Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Zhijun Wang, Jianhua Xie, Yujiao Yang, Fan Zhang, Shengnan Wang, Ting Wu, Mingyue Shen, Mingyong Xie

ABSTRACT

Natural polysaccharides and their modified derivatives are crucial supplements to the prevention of inflammation. This study aimed to evaluate the effect of sulfated modification on the anti-inflammatory and anti-oxidative activities of Cyclocarya paliurus polysaccharides (CP). A sulfated CP, S-CP1-4 was obtained using chlorosulfonic acid-pyridine method. The chemical components and FT-IR spectrum confirmed that sulfated group was synthesized to the polysaccharide chains successfully. S-CP1-4 was found to inhibit nitric oxide production, phagocytic activity and the release of interleukin (IL)-6 and IL-1β in lipopolysaccharide-treated macrophage cells, RAW 264.7. S-CP1-4 significantly decreased the secretion of IL-6 and TNF-α and the thymus and spleen indexes, and increased the production of IL-10 in lipopolysaccharide-treated mice. S-CP1-4 could better protect the liver by inhibiting the activities of alanine aminotransferase and aspartate aminotransferase, and malondialdehyde level while increasing the superoxide dismutase activity and total anti-oxidative capacity. These results suggested that S-CP1-4 may be an effective anti-inflammatory agent, and sulfated modification may be a reliable method for the development of food supplements. More... »

PAGES

40402

References to SciGraph publications

  • 2015-12. Ganoderma neo-japonicum Imazeki revisited: Domestication study and antioxidant properties of its basidiocarps and mycelia in SCIENTIFIC REPORTS
  • 2016-12. Dioscorea bulbifera polysaccharide and cyclophosphamide combination enhances anti-cervical cancer effect and attenuates immunosuppression and oxidative stress in mice in SCIENTIFIC REPORTS
  • 2016-07. A proteomic analysis of mushroom polysaccharide-treated HepG2 cells in SCIENTIFIC REPORTS
  • 2009-06. Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis in EUROPEAN JOURNAL OF NUTRITION
  • 2012-01. Inflammasomes in health and disease in NATURE
  • 2015-05. Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model in SCIENTIFIC REPORTS
  • 2013-03. Neutrophil recruitment and function in health and inflammation in NATURE REVIEWS IMMUNOLOGY
  • 2015-06. Structure-Activity Relationships of Sulfated Glycoproteins from Codium fragile on Nitric Oxide Releasing Capacity from RAW264.7 Cells in JOURNAL OF MARINE BIOTECHNOLOGY
  • 2002-12. Inflammation and cancer in NATURE
  • 2003-12. Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging in INTERNATIONAL JOURNAL OF OBESITY
  • 2015-04. Astragalus polysaccharide attenuates lipopolysaccharide-induced inflammatory responses in microglial cells: regulation of protein kinase B and nuclear factor-κB signaling in INFLAMMATION RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep40402

    DOI

    http://dx.doi.org/10.1038/srep40402

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042565205

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28094275


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