NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Masayuki Nakano, Yasuhisa Tamura, Masanori Yamato, Satoshi Kume, Asami Eguchi, Kumi Takata, Yasuyoshi Watanabe, Yosky Kataoka

ABSTRACT

NG2-expressing neural progenitor cells (i.e., NG2 glial cells) maintain their proliferative and migratory activities even in the adult mammalian central nervous system (CNS) and produce myelinating oligodendrocytes and astrocytes. Although NG2 glial cells have been observed in close proximity to neuronal cell bodies in order to receive synaptic inputs, substantive non-proliferative roles of NG2 glial cells in the adult CNS remain unclear. In the present study, we generated NG2-HSVtk transgenic rats and selectively ablated NG2 glial cells in the adult CNS. Ablation of NG2 glial cells produced defects in hippocampal neurons due to excessive neuroinflammation via activation of the interleukin-1 beta (IL-1β) pro-inflammatory pathway, resulting in hippocampal atrophy. Furthermore, we revealed that the loss of NG2 glial cell-derived hepatocyte growth factor (HGF) exacerbated these abnormalities. Our findings suggest that NG2 glial cells maintain neuronal function and survival via the control of neuroimmunological function. More... »

PAGES

42041

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep42041

    DOI

    http://dx.doi.org/10.1038/srep42041

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083820366

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28195192


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