Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05

AUTHORS

Z T Freeman, K A Rice, P L Soto, K A M Pate, M R Weed, N A Ator, I G DeLeon, D F Wong, Y Zhou, J L Mankowski, M C Zink, R J Adams, E K Hutchinson

ABSTRACT

Self-injurious behavior (SIB) is a common comorbidity of psychiatric disorders but there is a dearth of information about neurological mechanisms underlying the behavior, and few animal models exist. SIB in humans is characterized by any intentional self-directed behavior that leads to wounds, whereas in macaques it is not always accompanied by wounds. We describe a cohort of rhesus macaques displaying SIB as adults, in which changes within the central nervous system were associated with the SIB. In these macaques, increases in central nervous system striatal dopamine (DA) receptor binding (BPND) measured by positron emission tomography (PET) [11C]raclopride imaging correlated with severity of wounding (rs=0.662, P=0.014). Furthermore, utilizing standardized cognitive function tests, we showed that impulsivity (stop signal reaction time, SSRT) and deficits in attentional set shifting (intra-/extradimensional shift) were correlated with increased severity of SIB (rs=0.563, P=0.045 and rs=0.692, P=0.009, respectively). We also tested the efficacy of guanfacine, an α2A adrenergic agonist that acts to improve postsynaptic transmission of neuronal impulses, in reducing SIB. A subset of these animals were enrolled in a randomized experimenter-blinded study that demonstrated guanfacine decreased the severity of wounding in treated animals compared with vehicle-only-treated controls (P=0.043), with residual beneficial effects seen for several weeks after cessation of therapy. Animals with the highest severity of SIB that received guanfacine also showed the most significant improvement (rs=-0.761, P=0.009). The elevated PET BPND was likely due to low intrasynaptic DA, which in turn may have been improved by guanfacine. With underlying physiology potentially representative of the human condition and the ability to affect outcome measures of disease using pharmacotherapy, this model represents a unique opportunity to further our understanding of the biology and treatment of SIB in both animals and humans. More... »

PAGES

e567

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/tp.2015.61

DOI

http://dx.doi.org/10.1038/tp.2015.61

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044251613

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25989141


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenergic alpha-2 Receptor Agonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Attention", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Behavior, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carbon Radioisotopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognition Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dopamine Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guanfacine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Impulsive Behavior", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macaca mulatta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neostriatum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuropsychological Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Raclopride", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Random Allocation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reaction Time", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Dopamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Self-Injurious Behavior", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Freeman", 
        "givenName": "Z T", 
        "id": "sg:person.01226077341.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226077341.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "1] Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA [2] Division of Veterinary Resources, National Institutes of Health, Bethesda, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rice", 
        "givenName": "K A", 
        "id": "sg:person.01261061433.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261061433.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soto", 
        "givenName": "P L", 
        "id": "sg:person.01060526466.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060526466.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pate", 
        "givenName": "K A M", 
        "id": "sg:person.0616721641.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616721641.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weed", 
        "givenName": "M R", 
        "id": "sg:person.01170607231.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170607231.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ator", 
        "givenName": "N A", 
        "id": "sg:person.0652766177.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652766177.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "1] Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA [2] Department of Behavioral Psychology, Kennedy Krieger Institute, Baltimore, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "DeLeon", 
        "givenName": "I G", 
        "id": "sg:person.01222620360.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222620360.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "1] Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA [2] Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, USA [3] Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "D F", 
        "id": "sg:person.010017112322.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010017112322.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Y", 
        "id": "sg:person.0631105275.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631105275.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mankowski", 
        "givenName": "J L", 
        "id": "sg:person.01023515003.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023515003.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zink", 
        "givenName": "M C", 
        "id": "sg:person.0625775464.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625775464.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adams", 
        "givenName": "R J", 
        "id": "sg:person.0632546202.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632546202.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Division of Veterinary Resources, National Institutes of Health, Bethesda, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hutchinson", 
        "givenName": "E K", 
        "id": "sg:person.0651703733.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651703733.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1866-1955-4-21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000267876", 
          "https://doi.org/10.1186/1866-1955-4-21"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.317.7156.441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000470511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0735-7044.110.5.872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002484299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0773.2003.930105.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003820097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0926-6410(99)00020-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005204574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.890020304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006895691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2788.2012.01537.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007243553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-011-2408-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007771715", 
          "https://doi.org/10.1007/s00213-011-2408-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2788.2012.01628.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009638864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1901/jaba.1996.29-239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014231638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198111053051902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014609996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2006.06.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014929270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-7967(66)90024-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017992063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1098-2779(200102)7:1<3::aid-mrdd1002>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018354797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygcen.2012.11.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019191923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/a0027342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023247529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2006.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024901617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajp.10063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026271978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-8749.1995.tb15017.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026448912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-8749.1995.tb15017.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026448912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2788.1978.tb00960.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028179884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.1996.0131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028515403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajp.10075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028605635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199606133342403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029700045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneumeth.2008.09.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030421555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0001-6918(99)00005-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031503146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(00)00111-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033181767", 
          "https://doi.org/10.1016/s0893-133x(00)00111-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1901/jaba.1990.23-99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034274804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2012.119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034957805", 
          "https://doi.org/10.1038/npp.2012.119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-011-9332-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035378978", 
          "https://doi.org/10.1007/s11481-011-9332-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-011-9332-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035378978", 
          "https://doi.org/10.1007/s11481-011-9332-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd009084.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035393246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajp.20037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035746174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4324/9781410615695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036585736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-1781(91)90054-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036780572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2788.1990.tb01529.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037564794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(98)00026-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038140416", 
          "https://doi.org/10.1016/s0893-133x(98)00026-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2097-04.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040388682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.11.5539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041127826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/h0080369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042900661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ndt.s1711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045059662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2788.2010.01337.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045092210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14656566.2010.517523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053079606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-973462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057505734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/cap.1999.9.285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059240744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.158.7.1067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063493970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.00108s3409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064737168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1521/pedi.2004.18.4.358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067633113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/1500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070913786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074581325", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074708904", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077112279", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077888893", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078590225", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079159042", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083042116", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-05", 
    "datePublishedReg": "2015-05-01", 
    "description": "Self-injurious behavior (SIB) is a common comorbidity of psychiatric disorders but there is a dearth of information about neurological mechanisms underlying the behavior, and few animal models exist. SIB in humans is characterized by any intentional self-directed behavior that leads to wounds, whereas in macaques it is not always accompanied by wounds. We describe a cohort of rhesus macaques displaying SIB as adults, in which changes within the central nervous system were associated with the SIB. In these macaques, increases in central nervous system striatal dopamine (DA) receptor binding (BPND) measured by positron emission tomography (PET) [11C]raclopride imaging correlated with severity of wounding (rs=0.662, P=0.014). Furthermore, utilizing standardized cognitive function tests, we showed that impulsivity (stop signal reaction time, SSRT) and deficits in attentional set shifting (intra-/extradimensional shift) were correlated with increased severity of SIB (rs=0.563, P=0.045 and rs=0.692, P=0.009, respectively). We also tested the efficacy of guanfacine, an \u03b12A adrenergic agonist that acts to improve postsynaptic transmission of neuronal impulses, in reducing SIB. A subset of these animals were enrolled in a randomized experimenter-blinded study that demonstrated guanfacine decreased the severity of wounding in treated animals compared with vehicle-only-treated controls (P=0.043), with residual beneficial effects seen for several weeks after cessation of therapy. Animals with the highest severity of SIB that received guanfacine also showed the most significant improvement (rs=-0.761, P=0.009). The elevated PET BPND was likely due to low intrasynaptic DA, which in turn may have been improved by guanfacine. With underlying physiology potentially representative of the human condition and the ability to affect outcome measures of disease using pharmacotherapy, this model represents a unique opportunity to further our understanding of the biology and treatment of SIB in both animals and humans. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/tp.2015.61", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2692458", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7028845", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439556", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439636", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2685775", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045271", 
        "issn": [
          "2158-3188"
        ], 
        "name": "Translational Psychiatry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior", 
    "pagination": "e567", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d2c90f4ccead3433fbae9ae98e07053801f7783b73a95f92ff2b82548ed09975"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25989141"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101562664"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/tp.2015.61"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044251613"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/tp.2015.61", 
      "https://app.dimensions.ai/details/publication/pub.1044251613"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/tp/journal/v5/n5/full/tp201561a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/tp.2015.61'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/tp.2015.61'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/tp.2015.61'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/tp.2015.61'


 

This table displays all metadata directly associated to this object as RDF triples.

419 TRIPLES      21 PREDICATES      105 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/tp.2015.61 schema:about N0d89b2bba3944f638603c20282194752
2 N1d52a51eccec40f88b037c855234d8e3
3 N261dead06cb44abb95382717233d7025
4 N315cb0cbfef04596acda142ff167fdd3
5 N467a2a652fd74f688d31002874ee7c8a
6 N55ad11ebb1f446ccb25ac3889f011728
7 N63421f99fa954d8b8f2ccc594adc89be
8 N7d2eabcc5f18495da2de0896837ddce2
9 N8fb6ec31e98e40429d4b7d0044cc285b
10 N90e072fa350a4547859e6a88507ac7ca
11 N95b3ad3dae544adf89d78f9bd550e8b7
12 N98660322901b474d9ee9191c1279d570
13 Na11b2bd5bb6446dc9cf8ba981345254d
14 Na274630ec4a34e60b59bad64bf66fd95
15 Na83b032c00314fdba362bca375398439
16 Nadb3f331ca8c4c968d1e6fbd7e5700e7
17 Nbedc464806a142ad95cecf7ebc7f40c7
18 Nc80d991d83e04afbabb6905371e7db16
19 Nca8c12642b26466783567b187a79c7b4
20 Nd298d8b14c684e8ba8cce47688a6b06a
21 Ndc243ebb93c148d18ddb304c131dd270
22 Ne3d2eb14bc8d424a8cf6f824010a4ac5
23 anzsrc-for:11
24 anzsrc-for:1109
25 schema:author Ncf2394113680463ba699edcec6c96b7d
26 schema:citation sg:pub.10.1007/s00213-011-2408-z
27 sg:pub.10.1007/s11481-011-9332-1
28 sg:pub.10.1016/s0893-133x(00)00111-1
29 sg:pub.10.1016/s0893-133x(98)00026-8
30 sg:pub.10.1038/npp.2012.119
31 sg:pub.10.1186/1866-1955-4-21
32 https://app.dimensions.ai/details/publication/pub.1074581325
33 https://app.dimensions.ai/details/publication/pub.1074708904
34 https://app.dimensions.ai/details/publication/pub.1077112279
35 https://app.dimensions.ai/details/publication/pub.1077888893
36 https://app.dimensions.ai/details/publication/pub.1078590225
37 https://app.dimensions.ai/details/publication/pub.1079159042
38 https://app.dimensions.ai/details/publication/pub.1083042116
39 https://doi.org/10.1002/1098-2779(200102)7:1<3::aid-mrdd1002>3.0.co;2-#
40 https://doi.org/10.1002/14651858.cd009084.pub2
41 https://doi.org/10.1002/ajp.10063
42 https://doi.org/10.1002/ajp.10075
43 https://doi.org/10.1002/ajp.20037
44 https://doi.org/10.1002/syn.890020304
45 https://doi.org/10.1016/0005-7967(66)90024-6
46 https://doi.org/10.1016/0165-1781(91)90054-s
47 https://doi.org/10.1016/j.jneumeth.2008.09.020
48 https://doi.org/10.1016/j.neuroimage.2006.06.038
49 https://doi.org/10.1016/j.schres.2006.08.014
50 https://doi.org/10.1016/j.ygcen.2012.11.025
51 https://doi.org/10.1016/s0001-6918(99)00005-0
52 https://doi.org/10.1016/s0926-6410(99)00020-8
53 https://doi.org/10.1034/j.1600-0773.2003.930105.x
54 https://doi.org/10.1037/0735-7044.110.5.872
55 https://doi.org/10.1037/a0027342
56 https://doi.org/10.1037/h0080369
57 https://doi.org/10.1055/s-2007-973462
58 https://doi.org/10.1056/nejm198111053051902
59 https://doi.org/10.1056/nejm199606133342403
60 https://doi.org/10.1073/pnas.93.11.5539
61 https://doi.org/10.1089/cap.1999.9.285
62 https://doi.org/10.1098/rstb.1996.0131
63 https://doi.org/10.1111/j.1365-2788.1978.tb00960.x
64 https://doi.org/10.1111/j.1365-2788.1990.tb01529.x
65 https://doi.org/10.1111/j.1365-2788.2010.01337.x
66 https://doi.org/10.1111/j.1365-2788.2012.01537.x
67 https://doi.org/10.1111/j.1365-2788.2012.01628.x
68 https://doi.org/10.1111/j.1469-8749.1995.tb15017.x
69 https://doi.org/10.1136/bmj.317.7156.441
70 https://doi.org/10.1176/appi.ajp.158.7.1067
71 https://doi.org/10.1289/ehp.00108s3409
72 https://doi.org/10.1517/14656566.2010.517523
73 https://doi.org/10.1521/pedi.2004.18.4.358
74 https://doi.org/10.1523/jneurosci.2097-04.2005
75 https://doi.org/10.1901/jaba.1990.23-99
76 https://doi.org/10.1901/jaba.1996.29-239
77 https://doi.org/10.2147/ndt.s1711
78 https://doi.org/10.2741/1500
79 https://doi.org/10.4324/9781410615695
80 schema:datePublished 2015-05
81 schema:datePublishedReg 2015-05-01
82 schema:description Self-injurious behavior (SIB) is a common comorbidity of psychiatric disorders but there is a dearth of information about neurological mechanisms underlying the behavior, and few animal models exist. SIB in humans is characterized by any intentional self-directed behavior that leads to wounds, whereas in macaques it is not always accompanied by wounds. We describe a cohort of rhesus macaques displaying SIB as adults, in which changes within the central nervous system were associated with the SIB. In these macaques, increases in central nervous system striatal dopamine (DA) receptor binding (BPND) measured by positron emission tomography (PET) [11C]raclopride imaging correlated with severity of wounding (rs=0.662, P=0.014). Furthermore, utilizing standardized cognitive function tests, we showed that impulsivity (stop signal reaction time, SSRT) and deficits in attentional set shifting (intra-/extradimensional shift) were correlated with increased severity of SIB (rs=0.563, P=0.045 and rs=0.692, P=0.009, respectively). We also tested the efficacy of guanfacine, an α2A adrenergic agonist that acts to improve postsynaptic transmission of neuronal impulses, in reducing SIB. A subset of these animals were enrolled in a randomized experimenter-blinded study that demonstrated guanfacine decreased the severity of wounding in treated animals compared with vehicle-only-treated controls (P=0.043), with residual beneficial effects seen for several weeks after cessation of therapy. Animals with the highest severity of SIB that received guanfacine also showed the most significant improvement (rs=-0.761, P=0.009). The elevated PET BPND was likely due to low intrasynaptic DA, which in turn may have been improved by guanfacine. With underlying physiology potentially representative of the human condition and the ability to affect outcome measures of disease using pharmacotherapy, this model represents a unique opportunity to further our understanding of the biology and treatment of SIB in both animals and humans.
83 schema:genre research_article
84 schema:inLanguage en
85 schema:isAccessibleForFree true
86 schema:isPartOf N6e2687370d944abdbe3b11143fc4bad8
87 Nfde935da927746a2bfb35955a5cd7627
88 sg:journal.1045271
89 schema:name Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior
90 schema:pagination e567
91 schema:productId N085a1be0224a447490975f61322d7cb2
92 N28501ec7cf914e80af08ef146986e50f
93 N75e4395c6ea8494a97e8c9edacc76a65
94 Nb48c27e2cd3d4aca88dad4926be1d5ed
95 Nba13732c3f3048b9866d0b917a70425d
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044251613
97 https://doi.org/10.1038/tp.2015.61
98 schema:sdDatePublished 2019-04-10T16:49
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher Ne8760c50c58641a68633c186c9e7a366
101 schema:url http://www.nature.com/tp/journal/v5/n5/full/tp201561a.html
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N085a1be0224a447490975f61322d7cb2 schema:name pubmed_id
106 schema:value 25989141
107 rdf:type schema:PropertyValue
108 N0cb3f4dec0fc4a318eceaed2cb99b2a8 rdf:first sg:person.0651703733.12
109 rdf:rest rdf:nil
110 N0d89b2bba3944f638603c20282194752 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Guanfacine
112 rdf:type schema:DefinedTerm
113 N1d52a51eccec40f88b037c855234d8e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Self-Injurious Behavior
115 rdf:type schema:DefinedTerm
116 N2270d6085c274aeabbeeed76562e5111 rdf:first sg:person.010017112322.78
117 rdf:rest N6a10cbccc8294943bfbd7f506d0b4c64
118 N261dead06cb44abb95382717233d7025 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Male
120 rdf:type schema:DefinedTerm
121 N28501ec7cf914e80af08ef146986e50f schema:name nlm_unique_id
122 schema:value 101562664
123 rdf:type schema:PropertyValue
124 N315cb0cbfef04596acda142ff167fdd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Random Allocation
126 rdf:type schema:DefinedTerm
127 N3b594db0f28b4683b8fe6e15cdbb199f rdf:first sg:person.0625775464.88
128 rdf:rest Nfd31612ef5c64f82857c5102815acdc5
129 N467a2a652fd74f688d31002874ee7c8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Dopamine Antagonists
131 rdf:type schema:DefinedTerm
132 N55ad11ebb1f446ccb25ac3889f011728 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Disease Models, Animal
134 rdf:type schema:DefinedTerm
135 N5c8aa7922cb94a9bb74deafed3cae678 rdf:first sg:person.01261061433.38
136 rdf:rest N8b0b5f6526144356a3378fd49defea9b
137 N63421f99fa954d8b8f2ccc594adc89be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Reaction Time
139 rdf:type schema:DefinedTerm
140 N6a10cbccc8294943bfbd7f506d0b4c64 rdf:first sg:person.0631105275.40
141 rdf:rest Nd9693ce918ce48fc96e1c74ffcd3ebf3
142 N6e2687370d944abdbe3b11143fc4bad8 schema:issueNumber 5
143 rdf:type schema:PublicationIssue
144 N75e4395c6ea8494a97e8c9edacc76a65 schema:name doi
145 schema:value 10.1038/tp.2015.61
146 rdf:type schema:PropertyValue
147 N7d2eabcc5f18495da2de0896837ddce2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Positron-Emission Tomography
149 rdf:type schema:DefinedTerm
150 N886044457f4e483992ccf8cdb4f837b7 rdf:first sg:person.0652766177.64
151 rdf:rest Naabf7e3cb0d946b48db8da345acc87ea
152 N8b0b5f6526144356a3378fd49defea9b rdf:first sg:person.01060526466.01
153 rdf:rest Nbd1d0653150f41eb9e8b34ad85858d6d
154 N8fb6ec31e98e40429d4b7d0044cc285b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Cognition Disorders
156 rdf:type schema:DefinedTerm
157 N90e072fa350a4547859e6a88507ac7ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Neuropsychological Tests
159 rdf:type schema:DefinedTerm
160 N95b3ad3dae544adf89d78f9bd550e8b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Receptors, Dopamine
162 rdf:type schema:DefinedTerm
163 N98660322901b474d9ee9191c1279d570 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Cognition
165 rdf:type schema:DefinedTerm
166 Na11b2bd5bb6446dc9cf8ba981345254d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Adrenergic alpha-2 Receptor Agonists
168 rdf:type schema:DefinedTerm
169 Na274630ec4a34e60b59bad64bf66fd95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Impulsive Behavior
171 rdf:type schema:DefinedTerm
172 Na83b032c00314fdba362bca375398439 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Carbon Radioisotopes
174 rdf:type schema:DefinedTerm
175 Naabf7e3cb0d946b48db8da345acc87ea rdf:first sg:person.01222620360.15
176 rdf:rest N2270d6085c274aeabbeeed76562e5111
177 Nadb3f331ca8c4c968d1e6fbd7e5700e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Attention
179 rdf:type schema:DefinedTerm
180 Nb48c27e2cd3d4aca88dad4926be1d5ed schema:name dimensions_id
181 schema:value pub.1044251613
182 rdf:type schema:PropertyValue
183 Nba13732c3f3048b9866d0b917a70425d schema:name readcube_id
184 schema:value d2c90f4ccead3433fbae9ae98e07053801f7783b73a95f92ff2b82548ed09975
185 rdf:type schema:PropertyValue
186 Nbd1d0653150f41eb9e8b34ad85858d6d rdf:first sg:person.0616721641.29
187 rdf:rest Nc66d0f367a9041f2824dd7575426bc50
188 Nbedc464806a142ad95cecf7ebc7f40c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Macaca mulatta
190 rdf:type schema:DefinedTerm
191 Nc66d0f367a9041f2824dd7575426bc50 rdf:first sg:person.01170607231.83
192 rdf:rest N886044457f4e483992ccf8cdb4f837b7
193 Nc80d991d83e04afbabb6905371e7db16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Severity of Illness Index
195 rdf:type schema:DefinedTerm
196 Nca8c12642b26466783567b187a79c7b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Behavior, Animal
198 rdf:type schema:DefinedTerm
199 Ncf2394113680463ba699edcec6c96b7d rdf:first sg:person.01226077341.06
200 rdf:rest N5c8aa7922cb94a9bb74deafed3cae678
201 Nd298d8b14c684e8ba8cce47688a6b06a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Neostriatum
203 rdf:type schema:DefinedTerm
204 Nd9693ce918ce48fc96e1c74ffcd3ebf3 rdf:first sg:person.01023515003.44
205 rdf:rest N3b594db0f28b4683b8fe6e15cdbb199f
206 Ndc243ebb93c148d18ddb304c131dd270 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Animals
208 rdf:type schema:DefinedTerm
209 Ne3d2eb14bc8d424a8cf6f824010a4ac5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Raclopride
211 rdf:type schema:DefinedTerm
212 Ne8760c50c58641a68633c186c9e7a366 schema:name Springer Nature - SN SciGraph project
213 rdf:type schema:Organization
214 Nfd31612ef5c64f82857c5102815acdc5 rdf:first sg:person.0632546202.44
215 rdf:rest N0cb3f4dec0fc4a318eceaed2cb99b2a8
216 Nfde935da927746a2bfb35955a5cd7627 schema:volumeNumber 5
217 rdf:type schema:PublicationVolume
218 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
219 schema:name Medical and Health Sciences
220 rdf:type schema:DefinedTerm
221 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
222 schema:name Neurosciences
223 rdf:type schema:DefinedTerm
224 sg:grant.2439556 http://pending.schema.org/fundedItem sg:pub.10.1038/tp.2015.61
225 rdf:type schema:MonetaryGrant
226 sg:grant.2439636 http://pending.schema.org/fundedItem sg:pub.10.1038/tp.2015.61
227 rdf:type schema:MonetaryGrant
228 sg:grant.2685775 http://pending.schema.org/fundedItem sg:pub.10.1038/tp.2015.61
229 rdf:type schema:MonetaryGrant
230 sg:grant.2692458 http://pending.schema.org/fundedItem sg:pub.10.1038/tp.2015.61
231 rdf:type schema:MonetaryGrant
232 sg:grant.7028845 http://pending.schema.org/fundedItem sg:pub.10.1038/tp.2015.61
233 rdf:type schema:MonetaryGrant
234 sg:journal.1045271 schema:issn 2158-3188
235 schema:name Translational Psychiatry
236 rdf:type schema:Periodical
237 sg:person.010017112322.78 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
238 schema:familyName Wong
239 schema:givenName D F
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010017112322.78
241 rdf:type schema:Person
242 sg:person.01023515003.44 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
243 schema:familyName Mankowski
244 schema:givenName J L
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023515003.44
246 rdf:type schema:Person
247 sg:person.01060526466.01 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
248 schema:familyName Soto
249 schema:givenName P L
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060526466.01
251 rdf:type schema:Person
252 sg:person.01170607231.83 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
253 schema:familyName Weed
254 schema:givenName M R
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170607231.83
256 rdf:type schema:Person
257 sg:person.01222620360.15 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
258 schema:familyName DeLeon
259 schema:givenName I G
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222620360.15
261 rdf:type schema:Person
262 sg:person.01226077341.06 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
263 schema:familyName Freeman
264 schema:givenName Z T
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226077341.06
266 rdf:type schema:Person
267 sg:person.01261061433.38 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
268 schema:familyName Rice
269 schema:givenName K A
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261061433.38
271 rdf:type schema:Person
272 sg:person.0616721641.29 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
273 schema:familyName Pate
274 schema:givenName K A M
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616721641.29
276 rdf:type schema:Person
277 sg:person.0625775464.88 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
278 schema:familyName Zink
279 schema:givenName M C
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625775464.88
281 rdf:type schema:Person
282 sg:person.0631105275.40 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
283 schema:familyName Zhou
284 schema:givenName Y
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631105275.40
286 rdf:type schema:Person
287 sg:person.0632546202.44 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
288 schema:familyName Adams
289 schema:givenName R J
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632546202.44
291 rdf:type schema:Person
292 sg:person.0651703733.12 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
293 schema:familyName Hutchinson
294 schema:givenName E K
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651703733.12
296 rdf:type schema:Person
297 sg:person.0652766177.64 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
298 schema:familyName Ator
299 schema:givenName N A
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652766177.64
301 rdf:type schema:Person
302 sg:pub.10.1007/s00213-011-2408-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1007771715
303 https://doi.org/10.1007/s00213-011-2408-z
304 rdf:type schema:CreativeWork
305 sg:pub.10.1007/s11481-011-9332-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035378978
306 https://doi.org/10.1007/s11481-011-9332-1
307 rdf:type schema:CreativeWork
308 sg:pub.10.1016/s0893-133x(00)00111-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033181767
309 https://doi.org/10.1016/s0893-133x(00)00111-1
310 rdf:type schema:CreativeWork
311 sg:pub.10.1016/s0893-133x(98)00026-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038140416
312 https://doi.org/10.1016/s0893-133x(98)00026-8
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/npp.2012.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034957805
315 https://doi.org/10.1038/npp.2012.119
316 rdf:type schema:CreativeWork
317 sg:pub.10.1186/1866-1955-4-21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000267876
318 https://doi.org/10.1186/1866-1955-4-21
319 rdf:type schema:CreativeWork
320 https://app.dimensions.ai/details/publication/pub.1074581325 schema:CreativeWork
321 https://app.dimensions.ai/details/publication/pub.1074708904 schema:CreativeWork
322 https://app.dimensions.ai/details/publication/pub.1077112279 schema:CreativeWork
323 https://app.dimensions.ai/details/publication/pub.1077888893 schema:CreativeWork
324 https://app.dimensions.ai/details/publication/pub.1078590225 schema:CreativeWork
325 https://app.dimensions.ai/details/publication/pub.1079159042 schema:CreativeWork
326 https://app.dimensions.ai/details/publication/pub.1083042116 schema:CreativeWork
327 https://doi.org/10.1002/1098-2779(200102)7:1<3::aid-mrdd1002>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1018354797
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1002/14651858.cd009084.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035393246
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1002/ajp.10063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026271978
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1002/ajp.10075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028605635
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1002/ajp.20037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035746174
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1002/syn.890020304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006895691
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/0005-7967(66)90024-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017992063
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/0165-1781(91)90054-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1036780572
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/j.jneumeth.2008.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030421555
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/j.neuroimage.2006.06.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014929270
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/j.schres.2006.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024901617
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/j.ygcen.2012.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019191923
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/s0001-6918(99)00005-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031503146
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1016/s0926-6410(99)00020-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005204574
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1034/j.1600-0773.2003.930105.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003820097
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1037/0735-7044.110.5.872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002484299
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1037/a0027342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023247529
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1037/h0080369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042900661
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1055/s-2007-973462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057505734
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1056/nejm198111053051902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014609996
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1056/nejm199606133342403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029700045
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1073/pnas.93.11.5539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041127826
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1089/cap.1999.9.285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059240744
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1098/rstb.1996.0131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028515403
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1111/j.1365-2788.1978.tb00960.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028179884
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1111/j.1365-2788.1990.tb01529.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037564794
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1111/j.1365-2788.2010.01337.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045092210
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1111/j.1365-2788.2012.01537.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007243553
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1111/j.1365-2788.2012.01628.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009638864
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1111/j.1469-8749.1995.tb15017.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026448912
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1136/bmj.317.7156.441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000470511
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1176/appi.ajp.158.7.1067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063493970
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1289/ehp.00108s3409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064737168
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1517/14656566.2010.517523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053079606
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1521/pedi.2004.18.4.358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067633113
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1523/jneurosci.2097-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040388682
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1901/jaba.1990.23-99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034274804
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1901/jaba.1996.29-239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014231638
402 rdf:type schema:CreativeWork
403 https://doi.org/10.2147/ndt.s1711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045059662
404 rdf:type schema:CreativeWork
405 https://doi.org/10.2741/1500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070913786
406 rdf:type schema:CreativeWork
407 https://doi.org/10.4324/9781410615695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036585736
408 rdf:type schema:CreativeWork
409 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
410 schema:name 1] Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA [2] Division of Veterinary Resources, National Institutes of Health, Bethesda, MD, USA.
411 1] Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA [2] Department of Behavioral Psychology, Kennedy Krieger Institute, Baltimore, MD, USA.
412 1] Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA [2] Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, USA [3] Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
413 Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
414 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
415 Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, USA.
416 rdf:type schema:Organization
417 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
418 schema:name Division of Veterinary Resources, National Institutes of Health, Bethesda, MD, USA.
419 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...