Argon blocks the expression of locomotor sensitization to amphetamine through antagonism at the vesicular monoamine transporter-2 and mu-opioid receptor in ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07-07

AUTHORS

H N David, M Dhilly, M Degoulet, G Poisnel, C Meckler, N Vallée, J-É Blatteau, J-J Risso, M Lemaire, D Debruyne, J H Abraini

ABSTRACT

We investigated the effects of the noble gas argon on the expression of locomotor sensitization to amphetamine and amphetamine-induced changes in dopamine release and mu-opioid neurotransmission in the nucleus accumbens. We found (1) argon blocked the increase in carrier-mediated dopamine release induced by amphetamine in brain slices, but, in contrast, potentiated the decrease in KCl-evoked dopamine release induced by amphetamine, thereby suggesting that argon inhibited the vesicular monoamine transporter-2; (2) argon blocked the expression of locomotor and mu-opioid neurotransmission sensitization induced by repeated amphetamine administration in a short-term model of sensitization in rats; (3) argon decreased the maximal number of binding sites and increased the dissociation constant of mu-receptors in membrane preparations, thereby indicating that argon is a mu-receptor antagonist; (4) argon blocked the expression of locomotor sensitization and context-dependent locomotor activity induced by repeated administration of amphetamine in a long-term model of sensitization. Taken together, these data indicate that argon could be of potential interest for treating drug addiction and dependence. More... »

PAGES

e594-e594

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/tp.2015.27

DOI

http://dx.doi.org/10.1038/tp.2015.27

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008655737

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26151922


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