AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Marina Riggio, María C Perrone, María L Polo, María J Rodriguez, María May, Martín Abba, Claudia Lanari, Virginia Novaro

ABSTRACT

The purpose of this study was to elucidate the mechanisms associated with the specific effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the abundance of specific AKT isoforms in IBH-6 and T47D human breast cancer cell lines and showed that AKT1 promoted cell proliferation, through S6 and cyclin D1 upregulation, but it inhibited cell migration and invasion through β1-integrin and focal adhesion kinase (FAK) downregulation. In contrast, AKT2 promoted cell migration and invasion through F-actin and vimentin induction. Thus, while overexpression of AKT1 promoted local tumor growth, downregulation of AKT1 or overexpression of AKT2 promoted peritumoral invasion and lung metastasis. Furthermore, we evaluated The Cancer Genome Atlas (TCGA) dataset for invasive breast carcinomas and found that increased AKT2 but not AKT1 mRNA levels correlated with a worse clinical outcome. We conclude that AKT isoforms play specific roles in different steps of breast cancer progression, with AKT1 involved in the local tumor growth and AKT2 involved in the distant tumor dissemination, having AKT2 a poorer prognostic value and consequently being a worthwhile target for therapy. More... »

PAGES

44244

References to SciGraph publications

  • 2005-11. The Akt/PKB pathway: molecular target for cancer drug discovery in ONCOGENE
  • 2013-10. Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis in ADVANCES IN THERAPY
  • 2014-06. Relationship of PIK3CA mutation and pathway activity with antiproliferative response to aromatase inhibition in BREAST CANCER RESEARCH
  • 2010-05. Guidelines for the welfare and use of animals in cancer research in BRITISH JOURNAL OF CANCER
  • 2014-12. Differential subcellular and extracellular localisations of proteins required for insulin-like growth factor- and extracellular matrix-induced signalling events in breast cancer progression in BMC CANCER
  • 2016-07. Mutation of genes of the PI3K/AKT pathway in breast cancer supports their potential importance as biomarker for breast cancer aggressiveness in VIRCHOWS ARCHIV
  • 2003-04. Akt kinases in breast cancer and the results of adjuvant therapy in BREAST CANCER RESEARCH
  • 2014-10. β1 and β4 integrins: from breast development to clinical practice in BREAST CANCER RESEARCH
  • 2011-07. PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs in ONCOGENE
  • 2006-06. Expression and localisation of Akt-1, Akt-2 and Akt-3 correlate with clinical outcome of prostate cancer patients in BRITISH JOURNAL OF CANCER
  • 2013-12. Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice in BMC CANCER
  • 2010-01. Integrins in cancer: biological implications and therapeutic opportunities in NATURE REVIEWS CANCER
  • 2013-08. β1-integrin via NF-κB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer in BREAST CANCER RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep44244

    DOI

    http://dx.doi.org/10.1038/srep44244

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084132139

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28287129


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