A Comprehensive Analysis of Metabolomics and Transcriptomics in Cervical Cancer View Full Text


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Article Info

DATE

2017-02-22

AUTHORS

Kai Yang, Bairong Xia, Wenjie Wang, Jinlong Cheng, Mingzhu Yin, Hongyu Xie, Junnan Li, Libing Ma, Chunyan Yang, Ang Li, Xin Fan, Harman S. Dhillon, Yan Hou, Ge Lou, Kang Li

ABSTRACT

Cervical cancer (CC) still remains a common and deadly malignancy among females in developing countries. More accurate and reliable diagnostic methods/biomarkers should be discovered. In this study, we performed a comprehensive analysis of metabolomics (285 samples) and transcriptomics (52 samples) on the potential diagnostic implication and metabolic characteristic description in cervical cancer. Sixty-two metabolites were different between CC and normal controls (NOR), in which 5 metabolites (bilirubin, LysoPC(17:0), n-oleoyl threonine, 12-hydroxydodecanoic acid and tetracosahexaenoic acid) were selected as candidate biomarkers for CC. The AUC value, sensitivity (SE), and specificity (SP) of these 5 biomarkers were 0.99, 0.98 and 0.99, respectively. We further analysed the genes in 7 significantly enriched pathways, of which 117 genes, that were expressed differentially, were mainly involved in catalytic activity. Finally, a fully connected network of metabolites and genes in these pathways was built, which can increase the credibility of our selected metabolites. In conclusion, our biomarkers from metabolomics could set a path for CC diagnosis and screening. Our results also showed that variables of both transcriptomics and metabolomics were associated with CC. More... »

PAGES

43353

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    http://scigraph.springernature.com/pub.10.1038/srep43353

    DOI

    http://dx.doi.org/10.1038/srep43353

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083855872

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28225065


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    324 Key Laboratory of Cardiovascular Medicine Research, Harbin Medical University, Ministry of Education, 150086, Harbin, P.R. China
    325 schema:name Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, 150086, Harbin, P.R. China
    326 Department of Gynecology Oncology, the Tumor Hospital, Harbin Medical University, 150086, Harbin, P.R. China
    327 Harbin Medical University, 150086, Harbin, P.R. China
    328 Key Laboratory of Cardiovascular Medicine Research, Harbin Medical University, Ministry of Education, 150086, Harbin, P.R. China
    329 rdf:type schema:Organization
    330 grid-institutes:grid.412068.9 schema:alternateName School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 150040, Harbin, Heilongjiang, P.R. China
    331 schema:name School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 150040, Harbin, Heilongjiang, P.R. China
    332 rdf:type schema:Organization
     




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