Effects of multiple genetic loci on the pathogenesis from serum urate to gout View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-02

AUTHORS

Zheng Dong, Jingru Zhou, Shuai Jiang, Yuan Li, Dongbao Zhao, Chengde Yang, Yanyun Ma, Yi Wang, Hongjun He, Hengdong Ji, Yajun Yang, Xiaofeng Wang, Xia Xu, Yafei Pang, Hejian Zou, Li Jin, Jiucun Wang

ABSTRACT

Gout is a common arthritis resulting from increased serum urate, and many loci have been identified that are associated with serum urate and gout. However, their influence on the progression from elevated serum urate levels to gout is unclear. This study aims to explore systematically the effects of genetic variants on the pathogenesis in approximately 5,000 Chinese individuals. Six genes (PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A) were determined to be associated with serum urate (PFDR < 0.05) in the Chinese population for the first time. ABCG2 and a novel gene, SLC17A4, contributed to the development of gout from hyperuricemia (OR = 1.56, PFDR = 3.68E-09; OR = 1.27, PFDR = 0.013, respectively). Also, HNF4G is a novel gene associated with susceptibility to gout (OR = 1.28, PFDR = 1.08E-03). In addition, A1CF and TRIM46 were identified as associated with gout in the Chinese population for the first time (PFDR < 0.05). The present study systematically determined genetic effects on the progression from elevated serum urate to gout and suggests that urate-associated genes functioning as urate transporters may play a specific role in the pathogenesis of gout. Furthermore, two novel gout-associated genes (HNF4G and SLC17A4) were identified. More... »

PAGES

43614

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep43614

DOI

http://dx.doi.org/10.1038/srep43614

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084131531

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28252667


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357 grid-institutes:grid.8547.e schema:alternateName Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China
358 State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University Jiangwan Campus, Shanghai, China
359 schema:name Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China
360 Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu Province, China
361 Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China
362 State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University Jiangwan Campus, Shanghai, China
363 rdf:type schema:Organization
 




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