Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice View Full Text


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Article Info

DATE

2017-01-27

AUTHORS

D. Gagnon, S. Petryszyn, M. G. Sanchez, C. Bories, J. M. Beaulieu, Y. De Koninck, A. Parent, M. Parent

ABSTRACT

The loss of nigrostriatal dopamine neurons in Parkinson's disease induces a reduction in the number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D1 or D2 dopamine receptor. Consequences on MSNs expressing both receptors (D1/D2 MSNs) are currently unknown. We looked for changes induced by dopamine denervation in the density, regional distribution and morphological features of D1/D2 MSNs, by comparing 6-OHDA-lesioned double BAC transgenic mice (Drd1a-tdTomato/Drd2-EGFP) to sham-lesioned animals. D1/D2 MSNs are uniformly distributed throughout the dorsal striatum (1.9% of MSNs). In contrast, they are heterogeneously distributed and more numerous in the ventral striatum (14.6% in the shell and 7.3% in the core). Compared to D1 and D2 MSNs, D1/D2 MSNs are endowed with a smaller cell body and a less profusely arborized dendritic tree with less dendritic spines. The dendritic spine density of D1/D2 MSNs, but also of D1 and D2 MSNs, is significantly reduced in 6-OHDA-lesioned mice. In contrast to D1 and D2 MSNs, the extent of dendritic arborization of D1/D2 MSNs appears unaltered in 6-OHDA-lesioned mice. Our data indicate that D1/D2 MSNs in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation that characterizes Parkinson's disease. More... »

PAGES

41432

References to SciGraph publications

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  • 2006-01-15. Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models in NATURE NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep41432

    DOI

    http://dx.doi.org/10.1038/srep41432

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1074226012

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28128287


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    33 schema:description The loss of nigrostriatal dopamine neurons in Parkinson's disease induces a reduction in the number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D<sub>1</sub> or D<sub>2</sub> dopamine receptor. Consequences on MSNs expressing both receptors (D<sub>1</sub>/D<sub>2</sub> MSNs) are currently unknown. We looked for changes induced by dopamine denervation in the density, regional distribution and morphological features of D<sub>1</sub>/D<sub>2</sub> MSNs, by comparing 6-OHDA-lesioned double BAC transgenic mice (Drd1a-tdTomato/Drd2-EGFP) to sham-lesioned animals. D<sub>1</sub>/D<sub>2</sub> MSNs are uniformly distributed throughout the dorsal striatum (1.9% of MSNs). In contrast, they are heterogeneously distributed and more numerous in the ventral striatum (14.6% in the shell and 7.3% in the core). Compared to D<sub>1</sub> and D<sub>2</sub> MSNs, D<sub>1</sub>/D<sub>2</sub> MSNs are endowed with a smaller cell body and a less profusely arborized dendritic tree with less dendritic spines. The dendritic spine density of D<sub>1</sub>/D<sub>2</sub> MSNs, but also of D<sub>1</sub> and D<sub>2</sub> MSNs, is significantly reduced in 6-OHDA-lesioned mice. In contrast to D<sub>1</sub> and D<sub>2</sub> MSNs, the extent of dendritic arborization of D<sub>1</sub>/D<sub>2</sub> MSNs appears unaltered in 6-OHDA-lesioned mice. Our data indicate that D<sub>1</sub>/D<sub>2</sub> MSNs in the mouse striatum form a distinct neuronal population that is affected differently by dopamine deafferentation that characterizes Parkinson's disease.
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