2016.224"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27898073"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/tp.2016.224", 
          "https://app.dimensions.ai/details/publication/pub.1035125449"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T21:00", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_704.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/tp.2016.224"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/tp.2016.224'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/tp.2016.224'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/tp.2016.224'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/tp.2016.224'


     

    This table displays all metadata directly associated to this object as RDF triples.

    344 TRIPLES      21 PREDICATES      126 URIs      93 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/tp.2016.224 schema:about N016637ea34404fa691f1cd4a983334dd
    2 N041cadb2bc16455386504f5404dcd523
    3 N0d479df1755642bd9ba03e26de8e2d68
    4 N16c0e833f2cc47d1ba720259fab84775
    5 N1e1d7383c09a4b2aa259245da17be6e3
    6 N39a7ab55514b45b7bbd067bd085227e1
    7 N53918809fbeb48669816c0c73d3afd61
    8 N5caa1ac47232487bb153657b384442a1
    9 N61fb9f6f903444bb9d7608e900aaa1a4
    10 N7aa42dd861ac4653a5175d1dbbf0a530
    11 N7c694a53daef4a619565da408ca9d5fb
    12 N8f1cf68bedcc413aa13f7282049e08e2
    13 Nb061d93fb4434081915a79a0c3f41514
    14 Nbbeaa5bd71f849c88d11ba488acdc49a
    15 Nbc52a12caf8e442399b57953507eb4ba
    16 Nbf7d53110ea14417abb673c94cb46241
    17 Nda6d394617ab469e8087e53aa98ede34
    18 anzsrc-for:11
    19 anzsrc-for:1103
    20 schema:author N0f68b799c9be473184afd780b59b6914
    21 schema:citation sg:pub.10.1038/mp.2008.7
    22 sg:pub.10.1038/mp.2011.154
    23 sg:pub.10.1038/mp.2013.127
    24 sg:pub.10.1038/mp.2014.63
    25 sg:pub.10.1038/mp.2014.82
    26 sg:pub.10.1038/nature12929
    27 sg:pub.10.1038/nature12975
    28 sg:pub.10.1038/nn.2719
    29 sg:pub.10.1038/nn.3276
    30 sg:pub.10.1038/nn.3922
    31 sg:pub.10.1038/npp.2010.87
    32 sg:pub.10.1038/npp.2011.267
    33 sg:pub.10.1038/npp.2015.218
    34 sg:pub.10.1038/nrn3229
    35 sg:pub.10.1038/sj.mp.4001558
    36 sg:pub.10.1038/sj.mp.4001792
    37 sg:pub.10.1038/sj.mp.4001830
    38 sg:pub.10.1038/sj.mp.4002098
    39 sg:pub.10.1038/sj.npp.1300451
    40 sg:pub.10.1038/tp.2015.118
    41 sg:pub.10.1038/tp.2015.119
    42 sg:pub.10.1038/tp.2015.69
    43 sg:pub.10.1186/gm546
    44 sg:pub.10.1186/s13041-014-0088-4
    45 sg:pub.10.1385/jmn:24:2:315
    46 schema:datePublished 2016-11-29
    47 schema:datePublishedReg 2016-11-29
    48 schema:description The postsynaptic density (PSD) contains a complex set of proteins of known relevance to neuropsychiatric disorders such as schizophrenia and bipolar disorder. We enriched for this anatomical structure in the anterior cingulate cortex of 16 bipolar disorder samples and 20 controls from the Stanley Medical Research Institute. Unbiased shotgun proteomics incorporating label-free quantitation was used to identify differentially expressed proteins. Quantitative investigation of the PSD identified 2033 proteins, among which 288 were found to be differentially expressed. Validation of expression changes of DNM1, DTNA, NDUFV2, SEPT11 and SSBP was performed by western blotting. Bioinformatics analysis of the differentially expressed proteins implicated metabolic pathways including mitochondrial function, the tricarboxylic acid cycle, oxidative phosphorylation, protein translation and calcium signaling. The data implicate PSD-associated proteins, and specifically mitochondrial function in bipolar disorder. They relate synaptic function in bipolar disorder and the energy pathways that underpin it. Overall, our findings add to a growing literature linking the PSD and mitochondrial function in psychiatric disorders generally, and suggest that mitochondrial function associated with the PSD is particularly important in bipolar disorder.
    49 schema:genre article
    50 schema:isAccessibleForFree true
    51 schema:isPartOf N135e112bd0384420b56dfc998bfc8aa6
    52 N41cc15b90a8c4cc69efba1c3cf43003b
    53 sg:journal.1045271
    54 schema:keywords DTNA
    55 Dnm1
    56 Institute
    57 Medical Research Institute
    58 NDUFV2
    59 Research Institute
    60 SSBP
    61 Stanley Medical Research Institute
    62 Western blotting
    63 acid cycle
    64 analysis
    65 anatomical structures
    66 anterior cingulate cortex
    67 bioinformatics analysis
    68 bipolar disorder
    69 bipolar disorder sample
    70 blotting
    71 calcium signaling
    72 changes
    73 cingulate cortex
    74 complex set
    75 control
    76 cortex
    77 cycle
    78 density
    79 disorder sample
    80 disorders
    81 energy pathways
    82 expression changes
    83 findings
    84 function
    85 investigation
    86 label-free quantitation
    87 literature
    88 metabolic pathways
    89 mitochondrial function
    90 neuropsychiatric disorders
    91 oxidative phosphorylation
    92 pathway
    93 phosphorylation
    94 postsynaptic density
    95 protein
    96 protein translation
    97 proteomic analysis
    98 proteomics
    99 psychiatric disorders
    100 quantitation
    101 quantitative investigation
    102 relevance
    103 samples
    104 schizophrenia
    105 set
    106 shotgun proteomics
    107 signaling
    108 structure
    109 synaptic function
    110 translation
    111 tricarboxylic acid cycle
    112 validation
    113 schema:name Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder
    114 schema:pagination e959-e959
    115 schema:productId N65e4ac68ab8945c1b5be1ebc55e5daae
    116 N7b2b7819b079468eb4019041c02cfa5c
    117 Nd0385fc54964479a948eba4aed782dc1
    118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035125449
    119 https://doi.org/10.1038/tp.2016.224
    120 schema:sdDatePublished 2022-11-24T21:00
    121 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    122 schema:sdPublisher N19d0e09847a14e7db05cadf65d52c23d
    123 schema:url https://doi.org/10.1038/tp.2016.224
    124 sgo:license sg:explorer/license/
    125 sgo:sdDataset articles
    126 rdf:type schema:ScholarlyArticle
    127 N016637ea34404fa691f1cd4a983334dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Reference Values
    129 rdf:type schema:DefinedTerm
    130 N01f8663c64074b539cc8aa76007bca24 rdf:first sg:person.01056412062.25
    131 rdf:rest N13d1eee4533b4a5785b21137c1542f4f
    132 N041cadb2bc16455386504f5404dcd523 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Proteomics
    134 rdf:type schema:DefinedTerm
    135 N0d479df1755642bd9ba03e26de8e2d68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Adult
    137 rdf:type schema:DefinedTerm
    138 N0f68b799c9be473184afd780b59b6914 rdf:first sg:person.0736776645.17
    139 rdf:rest N68b7d254208b4131aacf29b995becee3
    140 N116960c276d04b669b3b8e8048cc6d62 rdf:first sg:person.01250123344.62
    141 rdf:rest rdf:nil
    142 N135e112bd0384420b56dfc998bfc8aa6 schema:volumeNumber 6
    143 rdf:type schema:PublicationVolume
    144 N13d1eee4533b4a5785b21137c1542f4f rdf:first sg:person.01360510644.33
    145 rdf:rest N14910411e6b343a8964a3ee1be052956
    146 N14910411e6b343a8964a3ee1be052956 rdf:first sg:person.01014656545.85
    147 rdf:rest N116960c276d04b669b3b8e8048cc6d62
    148 N16c0e833f2cc47d1ba720259fab84775 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Gyrus Cinguli
    150 rdf:type schema:DefinedTerm
    151 N19d0e09847a14e7db05cadf65d52c23d schema:name Springer Nature - SN SciGraph project
    152 rdf:type schema:Organization
    153 N1e1d7383c09a4b2aa259245da17be6e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Energy Metabolism
    155 rdf:type schema:DefinedTerm
    156 N39a7ab55514b45b7bbd067bd085227e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Mitochondria
    158 rdf:type schema:DefinedTerm
    159 N3d715793b5574fd2a4b3bf2eeaf05be0 rdf:first sg:person.01210514711.19
    160 rdf:rest N84b18d78dd1640a19167d58b456340da
    161 N41cc15b90a8c4cc69efba1c3cf43003b schema:issueNumber 11
    162 rdf:type schema:PublicationIssue
    163 N53918809fbeb48669816c0c73d3afd61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Bipolar Disorder
    165 rdf:type schema:DefinedTerm
    166 N5caa1ac47232487bb153657b384442a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Mass Spectrometry
    168 rdf:type schema:DefinedTerm
    169 N61fb9f6f903444bb9d7608e900aaa1a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Post-Synaptic Density
    171 rdf:type schema:DefinedTerm
    172 N65e4ac68ab8945c1b5be1ebc55e5daae schema:name doi
    173 schema:value 10.1038/tp.2016.224
    174 rdf:type schema:PropertyValue
    175 N68b7d254208b4131aacf29b995becee3 rdf:first sg:person.01213772572.59
    176 rdf:rest N3d715793b5574fd2a4b3bf2eeaf05be0
    177 N7aa42dd861ac4653a5175d1dbbf0a530 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Male
    179 rdf:type schema:DefinedTerm
    180 N7b2b7819b079468eb4019041c02cfa5c schema:name pubmed_id
    181 schema:value 27898073
    182 rdf:type schema:PropertyValue
    183 N7c694a53daef4a619565da408ca9d5fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Blotting, Western
    185 rdf:type schema:DefinedTerm
    186 N84b18d78dd1640a19167d58b456340da rdf:first sg:person.01332336073.70
    187 rdf:rest N01f8663c64074b539cc8aa76007bca24
    188 N8f1cf68bedcc413aa13f7282049e08e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Mitochondrial Diseases
    190 rdf:type schema:DefinedTerm
    191 Nb061d93fb4434081915a79a0c3f41514 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Female
    193 rdf:type schema:DefinedTerm
    194 Nbbeaa5bd71f849c88d11ba488acdc49a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Schizophrenia
    196 rdf:type schema:DefinedTerm
    197 Nbc52a12caf8e442399b57953507eb4ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Middle Aged
    199 rdf:type schema:DefinedTerm
    200 Nbf7d53110ea14417abb673c94cb46241 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Humans
    202 rdf:type schema:DefinedTerm
    203 Nd0385fc54964479a948eba4aed782dc1 schema:name dimensions_id
    204 schema:value pub.1035125449
    205 rdf:type schema:PropertyValue
    206 Nda6d394617ab469e8087e53aa98ede34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Synaptic Transmission
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Medical and Health Sciences
    211 rdf:type schema:DefinedTerm
    212 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Clinical Sciences
    214 rdf:type schema:DefinedTerm
    215 sg:journal.1045271 schema:issn 2158-3188
    216 schema:name Translational Psychiatry
    217 schema:publisher Springer Nature
    218 rdf:type schema:Periodical
    219 sg:person.01014656545.85 schema:affiliation grid-institutes:grid.7886.1
    220 schema:familyName Cagney
    221 schema:givenName G
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014656545.85
    223 rdf:type schema:Person
    224 sg:person.01056412062.25 schema:affiliation grid-institutes:grid.7886.1
    225 schema:familyName Wynne
    226 schema:givenName K
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056412062.25
    228 rdf:type schema:Person
    229 sg:person.01210514711.19 schema:affiliation grid-institutes:grid.414315.6
    230 schema:familyName Lopez
    231 schema:givenName L M
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210514711.19
    233 rdf:type schema:Person
    234 sg:person.01213772572.59 schema:affiliation grid-institutes:grid.4912.e
    235 schema:familyName Dicker
    236 schema:givenName P
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213772572.59
    238 rdf:type schema:Person
    239 sg:person.01250123344.62 schema:affiliation grid-institutes:grid.414315.6
    240 schema:familyName Cotter
    241 schema:givenName D R
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250123344.62
    243 rdf:type schema:Person
    244 sg:person.01332336073.70 schema:affiliation grid-institutes:grid.414315.6
    245 schema:familyName Hryniewiecka
    246 schema:givenName M
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332336073.70
    248 rdf:type schema:Person
    249 sg:person.01360510644.33 schema:affiliation grid-institutes:grid.414315.6
    250 schema:familyName English
    251 schema:givenName J A
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360510644.33
    253 rdf:type schema:Person
    254 sg:person.0736776645.17 schema:affiliation grid-institutes:grid.414315.6
    255 schema:familyName Föcking
    256 schema:givenName M
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736776645.17
    258 rdf:type schema:Person
    259 sg:pub.10.1038/mp.2008.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021697054
    260 https://doi.org/10.1038/mp.2008.7
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/mp.2011.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034396329
    263 https://doi.org/10.1038/mp.2011.154
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/mp.2013.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047416335
    266 https://doi.org/10.1038/mp.2013.127
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/mp.2014.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004708179
    269 https://doi.org/10.1038/mp.2014.63
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/mp.2014.82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046573823
    272 https://doi.org/10.1038/mp.2014.82
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nature12929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049383355
    275 https://doi.org/10.1038/nature12929
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nature12975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000329485
    278 https://doi.org/10.1038/nature12975
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/nn.2719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006055325
    281 https://doi.org/10.1038/nn.2719
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/nn.3276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035590976
    284 https://doi.org/10.1038/nn.3276
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/nn.3922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023495141
    287 https://doi.org/10.1038/nn.3922
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/npp.2010.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047645475
    290 https://doi.org/10.1038/npp.2010.87
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/npp.2011.267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033660338
    293 https://doi.org/10.1038/npp.2011.267
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/npp.2015.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008142780
    296 https://doi.org/10.1038/npp.2015.218
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/nrn3229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037495157
    299 https://doi.org/10.1038/nrn3229
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/sj.mp.4001558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036287924
    302 https://doi.org/10.1038/sj.mp.4001558
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/sj.mp.4001792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006242137
    305 https://doi.org/10.1038/sj.mp.4001792
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/sj.mp.4001830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031108022
    308 https://doi.org/10.1038/sj.mp.4001830
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/sj.mp.4002098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053352415
    311 https://doi.org/10.1038/sj.mp.4002098
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/sj.npp.1300451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025847412
    314 https://doi.org/10.1038/sj.npp.1300451
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/tp.2015.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046771966
    317 https://doi.org/10.1038/tp.2015.118
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/tp.2015.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000330429
    320 https://doi.org/10.1038/tp.2015.119
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/tp.2015.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044558210
    323 https://doi.org/10.1038/tp.2015.69
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1186/gm546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031790039
    326 https://doi.org/10.1186/gm546
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1186/s13041-014-0088-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004295629
    329 https://doi.org/10.1186/s13041-014-0088-4
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1385/jmn:24:2:315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015514598
    332 https://doi.org/10.1385/jmn:24:2:315
    333 rdf:type schema:CreativeWork
    334 grid-institutes:grid.414315.6 schema:alternateName Department of Psychiatry, Beaumont Hospital, Dublin, Ireland
    335 Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    336 schema:name Department of Psychiatry, Beaumont Hospital, Dublin, Ireland
    337 Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    338 rdf:type schema:Organization
    339 grid-institutes:grid.4912.e schema:alternateName Departments of Epidemiology and Public Health, Royal College of Surgeons in Ireland, Dublin, Ireland
    340 schema:name Departments of Epidemiology and Public Health, Royal College of Surgeons in Ireland, Dublin, Ireland
    341 rdf:type schema:Organization
    342 grid-institutes:grid.7886.1 schema:alternateName Proteome Research Centre, UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
    343 schema:name Proteome Research Centre, UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
    344 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...