Zika virus disrupts molecular fingerprinting of human neurospheres View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Patricia P. Garcez, Juliana Minardi Nascimento, Janaina Mota de Vasconcelos, Rodrigo Madeiro da Costa, Rodrigo Delvecchio, Pablo Trindade, Erick Correia Loiola, Luiza M. Higa, Juliana S. Cassoli, Gabriela Vitória, Patricia C. Sequeira, Jaroslaw Sochacki, Renato S. Aguiar, Hellen Thais Fuzii, Ana M. Bispo de Filippis, João Lídio da Silva Gonçalves Vianez Júnior, Amilcar Tanuri, Daniel Martins-de-Souza, Stevens K. Rehen

ABSTRACT

Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is circulating in Brazil. Combining proteomics and mRNA transcriptional profiling, over 500 proteins and genes associated with the Brazilian ZIKV infection were found to be differentially expressed. These genes and proteins provide an interactome map, which indicates that ZIKV controls the expression of RNA processing bodies, miRNA biogenesis and splicing factors required for self-replication. It also suggests that impairments in the molecular pathways underpinning cell cycle and neuronal differentiation are caused by ZIKV. These results point to biological mechanisms implicated in brain malformations, which are important to further the understanding of ZIKV infection and can be exploited as therapeutic potential targets to mitigate it. More... »

PAGES

40780

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep40780

DOI

http://dx.doi.org/10.1038/srep40780

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1074211841

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28112162


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Induced Pluripotent Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neural Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeny", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcriptome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zika Virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zika Virus Infection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil", 
            "Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garcez", 
        "givenName": "Patricia P.", 
        "id": "sg:person.0576661143.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576661143.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil", 
            "Institute of Biology, Department of Biochemistry and Tissue Biology, University of Campinas (UNICAMP), Campinas, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nascimento", 
        "givenName": "Juliana Minardi", 
        "id": "sg:person.01247626443.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247626443.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Evandro Chagas", 
          "id": "https://www.grid.ac/institutes/grid.419134.a", 
          "name": [
            "Center for Technological Innovation, Evandro Chagas Institute, Bel\u00e9m, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Vasconcelos", 
        "givenName": "Janaina Mota", 
        "id": "sg:person.01066615140.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066615140.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u2019Or Institute for Research and Education", 
          "id": "https://www.grid.ac/institutes/grid.472984.4", 
          "name": [
            "D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "da Costa", 
        "givenName": "Rodrigo Madeiro", 
        "id": "sg:person.0670202757.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670202757.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delvecchio", 
        "givenName": "Rodrigo", 
        "id": "sg:person.01247234671.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247234671.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u2019Or Institute for Research and Education", 
          "id": "https://www.grid.ac/institutes/grid.472984.4", 
          "name": [
            "D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trindade", 
        "givenName": "Pablo", 
        "id": "sg:person.01242220637.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242220637.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u2019Or Institute for Research and Education", 
          "id": "https://www.grid.ac/institutes/grid.472984.4", 
          "name": [
            "D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loiola", 
        "givenName": "Erick Correia", 
        "id": "sg:person.01044622061.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044622061.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Higa", 
        "givenName": "Luiza M.", 
        "id": "sg:person.01307573513.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307573513.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Institute of Biology, Department of Biochemistry and Tissue Biology, University of Campinas (UNICAMP), Campinas, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cassoli", 
        "givenName": "Juliana S.", 
        "id": "sg:person.01355703477.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355703477.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u2019Or Institute for Research and Education", 
          "id": "https://www.grid.ac/institutes/grid.472984.4", 
          "name": [
            "D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vit\u00f3ria", 
        "givenName": "Gabriela", 
        "id": "sg:person.016410332273.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016410332273.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Institute Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sequeira", 
        "givenName": "Patricia C.", 
        "id": "sg:person.01145205501.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145205501.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u2019Or Institute for Research and Education", 
          "id": "https://www.grid.ac/institutes/grid.472984.4", 
          "name": [
            "D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sochacki", 
        "givenName": "Jaroslaw", 
        "id": "sg:person.07507225655.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07507225655.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aguiar", 
        "givenName": "Renato S.", 
        "id": "sg:person.0631201700.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631201700.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Para", 
          "id": "https://www.grid.ac/institutes/grid.271300.7", 
          "name": [
            "Federal University of Par\u00e1, Bel\u00e9m, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fuzii", 
        "givenName": "Hellen Thais", 
        "id": "sg:person.0627435043.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627435043.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Institute Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Filippis", 
        "givenName": "Ana M. Bispo", 
        "id": "sg:person.0603040431.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603040431.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Evandro Chagas", 
          "id": "https://www.grid.ac/institutes/grid.419134.a", 
          "name": [
            "Center for Technological Innovation, Evandro Chagas Institute, Bel\u00e9m, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "da Silva Gon\u00e7alves Vianez J\u00fanior", 
        "givenName": "Jo\u00e3o L\u00eddio", 
        "id": "sg:person.010355602641.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010355602641.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanuri", 
        "givenName": "Amilcar", 
        "id": "sg:person.01116260232.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116260232.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Institute of Biology, Department of Biochemistry and Tissue Biology, University of Campinas (UNICAMP), Campinas, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martins-de-Souza", 
        "givenName": "Daniel", 
        "id": "sg:person.0624531734.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624531734.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "D\u2019Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil", 
            "Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rehen", 
        "givenName": "Stevens K.", 
        "id": "sg:person.0620075062.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620075062.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1600651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000811266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btu033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000848409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/mst197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001444669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/058883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003885087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/058883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003885087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/058883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003885087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.21132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004411241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2016.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004670226", 
          "https://doi.org/10.1038/cr.2016.58"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaf6116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005431451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(15)00504-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006533660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/18.3.502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007526298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007540814", 
          "https://doi.org/10.1038/nmeth.2109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2016.02.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010456757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2893.2003.00447.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011155948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1408.080287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013275468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro.2016.125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014137727", 
          "https://doi.org/10.1038/nrmicro.2016.125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2016.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015134661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00836-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015196925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0067437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015332691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2013-14-4-r36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015459845", 
          "https://doi.org/10.1186/gb-2013-14-4-r36"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.2016161584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015993077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00397-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016071312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkw765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016954976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02418-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017319783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1004199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017506047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0906413106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017988153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019617574", 
          "https://doi.org/10.1038/nature12517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024020914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2016.04.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025190922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1004319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025403782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2496(02)00028-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025441488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2496(02)00028-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025441488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2016.04.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025520011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025733953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.04.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027001647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/514681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027586828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2016.03.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027748093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tiv.2015.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028652091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/rna.8.6.17836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029004073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2012.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030124536", 
          "https://doi.org/10.1038/nprot.2012.016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031035095", 
          "https://doi.org/10.1038/nbt.1621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.smim.2007.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031437893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032318578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032502527", 
          "https://doi.org/10.1038/nmeth.2767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1305.070015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033376034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.a.20357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036783623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037623568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2012.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039192459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(16)00095-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039984193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2008.211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039987283", 
          "https://doi.org/10.1038/nprot.2008.211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2016.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040830162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/wdev.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041627660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.07-104455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042176121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042520331", 
          "https://doi.org/10.1038/nn.4280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/mst010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045545793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047610281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature18296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047862100", 
          "https://doi.org/10.1038/nature18296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2013.05.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049880022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3727/096368911x600957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051631185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3727/096368911x600957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051631185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00354-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052159487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2015.12.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052659726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5966/sctm.2013-0080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073577421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1201630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078681482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1558-5646.1985.tb00420.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085717760"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is circulating in Brazil. Combining proteomics and mRNA transcriptional profiling, over 500 proteins and genes associated with the Brazilian ZIKV infection were found to be differentially expressed. These genes and proteins provide an interactome map, which indicates that ZIKV controls the expression of RNA processing bodies, miRNA biogenesis and splicing factors required for self-replication. It also suggests that impairments in the molecular pathways underpinning cell cycle and neuronal differentiation are caused by ZIKV. These results point to biological mechanisms implicated in brain malformations, which are important to further the understanding of ZIKV infection and can be exploited as therapeutic potential targets to mitigate it.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep40780", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4481309", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4481542", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4478953", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5073107", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Zika virus disrupts molecular fingerprinting of human neurospheres", 
    "pagination": "40780", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cd760188d2d66ce907d40d70816a9340a5a12b386236cb2244fb1f0a77bfb741"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28112162"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep40780"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1074211841"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep40780", 
      "https://app.dimensions.ai/details/publication/pub.1074211841"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11691_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/srep40780"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep40780'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep40780'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep40780'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep40780'


 

This table displays all metadata directly associated to this object as RDF triples.

466 TRIPLES      21 PREDICATES      103 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep40780 schema:about N0372b9c12ed74fb2910c27c89ce6957e
2 N4540697a7a7f4cffa36f3107ebf6e224
3 N56f923dcb0634cbebb1e2ab4a32262e6
4 N776b6d0ff95e4ebfaf8b9ec55dd26ed6
5 N88c426fbc34b40838fa51ebfe623995b
6 N98d963c30c1648faa93f3c098d7fe67e
7 N9c78c929a29b4533bffcf0d9f282a193
8 Na92749c83a7c44cf8f224aa4f808a398
9 Nc73b63de84244298aaf389ffcc3d74a7
10 Ne4531ebced1b40fb95c84586558f1a07
11 Nf03d4d74ade7410c836d5b57e418e9a3
12 Nf6012bf9e46946728e53e7885b230de3
13 Nff50f0dc0d0541ff9464bb197e4931f9
14 anzsrc-for:06
15 anzsrc-for:0601
16 schema:author Nea66f49cd9f34fc38ea7ec46be370699
17 schema:citation sg:pub.10.1038/cr.2016.58
18 sg:pub.10.1038/nature12517
19 sg:pub.10.1038/nature18296
20 sg:pub.10.1038/nbt.1621
21 sg:pub.10.1038/nmeth.2109
22 sg:pub.10.1038/nmeth.2767
23 sg:pub.10.1038/nn.4280
24 sg:pub.10.1038/nprot.2008.211
25 sg:pub.10.1038/nprot.2012.016
26 sg:pub.10.1038/nrmicro.2016.125
27 sg:pub.10.1186/gb-2013-14-4-r36
28 https://doi.org/10.1002/cyto.a.20357
29 https://doi.org/10.1002/dvdy.21132
30 https://doi.org/10.1002/wdev.89
31 https://doi.org/10.1016/j.cell.2016.04.032
32 https://doi.org/10.1016/j.cmet.2012.08.004
33 https://doi.org/10.1016/j.febslet.2013.05.030
34 https://doi.org/10.1016/j.smim.2007.01.003
35 https://doi.org/10.1016/j.stem.2015.12.009
36 https://doi.org/10.1016/j.stem.2016.02.016
37 https://doi.org/10.1016/j.stem.2016.03.012
38 https://doi.org/10.1016/j.stem.2016.04.009
39 https://doi.org/10.1016/j.stem.2016.04.014
40 https://doi.org/10.1016/j.stem.2016.04.017
41 https://doi.org/10.1016/j.stem.2016.08.005
42 https://doi.org/10.1016/j.tiv.2015.05.008
43 https://doi.org/10.1016/s0022-2496(02)00028-7
44 https://doi.org/10.1016/s1473-3099(15)00504-6
45 https://doi.org/10.1016/s1473-3099(16)00095-5
46 https://doi.org/10.1046/j.1365-2893.2003.00447.x
47 https://doi.org/10.1056/nejmoa1600651
48 https://doi.org/10.1073/pnas.0906413106
49 https://doi.org/10.1093/bioinformatics/18.3.502
50 https://doi.org/10.1093/bioinformatics/bts199
51 https://doi.org/10.1093/bioinformatics/btu033
52 https://doi.org/10.1093/molbev/mst010
53 https://doi.org/10.1093/molbev/mst197
54 https://doi.org/10.1093/nar/gkn760
55 https://doi.org/10.1093/nar/gkn923
56 https://doi.org/10.1093/nar/gkp667
57 https://doi.org/10.1093/nar/gkt206
58 https://doi.org/10.1093/nar/gkw765
59 https://doi.org/10.1096/fj.07-104455
60 https://doi.org/10.1101/058883
61 https://doi.org/10.1111/j.1558-5646.1985.tb00420.x
62 https://doi.org/10.1126/science.aaf6116
63 https://doi.org/10.1128/jvi.00354-15
64 https://doi.org/10.1128/jvi.00397-10
65 https://doi.org/10.1128/jvi.00836-09
66 https://doi.org/10.1128/jvi.02418-10
67 https://doi.org/10.1148/radiol.2016161584
68 https://doi.org/10.1155/2011/514681
69 https://doi.org/10.1371/journal.pone.0067437
70 https://doi.org/10.1371/journal.ppat.1004199
71 https://doi.org/10.1371/journal.ppat.1004319
72 https://doi.org/10.3201/eid1305.070015
73 https://doi.org/10.3201/eid1408.080287
74 https://doi.org/10.3727/096368911x600957
75 https://doi.org/10.4049/jimmunol.1201630
76 https://doi.org/10.4161/rna.8.6.17836
77 https://doi.org/10.5966/sctm.2013-0080
78 schema:datePublished 2017-12
79 schema:datePublishedReg 2017-12-01
80 schema:description Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is circulating in Brazil. Combining proteomics and mRNA transcriptional profiling, over 500 proteins and genes associated with the Brazilian ZIKV infection were found to be differentially expressed. These genes and proteins provide an interactome map, which indicates that ZIKV controls the expression of RNA processing bodies, miRNA biogenesis and splicing factors required for self-replication. It also suggests that impairments in the molecular pathways underpinning cell cycle and neuronal differentiation are caused by ZIKV. These results point to biological mechanisms implicated in brain malformations, which are important to further the understanding of ZIKV infection and can be exploited as therapeutic potential targets to mitigate it.
81 schema:genre research_article
82 schema:inLanguage en
83 schema:isAccessibleForFree true
84 schema:isPartOf N3f7359f559914d57874e1c25405e7d99
85 Nb3f525f9229445069a806e82ff6859f1
86 sg:journal.1045337
87 schema:name Zika virus disrupts molecular fingerprinting of human neurospheres
88 schema:pagination 40780
89 schema:productId N0c60cbcd707643769f7207905f75ac6d
90 N258599479823478ba09984bea203308a
91 N8b26516a36f04566a1cf128902480edb
92 Nabc118d7d74f49e9ad44eed98537679a
93 Naf44dab9d2f54f9cb04d60e7f11c7ab3
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074211841
95 https://doi.org/10.1038/srep40780
96 schema:sdDatePublished 2019-04-11T11:16
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher Nd2027d00c974498e8e8aeb8ba4d58765
99 schema:url http://www.nature.com/articles/srep40780
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N0372b9c12ed74fb2910c27c89ce6957e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Induced Pluripotent Stem Cells
105 rdf:type schema:DefinedTerm
106 N08f3d526ef0145c4b54238f5ec4ae852 rdf:first sg:person.0603040431.86
107 rdf:rest N367a24128e6e4fb6bb587b63146bb19c
108 N0c60cbcd707643769f7207905f75ac6d schema:name pubmed_id
109 schema:value 28112162
110 rdf:type schema:PropertyValue
111 N11d692952d8f48dba3fa90accfd35e8a rdf:first sg:person.01066615140.72
112 rdf:rest N306661c188c94300a35d240b52712d2f
113 N14b42a6ea9234ae093dbfc7bd647cbe2 rdf:first sg:person.0631201700.34
114 rdf:rest Nc0df5f5bd07c4ed2962e8014cb415dd8
115 N1610efbd084149e586b08da1f4b16d80 rdf:first sg:person.01247234671.73
116 rdf:rest N89bd955787ac4c9aa3fbe6d5cb9be266
117 N258599479823478ba09984bea203308a schema:name doi
118 schema:value 10.1038/srep40780
119 rdf:type schema:PropertyValue
120 N306661c188c94300a35d240b52712d2f rdf:first sg:person.0670202757.81
121 rdf:rest N1610efbd084149e586b08da1f4b16d80
122 N312290486e2840c7a8d7ca5c70bff0bb rdf:first sg:person.01355703477.06
123 rdf:rest Nad345f7d9c124387809ae7c73627dece
124 N367a24128e6e4fb6bb587b63146bb19c rdf:first sg:person.010355602641.46
125 rdf:rest N9ff38481a53949ce8bcb21badd52f2bf
126 N3f7359f559914d57874e1c25405e7d99 schema:issueNumber 1
127 rdf:type schema:PublicationIssue
128 N4540697a7a7f4cffa36f3107ebf6e224 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Genomics
130 rdf:type schema:DefinedTerm
131 N48f529b0b5ed4766ab8742b328ca7026 rdf:first sg:person.0624531734.09
132 rdf:rest Nf604e74ab83d49ea84ca23948190d83e
133 N56f923dcb0634cbebb1e2ab4a32262e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Neural Stem Cells
135 rdf:type schema:DefinedTerm
136 N776b6d0ff95e4ebfaf8b9ec55dd26ed6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Immunohistochemistry
138 rdf:type schema:DefinedTerm
139 N7969a423577b433b8278bc43253f3a61 rdf:first sg:person.01044622061.24
140 rdf:rest Nfa9113b57e8942099ccafb8ff1520ad1
141 N83692c49d23147f58f63632c85c7fdd4 rdf:first sg:person.01145205501.00
142 rdf:rest Na4f5e4634d404824ac124f123a904f99
143 N88c426fbc34b40838fa51ebfe623995b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Zika Virus
145 rdf:type schema:DefinedTerm
146 N89bd955787ac4c9aa3fbe6d5cb9be266 rdf:first sg:person.01242220637.68
147 rdf:rest N7969a423577b433b8278bc43253f3a61
148 N8b26516a36f04566a1cf128902480edb schema:name dimensions_id
149 schema:value pub.1074211841
150 rdf:type schema:PropertyValue
151 N98d963c30c1648faa93f3c098d7fe67e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Zika Virus Infection
153 rdf:type schema:DefinedTerm
154 N9c78c929a29b4533bffcf0d9f282a193 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Biomarkers
156 rdf:type schema:DefinedTerm
157 N9ff38481a53949ce8bcb21badd52f2bf rdf:first sg:person.01116260232.38
158 rdf:rest N48f529b0b5ed4766ab8742b328ca7026
159 Na4f5e4634d404824ac124f123a904f99 rdf:first sg:person.07507225655.54
160 rdf:rest N14b42a6ea9234ae093dbfc7bd647cbe2
161 Na92749c83a7c44cf8f224aa4f808a398 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Humans
163 rdf:type schema:DefinedTerm
164 Nabc118d7d74f49e9ad44eed98537679a schema:name readcube_id
165 schema:value cd760188d2d66ce907d40d70816a9340a5a12b386236cb2244fb1f0a77bfb741
166 rdf:type schema:PropertyValue
167 Nad345f7d9c124387809ae7c73627dece rdf:first sg:person.016410332273.80
168 rdf:rest N83692c49d23147f58f63632c85c7fdd4
169 Naf44dab9d2f54f9cb04d60e7f11c7ab3 schema:name nlm_unique_id
170 schema:value 101563288
171 rdf:type schema:PropertyValue
172 Nb3f525f9229445069a806e82ff6859f1 schema:volumeNumber 7
173 rdf:type schema:PublicationVolume
174 Nc0df5f5bd07c4ed2962e8014cb415dd8 rdf:first sg:person.0627435043.53
175 rdf:rest N08f3d526ef0145c4b54238f5ec4ae852
176 Nc522cc2abb984c188b8ed330a712a0a6 rdf:first sg:person.01247626443.24
177 rdf:rest N11d692952d8f48dba3fa90accfd35e8a
178 Nc73b63de84244298aaf389ffcc3d74a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Transcriptome
180 rdf:type schema:DefinedTerm
181 Nd2027d00c974498e8e8aeb8ba4d58765 schema:name Springer Nature - SN SciGraph project
182 rdf:type schema:Organization
183 Ne4531ebced1b40fb95c84586558f1a07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Proteome
185 rdf:type schema:DefinedTerm
186 Nea66f49cd9f34fc38ea7ec46be370699 rdf:first sg:person.0576661143.72
187 rdf:rest Nc522cc2abb984c188b8ed330a712a0a6
188 Nf03d4d74ade7410c836d5b57e418e9a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Cell Cycle
190 rdf:type schema:DefinedTerm
191 Nf6012bf9e46946728e53e7885b230de3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Phylogeny
193 rdf:type schema:DefinedTerm
194 Nf604e74ab83d49ea84ca23948190d83e rdf:first sg:person.0620075062.38
195 rdf:rest rdf:nil
196 Nfa9113b57e8942099ccafb8ff1520ad1 rdf:first sg:person.01307573513.00
197 rdf:rest N312290486e2840c7a8d7ca5c70bff0bb
198 Nff50f0dc0d0541ff9464bb197e4931f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Neurons
200 rdf:type schema:DefinedTerm
201 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
202 schema:name Biological Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
205 schema:name Biochemistry and Cell Biology
206 rdf:type schema:DefinedTerm
207 sg:grant.4478953 http://pending.schema.org/fundedItem sg:pub.10.1038/srep40780
208 rdf:type schema:MonetaryGrant
209 sg:grant.4481309 http://pending.schema.org/fundedItem sg:pub.10.1038/srep40780
210 rdf:type schema:MonetaryGrant
211 sg:grant.4481542 http://pending.schema.org/fundedItem sg:pub.10.1038/srep40780
212 rdf:type schema:MonetaryGrant
213 sg:grant.5073107 http://pending.schema.org/fundedItem sg:pub.10.1038/srep40780
214 rdf:type schema:MonetaryGrant
215 sg:journal.1045337 schema:issn 2045-2322
216 schema:name Scientific Reports
217 rdf:type schema:Periodical
218 sg:person.010355602641.46 schema:affiliation https://www.grid.ac/institutes/grid.419134.a
219 schema:familyName da Silva Gonçalves Vianez Júnior
220 schema:givenName João Lídio
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010355602641.46
222 rdf:type schema:Person
223 sg:person.01044622061.24 schema:affiliation https://www.grid.ac/institutes/grid.472984.4
224 schema:familyName Loiola
225 schema:givenName Erick Correia
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044622061.24
227 rdf:type schema:Person
228 sg:person.01066615140.72 schema:affiliation https://www.grid.ac/institutes/grid.419134.a
229 schema:familyName de Vasconcelos
230 schema:givenName Janaina Mota
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066615140.72
232 rdf:type schema:Person
233 sg:person.01116260232.38 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
234 schema:familyName Tanuri
235 schema:givenName Amilcar
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116260232.38
237 rdf:type schema:Person
238 sg:person.01145205501.00 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
239 schema:familyName Sequeira
240 schema:givenName Patricia C.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145205501.00
242 rdf:type schema:Person
243 sg:person.01242220637.68 schema:affiliation https://www.grid.ac/institutes/grid.472984.4
244 schema:familyName Trindade
245 schema:givenName Pablo
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242220637.68
247 rdf:type schema:Person
248 sg:person.01247234671.73 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
249 schema:familyName Delvecchio
250 schema:givenName Rodrigo
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247234671.73
252 rdf:type schema:Person
253 sg:person.01247626443.24 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
254 schema:familyName Nascimento
255 schema:givenName Juliana Minardi
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247626443.24
257 rdf:type schema:Person
258 sg:person.01307573513.00 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
259 schema:familyName Higa
260 schema:givenName Luiza M.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307573513.00
262 rdf:type schema:Person
263 sg:person.01355703477.06 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
264 schema:familyName Cassoli
265 schema:givenName Juliana S.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355703477.06
267 rdf:type schema:Person
268 sg:person.016410332273.80 schema:affiliation https://www.grid.ac/institutes/grid.472984.4
269 schema:familyName Vitória
270 schema:givenName Gabriela
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016410332273.80
272 rdf:type schema:Person
273 sg:person.0576661143.72 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
274 schema:familyName Garcez
275 schema:givenName Patricia P.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576661143.72
277 rdf:type schema:Person
278 sg:person.0603040431.86 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
279 schema:familyName de Filippis
280 schema:givenName Ana M. Bispo
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603040431.86
282 rdf:type schema:Person
283 sg:person.0620075062.38 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
284 schema:familyName Rehen
285 schema:givenName Stevens K.
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620075062.38
287 rdf:type schema:Person
288 sg:person.0624531734.09 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
289 schema:familyName Martins-de-Souza
290 schema:givenName Daniel
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624531734.09
292 rdf:type schema:Person
293 sg:person.0627435043.53 schema:affiliation https://www.grid.ac/institutes/grid.271300.7
294 schema:familyName Fuzii
295 schema:givenName Hellen Thais
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627435043.53
297 rdf:type schema:Person
298 sg:person.0631201700.34 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
299 schema:familyName Aguiar
300 schema:givenName Renato S.
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631201700.34
302 rdf:type schema:Person
303 sg:person.0670202757.81 schema:affiliation https://www.grid.ac/institutes/grid.472984.4
304 schema:familyName da Costa
305 schema:givenName Rodrigo Madeiro
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670202757.81
307 rdf:type schema:Person
308 sg:person.07507225655.54 schema:affiliation https://www.grid.ac/institutes/grid.472984.4
309 schema:familyName Sochacki
310 schema:givenName Jaroslaw
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07507225655.54
312 rdf:type schema:Person
313 sg:pub.10.1038/cr.2016.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004670226
314 https://doi.org/10.1038/cr.2016.58
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/nature12517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019617574
317 https://doi.org/10.1038/nature12517
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/nature18296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047862100
320 https://doi.org/10.1038/nature18296
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/nbt.1621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031035095
323 https://doi.org/10.1038/nbt.1621
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/nmeth.2109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007540814
326 https://doi.org/10.1038/nmeth.2109
327 rdf:type schema:CreativeWork
328 sg:pub.10.1038/nmeth.2767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032502527
329 https://doi.org/10.1038/nmeth.2767
330 rdf:type schema:CreativeWork
331 sg:pub.10.1038/nn.4280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042520331
332 https://doi.org/10.1038/nn.4280
333 rdf:type schema:CreativeWork
334 sg:pub.10.1038/nprot.2008.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039987283
335 https://doi.org/10.1038/nprot.2008.211
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/nprot.2012.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030124536
338 https://doi.org/10.1038/nprot.2012.016
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/nrmicro.2016.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014137727
341 https://doi.org/10.1038/nrmicro.2016.125
342 rdf:type schema:CreativeWork
343 sg:pub.10.1186/gb-2013-14-4-r36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015459845
344 https://doi.org/10.1186/gb-2013-14-4-r36
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1002/cyto.a.20357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036783623
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1002/dvdy.21132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004411241
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1002/wdev.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041627660
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/j.cell.2016.04.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027001647
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/j.cmet.2012.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039192459
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/j.febslet.2013.05.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049880022
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/j.smim.2007.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031437893
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/j.stem.2015.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052659726
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/j.stem.2016.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010456757
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/j.stem.2016.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027748093
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/j.stem.2016.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040830162
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1016/j.stem.2016.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025190922
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1016/j.stem.2016.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025520011
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1016/j.stem.2016.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015134661
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1016/j.tiv.2015.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028652091
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1016/s0022-2496(02)00028-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025441488
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1016/s1473-3099(15)00504-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006533660
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1016/s1473-3099(16)00095-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039984193
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1046/j.1365-2893.2003.00447.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011155948
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1056/nejmoa1600651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000811266
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1073/pnas.0906413106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017988153
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1093/bioinformatics/18.3.502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007526298
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1093/bioinformatics/bts199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037623568
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1093/bioinformatics/btu033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000848409
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1093/molbev/mst010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045545793
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1093/molbev/mst197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001444669
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1093/nar/gkn760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032318578
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1093/nar/gkn923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047610281
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1093/nar/gkp667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025733953
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1093/nar/gkt206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024020914
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1093/nar/gkw765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016954976
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1096/fj.07-104455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042176121
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1101/058883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003885087
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1111/j.1558-5646.1985.tb00420.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1085717760
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1126/science.aaf6116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005431451
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1128/jvi.00354-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052159487
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1128/jvi.00397-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016071312
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1128/jvi.00836-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015196925
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1128/jvi.02418-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017319783
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1148/radiol.2016161584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015993077
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1155/2011/514681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027586828
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1371/journal.pone.0067437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015332691
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1371/journal.ppat.1004199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017506047
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1371/journal.ppat.1004319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025403782
433 rdf:type schema:CreativeWork
434 https://doi.org/10.3201/eid1305.070015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033376034
435 rdf:type schema:CreativeWork
436 https://doi.org/10.3201/eid1408.080287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013275468
437 rdf:type schema:CreativeWork
438 https://doi.org/10.3727/096368911x600957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051631185
439 rdf:type schema:CreativeWork
440 https://doi.org/10.4049/jimmunol.1201630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078681482
441 rdf:type schema:CreativeWork
442 https://doi.org/10.4161/rna.8.6.17836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029004073
443 rdf:type schema:CreativeWork
444 https://doi.org/10.5966/sctm.2013-0080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073577421
445 rdf:type schema:CreativeWork
446 https://www.grid.ac/institutes/grid.271300.7 schema:alternateName Federal University of Para
447 schema:name Federal University of Pará, Belém, Brazil
448 rdf:type schema:Organization
449 https://www.grid.ac/institutes/grid.411087.b schema:alternateName State University of Campinas
450 schema:name D’Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
451 Institute of Biology, Department of Biochemistry and Tissue Biology, University of Campinas (UNICAMP), Campinas, Brazil
452 rdf:type schema:Organization
453 https://www.grid.ac/institutes/grid.418068.3 schema:alternateName Oswaldo Cruz Foundation
454 schema:name Institute Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
455 rdf:type schema:Organization
456 https://www.grid.ac/institutes/grid.419134.a schema:alternateName Instituto Evandro Chagas
457 schema:name Center for Technological Innovation, Evandro Chagas Institute, Belém, Brazil
458 rdf:type schema:Organization
459 https://www.grid.ac/institutes/grid.472984.4 schema:alternateName D’Or Institute for Research and Education
460 schema:name D’Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
461 rdf:type schema:Organization
462 https://www.grid.ac/institutes/grid.8536.8 schema:alternateName Federal University of Rio de Janeiro
463 schema:name D’Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
464 Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
465 Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
466 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...