First steps to define murine amniotic fluid stem cell microenvironment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

E Bertin, M Piccoli, C Franzin, G Spiro, S Donà, A Dedja, F Schiavi, E Taschin, P Bonaldo, P Braghetta, P De Coppi, M Pozzobon

ABSTRACT

Stem cell niche refers to the microenvironment where stem cells reside in living organisms. Several elements define the niche and regulate stem cell characteristics, such as stromal support cells, gap junctions, soluble factors, extracellular matrix proteins, blood vessels and neural inputs. In the last years, different studies demonstrated the presence of cKit+ cells in human and murine amniotic fluid, which have been defined as amniotic fluid stem (AFS) cells. Firstly, we characterized the murine cKit+ cells present both in the amniotic fluid and in the amnion. Secondly, to analyze the AFS cell microenvironment, we injected murine YFP+ embryonic stem cells (ESC) into the amniotic fluid of E13.5 wild type embryos. Four days after transplantation we found that YFP+ sorted cells maintained the expression of pluripotency markers and that ESC adherent to the amnion were more similar to original ESC in respect to those isolated from the amniotic fluid. Moreover, cytokines evaluation and oxygen concentration analysis revealed in this microenvironment the presence of factors that are considered key regulators in stem cell niches. This is the first indication that AFS cells reside in a microenvironment that possess specific characteristics able to maintain stemness of resident and exogenous stem cells. More... »

PAGES

37080

References to SciGraph publications

  • 2013. Isolation of c-Kit+ Human Amniotic Fluid Stem Cells from Second Trimester in STEM CELL NICHE
  • 2015-10. Heterogeneous lineage marker expression in naive embryonic stem cells is mostly due to spontaneous differentiation in SCIENTIFIC REPORTS
  • 1981-07. Establishment in culture of pluripotential cells from mouse embryos in NATURE
  • 2007-01. Isolation of amniotic stem cell lines with potential for therapy in NATURE BIOTECHNOLOGY
  • 2007-05. Bone marrow mesenchymal stem cells are abnormal in multiple myeloma in LEUKEMIA
  • 2001-11. Stem cells find their niche in NATURE
  • 2012-01. Quantitative and semiquantitative immunoassay of growth factors and cytokines in the conditioned medium of STO and CF-1 mouse feeder cells in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - ANIMAL
  • 2006-12. Mining the Wnt pathway for cancer therapeutics in NATURE REVIEWS DRUG DISCOVERY
  • 2005-02. Rejuvenation of aged progenitor cells by exposure to a young systemic environment in NATURE
  • 2003-10. Identification of the haematopoietic stem cell niche and control of the niche size in NATURE
  • 2007-09. Intrinsic Changes and Extrinsic Influences of Myogenic Stem Cell Function During Aging in STEM CELL REVIEWS AND REPORTS
  • 2007-12. Nanog safeguards pluripotency and mediates germline development in NATURE
  • 2010-09. Murine amniotic fluid stem cells contribute mesenchymal but not epithelial components to reconstituted mammary ducts in STEM CELL RESEARCH & THERAPY
  • 2008-06. Optimized mouse ES cell culture system by suspension growth in a fully defined medium in NATURE PROTOCOLS
  • 2012-01-25. Endothelial and perivascular cells maintain haematopoietic stem cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep37080

    DOI

    http://dx.doi.org/10.1038/srep37080

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030623412

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27845396


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