Prognostic implications of aspiration pneumonia in patients with community acquired pneumonia: A systematic review with meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12-07

AUTHORS

Kosaku Komiya, Bruce K. Rubin, Jun-ichi Kadota, Hiroshi Mukae, Tomohiro Akaba, Hiroshi Moro, Nobumasa Aoki, Hiroki Tsukada, Shingo Noguchi, Nobuaki Shime, Osamu Takahashi, Shigeru Kohno

ABSTRACT

Aspiration pneumonia is thought to be associated with a poor outcome in patients with community acquired pneumonia (CAP). However, there has been no systematic review regarding the impact of aspiration pneumonia on the outcomes in patients with CAP. This review was conducted using the MOOSE guidelines: Patients: patients defined CAP. Exposure: aspiration pneumonia defined as pneumonia in patients who have aspiration risk. Comparison: confirmed pneumonia in patients who were not considered to be at high risk for oral aspiration. Outcomes: mortality, hospital readmission or recurrent pneumonia. Three investigators independently identified published cohort studies from PubMed, CENTRAL database, and EMBASE. Nineteen studies were included for this systematic review. Aspiration pneumonia increased in-hospital mortality (relative risk, 3.62; 95% CI, 2.65–4.96; P < 0.001, seven studies) and 30-day mortality (3.57; 2.18–5.86; P < 0.001, five studies). In contrast, aspiration pneumonia was associated with decreased ICU mortality (relative risk, 0.40; 95% CI, 0.26–0.60; P < 0.00001, four studies). Although there are insufficient data to perform a meta-analysis on long-term mortality, recurrent pneumonia, and hospital readmission, the few reported studies suggest that aspiration pneumonia is also associated with these poor outcomes. In conclusion, aspiration pneumonia was associated with both higher in-hospital and 30-day mortality in patients with CAP outside ICU settings. More... »

PAGES

38097

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep38097

DOI

http://dx.doi.org/10.1038/srep38097

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013028538

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27924871


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37 aspiration
38 aspiration pneumonia
39 aspiration risk
40 cap
41 central database
42 cohort study
43 community
44 conclusion
45 contrast
46 data
47 database
48 guidelines
49 high risk
50 hospital
51 hospital mortality
52 hospital readmission
53 impact
54 implications
55 insufficient data
56 investigators
57 long-term mortality
58 mortality
59 oral aspiration
60 outcomes
61 patients
62 pneumonia
63 poor outcome
64 prognostic implications
65 readmission
66 recurrent pneumonia
67 review
68 risk
69 setting
70 study
71 systematic review
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