Epidermal CD147 expression plays a key role in IL-22-induced psoriatic dermatitis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-08

AUTHORS

Cong Peng, ShengXi Zhang, Li Lei, Xu Zhang, Xuekun Jia, Zhongling Luo, Xiaoyan Huang, Yanhong Kuang, Weiqi Zeng, Juan Su, Xiang Chen

ABSTRACT

Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and terminal differentiation. Interleukin-22 (IL-22) and the transcription factor Stat3 play pivotal roles in the pathogenesis of psoriasis. CD147 is a transmembrane glycosylation protein that belongs to the immunoglobulin superfamily. Our previous studies have shown that CD147 is a marker of high keratinocyte proliferation and poor keratinocyte differentiation as well as a psoriasis susceptibility gene. The current study demonstrates that CD147 is highly expressed in psoriatic skin lesions. Specific CD147 over-expression in the epidermis of K5-promoter transgenic mice promotes imiquimod (IMQ)-induced psoriasis-like inflammation characterized by acanthosis, granular layer loss and inflammatory cell infiltration. We also found that IL-22 increases CD147 transcription in vitro and in vivo and that Stat3 binds directly to the CD147 promoter between positions −854 and −440, suggesting that CD147 expression is up-regulated in patients with psoriasis through Stat3 activation. In addition, CD147 knockdown dramatically blocks IL-22-mediated Stat3 activation as well as IL-22-induced cytokine, chemokine and antimicrobial factor expression. Together, these findings show that CD147 is a novel and key mediator of IL-22-induced psoriatic alterations in the epidermis and might be a therapeutic target in patients with psoriasis. More... »

PAGES

44172

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep44172

DOI

http://dx.doi.org/10.1038/srep44172

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084132070

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28272440


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44 binds
45 cell infiltration
46 chemokines
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50 dermatitis
51 differentiation
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53 epidermis
54 expression
55 factor expression
56 findings
57 genes
58 glycosylation proteins
59 high keratinocyte proliferation
60 imiquimod
61 immunoglobulin
62 increase
63 infiltration
64 inflammation
65 inflammatory cell infiltration
66 inflammatory skin disease
67 interleukin-22
68 keratinocyte differentiation
69 keratinocyte proliferation
70 key mediator
71 key role
72 knockdown
73 layer loss
74 lesions
75 loss
76 markers
77 mediators
78 pathogenesis
79 pathogenesis of psoriasis
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81 pivotal role
82 position
83 previous studies
84 proliferation
85 promoter
86 protein
87 psoriasis
88 psoriasis susceptibility gene
89 psoriasis-like inflammation
90 psoriatic dermatitis
91 psoriatic skin lesions
92 role
93 skin diseases
94 skin lesions
95 study
96 susceptibility genes
97 target
98 terminal differentiation
99 therapeutic target
100 transcription
101 transcription factor STAT3
102 vitro
103 vivo
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