The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Carolina Q. Sacramento, Gabrielle R. de Melo, Caroline S. de Freitas, Natasha Rocha, Lucas Villas Bôas Hoelz, Milene Miranda, Natalia Fintelman-Rodrigues, Andressa Marttorelli, André C. Ferreira, Giselle Barbosa-Lima, Juliana L. Abrantes, Yasmine Rangel Vieira, Mônica M. Bastos, Eduardo de Mello Volotão, Estevão Portela Nunes, Diogo A. Tschoeke, Luciana Leomil, Erick Correia Loiola, Pablo Trindade, Stevens K. Rehen, Fernando A. Bozza, Patrícia T. Bozza, Nubia Boechat, Fabiano L. Thompson, Ana M. B. de Filippis, Karin Brüning, Thiago Moreno L. Souza

ABSTRACT

Zika virus (ZIKV) is a member of the Flaviviridae family, along with other agents of clinical significance such as dengue (DENV) and hepatitis C (HCV) viruses. Since ZIKV causes neurological disorders during fetal development and in adulthood, antiviral drugs are necessary. Sofosbuvir is clinically approved for use against HCV and targets the protein that is most conserved among the members of the Flaviviridae family, the viral RNA polymerase. Indeed, we found that sofosbuvir inhibits ZIKV RNA polymerase, targeting conserved amino acid residues. Sofosbuvir inhibited ZIKV replication in different cellular systems, such as hepatoma (Huh-7) cells, neuroblastoma (SH-Sy5y) cells, neural stem cells (NSC) and brain organoids. In addition to the direct inhibition of the viral RNA polymerase, we observed that sofosbuvir also induced an increase in A-to-G mutations in the viral genome. Together, our data highlight a potential secondary use of sofosbuvir, an anti-HCV drug, against ZIKV. More... »

PAGES

40920

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep40920

DOI

http://dx.doi.org/10.1038/srep40920

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019807892

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28098253


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Directed RNA Polymerases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sofosbuvir", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Replication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zika Virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zika Virus Infection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sacramento", 
        "givenName": "Carolina Q.", 
        "id": "sg:person.01071733610.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071733610.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Melo", 
        "givenName": "Gabrielle R.", 
        "id": "sg:person.01047203351.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047203351.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Freitas", 
        "givenName": "Caroline S.", 
        "id": "sg:person.01001070151.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001070151.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rocha", 
        "givenName": "Natasha", 
        "id": "sg:person.011365155563.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011365155563.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Instituto de Tecnologia de F\u00e1rmacos (Farmanguinhos), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoelz", 
        "givenName": "Lucas Villas B\u00f4as", 
        "id": "sg:person.0652774363.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652774363.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Laborat\u00f3rio de V\u00edrus Respirat\u00f3rio e do Sarampo, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miranda", 
        "givenName": "Milene", 
        "id": "sg:person.01066750476.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066750476.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fintelman-Rodrigues", 
        "givenName": "Natalia", 
        "id": "sg:person.0610016545.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610016545.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marttorelli", 
        "givenName": "Andressa", 
        "id": "sg:person.0755505210.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755505210.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferreira", 
        "givenName": "Andr\u00e9 C.", 
        "id": "sg:person.013234052175.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013234052175.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barbosa-Lima", 
        "givenName": "Giselle", 
        "id": "sg:person.01153444206.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153444206.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abrantes", 
        "givenName": "Juliana L.", 
        "id": "sg:person.01241421440.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241421440.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vieira", 
        "givenName": "Yasmine Rangel", 
        "id": "sg:person.0647234454.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647234454.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Instituto de Tecnologia de F\u00e1rmacos (Farmanguinhos), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bastos", 
        "givenName": "M\u00f4nica M.", 
        "id": "sg:person.01026435223.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026435223.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Virologia Comparada e Ambiental, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Mello Volot\u00e3o", 
        "givenName": "Eduardo", 
        "id": "sg:person.01075271340.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075271340.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nunes", 
        "givenName": "Estev\u00e3o Portela", 
        "id": "sg:person.0770471240.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770471240.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil", 
            "SAGE \u2013COPPE, UFRJ, Rio de Janeiro, RJ, Brazil", 
            "N\u00facleo em Ecologia e Desenvolvimento S\u00f3cio-Ambiental de Maca\u00e9 (NUPEM), Universidade Federal do Rio de Janeiro, Maca\u00e9, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tschoeke", 
        "givenName": "Diogo A.", 
        "id": "sg:person.01020631046.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020631046.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil", 
            "SAGE \u2013COPPE, UFRJ, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leomil", 
        "givenName": "Luciana", 
        "id": "sg:person.01175527360.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175527360.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u2019Or Institute for Research and Education", 
          "id": "https://www.grid.ac/institutes/grid.472984.4", 
          "name": [
            "D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loiola", 
        "givenName": "Erick Correia", 
        "id": "sg:person.01044622061.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044622061.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u2019Or Institute for Research and Education", 
          "id": "https://www.grid.ac/institutes/grid.472984.4", 
          "name": [
            "D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trindade", 
        "givenName": "Pablo", 
        "id": "sg:person.01242220637.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242220637.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u2019Or Institute for Research and Education", 
          "id": "https://www.grid.ac/institutes/grid.472984.4", 
          "name": [
            "Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil", 
            "D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rehen", 
        "givenName": "Stevens K.", 
        "id": "sg:person.0620075062.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620075062.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bozza", 
        "givenName": "Fernando A.", 
        "id": "sg:person.0623022020.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623022020.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bozza", 
        "givenName": "Patr\u00edcia T.", 
        "id": "sg:person.01372154212.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372154212.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Instituto de Tecnologia de F\u00e1rmacos (Farmanguinhos), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boechat", 
        "givenName": "Nubia", 
        "id": "sg:person.01371707333.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371707333.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil", 
            "SAGE \u2013COPPE, UFRJ, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Fabiano L.", 
        "id": "sg:person.0774170606.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774170606.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Flaviv\u00edrus, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Filippis", 
        "givenName": "Ana M. B.", 
        "id": "sg:person.0603040431.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603040431.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "BMK Consortium: Blanver Farmoqu\u00edmica Ltda; Microbiol\u00f3gica Qu\u00edmica e Farmac\u00eauticaLtda; Karin Bruning & Cia, Ltda, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Br\u00fcning", 
        "givenName": "Karin", 
        "id": "sg:person.011333743177.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011333743177.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Laborat\u00f3rio de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil", 
            "Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil", 
            "National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Souza", 
        "givenName": "Thiago Moreno L.", 
        "id": "sg:person.015674204142.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015674204142.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/jvi.01531-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000409028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.00072-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003001724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889892009944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003451988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0976-500x.142464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003550919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0035-9203(52)90042-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005056513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaf6116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005431451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0132384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007039549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2016.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007795911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmsr1604338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007998032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.08.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008328486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btt593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010435278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1514978112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010793153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1259210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011175506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(97)77022-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012539276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.antiviral.2005.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013728936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1003549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014828304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016285310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmv.24678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017468925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btr026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018328066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid2102.141363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021969853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/061671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022496200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/061671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022496200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/061671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022496200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/051268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023628023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/051268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023628023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/051268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023628023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025717041", 
          "https://doi.org/10.1038/nm.4184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jiw226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028780031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1601824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028791187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(16)00564-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030395368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1993.1626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030443070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(16)00125-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030724898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ogx.0000483239.08585.8d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031065528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ogx.0000483239.08585.8d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031065528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-6-255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032032619", 
          "https://doi.org/10.1186/1471-2105-6-255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(16)00562-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034482872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0004695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037081464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.antiviral.2007.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038425234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.105.020057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039019655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12033-008-9127-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039252648", 
          "https://doi.org/10.1007/s12033-008-9127-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/med.21274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039910832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1602412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039969284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(16)00095-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039984193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-05-504449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041084339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep22635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041282883", 
          "https://doi.org/10.1038/srep22635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/med.21281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042336904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaf5036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043016870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0017288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043584914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid2207.160375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043624854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m607273200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045673518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.9.9.868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046849268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/viro.1996.0067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047787456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1440-1746.2000.02114.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056739579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/cmb.2013.0084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059246193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/dna.2013.2193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059252916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/0929867321666131228205935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069163508"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Zika virus (ZIKV) is a member of the Flaviviridae family, along with other agents of clinical significance such as dengue (DENV) and hepatitis C (HCV) viruses. Since ZIKV causes neurological disorders during fetal development and in adulthood, antiviral drugs are necessary. Sofosbuvir is clinically approved for use against HCV and targets the protein that is most conserved among the members of the Flaviviridae family, the viral RNA polymerase. Indeed, we found that sofosbuvir inhibits ZIKV RNA polymerase, targeting conserved amino acid residues. Sofosbuvir inhibited ZIKV replication in different cellular systems, such as hepatoma (Huh-7) cells, neuroblastoma (SH-Sy5y) cells, neural stem cells (NSC) and brain organoids. In addition to the direct inhibition of the viral RNA polymerase, we observed that sofosbuvir also induced an increase in A-to-G mutations in the viral genome. Together, our data highlight a potential secondary use of sofosbuvir, an anti-HCV drug, against ZIKV.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep40920", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication", 
    "pagination": "40920", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5e6015abf57d3728ae69e7d070a5d4e534a08177a092d6ad3d4d3fa4708dafc6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28098253"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep40920"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019807892"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep40920", 
      "https://app.dimensions.ai/details/publication/pub.1019807892"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000559.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/srep40920"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep40920'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep40920'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep40920'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep40920'


 

This table displays all metadata directly associated to this object as RDF triples.

475 TRIPLES      21 PREDICATES      92 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep40920 schema:about N110b726104e640be8ac06fa26536cc96
2 N350dfce61cd84ba78862ef89462a9de2
3 N3c08407ffc5443dbaf44e4669d0ffd69
4 N5278dc61ec8b41269e1086a8f92b25f5
5 N5387376c869b46bba56169479fdc02d3
6 N5c35c247f9044b75acec10e0cb8479b0
7 N7a942931d3a5448a927411f496c87e41
8 N88289584b5e845f99264df240faf47f4
9 N98f6aeee408944af8084f14fea58fbf0
10 Naac9d0c3f098432c8e13dddecc12b64c
11 Nbf7077aa47ac429f86c1105d85cf01b0
12 Nda452dc606c4474089b6826aa7641a16
13 anzsrc-for:11
14 anzsrc-for:1108
15 schema:author N60bcc53f38314273b31f6c2d8274f682
16 schema:citation sg:pub.10.1007/s12033-008-9127-7
17 sg:pub.10.1038/nm.4184
18 sg:pub.10.1038/srep22635
19 sg:pub.10.1186/1471-2105-6-255
20 https://doi.org/10.1002/jmv.24678
21 https://doi.org/10.1002/med.21274
22 https://doi.org/10.1002/med.21281
23 https://doi.org/10.1006/jmbi.1993.1626
24 https://doi.org/10.1006/viro.1996.0067
25 https://doi.org/10.1016/0035-9203(52)90042-4
26 https://doi.org/10.1016/j.antiviral.2005.04.002
27 https://doi.org/10.1016/j.antiviral.2007.08.011
28 https://doi.org/10.1016/j.celrep.2016.08.038
29 https://doi.org/10.1016/j.chom.2016.07.004
30 https://doi.org/10.1016/s0076-6879(97)77022-8
31 https://doi.org/10.1016/s0140-6736(16)00562-6
32 https://doi.org/10.1016/s0140-6736(16)00564-x
33 https://doi.org/10.1016/s1473-3099(16)00095-5
34 https://doi.org/10.1016/s1473-3099(16)00125-0
35 https://doi.org/10.1046/j.1440-1746.2000.02114.x
36 https://doi.org/10.1056/nejmoa1601824
37 https://doi.org/10.1056/nejmoa1602412
38 https://doi.org/10.1056/nejmsr1604338
39 https://doi.org/10.1073/pnas.1514978112
40 https://doi.org/10.1074/jbc.m607273200
41 https://doi.org/10.1089/cmb.2013.0084
42 https://doi.org/10.1089/dna.2013.2193
43 https://doi.org/10.1093/bioinformatics/btr026
44 https://doi.org/10.1093/bioinformatics/btt593
45 https://doi.org/10.1093/infdis/jiw226
46 https://doi.org/10.1093/nar/gkg563
47 https://doi.org/10.1097/01.ogx.0000483239.08585.8d
48 https://doi.org/10.1101/051268
49 https://doi.org/10.1101/061671
50 https://doi.org/10.1101/gr.9.9.868
51 https://doi.org/10.1107/s0021889892009944
52 https://doi.org/10.1124/mol.105.020057
53 https://doi.org/10.1126/science.1259210
54 https://doi.org/10.1126/science.aaf5036
55 https://doi.org/10.1126/science.aaf6116
56 https://doi.org/10.1128/cmr.00072-15
57 https://doi.org/10.1128/jvi.01531-10
58 https://doi.org/10.1182/blood-2013-05-504449
59 https://doi.org/10.1371/journal.pntd.0004695
60 https://doi.org/10.1371/journal.pone.0017288
61 https://doi.org/10.1371/journal.pone.0132384
62 https://doi.org/10.1371/journal.ppat.1003549
63 https://doi.org/10.2174/0929867321666131228205935
64 https://doi.org/10.3201/eid2102.141363
65 https://doi.org/10.3201/eid2207.160375
66 https://doi.org/10.4103/0976-500x.142464
67 schema:datePublished 2017-12
68 schema:datePublishedReg 2017-12-01
69 schema:description Zika virus (ZIKV) is a member of the Flaviviridae family, along with other agents of clinical significance such as dengue (DENV) and hepatitis C (HCV) viruses. Since ZIKV causes neurological disorders during fetal development and in adulthood, antiviral drugs are necessary. Sofosbuvir is clinically approved for use against HCV and targets the protein that is most conserved among the members of the Flaviviridae family, the viral RNA polymerase. Indeed, we found that sofosbuvir inhibits ZIKV RNA polymerase, targeting conserved amino acid residues. Sofosbuvir inhibited ZIKV replication in different cellular systems, such as hepatoma (Huh-7) cells, neuroblastoma (SH-Sy5y) cells, neural stem cells (NSC) and brain organoids. In addition to the direct inhibition of the viral RNA polymerase, we observed that sofosbuvir also induced an increase in A-to-G mutations in the viral genome. Together, our data highlight a potential secondary use of sofosbuvir, an anti-HCV drug, against ZIKV.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree true
73 schema:isPartOf N79f30bbced404aa19a867a89899dc8df
74 Na93e1526a0994d74a27162494af43043
75 sg:journal.1045337
76 schema:name The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
77 schema:pagination 40920
78 schema:productId N0ce923eb1a394575a39c854eaac9a526
79 N1996ba79bf614bc0bbfd137e02962751
80 N2c61203d18574208965bc5459e88a522
81 N94eedc5038f74ff4887174fb606573fe
82 Nf48fc73b8e9e4850bec29844dd039dc5
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019807892
84 https://doi.org/10.1038/srep40920
85 schema:sdDatePublished 2019-04-10T13:26
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher Nc59743a67c79460aa29cebfbd80377ea
88 schema:url http://www.nature.com/articles/srep40920
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N05cee09751fc45c289e1ba0ead9c62e6 rdf:first sg:person.0647234454.44
93 rdf:rest N405f206925dd4bc3a45d0147c105bdf4
94 N0cafa6dded984b849f01262c11a57e84 rdf:first sg:person.01020631046.13
95 rdf:rest N95073dc7b4164115abce59d2bf5e1725
96 N0ce923eb1a394575a39c854eaac9a526 schema:name readcube_id
97 schema:value 5e6015abf57d3728ae69e7d070a5d4e534a08177a092d6ad3d4d3fa4708dafc6
98 rdf:type schema:PropertyValue
99 N10794a8e8a29491f9e652e54776d902f rdf:first sg:person.01242220637.68
100 rdf:rest Nfd843f049dd84d8a918d5f88797f05a2
101 N110b726104e640be8ac06fa26536cc96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cell Survival
103 rdf:type schema:DefinedTerm
104 N122ac7d3a78a477ca0a474c8d350c3ed rdf:first sg:person.011333743177.08
105 rdf:rest N16201f5b8ee24c7d86a5b56e10be7b3c
106 N16201f5b8ee24c7d86a5b56e10be7b3c rdf:first sg:person.015674204142.23
107 rdf:rest rdf:nil
108 N1996ba79bf614bc0bbfd137e02962751 schema:name pubmed_id
109 schema:value 28098253
110 rdf:type schema:PropertyValue
111 N2841578befb7474f924040d5d79fbad4 schema:name BMK Consortium: Blanver Farmoquímica Ltda; Microbiológica Química e FarmacêuticaLtda; Karin Bruning & Cia, Ltda, Brazil
112 rdf:type schema:Organization
113 N2c61203d18574208965bc5459e88a522 schema:name dimensions_id
114 schema:value pub.1019807892
115 rdf:type schema:PropertyValue
116 N350dfce61cd84ba78862ef89462a9de2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Cell Line
118 rdf:type schema:DefinedTerm
119 N3c08407ffc5443dbaf44e4669d0ffd69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Zika Virus Infection
121 rdf:type schema:DefinedTerm
122 N405f206925dd4bc3a45d0147c105bdf4 rdf:first sg:person.01026435223.72
123 rdf:rest N9128752b2fa2491aa68475b4ece9a7b0
124 N489d85e4b2fd46b58c839c39b47d8a85 rdf:first sg:person.011365155563.59
125 rdf:rest N635bac0ab0904bb2ba7e017e8bf654db
126 N4e459869f8e54b77abb5808a1e0506a7 rdf:first sg:person.01047203351.91
127 rdf:rest N661484ae899749718e8084a8c8c14794
128 N5278dc61ec8b41269e1086a8f92b25f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Mutation
130 rdf:type schema:DefinedTerm
131 N5387376c869b46bba56169479fdc02d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name DNA-Directed RNA Polymerases
133 rdf:type schema:DefinedTerm
134 N5768574e5a2c4892b3c42582b80ff202 rdf:first sg:person.01044622061.24
135 rdf:rest N10794a8e8a29491f9e652e54776d902f
136 N5c35c247f9044b75acec10e0cb8479b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Humans
138 rdf:type schema:DefinedTerm
139 N60bcc53f38314273b31f6c2d8274f682 rdf:first sg:person.01071733610.80
140 rdf:rest N4e459869f8e54b77abb5808a1e0506a7
141 N63501a95c98848509a99c8f3140b26e6 rdf:first sg:person.0774170606.28
142 rdf:rest Nbf60d1d0171d4eb088255fd19bdb3517
143 N635bac0ab0904bb2ba7e017e8bf654db rdf:first sg:person.0652774363.55
144 rdf:rest Nd3e9596bb9b546af9d06662c85273086
145 N661484ae899749718e8084a8c8c14794 rdf:first sg:person.01001070151.17
146 rdf:rest N489d85e4b2fd46b58c839c39b47d8a85
147 N79f30bbced404aa19a867a89899dc8df schema:issueNumber 1
148 rdf:type schema:PublicationIssue
149 N7a942931d3a5448a927411f496c87e41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Viral Proteins
151 rdf:type schema:DefinedTerm
152 N84af54987179482fbaaffc7acf6ff4e0 rdf:first sg:person.01153444206.15
153 rdf:rest Ncbd2ee4a232d435a9eb8564fb60ddf99
154 N881d54e502564c7ba833b2b1e1b666e5 rdf:first sg:person.013234052175.40
155 rdf:rest N84af54987179482fbaaffc7acf6ff4e0
156 N88289584b5e845f99264df240faf47f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Antiviral Agents
158 rdf:type schema:DefinedTerm
159 N9128752b2fa2491aa68475b4ece9a7b0 rdf:first sg:person.01075271340.21
160 rdf:rest N974e2d849ad24fc0ae297e1397998a71
161 N921b2079e701474cae72f1b870316bee rdf:first sg:person.0623022020.90
162 rdf:rest Nf7dacc8be08a4e5c8a2d50cd58e47a22
163 N92eda98612aa44dd9b8ad6e812591df2 rdf:first sg:person.0610016545.56
164 rdf:rest Nf32615ae562147819cbfd20b2f8a1991
165 N94eedc5038f74ff4887174fb606573fe schema:name nlm_unique_id
166 schema:value 101563288
167 rdf:type schema:PropertyValue
168 N95073dc7b4164115abce59d2bf5e1725 rdf:first sg:person.01175527360.88
169 rdf:rest N5768574e5a2c4892b3c42582b80ff202
170 N974e2d849ad24fc0ae297e1397998a71 rdf:first sg:person.0770471240.38
171 rdf:rest N0cafa6dded984b849f01262c11a57e84
172 N98f6aeee408944af8084f14fea58fbf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Zika Virus
174 rdf:type schema:DefinedTerm
175 Na93e1526a0994d74a27162494af43043 schema:volumeNumber 7
176 rdf:type schema:PublicationVolume
177 Naac9d0c3f098432c8e13dddecc12b64c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Sofosbuvir
179 rdf:type schema:DefinedTerm
180 Nbf60d1d0171d4eb088255fd19bdb3517 rdf:first sg:person.0603040431.86
181 rdf:rest N122ac7d3a78a477ca0a474c8d350c3ed
182 Nbf7077aa47ac429f86c1105d85cf01b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Genome, Viral
184 rdf:type schema:DefinedTerm
185 Nc59743a67c79460aa29cebfbd80377ea schema:name Springer Nature - SN SciGraph project
186 rdf:type schema:Organization
187 Ncba7ec1826d340fa93e94fb5c7643073 rdf:first sg:person.01371707333.20
188 rdf:rest N63501a95c98848509a99c8f3140b26e6
189 Ncbd2ee4a232d435a9eb8564fb60ddf99 rdf:first sg:person.01241421440.39
190 rdf:rest N05cee09751fc45c289e1ba0ead9c62e6
191 Nd3e9596bb9b546af9d06662c85273086 rdf:first sg:person.01066750476.01
192 rdf:rest N92eda98612aa44dd9b8ad6e812591df2
193 Nda452dc606c4474089b6826aa7641a16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Virus Replication
195 rdf:type schema:DefinedTerm
196 Nf32615ae562147819cbfd20b2f8a1991 rdf:first sg:person.0755505210.93
197 rdf:rest N881d54e502564c7ba833b2b1e1b666e5
198 Nf48fc73b8e9e4850bec29844dd039dc5 schema:name doi
199 schema:value 10.1038/srep40920
200 rdf:type schema:PropertyValue
201 Nf7dacc8be08a4e5c8a2d50cd58e47a22 rdf:first sg:person.01372154212.85
202 rdf:rest Ncba7ec1826d340fa93e94fb5c7643073
203 Nfd843f049dd84d8a918d5f88797f05a2 rdf:first sg:person.0620075062.38
204 rdf:rest N921b2079e701474cae72f1b870316bee
205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical and Health Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
209 schema:name Medical Microbiology
210 rdf:type schema:DefinedTerm
211 sg:journal.1045337 schema:issn 2045-2322
212 schema:name Scientific Reports
213 rdf:type schema:Periodical
214 sg:person.01001070151.17 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
215 schema:familyName de Freitas
216 schema:givenName Caroline S.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001070151.17
218 rdf:type schema:Person
219 sg:person.01020631046.13 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
220 schema:familyName Tschoeke
221 schema:givenName Diogo A.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020631046.13
223 rdf:type schema:Person
224 sg:person.01026435223.72 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
225 schema:familyName Bastos
226 schema:givenName Mônica M.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026435223.72
228 rdf:type schema:Person
229 sg:person.01044622061.24 schema:affiliation https://www.grid.ac/institutes/grid.472984.4
230 schema:familyName Loiola
231 schema:givenName Erick Correia
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044622061.24
233 rdf:type schema:Person
234 sg:person.01047203351.91 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
235 schema:familyName de Melo
236 schema:givenName Gabrielle R.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047203351.91
238 rdf:type schema:Person
239 sg:person.01066750476.01 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
240 schema:familyName Miranda
241 schema:givenName Milene
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066750476.01
243 rdf:type schema:Person
244 sg:person.01071733610.80 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
245 schema:familyName Sacramento
246 schema:givenName Carolina Q.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071733610.80
248 rdf:type schema:Person
249 sg:person.01075271340.21 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
250 schema:familyName de Mello Volotão
251 schema:givenName Eduardo
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075271340.21
253 rdf:type schema:Person
254 sg:person.011333743177.08 schema:affiliation N2841578befb7474f924040d5d79fbad4
255 schema:familyName Brüning
256 schema:givenName Karin
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011333743177.08
258 rdf:type schema:Person
259 sg:person.011365155563.59 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
260 schema:familyName Rocha
261 schema:givenName Natasha
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011365155563.59
263 rdf:type schema:Person
264 sg:person.01153444206.15 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
265 schema:familyName Barbosa-Lima
266 schema:givenName Giselle
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153444206.15
268 rdf:type schema:Person
269 sg:person.01175527360.88 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
270 schema:familyName Leomil
271 schema:givenName Luciana
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175527360.88
273 rdf:type schema:Person
274 sg:person.01241421440.39 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
275 schema:familyName Abrantes
276 schema:givenName Juliana L.
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241421440.39
278 rdf:type schema:Person
279 sg:person.01242220637.68 schema:affiliation https://www.grid.ac/institutes/grid.472984.4
280 schema:familyName Trindade
281 schema:givenName Pablo
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242220637.68
283 rdf:type schema:Person
284 sg:person.013234052175.40 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
285 schema:familyName Ferreira
286 schema:givenName André C.
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013234052175.40
288 rdf:type schema:Person
289 sg:person.01371707333.20 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
290 schema:familyName Boechat
291 schema:givenName Nubia
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371707333.20
293 rdf:type schema:Person
294 sg:person.01372154212.85 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
295 schema:familyName Bozza
296 schema:givenName Patrícia T.
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372154212.85
298 rdf:type schema:Person
299 sg:person.015674204142.23 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
300 schema:familyName Souza
301 schema:givenName Thiago Moreno L.
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015674204142.23
303 rdf:type schema:Person
304 sg:person.0603040431.86 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
305 schema:familyName de Filippis
306 schema:givenName Ana M. B.
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603040431.86
308 rdf:type schema:Person
309 sg:person.0610016545.56 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
310 schema:familyName Fintelman-Rodrigues
311 schema:givenName Natalia
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610016545.56
313 rdf:type schema:Person
314 sg:person.0620075062.38 schema:affiliation https://www.grid.ac/institutes/grid.472984.4
315 schema:familyName Rehen
316 schema:givenName Stevens K.
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620075062.38
318 rdf:type schema:Person
319 sg:person.0623022020.90 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
320 schema:familyName Bozza
321 schema:givenName Fernando A.
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623022020.90
323 rdf:type schema:Person
324 sg:person.0647234454.44 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
325 schema:familyName Vieira
326 schema:givenName Yasmine Rangel
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647234454.44
328 rdf:type schema:Person
329 sg:person.0652774363.55 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
330 schema:familyName Hoelz
331 schema:givenName Lucas Villas Bôas
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652774363.55
333 rdf:type schema:Person
334 sg:person.0755505210.93 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
335 schema:familyName Marttorelli
336 schema:givenName Andressa
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755505210.93
338 rdf:type schema:Person
339 sg:person.0770471240.38 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
340 schema:familyName Nunes
341 schema:givenName Estevão Portela
342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770471240.38
343 rdf:type schema:Person
344 sg:person.0774170606.28 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
345 schema:familyName Thompson
346 schema:givenName Fabiano L.
347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774170606.28
348 rdf:type schema:Person
349 sg:pub.10.1007/s12033-008-9127-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039252648
350 https://doi.org/10.1007/s12033-008-9127-7
351 rdf:type schema:CreativeWork
352 sg:pub.10.1038/nm.4184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025717041
353 https://doi.org/10.1038/nm.4184
354 rdf:type schema:CreativeWork
355 sg:pub.10.1038/srep22635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041282883
356 https://doi.org/10.1038/srep22635
357 rdf:type schema:CreativeWork
358 sg:pub.10.1186/1471-2105-6-255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032032619
359 https://doi.org/10.1186/1471-2105-6-255
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1002/jmv.24678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017468925
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1002/med.21274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039910832
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1002/med.21281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042336904
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1006/jmbi.1993.1626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030443070
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1006/viro.1996.0067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047787456
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1016/0035-9203(52)90042-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005056513
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1016/j.antiviral.2005.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013728936
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1016/j.antiviral.2007.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038425234
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1016/j.celrep.2016.08.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008328486
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1016/j.chom.2016.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007795911
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1016/s0076-6879(97)77022-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012539276
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1016/s0140-6736(16)00562-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034482872
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1016/s0140-6736(16)00564-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030395368
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1016/s1473-3099(16)00095-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039984193
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1016/s1473-3099(16)00125-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030724898
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1046/j.1440-1746.2000.02114.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056739579
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1056/nejmoa1601824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028791187
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1056/nejmoa1602412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039969284
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1056/nejmsr1604338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007998032
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1073/pnas.1514978112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010793153
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1074/jbc.m607273200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045673518
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1089/cmb.2013.0084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059246193
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1089/dna.2013.2193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059252916
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1093/bioinformatics/btr026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018328066
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1093/bioinformatics/btt593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010435278
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1093/infdis/jiw226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028780031
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1093/nar/gkg563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016285310
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1097/01.ogx.0000483239.08585.8d schema:sameAs https://app.dimensions.ai/details/publication/pub.1031065528
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1101/051268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023628023
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1101/061671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022496200
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1101/gr.9.9.868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046849268
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1107/s0021889892009944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003451988
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1124/mol.105.020057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039019655
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1126/science.1259210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011175506
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1126/science.aaf5036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043016870
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1126/science.aaf6116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005431451
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1128/cmr.00072-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003001724
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1128/jvi.01531-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000409028
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1182/blood-2013-05-504449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041084339
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1371/journal.pntd.0004695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037081464
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1371/journal.pone.0017288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043584914
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1371/journal.pone.0132384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007039549
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1371/journal.ppat.1003549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014828304
446 rdf:type schema:CreativeWork
447 https://doi.org/10.2174/0929867321666131228205935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069163508
448 rdf:type schema:CreativeWork
449 https://doi.org/10.3201/eid2102.141363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021969853
450 rdf:type schema:CreativeWork
451 https://doi.org/10.3201/eid2207.160375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043624854
452 rdf:type schema:CreativeWork
453 https://doi.org/10.4103/0976-500x.142464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003550919
454 rdf:type schema:CreativeWork
455 https://www.grid.ac/institutes/grid.418068.3 schema:alternateName Oswaldo Cruz Foundation
456 schema:name Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil
457 Instituto de Tecnologia de Fármacos (Farmanguinhos), Fiocruz, Rio de Janeiro, RJ, Brazil
458 Laboratório de Flavivírus, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil
459 Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil
460 Laboratório de Virologia Comparada e Ambiental, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil
461 National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil
462 rdf:type schema:Organization
463 https://www.grid.ac/institutes/grid.472984.4 schema:alternateName D’Or Institute for Research and Education
464 schema:name D’Or Institute for Research and Education (IDOR), Rio de Janeiro, RJ, Brazil
465 Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
466 rdf:type schema:Organization
467 https://www.grid.ac/institutes/grid.8536.8 schema:alternateName Federal University of Rio de Janeiro
468 schema:name Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil
469 Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
470 Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
471 Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil
472 Laboratório de Vírus Respiratório e do Sarampo, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil
473 Núcleo em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé (NUPEM), Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro, Brazil
474 SAGE –COPPE, UFRJ, Rio de Janeiro, RJ, Brazil
475 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...