Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12-09

AUTHORS

Raphaële Castagné, Michelle Kelly-Irving, Gianluca Campanella, Florence Guida, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Jos Kleinjans, Theo de Kok, Soterios A. Kyrtopoulos, Thierry Lang, Silvia Stringhini, Roel Vermeulen, Paolo Vineis, Cyrille Delpierre, Marc Chadeau-Hyam

ABSTRACT

Consistent evidence is accumulating to link lower socioeconomic position (SEP) and poorer health, and the inflammatory system stands out as a potential pathway through which socioeconomic environment is biologically embedded. Using bloodderived genome-wide transcriptional profiles from 268 Italian participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we evaluated the association between early life, young and later adulthood SEP and the expression of 845 genes involved in human inflammatory responses. These were examined individually and jointly using several inflammatory scores. Our results consistently show that participants whose father had a manual (as compared to nonmanual) occupation exhibit, later in life, a higher inflammatory score, hence indicating an overall increased level of expression for the selected inflammatory-related genes. Adopting a life course approach, these associations remained statistically significant upon adjustment for later-in-life socioeconomic experiences. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated, and were replicated in an independent study. Our study provides additional evidence that childhood SEP is associated with a sustainable upregulation of the inflammatory transcriptome, independently of subsequent socioeconomic experiences. Our results support the hypothesis that early social inequalities impacts adult physiology. More... »

PAGES

38705

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep38705

DOI

http://dx.doi.org/10.1038/srep38705

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042385241

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27934951


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366 schema:name Piedmont Reference Centre for Epidemiology and Cancer Prevention (CPO Piemonte), Viale Settimio Severo nr. 65, 10133 Turin, Italy
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368 grid-institutes:grid.4691.a schema:alternateName Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy
369 schema:name Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy
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371 grid-institutes:grid.482968.9 schema:alternateName Institute of Social and Preventive Medicine, Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland
372 schema:name Institute of Social and Preventive Medicine, Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland
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374 grid-institutes:grid.5012.6 schema:alternateName Department of Toxicogenomics, Maastricht University, 6211 LK Maastricht, The Netherlands
375 schema:name Department of Toxicogenomics, Maastricht University, 6211 LK Maastricht, The Netherlands
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377 grid-institutes:grid.5477.1 schema:alternateName Institute for Risk Assessment Sciences (IRAS), Utrecht University, PO Box 80178, 3508 TD, Utrecht, The Netherlands
378 schema:name Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK
379 Institute for Risk Assessment Sciences (IRAS), Utrecht University, PO Box 80178, 3508 TD, Utrecht, The Netherlands
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381 grid-institutes:grid.7445.2 schema:alternateName Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK
382 MRC-PHE Centre for Environment and Health, Imperial College, Praed Street Wing, St Mary’s Campus, W2 1PG London, UK
383 schema:name Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK
384 HuGeF, Human Genetics Foundation, Via Nizza 52, 10126 Torino, Italy
385 MRC-PHE Centre for Environment and Health, Imperial College, Praed Street Wing, St Mary’s Campus, W2 1PG London, UK
386 rdf:type schema:Organization
 




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