Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Yun-Ji Lim, Min-Hee Yi, Ji-Ae Choi, Junghwan Lee, Ji-Ye Han, Sung-Hee Jo, Sung-Man Oh, Hyun Jin Cho, Dong Woon Kim, Min-Woong Kang, Chang-Hwa Song

ABSTRACT

Alteration of macrophage function has an important regulatory impact on the survival of intracellular mycobacteria. We found that macrophages infected with attenuated Mycobacterium tuberculosis (Mtb) strain H37Ra had elevated expression of M1-related molecules, whereas the M2 phenotype was dominant in macrophages infected with virulent Mtb H37Rv. Further, the TLR signalling pathway played an important role in modulating macrophage polarization against Mtb infection. Interestingly, endoplasmic reticulum (ER) stress was significantly increased in M1 polarized macrophages and these macrophages effectively removed intracellular Mtb, indicating that ER stress may be an important component of the host immune response to Mtb in M1 macrophages. This improved understanding of the mechanisms that regulate macrophage polarization could provide new therapeutic strategies for tuberculosis. More... »

PAGES

37211

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep37211

DOI

http://dx.doi.org/10.1038/srep37211

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043902641

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27845414


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep37211'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep37211'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep37211'


 

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