Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Madeleine Arseneault, Jean Monlong, Naveen S Vasudev, Ruhina S Laskar, Maryam Safisamghabadi, Patricia Harnden, Lars Egevad, Nazanin Nourbehesht, Pudchalaluck Panichnantakul, Ivana Holcatova, Antonin Brisuda, Vladimir Janout, Helena Kollarova, Lenka Foretova, Marie Navratilova, Dana Mates, Viorel Jinga, David Zaridze, Anush Mukeria, Pouria Jandaghi, Paul Brennan, Alvis Brazma, Jorg Tost, Ghislaine Scelo, Rosamonde E Banks, Mark Lathrop, Guillaume Bourque, Yasser Riazalhosseini

ABSTRACT

Recent genomic studies of sporadic clear cell renal cell carcinoma (ccRCC) have uncovered novel driver genes and pathways. Given the unequal incidence rates among men and women (male:female incidence ratio approaches 2:1), we compared the genome-wide distribution of the chromosomal abnormalities in both sexes. We observed a higher frequency for the somatic recurrent chromosomal copy number variations (CNVs) of autosomes in male subjects, whereas somatic loss of chromosome X was detected exclusively in female patients (17.1%). Furthermore, somatic loss of chromosome Y (LOY) was detected in about 40% of male subjects, while mosaic LOY was detected in DNA isolated from peripheral blood in 9.6% of them, and was the only recurrent CNV in constitutional DNA samples. LOY in constitutional DNA, but not in tumor DNA was associated with older age. Amongst Y-linked genes that were downregulated due to LOY, KDM5D and KDM6C epigenetic modifiers have functionally-similar X-linked homologs whose deficiency is involved in ccRCC progression. Our findings establish somatic LOY as a highly recurrent genetic defect in ccRCC that leads to downregulation of hitherto unsuspected epigenetic factors, and suggest that different mechanisms may underlie the somatic and mosaic LOY observed in tumors and peripheral blood, respectively. More... »

PAGES

44876

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep44876

DOI

http://dx.doi.org/10.1038/srep44876

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084132750

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28332632


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Renal Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Y", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Copy Number Variations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Demethylases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Minor Histocompatibility Antigens", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre", 
          "id": "https://www.grid.ac/institutes/grid.411640.6", 
          "name": [
            "Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada.", 
            "McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arseneault", 
        "givenName": "Madeleine", 
        "id": "sg:person.01321241122.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321241122.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre", 
          "id": "https://www.grid.ac/institutes/grid.411640.6", 
          "name": [
            "Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada.", 
            "McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Monlong", 
        "givenName": "Jean", 
        "id": "sg:person.01256031142.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256031142.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, LS9 7TF, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vasudev", 
        "givenName": "Naveen S", 
        "id": "sg:person.01364014257.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364014257.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Agency For Research On Cancer", 
          "id": "https://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69008 Lyon, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laskar", 
        "givenName": "Ruhina S", 
        "id": "sg:person.01302342572.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302342572.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre", 
          "id": "https://www.grid.ac/institutes/grid.411640.6", 
          "name": [
            "Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada.", 
            "McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Safisamghabadi", 
        "givenName": "Maryam", 
        "id": "sg:person.011355664453.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011355664453.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, LS9 7TF, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harnden", 
        "givenName": "Patricia", 
        "id": "sg:person.0622256311.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622256311.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Karolinska Institutet, Department of Pathology, SE-171 77 Stockholm, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Egevad", 
        "givenName": "Lars", 
        "id": "sg:person.01256746437.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256746437.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre", 
          "id": "https://www.grid.ac/institutes/grid.411640.6", 
          "name": [
            "Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada.", 
            "McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nourbehesht", 
        "givenName": "Nazanin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre", 
          "id": "https://www.grid.ac/institutes/grid.411640.6", 
          "name": [
            "Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada.", 
            "McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Panichnantakul", 
        "givenName": "Pudchalaluck", 
        "id": "sg:person.012441234515.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012441234515.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charles University", 
          "id": "https://www.grid.ac/institutes/grid.4491.8", 
          "name": [
            "First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University in Prague, Studni\u010dkova 7, Praha 2, 128 00 Prague, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holcatova", 
        "givenName": "Ivana", 
        "id": "sg:person.01130034234.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130034234.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital in Motol", 
          "id": "https://www.grid.ac/institutes/grid.412826.b", 
          "name": [
            "University Hospital Motol, V \u00davalu 84, 150 06 Prague, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brisuda", 
        "givenName": "Antonin", 
        "id": "sg:person.01010554662.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010554662.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Palack\u00fd University, Olomouc", 
          "id": "https://www.grid.ac/institutes/grid.10979.36", 
          "name": [
            "Department of Preventive Medicine, Faculty of Medicine, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Janout", 
        "givenName": "Vladimir", 
        "id": "sg:person.0643627174.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643627174.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Palack\u00fd University, Olomouc", 
          "id": "https://www.grid.ac/institutes/grid.10979.36", 
          "name": [
            "Department of Preventive Medicine, Faculty of Medicine, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kollarova", 
        "givenName": "Helena", 
        "id": "sg:person.012163663227.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012163663227.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Zluty Kopec 7, 656 53 Brno, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foretova", 
        "givenName": "Lenka", 
        "id": "sg:person.0752405000.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752405000.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Zluty Kopec 7, 656 53 Brno, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Navratilova", 
        "givenName": "Marie", 
        "id": "sg:person.01036742676.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036742676.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "National Institute of Public Health, Dr Leonte Anastasievici 1-3, sector 5, Bucuresti 050463, Romania."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mates", 
        "givenName": "Dana", 
        "id": "sg:person.01100145274.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100145274.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Carol Davila University of Medicine and Pharmacy", 
          "id": "https://www.grid.ac/institutes/grid.8194.4", 
          "name": [
            "Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, 20 Panduri Street, 050659 Bucharest, Romania."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jinga", 
        "givenName": "Viorel", 
        "id": "sg:person.0660455015.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660455015.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Russian N.N. Blokhin Cancer Research Centre, Kashirskoye shosse 24, Moscow 115478, Russian Federation."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zaridze", 
        "givenName": "David", 
        "id": "sg:person.0654401076.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654401076.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Russian N.N. Blokhin Cancer Research Centre, Kashirskoye shosse 24, Moscow 115478, Russian Federation."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukeria", 
        "givenName": "Anush", 
        "id": "sg:person.0734002663.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734002663.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre", 
          "id": "https://www.grid.ac/institutes/grid.411640.6", 
          "name": [
            "Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada.", 
            "McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jandaghi", 
        "givenName": "Pouria", 
        "id": "sg:person.01346073211.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346073211.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Agency For Research On Cancer", 
          "id": "https://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69008 Lyon, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brennan", 
        "givenName": "Paul", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European Bioinformatics Institute", 
          "id": "https://www.grid.ac/institutes/grid.225360.0", 
          "name": [
            "European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brazma", 
        "givenName": "Alvis", 
        "id": "sg:person.01301046330.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301046330.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre National de G\u00e9notypage", 
          "id": "https://www.grid.ac/institutes/grid.418135.a", 
          "name": [
            "Laboratory for Epigenetics &Environment, Centre National de G\u00e9notypage, CEA-Institut de G\u00e9nomique, 2 rue Gaston Cr\u00e9mieux, 91000 Evry, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tost", 
        "givenName": "Jorg", 
        "id": "sg:person.0576633207.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576633207.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Agency For Research On Cancer", 
          "id": "https://www.grid.ac/institutes/grid.17703.32", 
          "name": [
            "International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69008 Lyon, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scelo", 
        "givenName": "Ghislaine", 
        "id": "sg:person.0754766024.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754766024.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, LS9 7TF, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Banks", 
        "givenName": "Rosamonde E", 
        "id": "sg:person.01140157320.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140157320.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre", 
          "id": "https://www.grid.ac/institutes/grid.411640.6", 
          "name": [
            "Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada.", 
            "McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lathrop", 
        "givenName": "Mark", 
        "id": "sg:person.01132647725.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132647725.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre", 
          "id": "https://www.grid.ac/institutes/grid.411640.6", 
          "name": [
            "Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada.", 
            "McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bourque", 
        "givenName": "Guillaume", 
        "id": "sg:person.0615174463.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615174463.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University and G\u00e9nome Qu\u00e9bec Innovation Centre", 
          "id": "https://www.grid.ac/institutes/grid.411640.6", 
          "name": [
            "Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada.", 
            "McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riazalhosseini", 
        "givenName": "Yasser", 
        "id": "sg:person.01355536615.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355536615.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncomms6135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001274259", 
          "https://doi.org/10.1038/ncomms6135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001520036", 
          "https://doi.org/10.1038/ng.349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.158253.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008057766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.158253.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008057766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009539954", 
          "https://doi.org/10.1038/nature09639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.02482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011287188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/034165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011364079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/034165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011364079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/034165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011364079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013583491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197210)30:4<889::aid-cncr2820300405>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020083037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(15)00046-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020855424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2013.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021796751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2013.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021796751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00202476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022154976", 
          "https://doi.org/10.1007/bf00202476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00202476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022154976", 
          "https://doi.org/10.1007/bf00202476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0057886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025254695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028740665", 
          "https://doi.org/10.1038/nrc704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028740665", 
          "https://doi.org/10.1038/nrc704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.6743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030343113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-pathol-012414-040306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031244400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032969139", 
          "https://doi.org/10.1038/nature08672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032969139", 
          "https://doi.org/10.1038/nature08672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2014.05.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034208029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci81040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041849944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042520483", 
          "https://doi.org/10.1038/ng.2760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042935394", 
          "https://doi.org/10.1038/ng.3545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043326600", 
          "https://doi.org/10.1038/ng.2966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmedgenet-2014-102912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043518272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneph.2016.133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044753452", 
          "https://doi.org/10.1038/nrneph.2016.133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2014.06.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048813628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050842404", 
          "https://doi.org/10.1038/nature12222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(05)67774-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051340711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(05)67774-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051340711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m114.555052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053106423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jproteome.5b00333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055115062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/3.6.879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059645006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8493574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062655846"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Recent genomic studies of sporadic clear cell renal cell carcinoma (ccRCC) have uncovered novel driver genes and pathways. Given the unequal incidence rates among men and women (male:female incidence ratio approaches 2:1), we compared the genome-wide distribution of the chromosomal abnormalities in both sexes. We observed a higher frequency for the somatic recurrent chromosomal copy number variations (CNVs) of autosomes in male subjects, whereas somatic loss of chromosome X was detected exclusively in female patients (17.1%). Furthermore, somatic loss of chromosome Y (LOY) was detected in about 40% of male subjects, while mosaic LOY was detected in DNA isolated from peripheral blood in 9.6% of them, and was the only recurrent CNV in constitutional DNA samples. LOY in constitutional DNA, but not in tumor DNA was associated with older age. Amongst Y-linked genes that were downregulated due to LOY, KDM5D and KDM6C epigenetic modifiers have functionally-similar X-linked homologs whose deficiency is involved in ccRCC progression. Our findings establish somatic LOY as a highly recurrent genetic defect in ccRCC that leads to downregulation of hitherto unsuspected epigenetic factors, and suggest that different mechanisms may underlie the somatic and mosaic LOY observed in tumors and peripheral blood, respectively.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep44876", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3783487", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma", 
    "pagination": "44876", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b046733bd1590f407883066272bd16d054cd1928c5a4d42bd52dc3521a330199"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28332632"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep44876"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084132750"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep44876", 
      "https://app.dimensions.ai/details/publication/pub.1084132750"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000608.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2017/170323/srep44876/full/srep44876.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep44876'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep44876'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep44876'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep44876'


 

This table displays all metadata directly associated to this object as RDF triples.

451 TRIPLES      21 PREDICATES      72 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep44876 schema:about N0c280ea09db74f75865469d4d8e238ef
2 N1353d96099614812acc333328e603d64
3 N25dcb6fb57ad42f880c9e6e4ebac1292
4 N2bcf2030b07948808e920a4afd263442
5 N472e819859db4e1095c2731bf83de765
6 N65e8f30530264960bd36056649cef1f1
7 N7207aef6c260443a830af77194d2d7aa
8 N7e0aab92df2e4ea5820840c68b109c67
9 N7f28a56e958c46758bd76d1e10e9c11f
10 Na428a0443579443f876a39ee9f60f68d
11 Nc86eeeebd2094ca5be90c112c308b2bf
12 Nd1f5e26162894390909dfe8655d30286
13 Ne3f629fbb68f465babe9488b9559a576
14 anzsrc-for:06
15 anzsrc-for:0604
16 schema:author Nc16c5b211c7c42a48401506c79ed8366
17 schema:citation sg:pub.10.1007/bf00202476
18 sg:pub.10.1038/nature08672
19 sg:pub.10.1038/nature09639
20 sg:pub.10.1038/nature12222
21 sg:pub.10.1038/ncomms6135
22 sg:pub.10.1038/ng.2760
23 sg:pub.10.1038/ng.2966
24 sg:pub.10.1038/ng.349
25 sg:pub.10.1038/ng.3545
26 sg:pub.10.1038/nrc704
27 sg:pub.10.1038/nrneph.2016.133
28 https://doi.org/10.1002/1097-0142(197210)30:4<889::aid-cncr2820300405>3.0.co;2-1
29 https://doi.org/10.1016/j.ajhg.2013.04.012
30 https://doi.org/10.1016/j.cell.2007.02.004
31 https://doi.org/10.1016/j.celrep.2014.05.026
32 https://doi.org/10.1016/j.molcel.2014.06.028
33 https://doi.org/10.1016/s0022-5347(05)67774-9
34 https://doi.org/10.1016/s0140-6736(15)00046-x
35 https://doi.org/10.1021/acs.jproteome.5b00333
36 https://doi.org/10.1074/jbc.m114.555052
37 https://doi.org/10.1093/hmg/3.6.879
38 https://doi.org/10.1101/034165
39 https://doi.org/10.1101/gr.158253.113
40 https://doi.org/10.1126/science.8493574
41 https://doi.org/10.1136/jmedgenet-2014-102912
42 https://doi.org/10.1146/annurev-pathol-012414-040306
43 https://doi.org/10.1172/jci81040
44 https://doi.org/10.1371/journal.pone.0057886
45 https://doi.org/10.18632/oncotarget.6743
46 https://doi.org/10.7554/elife.02482
47 schema:datePublished 2017-12
48 schema:datePublishedReg 2017-12-01
49 schema:description Recent genomic studies of sporadic clear cell renal cell carcinoma (ccRCC) have uncovered novel driver genes and pathways. Given the unequal incidence rates among men and women (male:female incidence ratio approaches 2:1), we compared the genome-wide distribution of the chromosomal abnormalities in both sexes. We observed a higher frequency for the somatic recurrent chromosomal copy number variations (CNVs) of autosomes in male subjects, whereas somatic loss of chromosome X was detected exclusively in female patients (17.1%). Furthermore, somatic loss of chromosome Y (LOY) was detected in about 40% of male subjects, while mosaic LOY was detected in DNA isolated from peripheral blood in 9.6% of them, and was the only recurrent CNV in constitutional DNA samples. LOY in constitutional DNA, but not in tumor DNA was associated with older age. Amongst Y-linked genes that were downregulated due to LOY, KDM5D and KDM6C epigenetic modifiers have functionally-similar X-linked homologs whose deficiency is involved in ccRCC progression. Our findings establish somatic LOY as a highly recurrent genetic defect in ccRCC that leads to downregulation of hitherto unsuspected epigenetic factors, and suggest that different mechanisms may underlie the somatic and mosaic LOY observed in tumors and peripheral blood, respectively.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf N07b4bf5f95894d51a3bcfaa23504e9e0
54 Nb24c6e78b3df411a845c4eb49b2481b6
55 sg:journal.1045337
56 schema:name Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma
57 schema:pagination 44876
58 schema:productId N249bb1acba414de89846ac3fdd175916
59 N24d17645d5374116b345355f84f5a287
60 N816ee2cdd74c4169b1ede80be0bec32b
61 Nd73da92467cd4f269d8918354d2bfe39
62 Ne47b601379ef43adbfb2a6e62ac15ead
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084132750
64 https://doi.org/10.1038/srep44876
65 schema:sdDatePublished 2019-04-11T00:31
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N695161678edb4be5a5b8f0300e584c1b
68 schema:url http://www.nature.com/srep/2017/170323/srep44876/full/srep44876.html
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N0715b4fffda84ca8898484b830c32d17 rdf:first sg:person.01301046330.10
73 rdf:rest N5b2a6ea03cb74d25a055a517e358cf31
74 N07b4bf5f95894d51a3bcfaa23504e9e0 schema:issueNumber 1
75 rdf:type schema:PublicationIssue
76 N094d254a2fe94efa85f09ef9cce67a47 rdf:first sg:person.01036742676.46
77 rdf:rest N622e15c78007477a906f1e2d231cbf95
78 N0c280ea09db74f75865469d4d8e238ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Chromosomes, Human, Y
80 rdf:type schema:DefinedTerm
81 N1353d96099614812acc333328e603d64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Gene Expression Regulation, Neoplastic
83 rdf:type schema:DefinedTerm
84 N143bdc1fe6554c1497128afcb3b1fb41 rdf:first N8db753af6585405b834415b1a7b2912b
85 rdf:rest N8c02ddc903294cd18062bbf59f5053ac
86 N1d0bb8e3dcd24b8ea7f7f5b8556a1eb7 rdf:first sg:person.01130034234.44
87 rdf:rest Nd2aa6c99d8884476854ee3c7a5b9bb70
88 N249bb1acba414de89846ac3fdd175916 schema:name doi
89 schema:value 10.1038/srep44876
90 rdf:type schema:PropertyValue
91 N24d17645d5374116b345355f84f5a287 schema:name dimensions_id
92 schema:value pub.1084132750
93 rdf:type schema:PropertyValue
94 N25dcb6fb57ad42f880c9e6e4ebac1292 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Male
96 rdf:type schema:DefinedTerm
97 N2bcf2030b07948808e920a4afd263442 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 N345e7db4280c4a8bb473814f8aadce55 rdf:first sg:person.01256031142.86
101 rdf:rest N7bae7761c24f45458af95a93d05774c6
102 N3e22121555574fd98494d0a257d8daa4 rdf:first sg:person.0654401076.83
103 rdf:rest Nbb43e44ca4db4b2d82f2374a2dd5bc92
104 N43f0648381c840b8954650b901f47665 rdf:first sg:person.0754766024.58
105 rdf:rest N6ad386170e364022a61f2df98c78dd16
106 N472e819859db4e1095c2731bf83de765 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Minor Histocompatibility Antigens
108 rdf:type schema:DefinedTerm
109 N4985678e93554f5fba2c2a35be326a5b schema:name Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Zluty Kopec 7, 656 53 Brno, Czech Republic.
110 rdf:type schema:Organization
111 N4b7c2571992244e295ce277b25f90413 rdf:first sg:person.01355536615.06
112 rdf:rest rdf:nil
113 N5b2a6ea03cb74d25a055a517e358cf31 rdf:first sg:person.0576633207.74
114 rdf:rest N43f0648381c840b8954650b901f47665
115 N5b362938bd344c29a9e0a02f51b2b292 rdf:first sg:person.01132647725.77
116 rdf:rest Nf49a8909a94f460d93898e6b5226aa7d
117 N622e15c78007477a906f1e2d231cbf95 rdf:first sg:person.01100145274.50
118 rdf:rest Ne87812efeaf04c928085fceb19dceb5c
119 N65e8f30530264960bd36056649cef1f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Histone Demethylases
121 rdf:type schema:DefinedTerm
122 N6922fb41c7b948818aae480ef845d7f3 rdf:first sg:person.0643627174.70
123 rdf:rest N8b59fe928267427bbb8d75c04a5bf4dd
124 N695161678edb4be5a5b8f0300e584c1b schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N6ad386170e364022a61f2df98c78dd16 rdf:first sg:person.01140157320.06
127 rdf:rest N5b362938bd344c29a9e0a02f51b2b292
128 N6cc8aa279951442b8d5d415b20cc7d0d schema:name National Institute of Public Health, Dr Leonte Anastasievici 1-3, sector 5, Bucuresti 050463, Romania.
129 rdf:type schema:Organization
130 N6de13e8a63e44ea88ec0c0dcf9bfd7fc rdf:first N96028bf83bb84b14bcd99053b63021ac
131 rdf:rest N0715b4fffda84ca8898484b830c32d17
132 N6ebee1c2f4e64ab4a2a814295e657a01 schema:name Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, LS9 7TF, UK.
133 rdf:type schema:Organization
134 N7207aef6c260443a830af77194d2d7aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Epigenesis, Genetic
136 rdf:type schema:DefinedTerm
137 N7bae7761c24f45458af95a93d05774c6 rdf:first sg:person.01364014257.54
138 rdf:rest Naea6cf03539644d397787c1a0b0d60c6
139 N7e0aab92df2e4ea5820840c68b109c67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name DNA Copy Number Variations
141 rdf:type schema:DefinedTerm
142 N7f28a56e958c46758bd76d1e10e9c11f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Carcinoma, Renal Cell
144 rdf:type schema:DefinedTerm
145 N816ee2cdd74c4169b1ede80be0bec32b schema:name pubmed_id
146 schema:value 28332632
147 rdf:type schema:PropertyValue
148 N897f2978483a4fdf85484b99f3c9cc64 rdf:first sg:person.0622256311.37
149 rdf:rest Nc9258913e88f442cb86eec08e63187f7
150 N8b59fe928267427bbb8d75c04a5bf4dd rdf:first sg:person.012163663227.38
151 rdf:rest Nf75377aaa3ee4b7ab078dd5ebaacca20
152 N8c02ddc903294cd18062bbf59f5053ac rdf:first sg:person.012441234515.96
153 rdf:rest N1d0bb8e3dcd24b8ea7f7f5b8556a1eb7
154 N8db753af6585405b834415b1a7b2912b schema:affiliation https://www.grid.ac/institutes/grid.411640.6
155 schema:familyName Nourbehesht
156 schema:givenName Nazanin
157 rdf:type schema:Person
158 N8f20c017c5604c36b7b7655771178bce rdf:first sg:person.01346073211.90
159 rdf:rest N6de13e8a63e44ea88ec0c0dcf9bfd7fc
160 N94213b0cc066455ab8bb4ea6ae44e4c2 schema:name Russian N.N. Blokhin Cancer Research Centre, Kashirskoye shosse 24, Moscow 115478, Russian Federation.
161 rdf:type schema:Organization
162 N96028bf83bb84b14bcd99053b63021ac schema:affiliation https://www.grid.ac/institutes/grid.17703.32
163 schema:familyName Brennan
164 schema:givenName Paul
165 rdf:type schema:Person
166 Na428a0443579443f876a39ee9f60f68d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Cell Survival
168 rdf:type schema:DefinedTerm
169 Na7f18e0b5a5b40588ebfc3f9ea3699cc schema:name Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Zluty Kopec 7, 656 53 Brno, Czech Republic.
170 rdf:type schema:Organization
171 Naea6cf03539644d397787c1a0b0d60c6 rdf:first sg:person.01302342572.16
172 rdf:rest Nd218847f048647efae85000638881407
173 Nb24c6e78b3df411a845c4eb49b2481b6 schema:volumeNumber 7
174 rdf:type schema:PublicationVolume
175 Nb61b5c55bbf94d18b7bd37ffc9a4a296 schema:name Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, LS9 7TF, UK.
176 rdf:type schema:Organization
177 Nbb43e44ca4db4b2d82f2374a2dd5bc92 rdf:first sg:person.0734002663.28
178 rdf:rest N8f20c017c5604c36b7b7655771178bce
179 Nc16c5b211c7c42a48401506c79ed8366 rdf:first sg:person.01321241122.74
180 rdf:rest N345e7db4280c4a8bb473814f8aadce55
181 Nc72e3a26394a47e7b5f37e22c2ec1627 schema:name Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, LS9 7TF, UK.
182 rdf:type schema:Organization
183 Nc86eeeebd2094ca5be90c112c308b2bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Kidney Neoplasms
185 rdf:type schema:DefinedTerm
186 Nc9258913e88f442cb86eec08e63187f7 rdf:first sg:person.01256746437.20
187 rdf:rest N143bdc1fe6554c1497128afcb3b1fb41
188 Nd1f5e26162894390909dfe8655d30286 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Female
190 rdf:type schema:DefinedTerm
191 Nd218847f048647efae85000638881407 rdf:first sg:person.011355664453.86
192 rdf:rest N897f2978483a4fdf85484b99f3c9cc64
193 Nd2aa6c99d8884476854ee3c7a5b9bb70 rdf:first sg:person.01010554662.10
194 rdf:rest N6922fb41c7b948818aae480ef845d7f3
195 Nd73da92467cd4f269d8918354d2bfe39 schema:name readcube_id
196 schema:value b046733bd1590f407883066272bd16d054cd1928c5a4d42bd52dc3521a330199
197 rdf:type schema:PropertyValue
198 Ne3f629fbb68f465babe9488b9559a576 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Chromosome Deletion
200 rdf:type schema:DefinedTerm
201 Ne47b601379ef43adbfb2a6e62ac15ead schema:name nlm_unique_id
202 schema:value 101563288
203 rdf:type schema:PropertyValue
204 Ne7c800c54866487b8fd06808306ce72f schema:name Russian N.N. Blokhin Cancer Research Centre, Kashirskoye shosse 24, Moscow 115478, Russian Federation.
205 rdf:type schema:Organization
206 Ne87812efeaf04c928085fceb19dceb5c rdf:first sg:person.0660455015.51
207 rdf:rest N3e22121555574fd98494d0a257d8daa4
208 Nf49a8909a94f460d93898e6b5226aa7d rdf:first sg:person.0615174463.35
209 rdf:rest N4b7c2571992244e295ce277b25f90413
210 Nf75377aaa3ee4b7ab078dd5ebaacca20 rdf:first sg:person.0752405000.96
211 rdf:rest N094d254a2fe94efa85f09ef9cce67a47
212 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
213 schema:name Biological Sciences
214 rdf:type schema:DefinedTerm
215 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
216 schema:name Genetics
217 rdf:type schema:DefinedTerm
218 sg:grant.3783487 http://pending.schema.org/fundedItem sg:pub.10.1038/srep44876
219 rdf:type schema:MonetaryGrant
220 sg:journal.1045337 schema:issn 2045-2322
221 schema:name Scientific Reports
222 rdf:type schema:Periodical
223 sg:person.01010554662.10 schema:affiliation https://www.grid.ac/institutes/grid.412826.b
224 schema:familyName Brisuda
225 schema:givenName Antonin
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010554662.10
227 rdf:type schema:Person
228 sg:person.01036742676.46 schema:affiliation N4985678e93554f5fba2c2a35be326a5b
229 schema:familyName Navratilova
230 schema:givenName Marie
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036742676.46
232 rdf:type schema:Person
233 sg:person.01100145274.50 schema:affiliation N6cc8aa279951442b8d5d415b20cc7d0d
234 schema:familyName Mates
235 schema:givenName Dana
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100145274.50
237 rdf:type schema:Person
238 sg:person.01130034234.44 schema:affiliation https://www.grid.ac/institutes/grid.4491.8
239 schema:familyName Holcatova
240 schema:givenName Ivana
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130034234.44
242 rdf:type schema:Person
243 sg:person.01132647725.77 schema:affiliation https://www.grid.ac/institutes/grid.411640.6
244 schema:familyName Lathrop
245 schema:givenName Mark
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132647725.77
247 rdf:type schema:Person
248 sg:person.011355664453.86 schema:affiliation https://www.grid.ac/institutes/grid.411640.6
249 schema:familyName Safisamghabadi
250 schema:givenName Maryam
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011355664453.86
252 rdf:type schema:Person
253 sg:person.01140157320.06 schema:affiliation Nc72e3a26394a47e7b5f37e22c2ec1627
254 schema:familyName Banks
255 schema:givenName Rosamonde E
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140157320.06
257 rdf:type schema:Person
258 sg:person.012163663227.38 schema:affiliation https://www.grid.ac/institutes/grid.10979.36
259 schema:familyName Kollarova
260 schema:givenName Helena
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012163663227.38
262 rdf:type schema:Person
263 sg:person.012441234515.96 schema:affiliation https://www.grid.ac/institutes/grid.411640.6
264 schema:familyName Panichnantakul
265 schema:givenName Pudchalaluck
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012441234515.96
267 rdf:type schema:Person
268 sg:person.01256031142.86 schema:affiliation https://www.grid.ac/institutes/grid.411640.6
269 schema:familyName Monlong
270 schema:givenName Jean
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256031142.86
272 rdf:type schema:Person
273 sg:person.01256746437.20 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
274 schema:familyName Egevad
275 schema:givenName Lars
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256746437.20
277 rdf:type schema:Person
278 sg:person.01301046330.10 schema:affiliation https://www.grid.ac/institutes/grid.225360.0
279 schema:familyName Brazma
280 schema:givenName Alvis
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301046330.10
282 rdf:type schema:Person
283 sg:person.01302342572.16 schema:affiliation https://www.grid.ac/institutes/grid.17703.32
284 schema:familyName Laskar
285 schema:givenName Ruhina S
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302342572.16
287 rdf:type schema:Person
288 sg:person.01321241122.74 schema:affiliation https://www.grid.ac/institutes/grid.411640.6
289 schema:familyName Arseneault
290 schema:givenName Madeleine
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321241122.74
292 rdf:type schema:Person
293 sg:person.01346073211.90 schema:affiliation https://www.grid.ac/institutes/grid.411640.6
294 schema:familyName Jandaghi
295 schema:givenName Pouria
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346073211.90
297 rdf:type schema:Person
298 sg:person.01355536615.06 schema:affiliation https://www.grid.ac/institutes/grid.411640.6
299 schema:familyName Riazalhosseini
300 schema:givenName Yasser
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355536615.06
302 rdf:type schema:Person
303 sg:person.01364014257.54 schema:affiliation Nb61b5c55bbf94d18b7bd37ffc9a4a296
304 schema:familyName Vasudev
305 schema:givenName Naveen S
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364014257.54
307 rdf:type schema:Person
308 sg:person.0576633207.74 schema:affiliation https://www.grid.ac/institutes/grid.418135.a
309 schema:familyName Tost
310 schema:givenName Jorg
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576633207.74
312 rdf:type schema:Person
313 sg:person.0615174463.35 schema:affiliation https://www.grid.ac/institutes/grid.411640.6
314 schema:familyName Bourque
315 schema:givenName Guillaume
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615174463.35
317 rdf:type schema:Person
318 sg:person.0622256311.37 schema:affiliation N6ebee1c2f4e64ab4a2a814295e657a01
319 schema:familyName Harnden
320 schema:givenName Patricia
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622256311.37
322 rdf:type schema:Person
323 sg:person.0643627174.70 schema:affiliation https://www.grid.ac/institutes/grid.10979.36
324 schema:familyName Janout
325 schema:givenName Vladimir
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643627174.70
327 rdf:type schema:Person
328 sg:person.0654401076.83 schema:affiliation N94213b0cc066455ab8bb4ea6ae44e4c2
329 schema:familyName Zaridze
330 schema:givenName David
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654401076.83
332 rdf:type schema:Person
333 sg:person.0660455015.51 schema:affiliation https://www.grid.ac/institutes/grid.8194.4
334 schema:familyName Jinga
335 schema:givenName Viorel
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660455015.51
337 rdf:type schema:Person
338 sg:person.0734002663.28 schema:affiliation Ne7c800c54866487b8fd06808306ce72f
339 schema:familyName Mukeria
340 schema:givenName Anush
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734002663.28
342 rdf:type schema:Person
343 sg:person.0752405000.96 schema:affiliation Na7f18e0b5a5b40588ebfc3f9ea3699cc
344 schema:familyName Foretova
345 schema:givenName Lenka
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752405000.96
347 rdf:type schema:Person
348 sg:person.0754766024.58 schema:affiliation https://www.grid.ac/institutes/grid.17703.32
349 schema:familyName Scelo
350 schema:givenName Ghislaine
351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754766024.58
352 rdf:type schema:Person
353 sg:pub.10.1007/bf00202476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022154976
354 https://doi.org/10.1007/bf00202476
355 rdf:type schema:CreativeWork
356 sg:pub.10.1038/nature08672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032969139
357 https://doi.org/10.1038/nature08672
358 rdf:type schema:CreativeWork
359 sg:pub.10.1038/nature09639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009539954
360 https://doi.org/10.1038/nature09639
361 rdf:type schema:CreativeWork
362 sg:pub.10.1038/nature12222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050842404
363 https://doi.org/10.1038/nature12222
364 rdf:type schema:CreativeWork
365 sg:pub.10.1038/ncomms6135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001274259
366 https://doi.org/10.1038/ncomms6135
367 rdf:type schema:CreativeWork
368 sg:pub.10.1038/ng.2760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042520483
369 https://doi.org/10.1038/ng.2760
370 rdf:type schema:CreativeWork
371 sg:pub.10.1038/ng.2966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043326600
372 https://doi.org/10.1038/ng.2966
373 rdf:type schema:CreativeWork
374 sg:pub.10.1038/ng.349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001520036
375 https://doi.org/10.1038/ng.349
376 rdf:type schema:CreativeWork
377 sg:pub.10.1038/ng.3545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042935394
378 https://doi.org/10.1038/ng.3545
379 rdf:type schema:CreativeWork
380 sg:pub.10.1038/nrc704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028740665
381 https://doi.org/10.1038/nrc704
382 rdf:type schema:CreativeWork
383 sg:pub.10.1038/nrneph.2016.133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044753452
384 https://doi.org/10.1038/nrneph.2016.133
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1002/1097-0142(197210)30:4<889::aid-cncr2820300405>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020083037
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1016/j.ajhg.2013.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021796751
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1016/j.cell.2007.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013583491
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1016/j.celrep.2014.05.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034208029
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1016/j.molcel.2014.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048813628
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1016/s0022-5347(05)67774-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051340711
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1016/s0140-6736(15)00046-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020855424
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1021/acs.jproteome.5b00333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055115062
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1074/jbc.m114.555052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053106423
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1093/hmg/3.6.879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059645006
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1101/034165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011364079
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1101/gr.158253.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008057766
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1126/science.8493574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062655846
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1136/jmedgenet-2014-102912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043518272
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1146/annurev-pathol-012414-040306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031244400
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1172/jci81040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041849944
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1371/journal.pone.0057886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025254695
419 rdf:type schema:CreativeWork
420 https://doi.org/10.18632/oncotarget.6743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030343113
421 rdf:type schema:CreativeWork
422 https://doi.org/10.7554/elife.02482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011287188
423 rdf:type schema:CreativeWork
424 https://www.grid.ac/institutes/grid.10979.36 schema:alternateName Palacký University, Olomouc
425 schema:name Department of Preventive Medicine, Faculty of Medicine, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic.
426 rdf:type schema:Organization
427 https://www.grid.ac/institutes/grid.17703.32 schema:alternateName International Agency For Research On Cancer
428 schema:name International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69008 Lyon, France.
429 rdf:type schema:Organization
430 https://www.grid.ac/institutes/grid.225360.0 schema:alternateName European Bioinformatics Institute
431 schema:name European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK.
432 rdf:type schema:Organization
433 https://www.grid.ac/institutes/grid.411640.6 schema:alternateName McGill University and Génome Québec Innovation Centre
434 schema:name Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada.
435 McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, H3A 0G1, Canada.
436 rdf:type schema:Organization
437 https://www.grid.ac/institutes/grid.412826.b schema:alternateName University Hospital in Motol
438 schema:name University Hospital Motol, V Úvalu 84, 150 06 Prague, Czech Republic.
439 rdf:type schema:Organization
440 https://www.grid.ac/institutes/grid.418135.a schema:alternateName Centre National de Génotypage
441 schema:name Laboratory for Epigenetics &Environment, Centre National de Génotypage, CEA-Institut de Génomique, 2 rue Gaston Crémieux, 91000 Evry, France.
442 rdf:type schema:Organization
443 https://www.grid.ac/institutes/grid.4491.8 schema:alternateName Charles University
444 schema:name First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University in Prague, Studničkova 7, Praha 2, 128 00 Prague, Czech Republic.
445 rdf:type schema:Organization
446 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
447 schema:name Karolinska Institutet, Department of Pathology, SE-171 77 Stockholm, Sweden.
448 rdf:type schema:Organization
449 https://www.grid.ac/institutes/grid.8194.4 schema:alternateName Carol Davila University of Medicine and Pharmacy
450 schema:name Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, 20 Panduri Street, 050659 Bucharest, Romania.
451 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...