Cerebrospinal fluid lens-free microscopy: a new tool for the laboratory diagnosis of meningitis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Robin Delacroix, Sophie Nhu An Morel, Lionel Hervé, Thomas Bordy, Jean-Marc Dinten, Michel Drancourt, Cédric Allier

ABSTRACT

Cerebrospinal fluid cytology is performed by operator-dependant light microscopy as part of the routine laboratory work-flow diagnosis of meningitis. We evaluated operator-independent lens-free microscopy numeration of erythrocytes and leukocytes for the cytological diagnosis of meningitis. In a first step, prospective optical microscopy counts of leukocytes done by five different operators yielded an overall 16.7% misclassification of 72 cerebrospinal fluid specimens in meningitis/non-meningitis categories using a 10 leukocyte/μL cut-off. In a second step, the lens-free microscopy algorithm adapted for counting cerebrospinal fluid cells and discriminating leukocytes from erythrocytes was modified step-by-step in the prospective analysis of 215 cerebrospinal fluid specimens. The definite algorithm yielded a 100% sensitivity and a 86% specificity compared to confirmed diagnostics. In a third step, a blind lens-free microscopic analysis of 116 cerebrospinal fluid specimens, including six cases of microbiology-confirmed infectious meningitis, yielded a 100% sensitivity and a 79% specificity. Adapted lens-free microscopy is thus emerging as an operator-independent technique for the rapid numeration of leukocytes and erythrocytes in cerebrospinal fluid. In particular, this technique is well suited to the rapid diagnosis of meningitis at point-of-care laboratories. More... »

PAGES

39893

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep39893

DOI

http://dx.doi.org/10.1038/srep39893

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035897109

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28045084


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