Ontology type: schema:ScholarlyArticle Open Access: True
2012-08
AUTHORS ABSTRACTThe autistic spectrum disorders have a significant male bias in incidence, which is unexplained. The Sertoli cells of the immature testes secrete supra-adult levels of Müllerian-inhibiting substance/anti-Müllerian hormone (AMH) and inhibin B (InhB), with both hormones being putative regulators of brain development. We report here, that 82 boys with an autism spectrum disorder have normal levels of InhB and AMH. However, the boys' level of InhB correlated with their autism diagnostic interview-revised (ADI-R) scores for the social interaction (R=0.29, P=0.009, N=82) and communication domains (R=0.29, P=0.022, N=63), and with the number of autistic traits the boys exhibited (R=0.34 and 0.27, respectively). The strengths of the abovementioned correlates were stronger in the boys with milder autism (R=0.42 and 0.50, respectively), with AMH exhibiting a significant negative correlation to the ADI-R score in these boys (R=-0.44 and R=-0.39, respectively). Neither hormone correlated to the incidence of stereotyped and repetitive behaviours. This suggests that the male bias in the autistic spectrum has multiple determinants, which modulate the effects of an otherwise non-dimorphic pathology. Furthermore, AMH and InhB have opposing effects on the SMAD1/5/8 pathway, and opposing correlates to autistic traits, implicating the SMAD pathways as a putative point of molecular convergence for the autistic spectrum. More... »
PAGESe148
http://scigraph.springernature.com/pub.10.1038/tp.2012.72
DOIhttp://dx.doi.org/10.1038/tp.2012.72
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1025936139
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22872163
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Psychology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Psychology and Cognitive Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Anti-Mullerian Hormone",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Case-Control Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child Development Disorders, Pervasive",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Enzyme-Linked Immunosorbent Assay",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Inhibins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Linear Models",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sertoli Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sex Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Signal Transduction",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Otago",
"id": "https://www.grid.ac/institutes/grid.29980.3a",
"name": [
"Department of Anatomy, Otago School of Medical Sciences, The University of Otago, Dunedin, New Zealand"
],
"type": "Organization"
},
"familyName": "Pankhurst",
"givenName": "M W",
"id": "sg:person.01321063254.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321063254.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Otago",
"id": "https://www.grid.ac/institutes/grid.29980.3a",
"name": [
"Department of Anatomy, Otago School of Medical Sciences, The University of Otago, Dunedin, New Zealand"
],
"type": "Organization"
},
"familyName": "McLennan",
"givenName": "I S",
"id": "sg:person.0743252350.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743252350.43"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1002/bies.200900063",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000099638"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1025054610557",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001017582",
"https://doi.org/10.1023/a:1025054610557"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/glia.20522",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001272780"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1242/jcs.012450",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004015993"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-4547(19980115)51:2<139::aid-jnr2>3.0.co;2-e",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006211417"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1203/00006450-199507000-00013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008978035",
"https://doi.org/10.1203/00006450-199507000-00013"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0020533",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011169511"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09146",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012902412",
"https://doi.org/10.1038/nature09146"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09146",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012902412",
"https://doi.org/10.1038/nature09146"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejogrb.2004.02.030",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014532836"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mce.2003.09.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015238464"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(09)61376-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015758856"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02172145",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017747169",
"https://doi.org/10.1007/bf02172145"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02172145",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017747169",
"https://doi.org/10.1007/bf02172145"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0508304102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018160333"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0508304102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018160333"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cytogfr.2010.06.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018926990"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmra022784",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024834628"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.brainres.2010.09.101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025560520"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1364-6613(02)01904-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027124370"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mce.2004.07.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028280736"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0002863",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032193916"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn1805",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034212815",
"https://doi.org/10.1038/nrn1805"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn1805",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034212815",
"https://doi.org/10.1038/nrn1805"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tics.2011.07.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034906491"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-4731(77)90270-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036492370"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-4731(77)90270-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036492370"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs20110086",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037133808"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs20110086",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037133808"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09410",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037714920",
"https://doi.org/10.1038/nature09410"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09410",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037714920",
"https://doi.org/10.1038/nature09410"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn1494",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038541361",
"https://doi.org/10.1038/nrn1494"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn1494",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038541361",
"https://doi.org/10.1038/nrn1494"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn1494",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038541361",
"https://doi.org/10.1038/nrn1494"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbr.2011.02.048",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039965937"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s004410050697",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040313975",
"https://doi.org/10.1007/s004410050697"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s004410050697",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040313975",
"https://doi.org/10.1007/s004410050697"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cytogfr.2009.05.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041067152"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg2346",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044248970",
"https://doi.org/10.1038/nrg2346"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0902253106",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046435453"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.publhealth.28.021406.144007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048043515"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2010.08.040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051770184"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1138659",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062455231"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/endo.134.2.8299574",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064279042"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2003-030884",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064287053"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2006-1079",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064289350"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2010-1207",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064292271"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2012-1213",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064293434"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.81.2.571",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064298724"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.82.12.3976",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064299390"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.84.8.2724",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064300912"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jcem.81.2.8636269",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064320023"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jcem.84.8.5870",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064322820"
],
"type": "CreativeWork"
}
],
"datePublished": "2012-08",
"datePublishedReg": "2012-08-01",
"description": "The autistic spectrum disorders have a significant male bias in incidence, which is unexplained. The Sertoli cells of the immature testes secrete supra-adult levels of M\u00fcllerian-inhibiting substance/anti-M\u00fcllerian hormone (AMH) and inhibin B (InhB), with both hormones being putative regulators of brain development. We report here, that 82 boys with an autism spectrum disorder have normal levels of InhB and AMH. However, the boys' level of InhB correlated with their autism diagnostic interview-revised (ADI-R) scores for the social interaction (R=0.29, P=0.009, N=82) and communication domains (R=0.29, P=0.022, N=63), and with the number of autistic traits the boys exhibited (R=0.34 and 0.27, respectively). The strengths of the abovementioned correlates were stronger in the boys with milder autism (R=0.42 and 0.50, respectively), with AMH exhibiting a significant negative correlation to the ADI-R score in these boys (R=-0.44 and R=-0.39, respectively). Neither hormone correlated to the incidence of stereotyped and repetitive behaviours. This suggests that the male bias in the autistic spectrum has multiple determinants, which modulate the effects of an otherwise non-dimorphic pathology. Furthermore, AMH and InhB have opposing effects on the SMAD1/5/8 pathway, and opposing correlates to autistic traits, implicating the SMAD pathways as a putative point of molecular convergence for the autistic spectrum.",
"genre": "research_article",
"id": "sg:pub.10.1038/tp.2012.72",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2696438",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045271",
"issn": [
"2158-3188"
],
"name": "Translational Psychiatry",
"type": "Periodical"
},
{
"issueNumber": "8",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "2"
}
],
"name": "Inhibin B and anti-M\u00fcllerian hormone/M\u00fcllerian-inhibiting substance may contribute to the male bias in autism",
"pagination": "e148",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"7b8f6b998f5f56b9248177dbd56de51433700c74ce2348f2e592096e73754342"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"22872163"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101562664"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/tp.2012.72"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1025936139"
]
}
],
"sameAs": [
"https://doi.org/10.1038/tp.2012.72",
"https://app.dimensions.ai/details/publication/pub.1025936139"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T19:46",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000437.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/tp201272"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/tp.2012.72'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/tp.2012.72'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/tp.2012.72'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/tp.2012.72'
This table displays all metadata directly associated to this object as RDF triples.
267 TRIPLES
21 PREDICATES
85 URIs
34 LITERALS
22 BLANK NODES