miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Cheen P Khoo, Maria G Roubelakis, Jack B Schrader, Grigorios Tsaknakis, Rebecca Konietzny, Benedikt Kessler, Adrian L Harris, Suzanne M Watt

ABSTRACT

Circulating endothelial colony forming cells (ECFCs) contribute to vascular repair where they are a target for therapy. Since ECFC proliferative potential is increased in cord versus peripheral blood and to define regulatory factors controlling this proliferation, we compared the miRNA profiles of cord blood and peripheral blood ECFC-derived cells. Of the top 25 differentially regulated miRNAs selected, 22 were more highly expressed in peripheral blood ECFC-derived cells. After validating candidate miRNAs by q-RT-PCR, we selected miR-193a-3p for further investigation. The miR-193a-3p mimic reduced cord blood ECFC-derived cell proliferation, migration and vascular tubule formation, while the miR-193a-3p inhibitor significantly enhanced these parameters in peripheral blood ECFC-derived cells. Using in silico miRNA target database analyses combined with proteome arrays and luciferase reporter assays of miR-193a-3p mimic treated cord blood ECFC-derived cells, we identified 2 novel miR-193a-3p targets, the high mobility group box-1 (HMGB1) and the hypoxia upregulated-1 (HYOU1) gene products. HMGB1 silencing in cord blood ECFC-derived cells confirmed its role in regulating vascular function. Thus, we show, for the first time, that miR-193a-3p negatively regulates human ECFC vasculo/angiogenesis and propose that antagonising miR-193a-3p in less proliferative and less angiogenic ECFC-derived cells will enhance their vasculo/angiogenic function. More... »

PAGES

44137

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep44137

DOI

http://dx.doi.org/10.1038/srep44137

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084132037

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28276476


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Progenitor Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HMGB1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "NHS Blood and Transplant", 
          "id": "https://www.grid.ac/institutes/grid.436365.1", 
          "name": [
            "Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9BQ, UK.", 
            "Stem Cell Research, NHS Blood and Transplant, Oxford, OX3 9BQ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khoo", 
        "givenName": "Cheen P", 
        "id": "sg:person.01303572275.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303572275.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biomedical Research Foundation of the Academy of Athens", 
          "id": "https://www.grid.ac/institutes/grid.417975.9", 
          "name": [
            "Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9BQ, UK.", 
            "Stem Cell Research, NHS Blood and Transplant, Oxford, OX3 9BQ, UK.", 
            "Laboratory of Biology, National and Kapodistrian University of Athens Medical School, Athens 115 27, Greece.", 
            "Cell and Gene Therapy Laboratory, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, 11527, Greece."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roubelakis", 
        "givenName": "Maria G", 
        "id": "sg:person.01066064567.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066064567.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of York", 
          "id": "https://www.grid.ac/institutes/grid.5685.e", 
          "name": [
            "Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9BQ, UK.", 
            "Stem Cell Research, NHS Blood and Transplant, Oxford, OX3 9BQ, UK.", 
            "Department of Biology, University of York, York, YO10 5DD, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schrader", 
        "givenName": "Jack B", 
        "id": "sg:person.0725263637.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725263637.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "NHS Blood and Transplant", 
          "id": "https://www.grid.ac/institutes/grid.436365.1", 
          "name": [
            "Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9BQ, UK.", 
            "Stem Cell Research, NHS Blood and Transplant, Oxford, OX3 9BQ, UK.", 
            "Institute of Molecular Biology and Biotechnology, Foundation of Research &Technology, GR-70013 Heraklion, Crete."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsaknakis", 
        "givenName": "Grigorios", 
        "id": "sg:person.01167343675.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167343675.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Target Discovery Institute, NDM Research Building, Nuffield Department of Medicine, University of Oxford, OX3 7FZ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konietzny", 
        "givenName": "Rebecca", 
        "id": "sg:person.01214562542.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214562542.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Target Discovery Institute, NDM Research Building, Nuffield Department of Medicine, University of Oxford, OX3 7FZ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kessler", 
        "givenName": "Benedikt", 
        "id": "sg:person.0704460202.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704460202.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harris", 
        "givenName": "Adrian L", 
        "id": "sg:person.01151433574.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151433574.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "NHS Blood and Transplant", 
          "id": "https://www.grid.ac/institutes/grid.436365.1", 
          "name": [
            "Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9BQ, UK.", 
            "Stem Cell Research, NHS Blood and Transplant, Oxford, OX3 9BQ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watt", 
        "givenName": "Suzanne M", 
        "id": "sg:person.01016574523.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016574523.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1083/jcb.200304135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004385174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10456-013-9354-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004729491", 
          "https://doi.org/10.1007/s10456-013-9354-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10456-013-9354-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004729491", 
          "https://doi.org/10.1007/s10456-013-9354-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tec.2011.0037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005199251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/30.1.207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005297170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.111.239822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006593702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.111.239822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006593702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.1938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007949161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20111739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008594231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0054747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009424687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2011.06.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009896040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2012.09050.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010433018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.1973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011322304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-05-219378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011463236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-05-219378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011463236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-01-264812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012159630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/17460751.3.6.863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012292292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2015.03.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012439304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0151420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012443618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0151420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012443618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)62344-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015982577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1405388111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017403261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.1578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017619622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000232971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018017214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2045-824x-5-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018941636", 
          "https://doi.org/10.1186/2045-824x-5-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.1012511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018958520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2013.1896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019359115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2013.1896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019359115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2013.1896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019359115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0096155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020287568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1534734616649485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021549123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1534734616649485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021549123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci42980", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021681653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci42980", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021681653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/2162402x.2015.1122860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021981950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.4346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022111489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023682432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-013-9571-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024638969", 
          "https://doi.org/10.1007/s10585-013-9571-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2012.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025711537", 
          "https://doi.org/10.1038/onc.2012.49"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cca.2015.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027049054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-04-1396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027487069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jvs.2011.07.072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029435451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.114.304747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029448719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.114.304747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029448719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0113004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030152947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-08-3057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030833198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2010.07.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031044500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000345070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031555215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m114.621409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031730374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2011.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032296289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.178590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034965096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.178590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034965096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.25276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035559205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.2262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035766739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2016.02.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035897550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2012.1091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036038559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2012.1091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036038559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2010.12.119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036045496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00511-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036736969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.burns.2011.12.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038629723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.24423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040947637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bmb/ldt031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041408896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00244.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041567464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.25753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041888550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pr.2011.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043162694", 
          "https://doi.org/10.1038/pr.2011.22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.111.224048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044303667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.111.224048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044303667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000126373.52450.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044541674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000126373.52450.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044541674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.114.009124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045778476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.114.009124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045778476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10456-011-9222-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046627823", 
          "https://doi.org/10.1007/s10456-011-9222-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10456-011-9222-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046627823", 
          "https://doi.org/10.1007/s10456-011-9222-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.152.6.1197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048308228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb3330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048342056", 
          "https://doi.org/10.1038/ncb3330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a006692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050032290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00281-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051719075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12015-010-9157-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051834735", 
          "https://doi.org/10.1007/s12015-010-9157-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12015-010-9157-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051834735", 
          "https://doi.org/10.1007/s12015-010-9157-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jid.5701212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052688556", 
          "https://doi.org/10.1038/sj.jid.5701212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000257774.55970.f4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052927261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000257774.55970.f4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052927261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.2013.2996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059301816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.2008.0071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059309843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.2014.0005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059310968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tec.2011.0150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059317482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2013.2883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071532806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2013.2883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071532806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2045-8932.93547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072245889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2045-8932.93547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072245889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5966/sctm.2013-0092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073577425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5966/sctm.2014-0162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073577528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5966/sctm.2015-0096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073577625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.176.1.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077164332"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Circulating endothelial colony forming cells (ECFCs) contribute to vascular repair where they are a target for therapy. Since ECFC proliferative potential is increased in cord versus peripheral blood and to define regulatory factors controlling this proliferation, we compared the miRNA profiles of cord blood and peripheral blood ECFC-derived cells. Of the top 25 differentially regulated miRNAs selected, 22 were more highly expressed in peripheral blood ECFC-derived cells. After validating candidate miRNAs by q-RT-PCR, we selected miR-193a-3p for further investigation. The miR-193a-3p mimic reduced cord blood ECFC-derived cell proliferation, migration and vascular tubule formation, while the miR-193a-3p inhibitor significantly enhanced these parameters in peripheral blood ECFC-derived cells. Using in silico miRNA target database analyses combined with proteome arrays and luciferase reporter assays of miR-193a-3p mimic treated cord blood ECFC-derived cells, we identified 2 novel miR-193a-3p targets, the high mobility group box-1 (HMGB1) and the hypoxia upregulated-1 (HYOU1) gene products. HMGB1 silencing in cord blood ECFC-derived cells confirmed its role in regulating vascular function. Thus, we show, for the first time, that miR-193a-3p negatively regulates human ECFC vasculo/angiogenesis and propose that antagonising miR-193a-3p in less proliferative and less angiogenic ECFC-derived cells will enhance their vasculo/angiogenic function.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep44137", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5145717", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2762393", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5147615", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5140087", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration", 
    "pagination": "44137", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a739a003f6c5577b23ff8667630d82560a49ba36bcc7494426cb1a342a21f936"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28276476"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep44137"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084132037"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep44137", 
      "https://app.dimensions.ai/details/publication/pub.1084132037"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000608.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2017/170309/srep44137/full/srep44137.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep44137'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep44137'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep44137'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep44137'


 

This table displays all metadata directly associated to this object as RDF triples.

409 TRIPLES      21 PREDICATES      112 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep44137 schema:about N41885440aee24a6b80e304d29a52458b
2 N49504916e5c04a06ad0755a763c75f3e
3 N6fcc443801194d1b898ae3cefa1f2c1f
4 N7efa1b2d89054b2c912fe30088390232
5 Ndd869ea1c5c946608ad01fbb52948e99
6 Ne22f691a2b58423eba1e8d01ee4e7943
7 Nf7efe569bb4246599e32898b854bee63
8 Nfd22d84071854b948480e52325f7b5e5
9 anzsrc-for:06
10 anzsrc-for:0601
11 schema:author N63eea38e41d64e1b8cc5206f8906fe90
12 schema:citation sg:pub.10.1007/s10456-011-9222-4
13 sg:pub.10.1007/s10456-013-9354-9
14 sg:pub.10.1007/s10585-013-9571-z
15 sg:pub.10.1007/s12015-010-9157-y
16 sg:pub.10.1038/ncb3330
17 sg:pub.10.1038/onc.2012.49
18 sg:pub.10.1038/pr.2011.22
19 sg:pub.10.1038/sj.jid.5701212
20 sg:pub.10.1186/2045-824x-5-2
21 https://doi.org/10.1002/hep.25753
22 https://doi.org/10.1002/jcp.24423
23 https://doi.org/10.1002/jcp.25276
24 https://doi.org/10.1002/stem.1578
25 https://doi.org/10.1002/stem.1938
26 https://doi.org/10.1002/stem.1973
27 https://doi.org/10.1002/stem.2262
28 https://doi.org/10.1016/j.actbio.2011.09.002
29 https://doi.org/10.1016/j.bbrc.2010.07.012
30 https://doi.org/10.1016/j.bbrc.2010.12.119
31 https://doi.org/10.1016/j.burns.2011.12.019
32 https://doi.org/10.1016/j.cca.2015.06.017
33 https://doi.org/10.1016/j.cell.2009.01.002
34 https://doi.org/10.1016/j.clinthera.2016.02.028
35 https://doi.org/10.1016/j.jss.2011.06.069
36 https://doi.org/10.1016/j.jvs.2011.07.072
37 https://doi.org/10.1016/j.neuroscience.2015.03.032
38 https://doi.org/10.1016/s0002-9440(10)62344-9
39 https://doi.org/10.1016/s1535-6108(03)00281-2
40 https://doi.org/10.1073/pnas.1405388111
41 https://doi.org/10.1074/jbc.m114.621409
42 https://doi.org/10.1080/2162402x.2015.1122860
43 https://doi.org/10.1083/jcb.152.6.1197
44 https://doi.org/10.1083/jcb.200304135
45 https://doi.org/10.1084/jem.20111739
46 https://doi.org/10.1089/neu.2013.2996
47 https://doi.org/10.1089/scd.2008.0071
48 https://doi.org/10.1089/scd.2014.0005
49 https://doi.org/10.1089/ten.tec.2011.0037
50 https://doi.org/10.1089/ten.tec.2011.0150
51 https://doi.org/10.1093/bmb/ldt031
52 https://doi.org/10.1093/nar/30.1.207
53 https://doi.org/10.1101/cshperspect.a006692
54 https://doi.org/10.1111/j.1365-2141.2012.09050.x
55 https://doi.org/10.1128/jvi.00511-14
56 https://doi.org/10.1152/ajplung.00244.2013
57 https://doi.org/10.1159/000232971
58 https://doi.org/10.1159/000345070
59 https://doi.org/10.1161/01.atv.0000126373.52450.32
60 https://doi.org/10.1161/01.res.0000257774.55970.f4
61 https://doi.org/10.1161/atvbaha.111.224048
62 https://doi.org/10.1161/atvbaha.111.239822
63 https://doi.org/10.1161/circresaha.108.178590
64 https://doi.org/10.1161/circresaha.114.304747
65 https://doi.org/10.1161/circulationaha.114.009124
66 https://doi.org/10.1172/jci42980
67 https://doi.org/10.1177/1534734616649485
68 https://doi.org/10.1182/blood-2004-04-1396
69 https://doi.org/10.1182/blood-2004-08-3057
70 https://doi.org/10.1182/blood-2009-05-219378
71 https://doi.org/10.1182/blood-2010-01-264812
72 https://doi.org/10.1189/jlb.0113004
73 https://doi.org/10.1189/jlb.1012511
74 https://doi.org/10.1371/journal.pone.0054747
75 https://doi.org/10.1371/journal.pone.0096155
76 https://doi.org/10.1371/journal.pone.0151420
77 https://doi.org/10.18632/oncotarget.4346
78 https://doi.org/10.2217/17460751.3.6.863
79 https://doi.org/10.3892/ijo.2013.1896
80 https://doi.org/10.3892/ol.2012.1091
81 https://doi.org/10.3892/or.2013.2883
82 https://doi.org/10.4049/jimmunol.176.1.12
83 https://doi.org/10.4103/2045-8932.93547
84 https://doi.org/10.5966/sctm.2013-0092
85 https://doi.org/10.5966/sctm.2014-0162
86 https://doi.org/10.5966/sctm.2015-0096
87 schema:datePublished 2017-12
88 schema:datePublishedReg 2017-12-01
89 schema:description Circulating endothelial colony forming cells (ECFCs) contribute to vascular repair where they are a target for therapy. Since ECFC proliferative potential is increased in cord versus peripheral blood and to define regulatory factors controlling this proliferation, we compared the miRNA profiles of cord blood and peripheral blood ECFC-derived cells. Of the top 25 differentially regulated miRNAs selected, 22 were more highly expressed in peripheral blood ECFC-derived cells. After validating candidate miRNAs by q-RT-PCR, we selected miR-193a-3p for further investigation. The miR-193a-3p mimic reduced cord blood ECFC-derived cell proliferation, migration and vascular tubule formation, while the miR-193a-3p inhibitor significantly enhanced these parameters in peripheral blood ECFC-derived cells. Using in silico miRNA target database analyses combined with proteome arrays and luciferase reporter assays of miR-193a-3p mimic treated cord blood ECFC-derived cells, we identified 2 novel miR-193a-3p targets, the high mobility group box-1 (HMGB1) and the hypoxia upregulated-1 (HYOU1) gene products. HMGB1 silencing in cord blood ECFC-derived cells confirmed its role in regulating vascular function. Thus, we show, for the first time, that miR-193a-3p negatively regulates human ECFC vasculo/angiogenesis and propose that antagonising miR-193a-3p in less proliferative and less angiogenic ECFC-derived cells will enhance their vasculo/angiogenic function.
90 schema:genre research_article
91 schema:inLanguage en
92 schema:isAccessibleForFree true
93 schema:isPartOf N19b6b053f8d7414e95a203ec771291f0
94 N6d46dd0a25804b99bcde8050ca6c352b
95 sg:journal.1045337
96 schema:name miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration
97 schema:pagination 44137
98 schema:productId N0fddcafe99ef43178551240cd00f1474
99 N221c87b80e824cf9b2f5dafe13557cf7
100 N22945aeb2f0f493a8991303ff17f86f1
101 N8fbfd493d58a482c8428d912e0e530d6
102 N991604f6e1fd474ba46ad3bbcacb1fd0
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084132037
104 https://doi.org/10.1038/srep44137
105 schema:sdDatePublished 2019-04-10T21:55
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher N750d861f35f5439f9af54316f54a481d
108 schema:url http://www.nature.com/srep/2017/170309/srep44137/full/srep44137.html
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N0e5acc860a4d4e8dbc20c055583f2f56 rdf:first sg:person.0704460202.65
113 rdf:rest N7298acabd2cf4a5ab41e4db239a88200
114 N0fddcafe99ef43178551240cd00f1474 schema:name readcube_id
115 schema:value a739a003f6c5577b23ff8667630d82560a49ba36bcc7494426cb1a342a21f936
116 rdf:type schema:PropertyValue
117 N19b6b053f8d7414e95a203ec771291f0 schema:volumeNumber 7
118 rdf:type schema:PublicationVolume
119 N221c87b80e824cf9b2f5dafe13557cf7 schema:name nlm_unique_id
120 schema:value 101563288
121 rdf:type schema:PropertyValue
122 N22945aeb2f0f493a8991303ff17f86f1 schema:name pubmed_id
123 schema:value 28276476
124 rdf:type schema:PropertyValue
125 N41885440aee24a6b80e304d29a52458b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cell Movement
127 rdf:type schema:DefinedTerm
128 N49504916e5c04a06ad0755a763c75f3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Endothelial Cells
130 rdf:type schema:DefinedTerm
131 N4f0c1920c3834fc097dad95adb5fbbfd schema:name The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
132 rdf:type schema:Organization
133 N5104323bdbc34539a8772a41976ffe5d rdf:first sg:person.01016574523.27
134 rdf:rest rdf:nil
135 N63eea38e41d64e1b8cc5206f8906fe90 rdf:first sg:person.01303572275.46
136 rdf:rest Na984856bdb274756a596c0551e08a49d
137 N6d46dd0a25804b99bcde8050ca6c352b schema:issueNumber 1
138 rdf:type schema:PublicationIssue
139 N6fcc443801194d1b898ae3cefa1f2c1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Humans
141 rdf:type schema:DefinedTerm
142 N7298acabd2cf4a5ab41e4db239a88200 rdf:first sg:person.01151433574.57
143 rdf:rest N5104323bdbc34539a8772a41976ffe5d
144 N750d861f35f5439f9af54316f54a481d schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N7efa1b2d89054b2c912fe30088390232 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name MicroRNAs
148 rdf:type schema:DefinedTerm
149 N8fbfd493d58a482c8428d912e0e530d6 schema:name dimensions_id
150 schema:value pub.1084132037
151 rdf:type schema:PropertyValue
152 N991604f6e1fd474ba46ad3bbcacb1fd0 schema:name doi
153 schema:value 10.1038/srep44137
154 rdf:type schema:PropertyValue
155 Na984856bdb274756a596c0551e08a49d rdf:first sg:person.01066064567.10
156 rdf:rest Nf0b328f7a46e440c9d89d702cfe567f3
157 Nd3948fa6e9514a218f3ab89e7b838a4d rdf:first sg:person.01167343675.80
158 rdf:rest Nd87192b4483d4ed78a1b07e90367bf03
159 Nd87192b4483d4ed78a1b07e90367bf03 rdf:first sg:person.01214562542.69
160 rdf:rest N0e5acc860a4d4e8dbc20c055583f2f56
161 Ndd869ea1c5c946608ad01fbb52948e99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Endothelial Progenitor Cells
163 rdf:type schema:DefinedTerm
164 Ne22f691a2b58423eba1e8d01ee4e7943 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Cell Proliferation
166 rdf:type schema:DefinedTerm
167 Nf0b328f7a46e440c9d89d702cfe567f3 rdf:first sg:person.0725263637.80
168 rdf:rest Nd3948fa6e9514a218f3ab89e7b838a4d
169 Nf7efe569bb4246599e32898b854bee63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name HMGB1 Protein
171 rdf:type schema:DefinedTerm
172 Nfd22d84071854b948480e52325f7b5e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Down-Regulation
174 rdf:type schema:DefinedTerm
175 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
176 schema:name Biological Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
179 schema:name Biochemistry and Cell Biology
180 rdf:type schema:DefinedTerm
181 sg:grant.2762393 http://pending.schema.org/fundedItem sg:pub.10.1038/srep44137
182 rdf:type schema:MonetaryGrant
183 sg:grant.5140087 http://pending.schema.org/fundedItem sg:pub.10.1038/srep44137
184 rdf:type schema:MonetaryGrant
185 sg:grant.5145717 http://pending.schema.org/fundedItem sg:pub.10.1038/srep44137
186 rdf:type schema:MonetaryGrant
187 sg:grant.5147615 http://pending.schema.org/fundedItem sg:pub.10.1038/srep44137
188 rdf:type schema:MonetaryGrant
189 sg:journal.1045337 schema:issn 2045-2322
190 schema:name Scientific Reports
191 rdf:type schema:Periodical
192 sg:person.01016574523.27 schema:affiliation https://www.grid.ac/institutes/grid.436365.1
193 schema:familyName Watt
194 schema:givenName Suzanne M
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016574523.27
196 rdf:type schema:Person
197 sg:person.01066064567.10 schema:affiliation https://www.grid.ac/institutes/grid.417975.9
198 schema:familyName Roubelakis
199 schema:givenName Maria G
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066064567.10
201 rdf:type schema:Person
202 sg:person.01151433574.57 schema:affiliation N4f0c1920c3834fc097dad95adb5fbbfd
203 schema:familyName Harris
204 schema:givenName Adrian L
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151433574.57
206 rdf:type schema:Person
207 sg:person.01167343675.80 schema:affiliation https://www.grid.ac/institutes/grid.436365.1
208 schema:familyName Tsaknakis
209 schema:givenName Grigorios
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167343675.80
211 rdf:type schema:Person
212 sg:person.01214562542.69 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
213 schema:familyName Konietzny
214 schema:givenName Rebecca
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214562542.69
216 rdf:type schema:Person
217 sg:person.01303572275.46 schema:affiliation https://www.grid.ac/institutes/grid.436365.1
218 schema:familyName Khoo
219 schema:givenName Cheen P
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303572275.46
221 rdf:type schema:Person
222 sg:person.0704460202.65 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
223 schema:familyName Kessler
224 schema:givenName Benedikt
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704460202.65
226 rdf:type schema:Person
227 sg:person.0725263637.80 schema:affiliation https://www.grid.ac/institutes/grid.5685.e
228 schema:familyName Schrader
229 schema:givenName Jack B
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725263637.80
231 rdf:type schema:Person
232 sg:pub.10.1007/s10456-011-9222-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046627823
233 https://doi.org/10.1007/s10456-011-9222-4
234 rdf:type schema:CreativeWork
235 sg:pub.10.1007/s10456-013-9354-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004729491
236 https://doi.org/10.1007/s10456-013-9354-9
237 rdf:type schema:CreativeWork
238 sg:pub.10.1007/s10585-013-9571-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1024638969
239 https://doi.org/10.1007/s10585-013-9571-z
240 rdf:type schema:CreativeWork
241 sg:pub.10.1007/s12015-010-9157-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1051834735
242 https://doi.org/10.1007/s12015-010-9157-y
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/ncb3330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048342056
245 https://doi.org/10.1038/ncb3330
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/onc.2012.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025711537
248 https://doi.org/10.1038/onc.2012.49
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/pr.2011.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043162694
251 https://doi.org/10.1038/pr.2011.22
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/sj.jid.5701212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052688556
254 https://doi.org/10.1038/sj.jid.5701212
255 rdf:type schema:CreativeWork
256 sg:pub.10.1186/2045-824x-5-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018941636
257 https://doi.org/10.1186/2045-824x-5-2
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/hep.25753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041888550
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/jcp.24423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040947637
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/jcp.25276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035559205
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/stem.1578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017619622
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/stem.1938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007949161
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/stem.1973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011322304
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/stem.2262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035766739
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.actbio.2011.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032296289
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.bbrc.2010.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031044500
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.bbrc.2010.12.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036045496
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.burns.2011.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038629723
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.cca.2015.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027049054
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.cell.2009.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023682432
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.clinthera.2016.02.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035897550
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.jss.2011.06.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009896040
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.jvs.2011.07.072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029435451
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.neuroscience.2015.03.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012439304
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s0002-9440(10)62344-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015982577
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s1535-6108(03)00281-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051719075
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.1405388111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017403261
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1074/jbc.m114.621409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031730374
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1080/2162402x.2015.1122860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021981950
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1083/jcb.152.6.1197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048308228
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1083/jcb.200304135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004385174
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1084/jem.20111739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008594231
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1089/neu.2013.2996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059301816
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1089/scd.2008.0071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059309843
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1089/scd.2014.0005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059310968
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1089/ten.tec.2011.0037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005199251
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1089/ten.tec.2011.0150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059317482
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1093/bmb/ldt031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041408896
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1093/nar/30.1.207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005297170
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1101/cshperspect.a006692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050032290
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1111/j.1365-2141.2012.09050.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010433018
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1128/jvi.00511-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036736969
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1152/ajplung.00244.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041567464
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1159/000232971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018017214
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1159/000345070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031555215
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1161/01.atv.0000126373.52450.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044541674
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1161/01.res.0000257774.55970.f4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052927261
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1161/atvbaha.111.224048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044303667
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1161/atvbaha.111.239822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006593702
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1161/circresaha.108.178590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034965096
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1161/circresaha.114.304747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029448719
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1161/circulationaha.114.009124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045778476
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1172/jci42980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021681653
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1177/1534734616649485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021549123
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1182/blood-2004-04-1396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027487069
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1182/blood-2004-08-3057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030833198
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1182/blood-2009-05-219378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011463236
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1182/blood-2010-01-264812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012159630
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1189/jlb.0113004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030152947
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1189/jlb.1012511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018958520
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1371/journal.pone.0054747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009424687
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1371/journal.pone.0096155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020287568
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1371/journal.pone.0151420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012443618
370 rdf:type schema:CreativeWork
371 https://doi.org/10.18632/oncotarget.4346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022111489
372 rdf:type schema:CreativeWork
373 https://doi.org/10.2217/17460751.3.6.863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012292292
374 rdf:type schema:CreativeWork
375 https://doi.org/10.3892/ijo.2013.1896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019359115
376 rdf:type schema:CreativeWork
377 https://doi.org/10.3892/ol.2012.1091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036038559
378 rdf:type schema:CreativeWork
379 https://doi.org/10.3892/or.2013.2883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071532806
380 rdf:type schema:CreativeWork
381 https://doi.org/10.4049/jimmunol.176.1.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077164332
382 rdf:type schema:CreativeWork
383 https://doi.org/10.4103/2045-8932.93547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072245889
384 rdf:type schema:CreativeWork
385 https://doi.org/10.5966/sctm.2013-0092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073577425
386 rdf:type schema:CreativeWork
387 https://doi.org/10.5966/sctm.2014-0162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073577528
388 rdf:type schema:CreativeWork
389 https://doi.org/10.5966/sctm.2015-0096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073577625
390 rdf:type schema:CreativeWork
391 https://www.grid.ac/institutes/grid.417975.9 schema:alternateName Biomedical Research Foundation of the Academy of Athens
392 schema:name Cell and Gene Therapy Laboratory, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, 11527, Greece.
393 Laboratory of Biology, National and Kapodistrian University of Athens Medical School, Athens 115 27, Greece.
394 Stem Cell Research, NHS Blood and Transplant, Oxford, OX3 9BQ, UK.
395 Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9BQ, UK.
396 rdf:type schema:Organization
397 https://www.grid.ac/institutes/grid.436365.1 schema:alternateName NHS Blood and Transplant
398 schema:name Institute of Molecular Biology and Biotechnology, Foundation of Research &Technology, GR-70013 Heraklion, Crete.
399 Stem Cell Research, NHS Blood and Transplant, Oxford, OX3 9BQ, UK.
400 Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9BQ, UK.
401 rdf:type schema:Organization
402 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
403 schema:name Target Discovery Institute, NDM Research Building, Nuffield Department of Medicine, University of Oxford, OX3 7FZ, UK.
404 rdf:type schema:Organization
405 https://www.grid.ac/institutes/grid.5685.e schema:alternateName University of York
406 schema:name Department of Biology, University of York, York, YO10 5DD, UK.
407 Stem Cell Research, NHS Blood and Transplant, Oxford, OX3 9BQ, UK.
408 Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9BQ, UK.
409 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...