A network intervention that locates and intervenes with recently HIV-infected persons: The Transmission Reduction Intervention Project (TRIP) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Georgios K. Nikolopoulos, Eirini Pavlitina, Stephen Q. Muth, John Schneider, Mina Psichogiou, Leslie D. Williams, Dimitrios Paraskevis, Vana Sypsa, Gkikas Magiorkinis, Pavlo Smyrnov, Anya Korobchuk, Tetyana I. Vasylyeva, Britt Skaathun, Melpomeni Malliori, Evangelos Kafetzopoulos, Angelos Hatzakis, Samuel R. Friedman

ABSTRACT

Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013-2015) and focused on drug injector networks. Based on HIV status, testing history, and the results of an assay to detect recent infections, TRIP classified drug injector "Seeds" into groups: Recent Seeds (RS), and Control Seeds with Long-term HIV infection (LCS). The network members of RS and LCS were traced for two steps. The analysis included 23 RS, 171 network members of the RS, 19 LCS, and 65 network members of the LCS. The per-seed number of recents detected in the network of RS was 5 times the number in the network of LCS (Ratio RS vs. LCS: 5.23; 95% Confidence Interval (CI): 1.54-27.61). The proportion of recents among HIV positives in the network of RS (27%) was approximately 3 times (Ratio RS vs. LCS: 3.30; 95% CI: 1.04-10.43) that in the network of LCS (8%). Strategic network tracing that starts with recently infected persons could support public health efforts to find and treat people early in their HIV infection. More... »

PAGES

38100

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep38100

DOI

http://dx.doi.org/10.1038/srep38100

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024836773

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27917890


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