Promotion of natural tooth repair by small molecule GSK3 antagonists View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Vitor C. M. Neves, Rebecca Babb, Dhivya Chandrasekaran, Paul T. Sharpe

ABSTRACT

The restoration of dentine lost in deep caries lesions in teeth is a routine and common treatment that involves the use of inorganic cements based on calcium or silicon-based mineral aggregates. Such cements remain in the tooth and fail to degrade and thus normal mineral volume is never completely restored. Here we describe a novel, biological approach to dentine restoration that stimulates the natural formation of reparative dentine via the mobilisation of resident stem cells in the tooth pulp. Biodegradable, clinically-approved collagen sponges are used to deliver low doses of small molecule glycogen synthase kinase (GSK-3) antagonists that promote the natural processes of reparative dentine formation to completely restore dentine. Since the carrier sponge is degraded over time, dentine replaces the degraded sponge leading to a complete, effective natural repair. This simple, rapid natural tooth repair process could thus potentially provide a new approach to clinical tooth restoration. More... »

PAGES

39654

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep39654

DOI

http://dx.doi.org/10.1038/srep39654

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010662967

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28067250


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