Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Jing-wen Lin, Jan Sodenkamp, Deirdre Cunningham, Katrien Deroost, Tshibuayi Christine Tshitenge, Sarah McLaughlin, Tracey J. Lamb, Bradley Spencer-Dene, Caroline Hosking, Jai Ramesar, Chris J. Janse, Christine Graham, Anne O’Garra, Jean Langhorne

ABSTRACT

The influence of parasite genetic factors on immune responses and development of severe pathology of malaria is largely unknown. In this study, we performed genome-wide transcriptomic profiling of mouse whole blood during blood-stage infections of two strains of the rodent malaria parasite Plasmodium chabaudi that differ in virulence. We identified several transcriptomic signatures associated with the virulent infection, including signatures for platelet aggregation, stronger and prolonged anemia and lung inflammation. The first two signatures were detected prior to pathology. The anemia signature indicated deregulation of host erythropoiesis, and the lung inflammation signature was linked to increased neutrophil infiltration, more cell death and greater parasite sequestration in the lungs. This comparative whole-blood transcriptomics profiling of virulent and avirulent malaria shows the validity of this approach to inform severity of the infection and provide insight into pathogenic mechanisms. More... »

PAGES

41722

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep41722

DOI

http://dx.doi.org/10.1038/srep41722

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083524774

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28155887


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep41722'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep41722'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep41722'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep41722'


 

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