Alterations in metabolic pathways and networks in Alzheimer’s disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04

AUTHORS

R Kaddurah-Daouk, H Zhu, S Sharma, M Bogdanov, S G Rozen, W Matson, N O Oki, A A Motsinger-Reif, E Churchill, Z Lei, D Appleby, M A Kling, J Q Trojanowski, P M Doraiswamy, S E Arnold,

ABSTRACT

The pathogenic mechanisms of Alzheimer's disease (AD) remain largely unknown and clinical trials have not demonstrated significant benefit. Biochemical characterization of AD and its prodromal phase may provide new diagnostic and therapeutic insights. We used targeted metabolomics platform to profile cerebrospinal fluid (CSF) from AD (n=40), mild cognitive impairment (MCI, n=36) and control (n=38) subjects; univariate and multivariate analyses to define between-group differences; and partial least square-discriminant analysis models to classify diagnostic groups using CSF metabolomic profiles. A partial correlation network was built to link metabolic markers, protein markers and disease severity. AD subjects had elevated methionine (MET), 5-hydroxyindoleacetic acid (5-HIAA), vanillylmandelic acid, xanthosine and glutathione versus controls. MCI subjects had elevated 5-HIAA, MET, hypoxanthine and other metabolites versus controls. Metabolite ratios revealed changes within tryptophan, MET and purine pathways. Initial pathway analyses identified steps in several pathways that appear altered in AD and MCI. A partial correlation network showed total tau most directly related to norepinephrine and purine pathways; amyloid-β (Ab42) was related directly to an unidentified metabolite and indirectly to 5-HIAA and MET. These findings indicate that MCI and AD are associated with an overlapping pattern of perturbations in tryptophan, tyrosine, MET and purine pathways, and suggest that profound biochemical alterations are linked to abnormal Ab42 and tau metabolism. Metabolomics provides powerful tools to map interlinked biochemical pathway perturbations and study AD as a disease of network failure. More... »

PAGES

e244

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/tp.2013.18

DOI

http://dx.doi.org/10.1038/tp.2013.18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046765695

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23571809


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, Liquid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognitive Dysfunction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolic Networks and Pathways", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuropsychological Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA", 
            "Duke Institute for Brain Sciences, Duke University, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaddurah-Daouk", 
        "givenName": "R", 
        "id": "sg:person.0766311703.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766311703.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.414179.e", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "H", 
        "id": "sg:person.011743751357.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011743751357.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Edith Nourse Rogers Memorial Veterans Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414326.6", 
          "name": [
            "Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sharma", 
        "givenName": "S", 
        "id": "sg:person.01026161207.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026161207.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA", 
            "Weil Medical College, Cornell University, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bogdanov", 
        "givenName": "M", 
        "id": "sg:person.010522731454.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010522731454.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke NUS Graduate Medical School", 
          "id": "https://www.grid.ac/institutes/grid.428397.3", 
          "name": [
            "Program in Neurobiology and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rozen", 
        "givenName": "S G", 
        "id": "sg:person.013130175037.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013130175037.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Edith Nourse Rogers Memorial Veterans Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414326.6", 
          "name": [
            "Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matson", 
        "givenName": "W", 
        "id": "sg:person.01161612244.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161612244.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "North Carolina State University", 
          "id": "https://www.grid.ac/institutes/grid.40803.3f", 
          "name": [
            "Bioinformatics Research Center, Department of Statistics, North Carolina State University, Raleigh, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oki", 
        "givenName": "N O", 
        "id": "sg:person.0741671664.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741671664.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "North Carolina State University", 
          "id": "https://www.grid.ac/institutes/grid.40803.3f", 
          "name": [
            "Bioinformatics Research Center, Department of Statistics, North Carolina State University, Raleigh, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Motsinger-Reif", 
        "givenName": "A A", 
        "id": "sg:person.01010005064.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010005064.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.414179.e", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Churchill", 
        "givenName": "E", 
        "id": "sg:person.01165453344.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165453344.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke NUS Graduate Medical School", 
          "id": "https://www.grid.ac/institutes/grid.428397.3", 
          "name": [
            "Program in Neurobiology and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lei", 
        "givenName": "Z", 
        "id": "sg:person.01243233111.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243233111.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Penn Memory Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Appleby", 
        "givenName": "D", 
        "id": "sg:person.01137242375.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137242375.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA", 
            "Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kling", 
        "givenName": "M A", 
        "id": "sg:person.0601645550.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601645550.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trojanowski", 
        "givenName": "J Q", 
        "id": "sg:person.01043025611.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043025611.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA", 
            "Duke Institute for Brain Sciences, Duke University, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Doraiswamy", 
        "givenName": "P M", 
        "id": "sg:person.0636466710.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636466710.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA", 
            "Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arnold", 
        "givenName": "S E", 
        "id": "sg:person.012350323552.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012350323552.91"
        ], 
        "type": "Person"
      }, 
      {}
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1159/000082663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000576557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2010.01123.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000887787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2010.01123.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000887787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0031501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002460568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m500219200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009462507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tp.2011.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011872162", 
          "https://doi.org/10.1038/tp.2011.22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2012.03.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013090007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2012.03.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013090007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-1241.2009.02026.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015820015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-1241.2009.02026.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015820015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1214/009053606000000281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017239463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2202-10-125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018326032", 
          "https://doi.org/10.1186/1471-2202-10-125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn3012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018488901", 
          "https://doi.org/10.1038/nrn3012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000326301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019250868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2012.01.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020341519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/bc.2009.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022236606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tp.2011.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022403018", 
          "https://doi.org/10.1038/tp.2011.55"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2006.05.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022472533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023146162", 
          "https://doi.org/10.1038/nrm3314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.20394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023948491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2008.174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024538760", 
          "https://doi.org/10.1038/npp.2008.174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.34.7.939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024664401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.2007.00112.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024810055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-neuro-061010-113613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025448839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.56.3.303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030365018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0021643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038909040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.200618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042996843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2010.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043434426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2010.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051188573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainresbull.2005.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051648807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2010.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051906104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1194/jlr.m022376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052084650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1198/jasa.2009.0126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064200393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.32.2.164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064364243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-2009-1187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077941875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-2012-112138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078579915"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-04", 
    "datePublishedReg": "2013-04-01", 
    "description": "The pathogenic mechanisms of Alzheimer's disease (AD) remain largely unknown and clinical trials have not demonstrated significant benefit. Biochemical characterization of AD and its prodromal phase may provide new diagnostic and therapeutic insights. We used targeted metabolomics platform to profile cerebrospinal fluid (CSF) from AD (n=40), mild cognitive impairment (MCI, n=36) and control (n=38) subjects; univariate and multivariate analyses to define between-group differences; and partial least square-discriminant analysis models to classify diagnostic groups using CSF metabolomic profiles. A partial correlation network was built to link metabolic markers, protein markers and disease severity. AD subjects had elevated methionine (MET), 5-hydroxyindoleacetic acid (5-HIAA), vanillylmandelic acid, xanthosine and glutathione versus controls. MCI subjects had elevated 5-HIAA, MET, hypoxanthine and other metabolites versus controls. Metabolite ratios revealed changes within tryptophan, MET and purine pathways. Initial pathway analyses identified steps in several pathways that appear altered in AD and MCI. A partial correlation network showed total tau most directly related to norepinephrine and purine pathways; amyloid-\u03b2 (Ab42) was related directly to an unidentified metabolite and indirectly to 5-HIAA and MET. These findings indicate that MCI and AD are associated with an overlapping pattern of perturbations in tryptophan, tyrosine, MET and purine pathways, and suggest that profound biochemical alterations are linked to abnormal Ab42 and tau metabolism. Metabolomics provides powerful tools to map interlinked biochemical pathway perturbations and study AD as a disease of network failure.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/tp.2013.18", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2561611", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2669344", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2621348", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438591", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2434660", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045271", 
        "issn": [
          "2158-3188"
        ], 
        "name": "Translational Psychiatry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "name": "Alterations in metabolic pathways and networks in Alzheimer\u2019s disease", 
    "pagination": "e244", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "dec623f656368b644eafbc23af10c0e075322d2d46395156cbbce2fe68e0fb1c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23571809"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101562664"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/tp.2013.18"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046765695"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/tp.2013.18", 
      "https://app.dimensions.ai/details/publication/pub.1046765695"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000563.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/tp201318"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/tp.2013.18'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/tp.2013.18'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/tp.2013.18'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/tp.2013.18'


 

This table displays all metadata directly associated to this object as RDF triples.

367 TRIPLES      21 PREDICATES      77 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/tp.2013.18 schema:about N163007590f984a4094fbb43fab9ea8e6
2 N18ffc5ea9c6d4ad687fddfba8f10b4a2
3 N213d6d04cd9d4be4b5d54812cf3fc60a
4 N2eff9618fbc74a71b8e4e84b92d879c1
5 N4728d403fecd4d5399c1a484f41a5b11
6 N527f45a689f44555b99e91d8ed782ac8
7 N5d5eae845d7d49c6888d3b8959f10a60
8 N7b50cc2486e44507ac98236c8f3044ef
9 N7be7661bbad1491aaf3bc814f84f363d
10 N8735a373558c41cbbb7ecaf67d0878d4
11 N92d249ce2d6b4ab9b80d4cbd7f5a3baa
12 Na26d37d96a61435b9cfd24accbb9c808
13 Nbf45e8f9790d49018854b70a33b9c7d3
14 Nd7e5620f561f4337a1f921cee03f2ec4
15 Nfab0da6db2f94fb5a0dd5c1311e76b7f
16 anzsrc-for:11
17 anzsrc-for:1109
18 schema:author N723cdd30738d4b99b2ab494f4a65eaae
19 schema:citation sg:pub.10.1038/npp.2008.174
20 sg:pub.10.1038/nrm3314
21 sg:pub.10.1038/nrn3012
22 sg:pub.10.1038/tp.2011.22
23 sg:pub.10.1038/tp.2011.55
24 sg:pub.10.1186/1471-2202-10-125
25 https://doi.org/10.1001/archneur.56.3.303
26 https://doi.org/10.1002/jnr.20394
27 https://doi.org/10.1016/j.bmcl.2010.02.008
28 https://doi.org/10.1016/j.brainresbull.2005.12.001
29 https://doi.org/10.1016/j.freeradbiomed.2012.01.012
30 https://doi.org/10.1016/j.jalz.2010.06.001
31 https://doi.org/10.1016/j.neuint.2010.10.013
32 https://doi.org/10.1016/j.neurobiolaging.2006.05.027
33 https://doi.org/10.1016/j.ymeth.2012.03.023
34 https://doi.org/10.1074/jbc.m110.200618
35 https://doi.org/10.1074/jbc.m500219200
36 https://doi.org/10.1111/j.1582-4934.2010.01123.x
37 https://doi.org/10.1111/j.1742-1241.2009.02026.x
38 https://doi.org/10.1111/j.1750-3639.2007.00112.x
39 https://doi.org/10.1146/annurev-neuro-061010-113613
40 https://doi.org/10.1159/000082663
41 https://doi.org/10.1159/000326301
42 https://doi.org/10.1194/jlr.m022376
43 https://doi.org/10.1198/jasa.2009.0126
44 https://doi.org/10.1212/wnl.32.2.164
45 https://doi.org/10.1212/wnl.34.7.939
46 https://doi.org/10.1214/009053606000000281
47 https://doi.org/10.1371/journal.pone.0021643
48 https://doi.org/10.1371/journal.pone.0031501
49 https://doi.org/10.1515/bc.2009.033
50 https://doi.org/10.3233/jad-2009-1187
51 https://doi.org/10.3233/jad-2012-112138
52 schema:datePublished 2013-04
53 schema:datePublishedReg 2013-04-01
54 schema:description The pathogenic mechanisms of Alzheimer's disease (AD) remain largely unknown and clinical trials have not demonstrated significant benefit. Biochemical characterization of AD and its prodromal phase may provide new diagnostic and therapeutic insights. We used targeted metabolomics platform to profile cerebrospinal fluid (CSF) from AD (n=40), mild cognitive impairment (MCI, n=36) and control (n=38) subjects; univariate and multivariate analyses to define between-group differences; and partial least square-discriminant analysis models to classify diagnostic groups using CSF metabolomic profiles. A partial correlation network was built to link metabolic markers, protein markers and disease severity. AD subjects had elevated methionine (MET), 5-hydroxyindoleacetic acid (5-HIAA), vanillylmandelic acid, xanthosine and glutathione versus controls. MCI subjects had elevated 5-HIAA, MET, hypoxanthine and other metabolites versus controls. Metabolite ratios revealed changes within tryptophan, MET and purine pathways. Initial pathway analyses identified steps in several pathways that appear altered in AD and MCI. A partial correlation network showed total tau most directly related to norepinephrine and purine pathways; amyloid-β (Ab42) was related directly to an unidentified metabolite and indirectly to 5-HIAA and MET. These findings indicate that MCI and AD are associated with an overlapping pattern of perturbations in tryptophan, tyrosine, MET and purine pathways, and suggest that profound biochemical alterations are linked to abnormal Ab42 and tau metabolism. Metabolomics provides powerful tools to map interlinked biochemical pathway perturbations and study AD as a disease of network failure.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N02119de548ae4444af8d6db74f56370d
59 Nbc0f85b5f33a4d8ba6ed5802d700543e
60 sg:journal.1045271
61 schema:name Alterations in metabolic pathways and networks in Alzheimer’s disease
62 schema:pagination e244
63 schema:productId N1a725849af8b4158a86ab75de63e3c00
64 N4ca6080814d3412f945e08b6aec73ce9
65 N9ac42bd04c6a445f9bfb65327a8b6880
66 N9fe9561e4d764dd29f52625829bad03c
67 Nc78345830ab840d5ac1d2af79b28979f
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046765695
69 https://doi.org/10.1038/tp.2013.18
70 schema:sdDatePublished 2019-04-10T20:55
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Nd1ca45345b0542a5a98a73363fa2beee
73 schema:url https://www.nature.com/articles/tp201318
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N02119de548ae4444af8d6db74f56370d schema:issueNumber 4
78 rdf:type schema:PublicationIssue
79 N0a8db79f10584941897d08faf12f6fbc rdf:first sg:person.011743751357.36
80 rdf:rest N3c8dc9214175449e8339bcede5be606d
81 N163007590f984a4094fbb43fab9ea8e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Male
83 rdf:type schema:DefinedTerm
84 N18ffc5ea9c6d4ad687fddfba8f10b4a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Case-Control Studies
86 rdf:type schema:DefinedTerm
87 N1a725849af8b4158a86ab75de63e3c00 schema:name dimensions_id
88 schema:value pub.1046765695
89 rdf:type schema:PropertyValue
90 N213d6d04cd9d4be4b5d54812cf3fc60a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Metabolic Networks and Pathways
92 rdf:type schema:DefinedTerm
93 N265d6183ad5241668e8eb5a029920942 rdf:first sg:person.01010005064.54
94 rdf:rest Naa2aa3a89ea24611a469b744f1782cbf
95 N2eff9618fbc74a71b8e4e84b92d879c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N3c1476e906b443aca41fbac4c2d232bf rdf:first sg:person.01243233111.11
99 rdf:rest Naac77b790b244dd18f69d03ac2a5384e
100 N3c8dc9214175449e8339bcede5be606d rdf:first sg:person.01026161207.88
101 rdf:rest N629306eb420541da854d747fded5f681
102 N4728d403fecd4d5399c1a484f41a5b11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Aged
104 rdf:type schema:DefinedTerm
105 N490e03862f08498f83919aac46ad2751 rdf:first sg:person.0636466710.04
106 rdf:rest Nc0b543ec8b0645b5977d5dbaf6ae93c1
107 N4ca6080814d3412f945e08b6aec73ce9 schema:name readcube_id
108 schema:value dec623f656368b644eafbc23af10c0e075322d2d46395156cbbce2fe68e0fb1c
109 rdf:type schema:PropertyValue
110 N527f45a689f44555b99e91d8ed782ac8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Metabolomics
112 rdf:type schema:DefinedTerm
113 N5928f50d73144a95a293f39cb154ceaf rdf:first sg:person.01161612244.27
114 rdf:rest N7f743e628db444deb5a355ea07476c18
115 N5d5eae845d7d49c6888d3b8959f10a60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Prospective Studies
117 rdf:type schema:DefinedTerm
118 N629306eb420541da854d747fded5f681 rdf:first sg:person.010522731454.48
119 rdf:rest Ncb2c74e4723e4411b2e09278f71080e7
120 N723cdd30738d4b99b2ab494f4a65eaae rdf:first sg:person.0766311703.50
121 rdf:rest N0a8db79f10584941897d08faf12f6fbc
122 N72a870e73f4047a5bcbd794e630d9174 rdf:first N8fb937203c1b4138bad9f9775d389182
123 rdf:rest rdf:nil
124 N7b50cc2486e44507ac98236c8f3044ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Biomarkers
126 rdf:type schema:DefinedTerm
127 N7be7661bbad1491aaf3bc814f84f363d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Middle Aged
129 rdf:type schema:DefinedTerm
130 N7f743e628db444deb5a355ea07476c18 rdf:first sg:person.0741671664.24
131 rdf:rest N265d6183ad5241668e8eb5a029920942
132 N8735a373558c41cbbb7ecaf67d0878d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Cognitive Dysfunction
134 rdf:type schema:DefinedTerm
135 N92d249ce2d6b4ab9b80d4cbd7f5a3baa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Chromatography, Liquid
137 rdf:type schema:DefinedTerm
138 N9ac42bd04c6a445f9bfb65327a8b6880 schema:name pubmed_id
139 schema:value 23571809
140 rdf:type schema:PropertyValue
141 N9fe9561e4d764dd29f52625829bad03c schema:name doi
142 schema:value 10.1038/tp.2013.18
143 rdf:type schema:PropertyValue
144 Na26d37d96a61435b9cfd24accbb9c808 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Female
146 rdf:type schema:DefinedTerm
147 Naa2aa3a89ea24611a469b744f1782cbf rdf:first sg:person.01165453344.03
148 rdf:rest N3c1476e906b443aca41fbac4c2d232bf
149 Naac77b790b244dd18f69d03ac2a5384e rdf:first sg:person.01137242375.53
150 rdf:rest Nd1169c29a0e147b5897e6329fa67af4f
151 Nb4f3c10f3e5e4ba8b5c0213aa16b4355 rdf:first sg:person.01043025611.21
152 rdf:rest N490e03862f08498f83919aac46ad2751
153 Nbc0f85b5f33a4d8ba6ed5802d700543e schema:volumeNumber 3
154 rdf:type schema:PublicationVolume
155 Nbf45e8f9790d49018854b70a33b9c7d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Alzheimer Disease
157 rdf:type schema:DefinedTerm
158 Nc0b543ec8b0645b5977d5dbaf6ae93c1 rdf:first sg:person.012350323552.91
159 rdf:rest N72a870e73f4047a5bcbd794e630d9174
160 Nc78345830ab840d5ac1d2af79b28979f schema:name nlm_unique_id
161 schema:value 101562664
162 rdf:type schema:PropertyValue
163 Ncb2c74e4723e4411b2e09278f71080e7 rdf:first sg:person.013130175037.28
164 rdf:rest N5928f50d73144a95a293f39cb154ceaf
165 Nd1169c29a0e147b5897e6329fa67af4f rdf:first sg:person.0601645550.03
166 rdf:rest Nb4f3c10f3e5e4ba8b5c0213aa16b4355
167 Nd1ca45345b0542a5a98a73363fa2beee schema:name Springer Nature - SN SciGraph project
168 rdf:type schema:Organization
169 Nd7e5620f561f4337a1f921cee03f2ec4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Neuropsychological Tests
171 rdf:type schema:DefinedTerm
172 Nfab0da6db2f94fb5a0dd5c1311e76b7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Aged, 80 and over
174 rdf:type schema:DefinedTerm
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
179 schema:name Neurosciences
180 rdf:type schema:DefinedTerm
181 sg:grant.2434660 http://pending.schema.org/fundedItem sg:pub.10.1038/tp.2013.18
182 rdf:type schema:MonetaryGrant
183 sg:grant.2438591 http://pending.schema.org/fundedItem sg:pub.10.1038/tp.2013.18
184 rdf:type schema:MonetaryGrant
185 sg:grant.2561611 http://pending.schema.org/fundedItem sg:pub.10.1038/tp.2013.18
186 rdf:type schema:MonetaryGrant
187 sg:grant.2621348 http://pending.schema.org/fundedItem sg:pub.10.1038/tp.2013.18
188 rdf:type schema:MonetaryGrant
189 sg:grant.2669344 http://pending.schema.org/fundedItem sg:pub.10.1038/tp.2013.18
190 rdf:type schema:MonetaryGrant
191 sg:journal.1045271 schema:issn 2158-3188
192 schema:name Translational Psychiatry
193 rdf:type schema:Periodical
194 sg:person.01010005064.54 schema:affiliation https://www.grid.ac/institutes/grid.40803.3f
195 schema:familyName Motsinger-Reif
196 schema:givenName A A
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010005064.54
198 rdf:type schema:Person
199 sg:person.01026161207.88 schema:affiliation https://www.grid.ac/institutes/grid.414326.6
200 schema:familyName Sharma
201 schema:givenName S
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026161207.88
203 rdf:type schema:Person
204 sg:person.01043025611.21 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
205 schema:familyName Trojanowski
206 schema:givenName J Q
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043025611.21
208 rdf:type schema:Person
209 sg:person.010522731454.48 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
210 schema:familyName Bogdanov
211 schema:givenName M
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010522731454.48
213 rdf:type schema:Person
214 sg:person.01137242375.53 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
215 schema:familyName Appleby
216 schema:givenName D
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137242375.53
218 rdf:type schema:Person
219 sg:person.01161612244.27 schema:affiliation https://www.grid.ac/institutes/grid.414326.6
220 schema:familyName Matson
221 schema:givenName W
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161612244.27
223 rdf:type schema:Person
224 sg:person.01165453344.03 schema:affiliation https://www.grid.ac/institutes/grid.414179.e
225 schema:familyName Churchill
226 schema:givenName E
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165453344.03
228 rdf:type schema:Person
229 sg:person.011743751357.36 schema:affiliation https://www.grid.ac/institutes/grid.414179.e
230 schema:familyName Zhu
231 schema:givenName H
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011743751357.36
233 rdf:type schema:Person
234 sg:person.012350323552.91 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
235 schema:familyName Arnold
236 schema:givenName S E
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012350323552.91
238 rdf:type schema:Person
239 sg:person.01243233111.11 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
240 schema:familyName Lei
241 schema:givenName Z
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243233111.11
243 rdf:type schema:Person
244 sg:person.013130175037.28 schema:affiliation https://www.grid.ac/institutes/grid.428397.3
245 schema:familyName Rozen
246 schema:givenName S G
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013130175037.28
248 rdf:type schema:Person
249 sg:person.0601645550.03 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
250 schema:familyName Kling
251 schema:givenName M A
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601645550.03
253 rdf:type schema:Person
254 sg:person.0636466710.04 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
255 schema:familyName Doraiswamy
256 schema:givenName P M
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636466710.04
258 rdf:type schema:Person
259 sg:person.0741671664.24 schema:affiliation https://www.grid.ac/institutes/grid.40803.3f
260 schema:familyName Oki
261 schema:givenName N O
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741671664.24
263 rdf:type schema:Person
264 sg:person.0766311703.50 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
265 schema:familyName Kaddurah-Daouk
266 schema:givenName R
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766311703.50
268 rdf:type schema:Person
269 sg:pub.10.1038/npp.2008.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024538760
270 https://doi.org/10.1038/npp.2008.174
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/nrm3314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023146162
273 https://doi.org/10.1038/nrm3314
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/nrn3012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018488901
276 https://doi.org/10.1038/nrn3012
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/tp.2011.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011872162
279 https://doi.org/10.1038/tp.2011.22
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/tp.2011.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022403018
282 https://doi.org/10.1038/tp.2011.55
283 rdf:type schema:CreativeWork
284 sg:pub.10.1186/1471-2202-10-125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018326032
285 https://doi.org/10.1186/1471-2202-10-125
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1001/archneur.56.3.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030365018
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1002/jnr.20394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023948491
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.bmcl.2010.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051906104
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.brainresbull.2005.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051648807
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.freeradbiomed.2012.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020341519
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.jalz.2010.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051188573
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.neuint.2010.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043434426
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.neurobiolaging.2006.05.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022472533
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.ymeth.2012.03.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013090007
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1074/jbc.m110.200618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042996843
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1074/jbc.m500219200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009462507
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1111/j.1582-4934.2010.01123.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000887787
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1111/j.1742-1241.2009.02026.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015820015
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1111/j.1750-3639.2007.00112.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024810055
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1146/annurev-neuro-061010-113613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025448839
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1159/000082663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000576557
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1159/000326301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019250868
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1194/jlr.m022376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052084650
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1198/jasa.2009.0126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064200393
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1212/wnl.32.2.164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064364243
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1212/wnl.34.7.939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024664401
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1214/009053606000000281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017239463
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1371/journal.pone.0021643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038909040
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1371/journal.pone.0031501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002460568
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1515/bc.2009.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022236606
336 rdf:type schema:CreativeWork
337 https://doi.org/10.3233/jad-2009-1187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077941875
338 rdf:type schema:CreativeWork
339 https://doi.org/10.3233/jad-2012-112138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078579915
340 rdf:type schema:CreativeWork
341 https://www.grid.ac/institutes/grid.25879.31 schema:alternateName University of Pennsylvania
342 schema:name Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
343 Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
344 Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
345 Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
346 Penn Memory Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.26009.3d schema:alternateName Duke University
349 schema:name Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
350 Duke Institute for Brain Sciences, Duke University, Durham, NC, USA
351 rdf:type schema:Organization
352 https://www.grid.ac/institutes/grid.40803.3f schema:alternateName North Carolina State University
353 schema:name Bioinformatics Research Center, Department of Statistics, North Carolina State University, Raleigh, NC, USA
354 rdf:type schema:Organization
355 https://www.grid.ac/institutes/grid.414179.e schema:alternateName Duke Medical Center
356 schema:name Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
357 rdf:type schema:Organization
358 https://www.grid.ac/institutes/grid.414326.6 schema:alternateName Edith Nourse Rogers Memorial Veterans Hospital
359 schema:name Department of Systems Biochemistry, Bedford VA Medical Center, Bedford, MA, USA
360 rdf:type schema:Organization
361 https://www.grid.ac/institutes/grid.428397.3 schema:alternateName Duke NUS Graduate Medical School
362 schema:name Program in Neurobiology and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, Singapore
363 rdf:type schema:Organization
364 https://www.grid.ac/institutes/grid.5386.8 schema:alternateName Cornell University
365 schema:name Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
366 Weil Medical College, Cornell University, New York, NY, USA
367 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...