Regulatory role of G9a and LSD1 in the Transcription of Olfactory Receptors during Leukaemia Cell Differentiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Hyeonsoo Jung, Yun-Cheol Chae, Ji-Young Kim, Oh-Seok Jeong, Hoon Kook, Sang-Beom Seo

ABSTRACT

Recent studies have reported the ectopic expression of olfactory receptors (ORs) in non-olfactory tissues, however, their physiological roles were not well elucidated. ORs are expressed in and function in different types of cancers. Here, we identified that the H3K9me2 levels of several OR promoters decreased during differentiation in the HL-60, human myeloid leukaemia cell line, by all-trans-retinoic acid (ATRA). We found that the differential OR promoters H3K9me2 levels were regulated by G9a and LSD1, resulting in the decrease of ORs transcription during HL-60 differentiation. G9a and LSD1 could regulate the expression of ORs in several non-olfactory cells via the methylation and demethylation of H3K9me2. In addition, we demonstrated that knockdown of OR significantly reduced cell proliferation. Therefore, the epigenetic regulation of ORs transcription is critical for carcinogenesis. More... »

PAGES

46182

References to SciGraph publications

  • 2016-12. Deorphanization and characterization of the ectopically expressed olfactory receptor OR51B5 in myelogenous leukemia cells in CELL DEATH DISCOVERY
  • 2000-11. The olfactory receptor gene superfamily: data mining, classification, and nomenclature in MAMMALIAN GENOME
  • 2005-09. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription in NATURE
  • 2008-11. De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-12. ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells in RETROVIROLOGY
  • 2007-06. p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway in NATURE GENETICS
  • 2004-02. Olfactory receptors in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2016-12. Functional characterization of the ectopically expressed olfactory receptor 2AT4 in human myelogenous leukemia in CELL DEATH DISCOVERY
  • 2009-10-08. JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin in NATURE
  • 2014-08. PSGR promotes prostatic intraepithelial neoplasia and prostate cancer xenograft growth through NF-κB in ONCOGENESIS
  • 2012-12. Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells in CELLULAR & MOLECULAR BIOLOGY LETTERS
  • 2012-05. Histone methylation: a dynamic mark in health, disease and inheritance in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep46182

    DOI

    http://dx.doi.org/10.1038/srep46182

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084538207

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28387360


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