Autism-specific maternal autoantibodies recognize critical proteins in developing brain View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07

AUTHORS

D Braunschweig, P Krakowiak, P Duncanson, R Boyce, R L Hansen, P Ashwood, I Hertz-Picciotto, I N Pessah, J Van de Water

ABSTRACT

Autism spectrum disorders (ASDs) are neurodevelopmental in origin, affecting an estimated 1 in 88 children in the United States. We previously described ASD-specific maternal autoantibodies that recognize fetal brain antigens. Herein, we demonstrate that lactate dehydrogenase A and B (LDH), cypin, stress-induced phosphoprotein 1 (STIP1), collapsin response mediator proteins 1 and 2 (CRMP1, CRMP2) and Y-box-binding protein to comprise the seven primary antigens of maternal autoantibody-related (MAR) autism. Exclusive reactivity to specific antigen combinations was noted in 23% of mothers of ASD children and only 1% of controls. ASD children from mothers with specific reactivity to LDH, STIP1 and CRMP1 and/or cypin (7% vs 0% in controls; P<0.0002; odds ratios of 24.2 (95% confidence interval: 1.45-405)) had elevated stereotypical behaviors compared with ASD children from mothers lacking these antibodies. We describe the first panel of clinically significant biomarkers with over 99% specificity for autism risk thereby advancing our understanding of the etiologic mechanisms and therapeutic possibilities for MAR autism. More... »

PAGES

e277

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/tp.2013.50

DOI

http://dx.doi.org/10.1038/tp.2013.50

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052159195

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23838888


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