Epigenetic origin of evolutionary novel centromeres View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-02-03

AUTHORS

Doron Tolomeo, Oronzo Capozzi, Roscoe R. Stanyon, Nicoletta Archidiacono, Pietro D’Addabbo, Claudia R. Catacchio, Stefania Purgato, Giovanni Perini, Werner Schempp, John Huddleston, Maika Malig, Evan E. Eichler, Mariano Rocchi

ABSTRACT

Most evolutionary new centromeres (ENC) are composed of large arrays of satellite DNA and surrounded by segmental duplications. However, the hypothesis is that ENCs are seeded in an anonymous sequence and only over time have acquired the complexity of "normal" centromeres. Up to now evidence to test this hypothesis was lacking. We recently discovered that the well-known polymorphism of orangutan chromosome 12 was due to the presence of an ENC. We sequenced the genome of an orangutan homozygous for the ENC, and we focused our analysis on the comparison of the ENC domain with respect to its wild type counterpart. No significant variations were found. This finding is the first clear evidence that ENC seedings are epigenetic in nature. The compaction of the ENC domain was found significantly higher than the corresponding WT region and, interestingly, the expression of the only gene embedded in the region was significantly repressed. More... »

PAGES

41980

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep41980

DOI

http://dx.doi.org/10.1038/srep41980

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083524764

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28155877


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