Imaging Cytometry of Human Leukocytes with Third Harmonic Generation Microscopy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Cheng-Ham Wu, Tzung-Dau Wang, Chia-Hung Hsieh, Shih-Hung Huang, Jong-Wei Lin, Szu-Chun Hsu, Hau-Tieng Wu, Yao-Ming Wu, Tzu-Ming Liu

ABSTRACT

Based on third-harmonic-generation (THG) microscopy and a k-means clustering algorithm, we developed a label-free imaging cytometry method to differentiate and determine the types of human leukocytes. According to the size and average intensity of cells in THG images, in a two-dimensional scatter plot, the neutrophils, monocytes, and lymphocytes in peripheral blood samples from healthy volunteers were clustered into three differentiable groups. Using these features in THG images, we could count the number of each of the three leukocyte types both in vitro and in vivo. The THG imaging-based counting results agreed well with conventional blood count results. In the future, we believe that the combination of this THG microscopy-based imaging cytometry approach with advanced texture analysis of sub-cellular features can differentiate and count more types of blood cells with smaller quantities of blood. More... »

PAGES

37210

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep37210

DOI

http://dx.doi.org/10.1038/srep37210

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035212445

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27845443


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