The 5′UTR variant of ERCC5 fails to influence outcomes in ovarian and lung cancer patients undergoing treatment with platinum-based drugs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Eliana Rulli, Federica Guffanti, Elisa Caiola, Monica Ganzinelli, Giovanna Damia, Marina C Garassino, Sheila Piva, Lorenzo Ceppi, Massimo Broggini, Mirko Marabese

ABSTRACT

The common polymorphic variant in the 5' untranslated region of the excision repair cross-complementation group 5 (ERCC5) gene was described to generate an upstream open reading frame that regulates both the basal ERCC5 expression and its ability to be synthesized following DNA damage. This variant was reported to affect response to platinum therapy in a cohort of patients with pediatric ependymoma. The role of this variant was investigated in two cohorts of cancer patients, specifically in non-small-cell lung cancer (NSCLC) patients (N = 137) and in epithelial ovarian carcinoma (EOC) patients (N = 240), treated in first-line with platinum-based compounds. Differently from what reported for pediatric ependymoma, the analysis of the polymorphism in NSCLC patients cohort was not able to detect any difference among patients harboring different genotypes both in progression free survival (HR = 0.93; 95%CI 0.64-1.33; p-value = 0.678) and overall survival (HR = 0.90; 95%CI 0.62-1.33; p-value = 0.625). These data were corroborated in a EOC patients cohort, where similar progression free survival (HR = 0.91; 95% CI 0.67-1.24; p-value = 0.561) and overall survival (HR = 0.98; 95% CI 0.71-1.35; p-value = 0.912) were found for the different genotypes. These data, obtained in appropriately sized populations, indicate that the effect of this ERCC5 polymorphism is likely to be relevant only in specific tumors. More... »

PAGES

39217

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep39217

DOI

http://dx.doi.org/10.1038/srep39217

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017613370

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27966655


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "5' Untranslated Regions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Non-Small-Cell Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Ovarian Epithelial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endonucleases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Glandular and Epithelial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharmacogenomic Variants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platinum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Mario Negri Institute for Pharmacological Research", 
          "id": "https://www.grid.ac/institutes/grid.4527.4", 
          "name": [
            "Laboratory of Methodology For Clinical Research, Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche \"Mario Negri\", 20156 Milan, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rulli", 
        "givenName": "Eliana", 
        "id": "sg:person.01053052275.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053052275.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mario Negri Institute for Pharmacological Research", 
          "id": "https://www.grid.ac/institutes/grid.4527.4", 
          "name": [
            "Laboratory of Molecular Pharmacology, Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche \"Mario Negri\", 20156 Milan, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guffanti", 
        "givenName": "Federica", 
        "id": "sg:person.01252221512.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252221512.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mario Negri Institute for Pharmacological Research", 
          "id": "https://www.grid.ac/institutes/grid.4527.4", 
          "name": [
            "Laboratory of Molecular Pharmacology, Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche \"Mario Negri\", 20156 Milan, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caiola", 
        "givenName": "Elisa", 
        "id": "sg:person.01356304623.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356304623.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ganzinelli", 
        "givenName": "Monica", 
        "id": "sg:person.0632444307.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632444307.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mario Negri Institute for Pharmacological Research", 
          "id": "https://www.grid.ac/institutes/grid.4527.4", 
          "name": [
            "Laboratory of Molecular Pharmacology, Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche \"Mario Negri\", 20156 Milan, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Damia", 
        "givenName": "Giovanna", 
        "id": "sg:person.01173403305.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173403305.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garassino", 
        "givenName": "Marina C", 
        "id": "sg:person.01314416105.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314416105.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Fatebenefratelli e Oftalmico", 
          "id": "https://www.grid.ac/institutes/grid.414759.a", 
          "name": [
            "Oncology Department, Ospedale Fatebenefratelli e Oftalmico, 20121 Milan, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piva", 
        "givenName": "Sheila", 
        "id": "sg:person.0753353605.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753353605.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera San Gerardo", 
          "id": "https://www.grid.ac/institutes/grid.415025.7", 
          "name": [
            "Clinic of Obstetrics and Gynecology, University of Milan Bicocca, San Gerardo Hospital, 20900 Monza, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ceppi", 
        "givenName": "Lorenzo", 
        "id": "sg:person.01133466663.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133466663.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mario Negri Institute for Pharmacological Research", 
          "id": "https://www.grid.ac/institutes/grid.4527.4", 
          "name": [
            "Laboratory of Molecular Pharmacology, Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche \"Mario Negri\", 20156 Milan, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broggini", 
        "givenName": "Massimo", 
        "id": "sg:person.01277571022.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277571022.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mario Negri Institute for Pharmacological Research", 
          "id": "https://www.grid.ac/institutes/grid.4527.4", 
          "name": [
            "Laboratory of Molecular Pharmacology, Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche \"Mario Negri\", 20156 Milan, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marabese", 
        "givenName": "Mirko", 
        "id": "sg:person.0746627751.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746627751.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.tpj.6500462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001370701", 
          "https://doi.org/10.1038/sj.tpj.6500462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1010600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003011924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.5607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005620277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-09599-8_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006712520", 
          "https://doi.org/10.1007/978-0-387-09599-8_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-09599-8_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006712520", 
          "https://doi.org/10.1007/978-0-387-09599-8_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a012609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007485947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2016.05.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009580035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.11.8547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009679622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/pgs-2015-0017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012489303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminoncol.2004.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014630694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminoncol.2004.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014630694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.2012.237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022698279", 
          "https://doi.org/10.1038/clpt.2012.237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks1111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026233314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028207374", 
          "https://doi.org/10.1038/nrm3822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/3-540-29623-9_7956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028760308", 
          "https://doi.org/10.1007/3-540-29623-9_7956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2005.02.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030605527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030663176", 
          "https://doi.org/10.1038/nrc2167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tpj.2014.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031164540", 
          "https://doi.org/10.1038/tpj.2014.32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tpj.2014.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031164540", 
          "https://doi.org/10.1038/tpj.2014.32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmicm1001885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039949294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2010.11.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040378318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e32835bd6ce", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040507144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e32835bd6ce", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040507144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2005.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045100611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.13.5806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045877435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(13)70310-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047147510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tpj.2011.50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049261734", 
          "https://doi.org/10.1038/tpj.2011.50"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19960611)66:6<779::aid-ijc12>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049846622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.261867.115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053376506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/igc.0b013e3181a12e09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061837895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/igc.0b013e3181a12e09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061837895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/igc.0b013e3181a12e09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061837895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/igc.0b013e3181a12e09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061837895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075255991", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078981819", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082424511", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "The common polymorphic variant in the 5' untranslated region of the excision repair cross-complementation group 5 (ERCC5) gene was described to generate an upstream open reading frame that regulates both the basal ERCC5 expression and its ability to be synthesized following DNA damage. This variant was reported to affect response to platinum therapy in a cohort of patients with pediatric ependymoma. The role of this variant was investigated in two cohorts of cancer patients, specifically in non-small-cell lung cancer (NSCLC) patients (N\u2009=\u2009137) and in epithelial ovarian carcinoma (EOC) patients (N\u2009=\u2009240), treated in first-line with platinum-based compounds. Differently from what reported for pediatric ependymoma, the analysis of the polymorphism in NSCLC patients cohort was not able to detect any difference among patients harboring different genotypes both in progression free survival (HR\u2009=\u20090.93; 95%CI 0.64-1.33; p-value\u2009=\u20090.678) and overall survival (HR\u2009=\u20090.90; 95%CI 0.62-1.33; p-value\u2009=\u20090.625). These data were corroborated in a EOC patients cohort, where similar progression free survival (HR\u2009=\u20090.91; 95% CI 0.67-1.24; p-value\u2009=\u20090.561) and overall survival (HR\u2009=\u20090.98; 95% CI 0.71-1.35; p-value\u2009=\u20090.912) were found for the different genotypes. These data, obtained in appropriately sized populations, indicate that the effect of this ERCC5 polymorphism is likely to be relevant only in specific tumors.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep39217", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "The 5\u2032UTR variant of ERCC5 fails to influence outcomes in ovarian and lung cancer patients undergoing treatment with platinum-based drugs", 
    "pagination": "39217", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "53ead305a04745dee1a989dda55167180778ed1ae07469d54e7d407083b966b2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27966655"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep39217"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017613370"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep39217", 
      "https://app.dimensions.ai/details/publication/pub.1017613370"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99809_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2016/161214/srep39217/full/srep39217.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep39217'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep39217'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep39217'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep39217'


 

This table displays all metadata directly associated to this object as RDF triples.

317 TRIPLES      21 PREDICATES      79 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep39217 schema:about N007a4596dbfe4c818c9df2a306cae8a8
2 N041ae31757334ef69db4de10fe9f199f
3 N2658d28e62c04dc099c25d7558646bcb
4 N33e5544f60cd49ac874d8cae12990218
5 N5f190bbaf294471181a2d46b96d89e3d
6 N7a4c6cc8fb824386a46d8c7cefc3cf29
7 N7f4099de67a94221ab9eaf0cd6824e8e
8 N819ace1ce71f497d8370342937e26a50
9 N8ce723d0b18446bc921a40bf8356fb5e
10 N9c501b5e44c24128839a9171126a0da8
11 Na22faa2f800746f08efa48cd6abbf0e5
12 Na6b22b33f65c4924aefe8be5c7ccd931
13 Na9363f6c7468446784ef9b796e79e6ac
14 Na9c944161ec04390ad7fd1d961160905
15 Nb29da38128294ab8800b1f3e2179d193
16 Nba626a31f71f450bbae69a1138a857e7
17 Nc4a0ae9a51aa48358515e3d947c0c00f
18 Nd03f13f02bd449e6a1978ee5f6153e06
19 Nda9c047a7da84d32b18d7ac09802836a
20 Nf6169579729b4a89829aca63ecd7bc58
21 Nfb35c05af5974b108b20a688d699bd41
22 anzsrc-for:11
23 anzsrc-for:1112
24 schema:author N5de9c6b04f7d45159c0f4d4e2af721c7
25 schema:citation sg:pub.10.1007/3-540-29623-9_7956
26 sg:pub.10.1007/978-0-387-09599-8_9
27 sg:pub.10.1038/clpt.2012.237
28 sg:pub.10.1038/nrc2167
29 sg:pub.10.1038/nrm3822
30 sg:pub.10.1038/sj.tpj.6500462
31 sg:pub.10.1038/tpj.2011.50
32 sg:pub.10.1038/tpj.2014.32
33 https://app.dimensions.ai/details/publication/pub.1075255991
34 https://app.dimensions.ai/details/publication/pub.1078981819
35 https://app.dimensions.ai/details/publication/pub.1082424511
36 https://doi.org/10.1002/(sici)1097-0215(19960611)66:6<779::aid-ijc12>3.0.co;2-z
37 https://doi.org/10.1016/j.critrevonc.2005.01.005
38 https://doi.org/10.1016/j.ctrv.2016.05.004
39 https://doi.org/10.1016/j.ejca.2010.11.029
40 https://doi.org/10.1016/j.jhep.2005.02.020
41 https://doi.org/10.1016/s1470-2045(13)70310-3
42 https://doi.org/10.1053/j.seminoncol.2004.11.004
43 https://doi.org/10.1056/nejmicm1001885
44 https://doi.org/10.1056/nejmra1010600
45 https://doi.org/10.1093/nar/gks1111
46 https://doi.org/10.1097/cad.0b013e32835bd6ce
47 https://doi.org/10.1101/cshperspect.a012609
48 https://doi.org/10.1101/gad.261867.115
49 https://doi.org/10.1111/igc.0b013e3181a12e09
50 https://doi.org/10.1200/jco.2007.11.8547
51 https://doi.org/10.1200/jco.2007.13.5806
52 https://doi.org/10.18632/oncotarget.5607
53 https://doi.org/10.2217/pgs-2015-0017
54 schema:datePublished 2016-12
55 schema:datePublishedReg 2016-12-01
56 schema:description The common polymorphic variant in the 5' untranslated region of the excision repair cross-complementation group 5 (ERCC5) gene was described to generate an upstream open reading frame that regulates both the basal ERCC5 expression and its ability to be synthesized following DNA damage. This variant was reported to affect response to platinum therapy in a cohort of patients with pediatric ependymoma. The role of this variant was investigated in two cohorts of cancer patients, specifically in non-small-cell lung cancer (NSCLC) patients (N = 137) and in epithelial ovarian carcinoma (EOC) patients (N = 240), treated in first-line with platinum-based compounds. Differently from what reported for pediatric ependymoma, the analysis of the polymorphism in NSCLC patients cohort was not able to detect any difference among patients harboring different genotypes both in progression free survival (HR = 0.93; 95%CI 0.64-1.33; p-value = 0.678) and overall survival (HR = 0.90; 95%CI 0.62-1.33; p-value = 0.625). These data were corroborated in a EOC patients cohort, where similar progression free survival (HR = 0.91; 95% CI 0.67-1.24; p-value = 0.561) and overall survival (HR = 0.98; 95% CI 0.71-1.35; p-value = 0.912) were found for the different genotypes. These data, obtained in appropriately sized populations, indicate that the effect of this ERCC5 polymorphism is likely to be relevant only in specific tumors.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N8e56002e54c442808903500fae397aa7
61 Nef9ac4bd07164e839f7a56c087ed618a
62 sg:journal.1045337
63 schema:name The 5′UTR variant of ERCC5 fails to influence outcomes in ovarian and lung cancer patients undergoing treatment with platinum-based drugs
64 schema:pagination 39217
65 schema:productId N0874ab44b45c4c93a8c9c0053901360c
66 N0bcdd30a906a4661ada301c520f1e0b9
67 N140fcebe7df1426fbf1ac4ea40d2411d
68 Ndd2238c2946d41d49eb004ab3edb6cab
69 Nfac86e06f6ae478abd265149f28849c2
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017613370
71 https://doi.org/10.1038/srep39217
72 schema:sdDatePublished 2019-04-11T09:32
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N8f2a27cadd2349c283f52739844059d2
75 schema:url http://www.nature.com/srep/2016/161214/srep39217/full/srep39217.html
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N007a4596dbfe4c818c9df2a306cae8a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Female
81 rdf:type schema:DefinedTerm
82 N041ae31757334ef69db4de10fe9f199f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name DNA-Binding Proteins
84 rdf:type schema:DefinedTerm
85 N0874ab44b45c4c93a8c9c0053901360c schema:name dimensions_id
86 schema:value pub.1017613370
87 rdf:type schema:PropertyValue
88 N0bcdd30a906a4661ada301c520f1e0b9 schema:name doi
89 schema:value 10.1038/srep39217
90 rdf:type schema:PropertyValue
91 N140fcebe7df1426fbf1ac4ea40d2411d schema:name nlm_unique_id
92 schema:value 101563288
93 rdf:type schema:PropertyValue
94 N1c5d17caea92437994a939ee7a2f6459 rdf:first sg:person.01173403305.42
95 rdf:rest Nd7ae7dffc8064011adbb959a26bf6c36
96 N2658d28e62c04dc099c25d7558646bcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name 5' Untranslated Regions
98 rdf:type schema:DefinedTerm
99 N33e5544f60cd49ac874d8cae12990218 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Platinum
101 rdf:type schema:DefinedTerm
102 N405a2364a08644d7ae3bcaa45440cbff rdf:first sg:person.01277571022.49
103 rdf:rest N589df983b3fc4467a9cf8884b021f1cf
104 N589df983b3fc4467a9cf8884b021f1cf rdf:first sg:person.0746627751.73
105 rdf:rest rdf:nil
106 N5c0cfea931ef49008f9f906208708b1c rdf:first sg:person.01252221512.03
107 rdf:rest Nc481992935224384b91c9ebe35ba33eb
108 N5de9c6b04f7d45159c0f4d4e2af721c7 rdf:first sg:person.01053052275.37
109 rdf:rest N5c0cfea931ef49008f9f906208708b1c
110 N5f190bbaf294471181a2d46b96d89e3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Aged
112 rdf:type schema:DefinedTerm
113 N7a4c6cc8fb824386a46d8c7cefc3cf29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Polymorphism, Genetic
115 rdf:type schema:DefinedTerm
116 N7f4099de67a94221ab9eaf0cd6824e8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Nuclear Proteins
118 rdf:type schema:DefinedTerm
119 N819ace1ce71f497d8370342937e26a50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Male
121 rdf:type schema:DefinedTerm
122 N8ce723d0b18446bc921a40bf8356fb5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Antineoplastic Agents
124 rdf:type schema:DefinedTerm
125 N8e56002e54c442808903500fae397aa7 schema:volumeNumber 6
126 rdf:type schema:PublicationVolume
127 N8f2a27cadd2349c283f52739844059d2 schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 N9c501b5e44c24128839a9171126a0da8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Treatment Outcome
131 rdf:type schema:DefinedTerm
132 Na22faa2f800746f08efa48cd6abbf0e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Transcription Factors
134 rdf:type schema:DefinedTerm
135 Na6b22b33f65c4924aefe8be5c7ccd931 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Carcinoma, Ovarian Epithelial
137 rdf:type schema:DefinedTerm
138 Na9363f6c7468446784ef9b796e79e6ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Humans
140 rdf:type schema:DefinedTerm
141 Na9c944161ec04390ad7fd1d961160905 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Survival Analysis
143 rdf:type schema:DefinedTerm
144 Nb29da38128294ab8800b1f3e2179d193 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Ovarian Neoplasms
146 rdf:type schema:DefinedTerm
147 Nba626a31f71f450bbae69a1138a857e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Lung Neoplasms
149 rdf:type schema:DefinedTerm
150 Nc481992935224384b91c9ebe35ba33eb rdf:first sg:person.01356304623.22
151 rdf:rest Nda5e6e1b4a09499aaa0d1c971fadbad5
152 Nc4a0ae9a51aa48358515e3d947c0c00f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Carcinoma, Non-Small-Cell Lung
154 rdf:type schema:DefinedTerm
155 Nd03f13f02bd449e6a1978ee5f6153e06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Neoplasms, Glandular and Epithelial
157 rdf:type schema:DefinedTerm
158 Nd7ae7dffc8064011adbb959a26bf6c36 rdf:first sg:person.01314416105.98
159 rdf:rest Ne3bcc202e47643359c6dacd1a29bc249
160 Nda5e6e1b4a09499aaa0d1c971fadbad5 rdf:first sg:person.0632444307.76
161 rdf:rest N1c5d17caea92437994a939ee7a2f6459
162 Nda9c047a7da84d32b18d7ac09802836a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Pharmacogenomic Variants
164 rdf:type schema:DefinedTerm
165 Ndd2238c2946d41d49eb004ab3edb6cab schema:name pubmed_id
166 schema:value 27966655
167 rdf:type schema:PropertyValue
168 Ne0922658dd154c448263d4915987c234 rdf:first sg:person.01133466663.08
169 rdf:rest N405a2364a08644d7ae3bcaa45440cbff
170 Ne3bcc202e47643359c6dacd1a29bc249 rdf:first sg:person.0753353605.44
171 rdf:rest Ne0922658dd154c448263d4915987c234
172 Nef9ac4bd07164e839f7a56c087ed618a schema:issueNumber 1
173 rdf:type schema:PublicationIssue
174 Nf6169579729b4a89829aca63ecd7bc58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Middle Aged
176 rdf:type schema:DefinedTerm
177 Nfac86e06f6ae478abd265149f28849c2 schema:name readcube_id
178 schema:value 53ead305a04745dee1a989dda55167180778ed1ae07469d54e7d407083b966b2
179 rdf:type schema:PropertyValue
180 Nfb35c05af5974b108b20a688d699bd41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Endonucleases
182 rdf:type schema:DefinedTerm
183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
184 schema:name Medical and Health Sciences
185 rdf:type schema:DefinedTerm
186 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
187 schema:name Oncology and Carcinogenesis
188 rdf:type schema:DefinedTerm
189 sg:journal.1045337 schema:issn 2045-2322
190 schema:name Scientific Reports
191 rdf:type schema:Periodical
192 sg:person.01053052275.37 schema:affiliation https://www.grid.ac/institutes/grid.4527.4
193 schema:familyName Rulli
194 schema:givenName Eliana
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053052275.37
196 rdf:type schema:Person
197 sg:person.01133466663.08 schema:affiliation https://www.grid.ac/institutes/grid.415025.7
198 schema:familyName Ceppi
199 schema:givenName Lorenzo
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133466663.08
201 rdf:type schema:Person
202 sg:person.01173403305.42 schema:affiliation https://www.grid.ac/institutes/grid.4527.4
203 schema:familyName Damia
204 schema:givenName Giovanna
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173403305.42
206 rdf:type schema:Person
207 sg:person.01252221512.03 schema:affiliation https://www.grid.ac/institutes/grid.4527.4
208 schema:familyName Guffanti
209 schema:givenName Federica
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252221512.03
211 rdf:type schema:Person
212 sg:person.01277571022.49 schema:affiliation https://www.grid.ac/institutes/grid.4527.4
213 schema:familyName Broggini
214 schema:givenName Massimo
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277571022.49
216 rdf:type schema:Person
217 sg:person.01314416105.98 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
218 schema:familyName Garassino
219 schema:givenName Marina C
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314416105.98
221 rdf:type schema:Person
222 sg:person.01356304623.22 schema:affiliation https://www.grid.ac/institutes/grid.4527.4
223 schema:familyName Caiola
224 schema:givenName Elisa
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356304623.22
226 rdf:type schema:Person
227 sg:person.0632444307.76 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
228 schema:familyName Ganzinelli
229 schema:givenName Monica
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632444307.76
231 rdf:type schema:Person
232 sg:person.0746627751.73 schema:affiliation https://www.grid.ac/institutes/grid.4527.4
233 schema:familyName Marabese
234 schema:givenName Mirko
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746627751.73
236 rdf:type schema:Person
237 sg:person.0753353605.44 schema:affiliation https://www.grid.ac/institutes/grid.414759.a
238 schema:familyName Piva
239 schema:givenName Sheila
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753353605.44
241 rdf:type schema:Person
242 sg:pub.10.1007/3-540-29623-9_7956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028760308
243 https://doi.org/10.1007/3-540-29623-9_7956
244 rdf:type schema:CreativeWork
245 sg:pub.10.1007/978-0-387-09599-8_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006712520
246 https://doi.org/10.1007/978-0-387-09599-8_9
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/clpt.2012.237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022698279
249 https://doi.org/10.1038/clpt.2012.237
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nrc2167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030663176
252 https://doi.org/10.1038/nrc2167
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nrm3822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028207374
255 https://doi.org/10.1038/nrm3822
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/sj.tpj.6500462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001370701
258 https://doi.org/10.1038/sj.tpj.6500462
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/tpj.2011.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049261734
261 https://doi.org/10.1038/tpj.2011.50
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/tpj.2014.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031164540
264 https://doi.org/10.1038/tpj.2014.32
265 rdf:type schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1075255991 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1078981819 schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1082424511 schema:CreativeWork
269 https://doi.org/10.1002/(sici)1097-0215(19960611)66:6<779::aid-ijc12>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1049846622
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.critrevonc.2005.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045100611
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.ctrv.2016.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009580035
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.ejca.2010.11.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040378318
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.jhep.2005.02.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030605527
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s1470-2045(13)70310-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047147510
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1053/j.seminoncol.2004.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014630694
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1056/nejmicm1001885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039949294
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1056/nejmra1010600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003011924
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1093/nar/gks1111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026233314
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1097/cad.0b013e32835bd6ce schema:sameAs https://app.dimensions.ai/details/publication/pub.1040507144
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1101/cshperspect.a012609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007485947
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1101/gad.261867.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053376506
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1111/igc.0b013e3181a12e09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061837895
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1200/jco.2007.11.8547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009679622
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1200/jco.2007.13.5806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045877435
300 rdf:type schema:CreativeWork
301 https://doi.org/10.18632/oncotarget.5607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005620277
302 rdf:type schema:CreativeWork
303 https://doi.org/10.2217/pgs-2015-0017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012489303
304 rdf:type schema:CreativeWork
305 https://www.grid.ac/institutes/grid.414759.a schema:alternateName Azienda Ospedaliera Fatebenefratelli e Oftalmico
306 schema:name Oncology Department, Ospedale Fatebenefratelli e Oftalmico, 20121 Milan, Italy.
307 rdf:type schema:Organization
308 https://www.grid.ac/institutes/grid.415025.7 schema:alternateName Azienda Ospedaliera San Gerardo
309 schema:name Clinic of Obstetrics and Gynecology, University of Milan Bicocca, San Gerardo Hospital, 20900 Monza, Italy.
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
312 schema:name Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
313 rdf:type schema:Organization
314 https://www.grid.ac/institutes/grid.4527.4 schema:alternateName Mario Negri Institute for Pharmacological Research
315 schema:name Laboratory of Methodology For Clinical Research, Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", 20156 Milan, Italy.
316 Laboratory of Molecular Pharmacology, Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", 20156 Milan, Italy.
317 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...