Ticks elicit variable fibrinogenolytic activities upon feeding on hosts with different immune backgrounds View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Ashish Vora, Vikas Taank, Sucharita M Dutta, John F Anderson, Durland Fish, Daniel E Sonenshine, John D Catravas, Hameeda Sultana, Girish Neelakanta

ABSTRACT

Ticks secrete several anti-hemostatic factors in their saliva to suppress the host innate and acquired immune defenses against infestations. Using Ixodes scapularis ticks and age-matched mice purchased from two independent commercial vendors with two different immune backgrounds as a model, we show that ticks fed on immunodeficient animals demonstrate decreased fibrinogenolytic activity in comparison to ticks fed on immunocompetent animals. Reduced levels of D-dimer (fibrin degradation product) were evident in ticks fed on immunodeficient animals in comparison to ticks fed on immunocompetent animals. Increased engorgement weights were noted for ticks fed on immunodeficient animals in comparison to ticks fed on immunocompetent animals. Furthermore, the LC-MS/MS and quantitative real-time-PCR analysis followed by inhibitor and antibody-blocking assays revealed that the arthropod HSP70-like molecule contributes to differential fibrinogenolysis during tick feeding. Collectively, these results not only indicate that ticks elicit variable fibrinogenolysis upon feeding on hosts with different immune backgrounds but also provide insights for the novel role of arthropod HSP70-like molecule in fibrinogenolysis during blood feeding. More... »

PAGES

44593

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep44593

DOI

http://dx.doi.org/10.1038/srep44593

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084132477

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28300174


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