Catch and Release: rare cell analysis from a functionalised medical wire View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Shukun Chen, Amin El-Heliebi, Gerlinde Tauber, Tanja Langsenlehner, Michaela Pötscher, Karl Kashofer, Zbigniew T Czyż, Bernhard Polzer, Sabine Riethdorf, Andra Kuske, Gerd Leitinger, Klaus Pantel, Thomas Kroneis, Peter Sedlmayr

ABSTRACT

Enumeration and especially molecular characterization of circulating tumour cells (CTCs) holds great promise for cancer management. We tested a modified type of an in vivo enrichment device (Catch&Release) for its ability to bind and detach cancer cells for the purpose of single-cell molecular downstream analysis in vitro. The evaluation showed that single-cell analysis using array comparative genome hybridization (array-CGH) and next generation sequencing (NGS) is feasible. We found array-CGH to be less noisy when whole genome amplification (WGA) was performed with Ampli1 as compared to GenomePlex (DLRS values 0.65 vs. 1.39). Moreover, Ampli1-processed cells allowed detection of smaller aberrations (median 14.0 vs. 49.9 Mb). Single-cell NGS data obtained from Ampli1-processed samples showed the expected non-synonymous mutations (deletion/SNP) according to bulk DNA. We conclude that clinical application of this refined in vivo enrichment device allows CTC enumeration and characterization, thus, representing a promising tool for personalized medicine. More... »

PAGES

43424

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep43424

DOI

http://dx.doi.org/10.1038/srep43424

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083863180

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28233867


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Separation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comparative Genomic Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cell Adhesion Molecule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Equipment Design", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "High-Throughput Nucleotide Sequencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Cells, Circulating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precision Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Single-Cell Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Shukun", 
        "id": "sg:person.01156337303.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156337303.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "El-Heliebi", 
        "givenName": "Amin", 
        "id": "sg:person.0677437314.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677437314.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Department of Therapeutic Radiology and Oncology, Medical University of Graz, Graz, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tauber", 
        "givenName": "Gerlinde", 
        "id": "sg:person.011213201757.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011213201757.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Department of Therapeutic Radiology and Oncology, Medical University of Graz, Graz, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Langsenlehner", 
        "givenName": "Tanja", 
        "id": "sg:person.01045707260.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045707260.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Department of Therapeutic Radiology and Oncology, Medical University of Graz, Graz, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "P\u00f6tscher", 
        "givenName": "Michaela", 
        "id": "sg:person.012606142757.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012606142757.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Institute of Pathology, Medical University of Graz, Graz, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kashofer", 
        "givenName": "Karl", 
        "id": "sg:person.0611223507.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611223507.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Regensburg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Czy\u017c", 
        "givenName": "Zbigniew T", 
        "id": "sg:person.01221203200.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221203200.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Regensburg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Polzer", 
        "givenName": "Bernhard", 
        "id": "sg:person.0774367300.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774367300.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Hamburg-Eppendorf", 
          "id": "https://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riethdorf", 
        "givenName": "Sabine", 
        "id": "sg:person.0737522203.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737522203.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Hamburg-Eppendorf", 
          "id": "https://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuske", 
        "givenName": "Andra", 
        "id": "sg:person.07744252561.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07744252561.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leitinger", 
        "givenName": "Gerd", 
        "id": "sg:person.01040447261.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040447261.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Hamburg-Eppendorf", 
          "id": "https://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pantel", 
        "givenName": "Klaus", 
        "id": "sg:person.01112361603.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112361603.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Gothenburg", 
          "id": "https://www.grid.ac/institutes/grid.8761.8", 
          "name": [
            "Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.", 
            "Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kroneis", 
        "givenName": "Thomas", 
        "id": "sg:person.0673564343.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673564343.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Graz", 
          "id": "https://www.grid.ac/institutes/grid.11598.34", 
          "name": [
            "Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sedlmayr", 
        "givenName": "Peter", 
        "id": "sg:person.01277005030.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277005030.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2005.08.140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002368597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(08)70340-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002719726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.55.3487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002782768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)09838-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005895738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1315815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006544800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0085907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007928473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000445112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008964838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-2821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009907076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-11-214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014551470", 
          "https://doi.org/10.1186/1479-5876-11-214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1320659110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018649983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019307928", 
          "https://doi.org/10.1038/nbt.1754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c3lc50644d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019414771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkq603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020792304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12307-014-0164-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021361613", 
          "https://doi.org/10.1007/s12307-014-0164-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmoldx.2014.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021506422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2012.1557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022356564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-12-4140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024514458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0067031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030405206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033699583", 
          "https://doi.org/10.1038/nrc1670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033699583", 
          "https://doi.org/10.1038/nrc1670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci41824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034485694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0800668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034531394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/erc-16-0201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034705566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4939-2990-0_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038507695", 
          "https://doi.org/10.1007/978-1-4939-2990-0_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4939-2990-0_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043085010", 
          "https://doi.org/10.1007/978-1-4939-2990-0_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0087663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043695054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/fly.19695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046734556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.22480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046967404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1373/clinchem.2013.216010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048272430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049332317", 
          "https://doi.org/10.1038/sj.bjc.6602889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049332317", 
          "https://doi.org/10.1038/sj.bjc.6602889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygcen.2013.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051359147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.26111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053143828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-15-1416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063225026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.11646/zootaxa.3641.4.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063373104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074521016", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Enumeration and especially molecular characterization of circulating tumour cells (CTCs) holds great promise for cancer management. We tested a modified type of an in vivo enrichment device (Catch&Release) for its ability to bind and detach cancer cells for the purpose of single-cell molecular downstream analysis in vitro. The evaluation showed that single-cell analysis using array comparative genome hybridization (array-CGH) and next generation sequencing (NGS) is feasible. We found array-CGH to be less noisy when whole genome amplification (WGA) was performed with Ampli1 as compared to GenomePlex (DLRS values 0.65 vs. 1.39). Moreover, Ampli1-processed cells allowed detection of smaller aberrations (median 14.0 vs. 49.9\u2009Mb). Single-cell NGS data obtained from Ampli1-processed samples showed the expected non-synonymous mutations (deletion/SNP) according to bulk DNA. We conclude that clinical application of this refined in vivo enrichment device allows CTC enumeration and characterization, thus, representing a promising tool for personalized medicine.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep43424", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6208606", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Catch and Release: rare cell analysis from a functionalised medical wire", 
    "pagination": "43424", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e0dfb697723c19323694c556efb331df357a9aa1a1e17e5a69c4697012935dfc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28233867"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep43424"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1083863180"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep43424", 
      "https://app.dimensions.ai/details/publication/pub.1083863180"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000575.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2017/170224/srep43424/full/srep43424.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep43424'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep43424'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep43424'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep43424'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      77 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep43424 schema:about N34c8e10d2d5b4cb881def7e944e892c1
2 N34e359ea7fa8413ea0ce95f96a4a3d57
3 N43152f422b46438c806a6295f3a245d2
4 N440038ea312b45c2b00de2be661c7c4c
5 N49aae5f0e81b4ff593fea09f26cd81a5
6 N52298f5b12a348e3acb71cb10149f493
7 N95affd5e5dd9456f9c9416959f173803
8 N9a8f9de93a43414d872915e6e7c3c70f
9 Nacca0746472544c1a5a725b7058c46bb
10 Naf4408747d9c44fa9181706608d4bec5
11 Nc20585ffebdb45b3baf9e4f8bc1d228e
12 Nc4abfa5818bc4e12afaa5c0a049327a0
13 Ncadb2baa91f8408e819167403d3699b4
14 Nddc21ab093c247378e92b651aea7506e
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author N19c61f8a1b984b278e252c750da2176f
18 schema:citation sg:pub.10.1007/978-1-4939-2990-0_16
19 sg:pub.10.1007/978-1-4939-2990-0_9
20 sg:pub.10.1007/s12307-014-0164-4
21 sg:pub.10.1038/nbt.1754
22 sg:pub.10.1038/nrc1670
23 sg:pub.10.1038/sj.bjc.6602889
24 sg:pub.10.1186/1479-5876-11-214
25 https://app.dimensions.ai/details/publication/pub.1074521016
26 https://doi.org/10.1002/ijc.26111
27 https://doi.org/10.1002/pros.22480
28 https://doi.org/10.1016/j.jmoldx.2014.06.001
29 https://doi.org/10.1016/j.ygcen.2013.01.007
30 https://doi.org/10.1016/s0140-6736(02)09838-0
31 https://doi.org/10.1016/s1470-2045(08)70340-1
32 https://doi.org/10.1039/c3lc50644d
33 https://doi.org/10.1056/nejmoa0800668
34 https://doi.org/10.1056/nejmoa1315815
35 https://doi.org/10.1073/pnas.1320659110
36 https://doi.org/10.1093/nar/gkq603
37 https://doi.org/10.1158/0008-5472.can-12-4140
38 https://doi.org/10.1158/1078-0432.ccr-05-2821
39 https://doi.org/10.1158/1078-0432.ccr-15-1416
40 https://doi.org/10.1159/000445112
41 https://doi.org/10.11646/zootaxa.3641.4.14
42 https://doi.org/10.1172/jci41824
43 https://doi.org/10.1200/jco.2005.08.140
44 https://doi.org/10.1200/jco.2014.55.3487
45 https://doi.org/10.1371/journal.pone.0067031
46 https://doi.org/10.1371/journal.pone.0085907
47 https://doi.org/10.1371/journal.pone.0087663
48 https://doi.org/10.1373/clinchem.2013.216010
49 https://doi.org/10.1530/erc-16-0201
50 https://doi.org/10.3892/ijo.2012.1557
51 https://doi.org/10.4161/fly.19695
52 schema:datePublished 2017-12
53 schema:datePublishedReg 2017-12-01
54 schema:description Enumeration and especially molecular characterization of circulating tumour cells (CTCs) holds great promise for cancer management. We tested a modified type of an in vivo enrichment device (Catch&Release) for its ability to bind and detach cancer cells for the purpose of single-cell molecular downstream analysis in vitro. The evaluation showed that single-cell analysis using array comparative genome hybridization (array-CGH) and next generation sequencing (NGS) is feasible. We found array-CGH to be less noisy when whole genome amplification (WGA) was performed with Ampli1 as compared to GenomePlex (DLRS values 0.65 vs. 1.39). Moreover, Ampli1-processed cells allowed detection of smaller aberrations (median 14.0 vs. 49.9 Mb). Single-cell NGS data obtained from Ampli1-processed samples showed the expected non-synonymous mutations (deletion/SNP) according to bulk DNA. We conclude that clinical application of this refined in vivo enrichment device allows CTC enumeration and characterization, thus, representing a promising tool for personalized medicine.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N1044bac94b4b43bcbb26dc64f5754288
59 N4553f807a496434597023f15221cbfbd
60 sg:journal.1045337
61 schema:name Catch and Release: rare cell analysis from a functionalised medical wire
62 schema:pagination 43424
63 schema:productId N0caf68f1f5e3468d94e23a45f472fc84
64 N1b1bc6d5b19d4b26a7d6b5ac472e8ea8
65 N7dc3ed1467ea4c9a8ec2106b8bd298d5
66 Nc75bc9c13cc94235a4d54d9b8bbac11b
67 Ne28e62c016ab48eea2b371d3c5b33a58
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083863180
69 https://doi.org/10.1038/srep43424
70 schema:sdDatePublished 2019-04-10T23:35
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Nc0a08246559446d1976845abd67c2a70
73 schema:url http://www.nature.com/srep/2017/170224/srep43424/full/srep43424.html
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N00a1ec9c6f424152b80ffa74c1d7a806 rdf:first sg:person.0774367300.52
78 rdf:rest N11227fd9d719405783a7d97f03efd2b4
79 N0caf68f1f5e3468d94e23a45f472fc84 schema:name nlm_unique_id
80 schema:value 101563288
81 rdf:type schema:PropertyValue
82 N1044bac94b4b43bcbb26dc64f5754288 schema:volumeNumber 7
83 rdf:type schema:PublicationVolume
84 N11227fd9d719405783a7d97f03efd2b4 rdf:first sg:person.0737522203.00
85 rdf:rest N714a73cbc5324ec7893d631101170773
86 N19c61f8a1b984b278e252c750da2176f rdf:first sg:person.01156337303.55
87 rdf:rest Nbfc96e1353fd42cfb65ac239ba284674
88 N1b1bc6d5b19d4b26a7d6b5ac472e8ea8 schema:name pubmed_id
89 schema:value 28233867
90 rdf:type schema:PropertyValue
91 N1bc3b55569a64a75a866011a28ebbd35 rdf:first sg:person.0673564343.43
92 rdf:rest N5d6a907aab3648b0ad4c81cd29fa44ca
93 N1d09718d68c14e779916327a0c1bf8d0 rdf:first sg:person.01221203200.46
94 rdf:rest N00a1ec9c6f424152b80ffa74c1d7a806
95 N34c8e10d2d5b4cb881def7e944e892c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Epithelial Cell Adhesion Molecule
97 rdf:type schema:DefinedTerm
98 N34e359ea7fa8413ea0ce95f96a4a3d57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Cell Adhesion
100 rdf:type schema:DefinedTerm
101 N43152f422b46438c806a6295f3a245d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 N440038ea312b45c2b00de2be661c7c4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Cell Count
106 rdf:type schema:DefinedTerm
107 N4553f807a496434597023f15221cbfbd schema:issueNumber 1
108 rdf:type schema:PublicationIssue
109 N49aae5f0e81b4ff593fea09f26cd81a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Neoplastic Cells, Circulating
111 rdf:type schema:DefinedTerm
112 N52298f5b12a348e3acb71cb10149f493 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Precision Medicine
114 rdf:type schema:DefinedTerm
115 N5d6a907aab3648b0ad4c81cd29fa44ca rdf:first sg:person.01277005030.51
116 rdf:rest rdf:nil
117 N6c22a5dfd2d340059c6f3ee39c93e5c6 rdf:first sg:person.01112361603.18
118 rdf:rest N1bc3b55569a64a75a866011a28ebbd35
119 N714a73cbc5324ec7893d631101170773 rdf:first sg:person.07744252561.74
120 rdf:rest Ne166ddf7877749238a44ffae37ca3337
121 N7ab81e3ef27a4215b30a95e1288e3b62 rdf:first sg:person.011213201757.23
122 rdf:rest Nbbeeae641d974ac49ce7d21ebb247532
123 N7dc3ed1467ea4c9a8ec2106b8bd298d5 schema:name dimensions_id
124 schema:value pub.1083863180
125 rdf:type schema:PropertyValue
126 N95affd5e5dd9456f9c9416959f173803 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Cell Separation
128 rdf:type schema:DefinedTerm
129 N9a8f9de93a43414d872915e6e7c3c70f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Comparative Genomic Hybridization
131 rdf:type schema:DefinedTerm
132 N9fe78113868e4faebd1e775a589fbc27 rdf:first sg:person.0611223507.11
133 rdf:rest N1d09718d68c14e779916327a0c1bf8d0
134 Nac6fe7dc184644e1a3a423c93f7daa53 schema:name Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Regensburg, Germany.
135 rdf:type schema:Organization
136 Nacca0746472544c1a5a725b7058c46bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Gene Expression
138 rdf:type schema:DefinedTerm
139 Naf4408747d9c44fa9181706608d4bec5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Neoplasms
141 rdf:type schema:DefinedTerm
142 Nbbeeae641d974ac49ce7d21ebb247532 rdf:first sg:person.01045707260.92
143 rdf:rest Nf1c2b53174c24c97af3f4e688fe47848
144 Nbfc96e1353fd42cfb65ac239ba284674 rdf:first sg:person.0677437314.30
145 rdf:rest N7ab81e3ef27a4215b30a95e1288e3b62
146 Nc0a08246559446d1976845abd67c2a70 schema:name Springer Nature - SN SciGraph project
147 rdf:type schema:Organization
148 Nc20585ffebdb45b3baf9e4f8bc1d228e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Antibodies
150 rdf:type schema:DefinedTerm
151 Nc4abfa5818bc4e12afaa5c0a049327a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name High-Throughput Nucleotide Sequencing
153 rdf:type schema:DefinedTerm
154 Nc75bc9c13cc94235a4d54d9b8bbac11b schema:name doi
155 schema:value 10.1038/srep43424
156 rdf:type schema:PropertyValue
157 Ncadb2baa91f8408e819167403d3699b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Equipment Design
159 rdf:type schema:DefinedTerm
160 Nddc21ab093c247378e92b651aea7506e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Single-Cell Analysis
162 rdf:type schema:DefinedTerm
163 Ne166ddf7877749238a44ffae37ca3337 rdf:first sg:person.01040447261.98
164 rdf:rest N6c22a5dfd2d340059c6f3ee39c93e5c6
165 Ne28e62c016ab48eea2b371d3c5b33a58 schema:name readcube_id
166 schema:value e0dfb697723c19323694c556efb331df357a9aa1a1e17e5a69c4697012935dfc
167 rdf:type schema:PropertyValue
168 Nf1c2b53174c24c97af3f4e688fe47848 rdf:first sg:person.012606142757.64
169 rdf:rest N9fe78113868e4faebd1e775a589fbc27
170 Nfb7feea33fc6453caa5dd97a503a82ba schema:name Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Regensburg, Germany.
171 rdf:type schema:Organization
172 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
173 schema:name Biological Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
176 schema:name Biochemistry and Cell Biology
177 rdf:type schema:DefinedTerm
178 sg:grant.6208606 http://pending.schema.org/fundedItem sg:pub.10.1038/srep43424
179 rdf:type schema:MonetaryGrant
180 sg:journal.1045337 schema:issn 2045-2322
181 schema:name Scientific Reports
182 rdf:type schema:Periodical
183 sg:person.01040447261.98 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
184 schema:familyName Leitinger
185 schema:givenName Gerd
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040447261.98
187 rdf:type schema:Person
188 sg:person.01045707260.92 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
189 schema:familyName Langsenlehner
190 schema:givenName Tanja
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045707260.92
192 rdf:type schema:Person
193 sg:person.01112361603.18 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
194 schema:familyName Pantel
195 schema:givenName Klaus
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112361603.18
197 rdf:type schema:Person
198 sg:person.011213201757.23 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
199 schema:familyName Tauber
200 schema:givenName Gerlinde
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011213201757.23
202 rdf:type schema:Person
203 sg:person.01156337303.55 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
204 schema:familyName Chen
205 schema:givenName Shukun
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156337303.55
207 rdf:type schema:Person
208 sg:person.01221203200.46 schema:affiliation Nac6fe7dc184644e1a3a423c93f7daa53
209 schema:familyName Czyż
210 schema:givenName Zbigniew T
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221203200.46
212 rdf:type schema:Person
213 sg:person.012606142757.64 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
214 schema:familyName Pötscher
215 schema:givenName Michaela
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012606142757.64
217 rdf:type schema:Person
218 sg:person.01277005030.51 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
219 schema:familyName Sedlmayr
220 schema:givenName Peter
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277005030.51
222 rdf:type schema:Person
223 sg:person.0611223507.11 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
224 schema:familyName Kashofer
225 schema:givenName Karl
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611223507.11
227 rdf:type schema:Person
228 sg:person.0673564343.43 schema:affiliation https://www.grid.ac/institutes/grid.8761.8
229 schema:familyName Kroneis
230 schema:givenName Thomas
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673564343.43
232 rdf:type schema:Person
233 sg:person.0677437314.30 schema:affiliation https://www.grid.ac/institutes/grid.11598.34
234 schema:familyName El-Heliebi
235 schema:givenName Amin
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677437314.30
237 rdf:type schema:Person
238 sg:person.0737522203.00 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
239 schema:familyName Riethdorf
240 schema:givenName Sabine
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737522203.00
242 rdf:type schema:Person
243 sg:person.0774367300.52 schema:affiliation Nfb7feea33fc6453caa5dd97a503a82ba
244 schema:familyName Polzer
245 schema:givenName Bernhard
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774367300.52
247 rdf:type schema:Person
248 sg:person.07744252561.74 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
249 schema:familyName Kuske
250 schema:givenName Andra
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07744252561.74
252 rdf:type schema:Person
253 sg:pub.10.1007/978-1-4939-2990-0_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038507695
254 https://doi.org/10.1007/978-1-4939-2990-0_16
255 rdf:type schema:CreativeWork
256 sg:pub.10.1007/978-1-4939-2990-0_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043085010
257 https://doi.org/10.1007/978-1-4939-2990-0_9
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s12307-014-0164-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021361613
260 https://doi.org/10.1007/s12307-014-0164-4
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nbt.1754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019307928
263 https://doi.org/10.1038/nbt.1754
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nrc1670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033699583
266 https://doi.org/10.1038/nrc1670
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/sj.bjc.6602889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049332317
269 https://doi.org/10.1038/sj.bjc.6602889
270 rdf:type schema:CreativeWork
271 sg:pub.10.1186/1479-5876-11-214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014551470
272 https://doi.org/10.1186/1479-5876-11-214
273 rdf:type schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1074521016 schema:CreativeWork
275 https://doi.org/10.1002/ijc.26111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053143828
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/pros.22480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046967404
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.jmoldx.2014.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021506422
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.ygcen.2013.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051359147
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0140-6736(02)09838-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005895738
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s1470-2045(08)70340-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002719726
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1039/c3lc50644d schema:sameAs https://app.dimensions.ai/details/publication/pub.1019414771
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1056/nejmoa0800668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034531394
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1056/nejmoa1315815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006544800
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1073/pnas.1320659110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018649983
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1093/nar/gkq603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020792304
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1158/0008-5472.can-12-4140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024514458
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1158/1078-0432.ccr-05-2821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009907076
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1158/1078-0432.ccr-15-1416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063225026
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1159/000445112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008964838
304 rdf:type schema:CreativeWork
305 https://doi.org/10.11646/zootaxa.3641.4.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063373104
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1172/jci41824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034485694
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1200/jco.2005.08.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002368597
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1200/jco.2014.55.3487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002782768
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1371/journal.pone.0067031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030405206
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1371/journal.pone.0085907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007928473
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1371/journal.pone.0087663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043695054
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1373/clinchem.2013.216010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048272430
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1530/erc-16-0201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034705566
322 rdf:type schema:CreativeWork
323 https://doi.org/10.3892/ijo.2012.1557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022356564
324 rdf:type schema:CreativeWork
325 https://doi.org/10.4161/fly.19695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046734556
326 rdf:type schema:CreativeWork
327 https://www.grid.ac/institutes/grid.11598.34 schema:alternateName Medical University of Graz
328 schema:name Department of Therapeutic Radiology and Oncology, Medical University of Graz, Graz, Austria.
329 Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.
330 Institute of Pathology, Medical University of Graz, Graz, Austria.
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.13648.38 schema:alternateName University Medical Center Hamburg-Eppendorf
333 schema:name Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.8761.8 schema:alternateName University of Gothenburg
336 schema:name Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.
337 Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden.
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...