PD-L1+MDSCs are increased in HCC patients and induced by soluble factor in the tumor microenvironment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12-14

AUTHORS

Tomoaki Iwata, Yasuteru Kondo, Osamu Kimura, Tatsuki Morosawa, Yasuyuki Fujisaka, Teruyuki Umetsu, Takayuki Kogure, Jun Inoue, Yu Nakagome, Tooru Shimosegawa

ABSTRACT

Myeloid-derived suppressor cells (MDSCs) could have important roles in immune regulation, and MDSCs can be induced in patients with various malignant tumors. The immune-suppressive functions of MDSCs in hepatocellular carcinoma (HCC) patients have not been clarified. Therefore, we tried to analyze the biological significance of MDSCs in HCC patients. We quantified PD-L1+MDSCs of HCC patients in various conditions by using multi-color flow cytometry analysis. PBMCs from HCC patients contained significantly higher percentages of PD-L1+MDSCs in comparison to those from healthy subjects (p < 0.001). The percentages of PD-L1+MDSCs were reduced by curative treatment for HCC (p < 0.05), and the percentages of PD-L1+MDSCs before treatment were inversely correlated with disease-free survival time. After we cocultivated PBMCs and several liver cancer cell lines in a transwell coculture system, the percentages of PD-L1+MDSCs were significantly increased compared with control (p < 0.05). The expression of M-CSF and VEGFA was higher in the cell lines that strongly induced PD-L1+MDSCs. Peripheral blood from HCC patients had significantly higher percentages of PD-L1+MDSCs in comparison to those of healthy subjects, and the percentages of PD-L1+MDSCs were reduced by HCC treatment, suggesting that we might use PD-L1+MDSCs as a new biomarker of HCC. More... »

PAGES

39296

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep39296

DOI

http://dx.doi.org/10.1038/srep39296

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032380678

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27966626


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